Tumor antigen for antitumor therapeutic vaccines therapeutic antigen of tumor. Medical search. Frequent questions

In the context of cancer, appropriately activated DCs can induce anti-tumor immunity by activating innate immune cells and tumor-specific lymphocytes that target cancer cells. (mdpi.com)
Vaccine strategies that concentrate on stimulating T cell immunity will at best generate reactive and persisting T cell responses that can suppress virus without preventing infection, limiting or preventing the damage the virus cause. (scielo.br)
Adoptive cellular therapy transmits the sensitized T cells to patients with low cellular immune function, which helps patients obtain antitumor immunity. (hindawi.com)
Survival rates for patients with locally advanced disease are poor after standard of care chemoradiation treatment, while immune therapeutic strategies including vaccines that target the virus-encoded E6 and E7 oncoproteins have mostly been ineffective in inducing regression of established HPV+ tumors despite promoting antigen-specific adaptive immunity. (bmj.com)
Conclusions Overall, these data provide strong support for therapeutic strategies promoting innate immune responses along with antigen-specific immunity, as evidenced by the therapeutic HPV peptide vaccine formulation in the present investigation, for potential clinical assessment in patients with HPV+ cancers. (bmj.com)
Here, we illustrated that myeloid cells in K14HPV16/H2b mice possess potent immunosuppressive activity toward antigen-presenting cells and CD8 + T cells, dampening antitumor immunity. (nih.gov)
These results established immunosuppressive myeloid cells in lymphoid organs as an HPV + cancer-induced means of circumventing tumor immunity that will require targeted abrogation to enable the induction of efficacious antitumor immune responses. (nih.gov)
In addition, whereas weak pre-existing immunity did not alter the protective thresholds of the vaccine-specific T cell response following subsequent immunization with CMV-based vaccine vectors, strong pre-existing immunity inhibited the development of vaccine-induced T cells and their control on tumor progression. (bmj.com)
Multimodal immunogenic cell death (ICD) together with autophagy often induced by OVs not only presents potent danger signals to dendritic cells but also efficiently cross-present tumor-associated antigens from cancer cells to dendritic cells to T cells to induce adaptive antitumor immunity. (biomedcentral.com)
OVs armed with GM-CSF (such as T-VEC and Pexa-Vec) or other immunostimulatory genes, induce potent anti-tumor immunity in both animal models and human patients. (biomedcentral.com)
Coadministration with a HDAC inhibitor inhibits innate immunity transiently to promote infection and spread of OVs, and significantly enhances anti-tumor immunity and improves the therapeutic index. (biomedcentral.com)
Combination with cyclophosphamide further induces ICD, depletes Treg, and thus potentiates antitumor immunity. (biomedcentral.com)
The antitumor immunity helps eliminate the uninfected cancer cells in primary and metastatic nodules, and enforce micrometastases in dormant state. (biomedcentral.com)
Dendritic cells (DCs) serve as professional antigen-presenting cells (APC) bridging innate and adaptive immunity, playing an essential role in triggering specific cellular and humoral responses against tumor and infectious antigens. (bvsalud.org)
However, the specific contribution of Trm cells to anti-tumor immunity is incompletely understood. (lifeboat.com)
Indeed, the use of peptides for eliciting specific antitumor adaptive immunity is hindered by two main limitations: the efficient selection of the most optimal candidate peptides and the use of a highly immunogenic platform to combine with the peptides to induce effective tumor-specific adaptive immune responses. (elifesciences.org)
These findings underscore the importance of survivin as a trigger for tumor-restricting immunity and provide therapeutic evidence of ROPs' anti-tumor potential, especially when combined with other immunostimulants, such as anti-4-1BB agonists. (ox.ac.uk)
Gene-modified tumor cells have been employed in a vaccination setting to trigger therapeutic antitumor immunity against metastatic renal cell carcinoma. (nova.edu)
At DFCI, she has initiated an integrated program of research and clinical activities that focuses on dissecting the basis of effective anti-tumor immunity. (nki.nl)
Studies in mice have found that certain bacterial immunostimulants can enhance the anti-tumor effects of ICIs by strengthening innate immunity and T cell functions . (microbiomepost.com)
Due to their proficiency at antigen presentation, DCs are key coordinators in the induction of antitumor immunity. (moffitt.org)
Theme co-leader, Jinming Gao, Ph.D., has collaborated with Zhijian "James" Chen, Ph.D., to develop nanoparticle vaccines to activate the STING pathway to boost antitumour immunity and the response to cancer immunotherapy. (utsouthwestern.edu)
Central to this proposal is the observation that all three classes of drugs augment discrete elements of host immunity, making their integration with therapeutic cancer vaccines ripe for exploration. (acgtfoundation.org)
In early phase clinical trials for both acute and chronic myeloid leukemias, we have observed the induction of anti-tumor immunity and associated clinical responses following K562/GM-CSF vaccination (see preliminary data). (acgtfoundation.org)
Thus, monocyte depletion by gemcitabine administration reduced the generation of these DC and increased vaccine-induced immunity, which rejected about 20% of LLC-OVA and B16-OVA tumors, which are non-responders to anti-PD-1. (unav.edu)
The presence of such cancer neoantigen recognizing T cells has been associated with effective antitumor immunity in humans. (patent-art.com)
Recent success of personalized cancer vaccines can be attributed to the RNA mutanome vaccine and peptide-based vaccine induced by poly-specific therapeutic immunity. (patent-art.com)
We have developed genetic and genomics approaches to explain the large variance in anti-tumor immunity across people, and to discover how tumors evolve to resist productive immunity. (massgeneral.org)
We've identified somatic mutations in tumors that are associated with anti-tumor immunity in patients, found T cell subtypes that are associated with a response to anti- PD-1 immunotherapy in melanoma and are studying their properties now (Sade-Feldman et al. (massgeneral.org)
2020. Enhanced antitumor immunity through sequential targeting of PI3Kδ and LAG3 . (cardiff.ac.uk)
2017. Effect of modified vaccinia Ankara-5T4 and low-dose cyclophosphamide on antitumor immunity in metastatic colorectal cancer: A randomized clinical trial . (cardiff.ac.uk)
Unique compared to other vaccines approved or under development, the GeoVax vaccine candidate is therefore specifically designed to provide a broader and more durable level of protective immunity against SARS-CoV-2, which may protect against emerging variants while avoiding the potential side effects that can limit vaccine utility and acceptance. (geovax.com)
The adaptive immune system, discovered by Paul Ehrlich, involves the production of circulating antibodies that can provide long lasting, systemic immunity that is specific to antigens expressed by a given pathogen. (aacrjournals.org)
Relationship between hematogenous tumor cell dissemination and cellular immunity in DCIS patients. (nature.com)

Strikingly, complete regressions of large established tumors depended on the tumor-infiltrating macrophages that were induced by this immunotherapy, because a small-molecule drug inhibitor targeting CSF-1R diminished the number of intratumoral macrophages and abrogated the complete remissions. (aacrjournals.org)
Tumor immunotherapy brings substantial and long-term clinical benefits that can even cure tumors. (hindawi.com)
Tumor immunotherapy refers to novel therapeutic measures that turn the immune system into a destructive force against tumors [ 1 ]. (hindawi.com)
In recent years, tumor immunotherapy has achieved significant success in various cancers and has been one of the hotspots in the life sciences, especially immune checkpoint inhibitors and adoptive cellular therapy [ 3 ]. (hindawi.com)
Checkpoint immunotherapy has had major successes in some cancers, but responses have been more limited in prostate cancer, while cancer vaccines have had a modest benefit. (pcf.org)
McNeel and team are developing prostate cancer vaccines and testing them in combination with checkpoint immunotherapy for the treatment of prostate cancer. (pcf.org)
The hypothesis is that checkpoint immunotherapy, which works by blocking the off-signals on T cells, will boost anti-tumor responses elicited by vaccines. (pcf.org)
This project will determine whether two prostate cancer vaccines is more effective than one, in combination with checkpoint immunotherapy. (pcf.org)
Dr. McNeel and team will conduct a clinical trial testing the combination of two therapeutic prostate cancer vaccines plus the checkpoint immunotherapy anti-PD1, which may result in an effective new therapy for prostate cancer patients. (pcf.org)
In recent years, immunotherapy to activate anti-cancer host immune cells to kill tumors has become a new area of research for the treatment of prostate cancer. (asmepress.com)
As an important component of immunotherapy, cancer vaccines have a unique position in the precise treatment of malignant tumors. (asmepress.com)
As the most important cancer vaccine based on monocytes, it is the only prostate cancer therapeutic vaccine approved by the US Food and Drug Administration at present, which plays an extremely important role in the immunotherapy of prostate cancer. (asmepress.com)
Currently, the complexity of immunotherapy and the specificity of prostate cancer mean that other prostate cancer vaccines have not shown expected clinical benefits in large randomized phase II and III trials, and further in-depth studies are still needed. (asmepress.com)
In the past decades, immunotherapy has been used to treat prostate cancer through anti-tumor effects driven by immune response. (asmepress.com)
Pembrolizumab has become an important therapeutic tool for prostate cancer immunotherapy [7, 8]. (asmepress.com)
As an important part of immunotherapy, cancer vaccines have unique and significant advantages against prostate cancer, including monocyte vaccines and dendritic cells,accines, viral vaccines, peptide vaccines and DNA/mRNA vaccines [9]. (asmepress.com)
Defined immune thresholds for tumor protection and the factors affecting such thresholds have not well been investigated in cancer immunotherapy. (bmj.com)
Combination with other immunotherapy regimens improve overall therapeutic efficacy. (biomedcentral.com)
Author information Abstract Immunotherapy is a growing therapeutic strategy in oncology based on the stimulation of innate and adaptive immune systems to induce the death of tumour cells. (ebi.ac.uk)
These results confirmed the feasibility of applying the described pipeline for the selection of peptide candidates and generation of therapeutic oncolytic cancer vaccine, filling a gap in the field of cancer immunotherapy, and paving the way to translate our pipeline into human therapeutic approach. (elifesciences.org)
Anti-cancer vaccination emerged as a promising and cost-effective immunotherapy, but the lack of immunogenicity has hindered the success of therapeutic vaccine development. (ox.ac.uk)
In the field of cancer immunotherapy, significant enthusiasm has been directed at the use of cancer vaccines in patients in order to elicit specific immune responses to target tumors. (alphavax.com)
The decision to initiate a cancer immunotherapy program for solid tumors was based on a careful analysis of current cancer therapies and developing strategies. (alphavax.com)
Novel immunotherapy strategy and therapeutic target has become a recent research focus in the effort of finding cures for NSCLC. (thno.org)
The sex hormone-gut microbiome axis plays a critical role in tumor immunotherapy, and further research in this area could lead to the development of novel approaches to cancer treatment. (microbiomepost.com)
It is suggested that manipulation of the gut microbiome could regulate the levels of sex hormones and enhance the antitumor efficacy of ICIs , thereby providing new avenues for tumor immunotherapy. (microbiomepost.com)
This CMN-001 is an autologous, tumor antigen-loaded dendritic cell immunotherapy. (moffitt.org)
Background Neoantigens, new immunogenic sequences arising from tumor mutations, have been associated with response to immunotherapy and are considered potential targets for vaccination. (unav.edu)
Immune-inflamed tumors are called hot tumors, while the latter two are collectively referred to as cold tumors, and they respond poorly to immunotherapy. (nature.com)
Developed as the next generation of immunotherapy, it uses personal and precision vaccines as well as T cell therapies to direct T cells directly toward a patient's tumors. (patent-art.com)
The first chimeric antigen receptor- (CAR-) T cell immunotherapy, anti-CD19 CAR-T for B cell lymphoma, was approved by the USFDA in August 2017. (patent-art.com)
Nat Biotech 2020), which are now being used to develop novel therapeutic approaches and targets for immunotherapy, such as personal tumor vaccines targeting multiple HLA-associated neoantigens in human tumors (together with Dr. Catherine Wu at DFCI, Ott et al. (massgeneral.org)
Because tumour dormancy provides a unique therapeutic window to prevent metastatic disease, we discuss on-going clinical trials and weigh the potential for immunotherapy to eradicate dormant disease. (nature.com)
Personalized anti-cancer vaccine combining mRNA and immunotherapy tested in melanoma trial. (cdc.gov)
Passive cellular immunotherapy references A number of immunologic interventions, both passive and active, can be directed against tumor cells. (msdmanuals.com)

The rapidly growing interest in therapeutic vaccines (i.e. active immunotherapies) for cancer and the documented efficacy of KLH as a superior carrier protein for cancer vaccines are creating a significant biopharmaceutical market for KLH formulations. (wikipedia.org)

However, the tumor microenvironment (TME) imposes different mechanisms that facilitate the impairment of DC functions, such as inefficient antigen presentation or polarization into immunosuppressive DCs. (mdpi.com)
Therefore, vaccination strategies to significantly enhance antitumor immune responses with multiple effector functions to overcome the prevailing immunosuppressive tumor microenvironment are necessary to achieve curative efficacy against established HPV+ tumors. (bmj.com)
Vaccination alone or in combination with anti-PD-1/anti-CTLA4 did not elicit tumor regression nor increase CD8 + T cells in the tumor microenvironment (TME), suggesting the presence of immune-suppressive barriers. (nih.gov)
Local administration or OV mediated-expression of ligands for Toll-like receptors can rescue the function of tumor-infiltrating CD8 + T cells inhibited by the immunosuppressive tumor microenvironment and thus enhances the antitumor effect. (biomedcentral.com)
In addition, ITI-3000 induced changes in the tumor microenvironment, including increased numbers of CD4 and CD8 T cells, reduced frequency of myeloid cells, and enhanced pro-inflammatory cytokine production. (biospace.com)
These include the role of host cell PD-L1 expression, efficacy of dual innate and adaptive checkpoints, the role of IFNα targeting, tumor-reprogrammed resident T cells, targeting tertiary lymphoid structures, strategies to facilitate T cell infiltration in tumor microenvironment, and synergistic interactions between radiation and checkpoint blockade. (utsouthwestern.edu)
Although RT is an important modality for cancer treatment, the consequential changes caused by RT in the tumor microenvironment (TME) have not yet been fully elucidated. (nature.com)
Furthermore, inflammatory mediators released by irradiated dying cells can attract and regulate immune cells in the tumor microenvironment (TME), further killing cancer cells. (nature.com)
Regardless of the therapeutic approach, the heterogeneity of pancreatic cancer cells and the complexity of its tumor microenvironment contribute to the emergence of drug resistance. (frontiersin.org)
CD4 + T cells contribute to the remodeling of the microenvironment required for sustained tumor regression upon oncogene inactivation. (nature.com)

Adoptive cellular therapy, especially chimeric antigen receptor (CAR) T cell therapy, has gained unprecedented success among hematologic tumors [ 11 ]. (hindawi.com)
Immunotherapies include checkpoint inhibitory antibodies, chimeric antigen receptor (CAR) T-cells, cancer vaccines, and oncolytic viruses. (moffitt.org)
The candidate combines an autologous chimeric antigen receptor (CAR) T cell therapy targeting the oncofetal antigen Claudin-6 (CLDN6) with a CLDN6-encoding CAR-T cell amplifying RNA vaccine (CARVac). (pipelinereview.com)
GEO-CM04S1 for Immunocompromised Patients - GEO-CM04S1 is being studied in an ongoing Phase 2 clinical trial (NCT04977024) to evaluate its safety and immunogenicity, compared to the Pfizer/BioNTech mRNA-based vaccine, in patients who have previously received either an allogeneic hematopoietic cell transplant, an autologous hematopoietic cell transplant or chimeric antigen receptor (CAR) T cell therapy. (geovax.com)
The basic principles of chimeric antigen receptor design. (msdmanuals.com)

These vaccines contain specific tumor-associated antigens conjugated to KLH to stimulate anti-tumor immune responses which can destroy tumor cells. (wikipedia.org)
Dendritic cells (DCs) are specialized antigen-presenting cells that have a notable role in the initiation and regulation of innate and adaptive immune responses. (mdpi.com)
Cytotoxic T lymphocyte-associated antigen-4 (CTLA-4) (also known as CD152) is a major negative regulator of T cell responses which interacts with the B7-1 (CD80) / B7-2 (CD86) ligands on the surface of an antigen-presenting cell. (scielo.br)
Tumor-promoting functions of macrophages include angiogenesis, metastasis formation, and suppression of Th1-type immune responses. (aacrjournals.org)
Patients will be evaluated for safety, clinical responses, immune system responses against the vaccine antigens (PAP and AR), as well as immune system changes that correlate with clinical responses. (pcf.org)
We present here preclinical evidence for the essential role of innate immune effector responses induced by a therapeutic HPV peptide vaccine incorporating two clinically relevant adjuvants QS-21 and CpG-ODN to induce sustained, complete regression of oral HPV tumors. (bmj.com)
Results Vaccination resulted in robust induction of antigen-specific anti-tumor CD8 effector T cell responses along with expanded repertoire of innate cytotoxic effector responses that included unique natural killer cell subsets. (bmj.com)
Background The capacity of cytomegalovirus (CMV) to elicit long-lasting strong T cell responses, and the ability to engineer the genome of this DNA virus positions CMV-based vaccine vectors highly suitable as a cancer vaccine platform. (bmj.com)
We here determined using CMV as a vaccine platform whether critical thresholds of vaccine-specific T cell responses can be established that relate to tumor protection, and which factors control such thresholds. (bmj.com)
However, low dose inoculations via the IP or SC route or IN vaccination elicited vaccine-induced CD8 + T cell responses that did not reach protective thresholds for tumor protection. (bmj.com)
This presentation reports results of pre-clinical mouse studies of a cancer vaccine that promotes potent, antigen-specific CD4 T cell responses to MCPγV-LT. The majority of Merkel cell carcinomas (MCC), a rare and highly aggressive type of neuroendocrine skin cancer, are associated with Merkel cell polyomavirus (MCPyV) infection. (biospace.com)
CD154) is a transmembrane protein expressed on the surface of activated T cells, particularly on CD4 T cells, which stimulates CD40-dependent activation of antigen-presenting cells (APCs), resulting in enhancement of T cell and antibody responses. (biospace.com)
Moreover, clinically applicable vaccination strategies that efficiently establish Trm cell responses remain largely unexplored and are expected to strongly protect against tumors. (lifeboat.com)
Here we demonstrated that a single intradermal administration of gene- or protein-based vaccines efficiently induces specific Trm cell responses against models of tumor-specific and self-antigens, which accumulated in vaccinated and distant non-vaccinated skin. (lifeboat.com)
In collaboration with the Duke University Medical Center in a Phase I/II clinical trial in patients with Stage IV CEA-expressing colon cancer, we found that treatment with our CEA alphavaccine resulted in two key outcomes: (i) the vaccine was able to "break self-tolerance" and (ii) a trend for enhanced survival in patients in the high-dose cohort with measurable T cell responses. (alphavax.com)
Stage III) to test the hypothesis that the vaccine elicits clinically relevant CEA-specific immune responses of greater magnitude and frequency than those measured in the Stage IV patients. (alphavax.com)
However, systematic analysis of T cell immune responses to MAGE-A3 antigen and corresponding antigen-specific TCR is still lacking. (thno.org)
Although immune checkpoint blockade (ICB) reinvigorates anti-tumor immune responses by disrupting co-inhibitory T-cell signaling, relapse frequently occurs after ICB treatment and acquired resistance often emergence after initial response [ 4 ]. (thno.org)
Proof of concept studies using antigen-loaded dendritic cells have been performed, establishing clear evidence of vaccine safety and bioactivity by stimulating immunologic and even clinical responses in cancer patients. (nova.edu)
The critical challenge remains to understand fully the mechanisms of action and to further optimize dendritic cell vaccines to produce effective, durable, and, ultimately, therapeutic antitumor responses. (nova.edu)
Interestingly, bacteria can 'imitate' the tumor-associated antigens leading to the induction of T cell responses. (microbiomepost.com)
Elucidation of these circadian responses with topical corticosteroids may provide a rational basis for the future re-evaluation of the appropriate therapeutic regimen with this class of drugs in dermatologic medicine. (researchgate.net)
To enhance vaccine potency and improve thus responses to ICI, we analyzed the gene expression profile of an immunosuppressive dendritic cell (DC) population induced during vaccination, with the goal of identifying druggable inhibitory mechanisms. (unav.edu)
Neoantigen cancer vaccines are capable of eliciting strong T cell responses to neoepitopes in patients with melanoma. (patent-art.com)
2017. Low-dose cyclophosphamide induces anti-tumor T-cell responses which associate with survival in metastatic colorectal cancer . (cardiff.ac.uk)
2015. Assessing the prognostic value of preoperative carcinoembryonic antigen-specific T-cell responses in colorectal cancer . (cardiff.ac.uk)
Dendritic cells (DC) are responsible for initiating all antigen-specific immune responses. (aacrjournals.org)
Importantly, DCs also help guide the immune system to respond to foreign antigens while avoiding the generation of autoimmune responses to self. (aacrjournals.org)
Upon completion of this activity, the participant should understand the critical roles of dendritic cells in guiding host immune responses, and the details of how they mature, process, and present antigens. (aacrjournals.org)
Researchers led by Ludwig Lausanne's Sara Bobisse, Alexandre Harari, Lana Kandalaft and Director George Coukos analyzed responses to the combination therapy of 18 patients with advanced ovarian cancer who had previously participated in a clinical trial evaluating a therapeutic regimen that incorporated the personalized cancer vaccine. (bionewscentral.com)
Ovarian cancer cells do, however, express neoantigens, which are randomly mutated proteins that can activate anti-tumor T cell responses. (bionewscentral.com)
To make the vaccine, researchers first coax precursor immune cells isolated from patients to turn into dendritic cells, which present cancer antigens to killer T cells to direct and activate their anti-tumor responses. (bionewscentral.com)
We were very happy that we could demonstrate how the combination therapy improved anti-tumor immune responses, and that those changes correlated to patient benefit," said Bobisse. (bionewscentral.com)
studies examining the mechanisms and efficacy of a novel cellular tumor vaccine strategy that uses antigen-loaded monocytes and an endogenous antigen transfer pathway to stimulate potent anti-tumor T cell responses (Project 3). (cancer.gov)
TAA has been tested previously against glioblastoma with minimal success, partly due to insufficient CD8+ T cell responses to low level antigen expression of individual epitopes. (cancer.gov)
Aim 2 is conducting preclinical work to determine if CDX-527 simultaneously depletes TRegs based on prior data of CD27-mediated Treg depletion and increases vaccine-induced immune responses. (cancer.gov)
The combination of P30-EPS with CDX-527 is expected to improve vaccine-induced CD8+ and CD4+ T cell responses. (cancer.gov)
This includes whether and how the immune system reacts to emerging tumours, whether antitumour immune responses are reactivated during treatment with immune-checkpoint inhibitors (ICIs), and whether unintended destructive immune pathologies accompany such treatment. (cdc.gov)

In addition, tumor-associated antigens (TAAs) produced by irradiated tumor cells can be captured by antigen-presenting cells (APCs) in the TME and presented to T cells. (nature.com)
CAR-T cells target the tumor-associated antigens (TAAs), such as CD19 in B cell malignancies and ERBB2 in breast cancers, which are also expressed in normal cells. (patent-art.com)
Project 1 will conduct a clinical trial to evaluate a peptide vaccine targeting Tumor-Associated Antigens (TAAs), given with an adjuvant poly-ICLC (Hiltonol). (cancer.gov)
TAAs) with high specificity to tumor cells. (msdmanuals.com)
Concomitant use of interferon enhances the expression of major histocompatibility complex (MHC) antigens and TAAs on tumor cells, thereby augmenting the killing of tumor cells by the infused effector cells. (msdmanuals.com)

However, advanced forms of cervical cancer, driven by HPV, are poorly responsive to immune response-enhancing treatments involving therapeutic vaccination against these viral neoantigens. (nih.gov)
Vaccination with LTS220A-UNITE (ITI-3000) induced antigen-specific CD4 Th1 cells that was associated with delayed tumor growth and enhanced survival in treated mice in both the prophylactic and therapeutic settings. (biospace.com)
Interestingly, vaccination-induced Trm cells strongly suppress the growth of melanoma, independently of circulating CD8 T cells, and were able to infiltrate melanoma tumors. (lifeboat.com)
Therefore, our work highlights the therapeutic potential of vaccination-induced Trm cells to achieve potent protection against skin malignancies. (lifeboat.com)
Emerging data suggest that the combination of DC-based vaccination with other cancer therapies may fully unleash the potential of DC-based cancer vaccines and improve patient survival. (moffitt.org)
2. Conduct a clinical trial in MDS testing K562/GM-CSF vaccination integrated with the systemic agent(s) identified in aim 1 as being most active in combination with GM-CSF tumor vaccines (years 2 and 3). (acgtfoundation.org)
Vaccination using optimized strategies may increase response rates to immune checkpoint inhibitors (ICI) in some tumors. (unav.edu)
In addition enhanced protective immune response was seen from giving mushroom extracts alongside influenza vaccine in one in vivo study and FVe, a protein from Enokitake (Flammulina velutipes) was seen to significantly increase the anti-tumour protection given by vaccination against HPV-16 in another 10,11. (mushroomnutrition.com)
2022. Persistent COVID-19 infection in Wiskott-Aldrich syndrome cleared following therapeutic vaccination: a case report . (cardiff.ac.uk)
and 5) minor changes to the recommendations about vaccination during pregnancy and vaccination of internationally adopted children, in accordance with new ACIP vaccine-specific recommendations for use of inactivated influenza vaccine and hepatitis B vaccine. (cdc.gov)
This report, ACIP recommendations for each vaccine, and other information about vaccination can be accessed at CDC's National Center for Immunization and Respiratory Diseases (proposed) (formerly known as the National Immunization Program) website at http//:www.cdc.gov/nip . (cdc.gov)
This report provides technical guidance about common vaccination concerns for clinicians and other health-care providers who administer vaccines to infants, children, adolescents, and adults. (cdc.gov)
Any person or institution that provides vaccination services should adopt these standards to improve vaccination delivery and protect infants, children, adolescents, and adults from vaccine-preventable diseases. (cdc.gov)

RCC is an immunogenic tumor, and spontaneous regressions have been documented. (medscape.com)
Here, we describe for the first time a streamlined pipeline for the generation of personalized cancer vaccines starting from the isolation and selection of the most immunogenic peptide candidates expressed on the tumor cells and ending in the generation of efficient therapeutic oncolytic cancer vaccines. (elifesciences.org)
These peptides were then tested in our previously described oncolytic cancer vaccine platform PeptiCRAd, a vaccine platform that combines an immunogenic oncolytic adenovirus (OAd) coated with tumor antigen peptides. (elifesciences.org)
Her laboratory has focused on the use of genomics-based approaches to discover immunogenic antigen targets and to understand the molecular basis of therapeutic response and resistance. (nki.nl)
There are increasing neoantigen-based cancer vaccines designed to target the unique immunogenic mutations in each patient's tumor. (patent-art.com)
NEC's proprietary machine learning algorithms are built upon decades of AI expertise, enabling us to prioritize and map the most immunogenic neoantigens on personalized vaccine blueprints. (nec.com)
Renal cell carcinoma is an immunogenic tumor, and spontaneous regressions have been documented. (medscape.com)

To address this issue and improve therapeutic efficacy, this study presents the examination of recombinant overlapping peptides (ROP) based on the tumor-associated antigen, survivin, on in vivo immunogenicity and anti-tumor efficacy using a melanoma C57/BL mouse model. (ox.ac.uk)
Adoptive cell therapy using engineered T-cell receptors (TCRs) targeting cancer-testis antigens, such as Melanoma-associated antigen 3 (MAGE-A3), is a potential approach for the treatment of NSCLC. (thno.org)
She has led early phase clinical trials to test personalized tumor vaccines in melanoma and glioblastoma. (nki.nl)
This nanovaccine, comprising a simple physical mixture of an antigen and a synthetic polymeric nanoparticle enhances antigen delivery and cross-presentation, generates a strong cytotoxic T-cell response with low systemic cytokine expression, and leads to potent tumor growth inhibition in melanoma, colon cancer and HPV tumor models. (utsouthwestern.edu)
There are other (or newer) ICIs (such as anti-PD1 and anti-PD-L1 antibodies), considered to be effective therapies in subsets of patients with a variety of tumor types such as metastatic melanoma, non-small cell lung cancer (NSCLC), prostate cancer, renal cell carcinoma, and so on. (patent-art.com)
Malignant primary brain tumors, like glioblastoma (GBM), are the most frequent cause of cancer death in children and young adults and account for more deaths than cancer of the kidney or melanoma. (cancer.gov)

Here, we show that successful treatment of cervical carcinoma in mouse models with synthetic long peptide (SLP) vaccines induced influx of cytokine-producing CD8 T cells that strongly altered the numbers and phenotype of intratumoral macrophages. (aacrjournals.org)
The therapeutic efficacy of the vaccine was dependent on CD8 T cells and in addition required NK cells subsets as shown by in vivo antibody depletion and adoptive transfer to HPV peptide vaccine non-responsive oral tumor bearing mice. (bmj.com)
8000 peptide targets from the CT26 tumor cell line. (elifesciences.org)
2015. Enhanced detection of antigen-specific CD4+ T cells using altered peptide flanking residue peptide-MHC class II multimers . (cardiff.ac.uk)
Aim 1 will evaluate the safety, identify the optimal dose and schedule, and preliminary therapeutic activity of a multi-TAA peptide vaccine targeting the EphA2, the CMV pp65 and Surviving antigens, tethered to P-30 (P30-EPS), in patients with glioblastoma. (cancer.gov)
Cumulative results will provide critical data on the feasibility and immunogenicity of the conjoined multi-peptide vaccine P30-EPS. (cancer.gov)
Glycan-antigens target DC receptors, resulting in DC internalization, loading of peptide antigen on both MHC-I and MHC-II to present to both CD8+ and CD8+T cells. (dc4u-technologies.nl)

Besides the isolation and identification of major histocompatibility complex I-restricted peptides from the surface of cancer cells, one of the challenges is eliciting an effective antitumor CD8+ T-cell-mediated response as part of therapeutic cancer vaccine. (elifesciences.org)
Therefore, the establishment of a solid pipeline for the downstream selection of clinically relevant peptides and the subsequent creation of therapeutic cancer vaccines are of utmost importance. (elifesciences.org)
These therapeutic methods, including but not limited to oncolytic virus therapies, T-cell therapies and cancer vaccines, are based on the body's ability to recognize mutated antigen peptides presented on the cell surface by MCH-receptors (also known as HLA-receptors in humans) and the disposal of the malignant cells by cytotoxic T-cells. (helsinki.fi)
Dendritic cells can be used as a vaccine by preparing together with either peptides or small portions of tumor antigens and they can then be injected into the body. (moffitt.org)
Neoantigens are mutated peptides present as HLA on the cell surface, and theoretically more attractive therapeutic targets because they are different from the others and seen as non-self by the immune system. (patent-art.com)
Increased durability of the immune response: Naked short peptides derived from antigens can directly bind to MHC I molecules, which allows rapid stimulation of CD8+ T cells, but duration is short as turnover of MHC I molecules is rapid. (dc4u-technologies.nl)

NK cells coordinate tumor immunosurveillance and the immune response against pathogens. (scielo.br)
These changes of the intratumoral myeloid composition coincided with macrophage recruitment by chemokines, including CCL2 and CCL5, and were completely dependent on a vaccine-induced influx of tumor-specific CD8 T cells. (aacrjournals.org)
Incubation of tumor cells with T cell-derived IFNγ and TNFα recapitulated the chemokine profile observed in vivo , confirming the capacity of antitumor CD8 T cells to mediate macrophage infiltration of tumors. (aacrjournals.org)
The nature of mitochondrial behavior in tumor-infiltrating T cells remains poorly understood. (bvsalud.org)
Genetic ablation of Mfn2 in CD8+ T cells dampens mitochondrial metabolism and function and promotes tumor progression. (bvsalud.org)
In tumor-infiltrating CD8+ T cells, MFN2 enhances mitochondria-endoplasmic reticulum (ER) contact by interacting with ER-embedded Ca2+-ATPase SERCA2, facilitating the mitochondrial Ca2+ influx required for efficient mitochondrial metabolism. (bvsalud.org)
Thus, we reveal a tethering-and-buffering mechanism of organelle cross-talk that regulates the metabolic fitness of tumor-infiltrating CD8+ T cells and highlights the therapeutic potential of enhancing MFN2 expression to optimize T cell function. (bvsalud.org)
Therefore, this article reviews the latest progress on prostate cancer vaccine, especially Sipuleucel-T vaccine based on mononuclear cells. (asmepress.com)
It is a type of autocellular immunotherapeutic vaccine, composed of peripheral mononuclear cells. (asmepress.com)
Sipuleucel-T consists of autologous peripheral blood mononuclear cells including antigen presenting cells (APCs). (asmepress.com)
The active components of Sipuleucel-T are autologous APCs and PAP-GM-CSF, in addition to T cells, B cells, natural killer cells, and other cells that specifically bind to PAP expressed in prostate cancer tissue to kill tumor cells. (asmepress.com)
Leveraging a transgenic mouse model of HPV-derived cancers, K14HPV16/H2b, we demonstrated that a potent nanoparticle-based E7 vaccine, but not a conventional "liquid" vaccine, induced E7 tumor antigen-specific CD8 + T cells in cervical tumor-bearing mice. (nih.gov)
Mice were subsequently challenged with tumor cells, and the tumor protection was monitored. (bmj.com)
Conclusions This study highlight the effectiveness of CMV-based vaccine vectors, and shows that demarcated thresholds of vaccine-specific T cells could be defined that correlate to tumor protection. (bmj.com)
They kill infected cancer and associated endothelial cells via direct oncolysis, and uninfected cells via tumor vasculature targeting and bystander effect. (biomedcentral.com)
In this paper, we have developed a population semi-mechanistic model able to characterize the mechanisms implied in tumour growth dynamic after the administration of CyaA-E7, a vaccine able to target antigen to dendritic cells, thus triggering a potent immune response. (ebi.ac.uk)
MCPyV integrates into the host genome, resulting in expression of a truncated form of the viral large T antigen (LT) in infected cells, and makes LT an attractive target for therapeutic cancer vaccines. (biospace.com)
To activate antigen-specific CD4 T cells in vivo, the investigators utilized the nucleic acid vaccine platform, UNITE (UNiversal Intracellular Targeted Expression), which fuses a tumor-associated antigen with lysosomal-associated membrane protein 1 (LAMP1). (biospace.com)
Here, we demonstrated that intradermal administration of clinically relevant vaccines efficiently induces Trm cells specific for tumor-specific and self-antigens that accumulate in vaccinated and non-vaccinated skin. (lifeboat.com)
Emerging evidence indicates that Trm cells develop in human solid cancers and play a key role in controlling tumor growth. (lifeboat.com)
The latter is a tool previously developed by Jacopo, 2020, able to identify tumor antigens similar to pathogen antigens in order to exploit molecular mimicry and tumor pathogen cross-reactive T cells in cancer vaccine development. (elifesciences.org)
Even though the idea of an immune system actively searching for and disposing of potential mutated tumor cells is over a century old, only recent developments in various fields such as mass spectrometry, immuno-checkpoint blockade strategies and in silico modelling have enabled the realization of the full potential of recruiting immune system to fight cancer and the possibilities of personalized therapies. (helsinki.fi)
This master thesis is a part of a project aiming to set up immunoaffinity-purification/MS based method in order to analyse the ligandome and determine T-cell recognized cancer associated antigens from tumor cells. (helsinki.fi)
In this study, we comprehensively screened HLA-A2 restricted MAGE-A3 tumor epitopes and characterized the corresponding TCRs using in vitro artificial antigen presentation cells (APC) system, single-cell transcriptome and TCR V(D)J sequencing, and machine-learning. (thno.org)
Importantly, T cells artificially expressing the MAGE-A3-Mp4 specific TCRs exhibited strong MAGE-A3+ tumor cell recognition and killing effect. (thno.org)
Tumor vaccines: from gene therapy to dendritic cells--the emerging frontier. (nova.edu)
Recent studies suggest that dendritic cells may be even more potent, because these cells can efficiently present tumor antigens to effector T cells, thereby circumventing the poor antigen-presenting properties of tumor cells. (nova.edu)
whereas inosine produced by certain bacteria could improve the response to ICIs by activating anti-tumor T cells . (microbiomepost.com)
They're injecting HER2 pulsed dendritic cells (MCC 20915) made from the patient back into their breast tumor before chemotherapy. (moffitt.org)
The active components of CMN-001 are autologous, matured dendritic cells, which have been co-electroporated with both in vitro transcribed (IVT) RNA from an autologous tumor specimen and CD40L RNA. (moffitt.org)
Evidence exists that immune activation against hematopoietic elements frequently occurs in MDS patients, based on the identification of lymphocytic infiltrates in the marrow, oligoclonal expansion of T cells, and excessive production of tumor necrosis factor alpha. (acgtfoundation.org)
K562 cells express many of the antigens shown to be overexpressed in myeloid leukemias and MDS. (acgtfoundation.org)
We demonstrate that Tconvs, but not Tregs, are the direct targets of SA-4-1BBL-mediated evasion of Treg suppression without contribution from antigen presenting cells (APCs). (louisville.edu)
The robust anti-tumor function of SA-4-1BBL involved a communication bridge between CD4 and NK cells without significant contribution from CD8 cells or B cells. (louisville.edu)
NK cells were found to be critical to the observed tumor suppression and required CD4+ T cell help for protective efficacy at both priming and effector stages. (louisville.edu)
Depletion of either NK or CD4 cells negated SA-4-1BBL's anti-tumor protection. (louisville.edu)
B16-OVA tumors benefited from a synergistic effect, reaching 75% of tumor rejection, but higher levels of exhausted T-cells in LLC-OVA tumors co-expressing PD-1, LAG3 and TIM3 precluded similar levels of efficacy. (unav.edu)
In this review, we discuss the changes in irradiated cancer cells and immune cells in the TME under different RT regimens and describe existing and potential molecules that could be targeted to improve the therapeutic effects of RT. (nature.com)
They are tumor-specific and not expressed by normal cells, which makes them ideal therapeutic targets. (patent-art.com)
While CAR-T therapies have shown significant promise in acute lymphoid leukaemia, treating solid cancers with CAR-T cells remains a challenge due to the lack of suitable tumor-associated antigens and low overall objective response rates. (patent-art.com)
In order to generate personalized cancer vaccine, somatic mutations within cancer cells can be identified using whole exome sequencing. (patent-art.com)
Recent findings show how T cells exert selection pressures on a tumor, influencing its genetic composition and future susceptibility to the immune system. (massgeneral.org)
2022. Whole blood-based measurement of SARS-CoV-2-specific T cells reveals asymptomatic infection and vaccine immunogenicity in healthy subjects and patients with solid organ cancers . (cardiff.ac.uk)
2021. Prognostic significance of interleukin-17A-producing colorectal tumour antigen-specific T cells . (cardiff.ac.uk)
2020. Cancer antigen discovery is enabled by RNA-sequencing of highly purified malignant and non-malignant cells . (cardiff.ac.uk)
2019. The nature of the human T cell response to the cancer antigen 5T4 is determined by the balance of regulatory and inflammatory T cells of the same antigen-specificity: implications for vaccine design . (cardiff.ac.uk)
They are exceptionally efficient at antigen presentation and also adept at generating just the right type of T cells in response to a given pathogen. (aacrjournals.org)
In the current study-which, like the previous one, was done in partnership with researchers at the University of Pennsylvania-patients received an infusion of their own vaccine-primed, circulating immune cells (specifically, T cells), followed by multiple periodic doses of their personalized vaccines. (bionewscentral.com)
These dendritic cells are then expanded in culture and pulsed with an extract of cancer cells from a patient's tumor that is chemically treated to improve uptake and processing of antigens by the cultured immune cells. (bionewscentral.com)
The vaccine is then injected into its corresponding patient's lymph nodes, the anatomical site where dendritic cells activate anti-tumor T cells. (bionewscentral.com)
It involves delivering the dendritic cell vaccine along with bevacizumab, a standard ovarian cancer therapy that targets VEGF-A. Aside from promoting blood vessel formation, this factor, secreted by cancer cells, also hampers killer T cell entry into tumors. (bionewscentral.com)
In the current study , patients received chemotherapy followed by ACT using vaccine-primed T cells that were expanded in culture in the presence of stimulatory immune factors. (bionewscentral.com)
Further, DNA sequences encoding neoantigens targeted by the T cells were found at higher levels in circulating tumor DNA, suggesting they had invited the destruction of tumor cells. (bionewscentral.com)
The main challenge in developing effective antigen-based immunotherapeutics is to efficiently target and trigger dendritic cells (DCs) in order to elicit a specific, potent, and long term immune response without adverse effects. (dc4u-technologies.nl)
We have identified inhibitory glycans which can be linked to antigens with the purpose to suppress the immune response by instructing DCs to differentiate and activate regulatory T-cells (Tregs). (dc4u-technologies.nl)
This work preceded more recent studies illustrating the how B cells transfer autoantigens to other antigen presenting cells, including dendritic cells and macrophages. (yale.edu)
A number of immunologic interventions, both passive and active, can be directed against tumor cells. (msdmanuals.com)
Lymphokine-activated killer (LAK) cells are produced from the patient's T cells which are extracted from the tumor and grown in a cell culture system with the lymphokine interleukin-2 (IL-2). (msdmanuals.com)
Tumor-infiltrating lymphocytes (TILs) may have greater tumoricidal activity than LAK cells. (msdmanuals.com)
However, the progenitor cells consist of T cells isolated from resected tumor tissue. (msdmanuals.com)
This process theoretically provides a line of T cells with greater tumor specificity than those obtained from the blood. (msdmanuals.com)
Tumor Antigens Many tumor cells produce antigens, which may be released in the bloodstream or remain on the cell surface. (msdmanuals.com)
Chimeric antigen receptors (CAR) recognize specific proteins on the surface of tumor cells. (msdmanuals.com)
In contrast to TCR T cells, CAR T cells recognize only relatively large proteins on the surface of tumor cells. (msdmanuals.com)
T-cell engagers are bispecific antibodies that recruit cytotoxic T cells to kill tumor cells. (msdmanuals.com)
The most frequently used engagers are antibodies targeting one tumor antigen and one molecule on T cells (mostly CD3). (msdmanuals.com)

4 According to the number of tumor-infiltrating lymphocytes, tumors can be divided into three phenotypes: immune-inflamed, immune-excluded, and immune-desert types. (nature.com)
Neoantigens can be presented by the major histocompatibility complex (MHC, also known as human leukocyte antigen (HLA) in humans) on the cell surface and recognized by the T lymphocytes. (patent-art.com)

Evidence has recently been obtained that two very different recombinatorial systems for lymphocyte antigen receptor diversification appeared at the beginning of vertebrate evolution approximately 500 million years ago. (scielo.br)
Jawed vertebrates (gnathostomes) generate a diverse repertoire of B and T cell antigen receptors through the rearrangement of immunoglobulin V, D, and J gene fragments, whereas jawless fish (agnathans) assemble diverse lymphocyte antigen receptor genes through the genomic rearrangement of leucine-rich repeat (LRR) - encoding molecules. (scielo.br)
The team has developed two prostate cancer vaccines, which activate the immune system against two prostate cancer associated proteins - the androgen receptor (AR), and prostatic acid phosphatase (PAP). (pcf.org)
Moreover, the tumor suppressive effect of SA-4-1BBL was shown to be a bona fide property of this molecule, as immunizing mice with an agonistic antibody to 4-1BB receptor did not confer any protection against TC-1 tumors. (louisville.edu)

Investigators have been enthusiastic about the use of active immunization for patients with solid tumors because of an over-reliance on surrogate and subjective endpoints, such as histologic evidence of tumor necrosis or lymphocyte infiltration, rather than objective cancer regressions. (alphavax.com)
Perspectives of tumor-infiltrating lymphocyte treatment in solid tumors. (msdmanuals.com)

This paper mainly reviews the clinical features, pathogenesis, and therapeutic strategies of neurologic ir-AEs. (hindawi.com)
Importantly, statins targeting the mevalonate pathway can suppress NFYC-37-induced cell proliferation and tumor growth, indicating the need for conducting a clinical trial with statins for treating patients with BLCA and high NFYC-37 levels, as most patients with BLCA have high NFYC-37 levels. (bvsalud.org)
Both vaccines are being tested in phase I and phase II clinical trials. (pcf.org)
The team will conduct a randomized phase II clinical trial in prostate cancer patients testing the PAP vaccine + the anti-PD1 checkpoint inhibitor pembrolizumab, versus the PAP vaccine + the AR vaccine + pembrolizumab. (pcf.org)
In this project, the team will study patients being treated with PARP-inhibitors in clinical trials to comprehensively characterize mutations that cause tumors to be sensitive to PARP-inhibitors, and the mutations that lead to acquired PARP-inhibitor resistance. (pcf.org)
Promising safety and immunogenicity results from the Company's five Phase I clinical studies that evaluated four different alphavaccines, have provided a considerable knowledge base of immunologic information as well as a theoretical framework for immunization against cancer antigens. (alphavax.com)
The Breast Oncology Department , for example, has developed innovative clinical trials for vaccines that offer new ways to treat various types and stages of breast cancer and improve patient outcomes. (moffitt.org)
TSE: 6701), a leader in IT, network and AI technologies, today announce positive preliminary immunogenicity and clinical data on TG4050, their jointly developed individualized neoantigen cancer vaccine. (nec.com)
Finally, we are adapting our unbiased analytical strategies into real-world therapeutics, having performed clinical trials (with our collaborator Dr. Catherine Wu), in which patients are vaccinated against their own tumors with a fully personal vaccine that is designed based on a computational analysis of their tumor genome. (massgeneral.org)
Patients enrolled in the trial received a therapeutic regimen that was shown to be promising in the previous clinical study . (bionewscentral.com)
We studied the relationship between KIR-human leukocyte antigen (HLA) combinations and the clinical outcomes of patients with Ebola virus disease (EVD). (cdc.gov)

Dendritic cell vaccines can potentially be used to treat different cancer types. (moffitt.org)

To view a multidisciplinary tumor board case discussion, see Memorial Sloan Kettering e-Tumor Boards: Metastatic Clear Cell Renal Cell Carcinoma . (medscape.com)
All these therapeutic approaches fight systemic disease, be it micro-metastatic or metastatic, with a proven therapeutic effect. (moffitt.org)
Neoantigen vaccines and immune checkpoint inhibition act as complementary treatments that might often be used together, especially for patients with large tumors or metastatic disease, and can lead to an increased tumor-specific immune response. (patent-art.com)

Keyhole limpet hemocyanin (KLH) is used extensively as a carrier protein in the production of antibodies for research, biotechnology and therapeutic applications. (wikipedia.org)
These immune-inhibitory effects inhibited synergistic effects of combining our oncoprotein vaccine with immune checkpoint-blocking antibodies. (nih.gov)
Such antibodies may have positive or negative effect on the efficacy of the vaccines. (louisville.edu)
GEO-CM02 as a Pan-Coronavirus Vaccine - First-generation SARS-CoV-2 vaccines were designed to encode the spike (S) protein of the SARS-CoV-2 virus with the goal of inducing high levels of neutralizing antibodies. (geovax.com)
However, potential limitations of narrowly focusing on the spike (S) protein are becoming apparent with emerging variants capable of partially escaping neutralization by vaccine induced antibodies. (geovax.com)
Antibodies targeting two tumor antigens and CD3 are being tested. (msdmanuals.com)

Cancer vaccines use tumor cell-associated antigens to induce a specific anti-tumor immune response that is durable and robust. (asmepress.com)
Antigen specific immunotherapeutics and -vaccines are considered as one of the most promising new developments in the search to cure cancer and induce tolerance in allergy patients. (dc4u-technologies.nl)
Lowering antigen dose: Current allergen based immunotherapeutics require high allergen doses to induce tolerance. (dc4u-technologies.nl)

Oncolytic viruses (OVs) are tumor-selective, multi-mechanistic antitumor agents. (biomedcentral.com)

OVs provide a number of potential advantages as cancer vaccines over conventional therapies. (biomedcentral.com)
The proposed model structure was successfully applied to describe antitumor effect of IL-12, suggesting its applicability to different immune-stimulatory therapies. (ebi.ac.uk)
In addition, a simulation exercise to evaluate in silico the impact on tumour size of possible combination therapies has been shown. (ebi.ac.uk)
Our results indicate that gemcitabine is a suitable combination therapy with vaccines aimed at enhancing PD-1 therapies by targeting vaccine-induced immunosuppressive DC. (unav.edu)
Building on the Duke Brain Tumor Program's longstanding focus on development, refinement, and testing of immunotherapies to treat low-grade gliomas and GBM, the Duke SPORE in Brain Cancer continues work to develop new or improve existing therapies to improve the life of patients with primary malignant brain tumors. (cancer.gov)

Our GlycoDC TM technology can either potentiate or suppress the immune system via specific targeting of DC receptors by these glycan modified antigen conjugates. (dc4u-technologies.nl)
Modification of these antigens by conjugation with a specific glycan structure enables specific targeting of certain DC receptors. (dc4u-technologies.nl)
Different glycans target specific but different DC receptors, leading to completely different DC processing, antigen presentation and T-cell response. (dc4u-technologies.nl)
We have identified glycans that can be covalently linked to antigens to target specific DC receptors with the purpose to boost the immune response. (dc4u-technologies.nl)
DC specific targeting: Glycated antigens target glycan-specific DC receptors, leading to specific DC internalization and antigen presentation. (dc4u-technologies.nl)

Tumor-specific antigens (TSAs), also known as neoantigens, are created by the process of genomic codon interchanges, editing, antigen processing and presentation. (patent-art.com)
Targeting neoantigens has the potential to maximize therapeutic specificity, while minimizing the risk of autoimmunity. (patent-art.com)
Neoantigens have been considered an important therapeutic approach to cancer treatment. (patent-art.com)

Antigens of choice include tumor antigens, allergens, self-antigens and pathogen related antigens. (dc4u-technologies.nl)

Furthermore, the therapy demonstrates promising outcomes in preventing or delaying tumor relapse and exhibits synergistic effects when combined with other treatments during relapses or disease progression. (bvsalud.org)

This type of mathematical approaches may be helpful to maximize the information obtained from experiments in mice, reducing the number of animals and the cost of developing new antitumor immunotherapies. (ebi.ac.uk)
The molecular identities of many tumor-associated antigens have been identified and this knowledge has provided a major stimulus for the development of new immunotherapies for the treatment of patients with cancers. (alphavax.com)
ATLANTA, GA, March 9, 2022 - GeoVax Labs, Inc. (Nasdaq: GOVX), a biotechnology company developing immunotherapies and vaccines against infectious diseases and cancer, today announced its financial results for the year ended December 31, 2021 and provided an update on product development programs. (geovax.com)

This report is intended to serve as a general reference on vaccines and immunization. (cdc.gov)

2022. COVID-19 vaccine response in people with multiple sclerosis . (cardiff.ac.uk)

1. Examine the in vivo effect of: a) DNA methyltransferase inhibitors, b) HDACi, and c) IMiDs on the response to GM-CSF tumor vaccines in a mouse model (year 1). (acgtfoundation.org)
GeoVax's vaccine candidate (GEO-CM02) encodes the spike (S) protein as the neutralizing antibody target as well as the membrane (M) and envelope (E) proteins as T-cell targets and to support in vivo virus-like particle formation to augment potency. (geovax.com)

ROPs and adjuvant immunostimulants represent a potent vaccine strategy for therapeutic purposes, increasing vaccine immunogenicity and improving survival against cancer. (ox.ac.uk)
The safety profile and early immunogenicity data against multiple patient-specific tumor targets in the first patients is a testimony of TG4050's potential and of the complementary synergies between the two companies. (nec.com)

As a result, the nuclear transcription factor Y subunit gamma (NFYC)-37, but not NFYC-50, is observed to promote cell proliferation and tumor growth in BLCA. (bvsalud.org)

Methods We used mEER and TC-1, two mouse tumor cell lines expressing HPV-16 E6 and E7 along with h-Ras for tumor induction in the tongue and vaginal mucosa in syngeneic C57BL/6J mice. (bmj.com)
General view of vaccine for prostate cancer (DC, dendritic cell). (asmepress.com)
The magnitude, kinetics and phenotype of the circulating tumor-specific CD8 + T cell response were determined. (bmj.com)
0.3% of the total circulating CD8 T cell population fully protects mice against lethal tumor challenge. (bmj.com)
The mathematical model developed presented the following main components: (1) tumour progression in the animals without treatment was described with a linear model, (2) vaccine effects were modelled assuming that vaccine triggers a non-instantaneous immune response inducing cell death. (ebi.ac.uk)
These posters to be presented at the AACR Meeting focus on the investigational nucleic acid platform, UNITE™ (UNiversal Intracellular Targeted Expression) for two vaccines, ITI-3000 for Merkel cell carcinoma (targeting the large T antigen of the Merkel cell polyomavirus) and Her2/Neu-LAMP DNA vaccine, both of which fuse a tumor associated antigen with lysosomal associated membrane protein 1 (LAMP-1). (biospace.com)
This proprietary lysosomal targeting technology results in enhanced antigen presentation and a balanced T cell response. (biospace.com)
The therapeutic approach to renal cell carcinoma (RCC) is guided by the probability of cure, which is related directly to the stage or degree of tumor dissemination. (medscape.com)
Characterizing tumor cell lines. (helsinki.fi)
The latest addition to oncotherapy is the use of dendritic cell (DC) vaccine therapy. (moffitt.org)
A dendritic cell vaccine is a cross between a vaccine and a cell therapy. (moffitt.org)
Now researchers at Moffitt are working to develop a dendritic cell vaccine targeting HER3, a protein involved in the growth and spread of many different cancer types. (moffitt.org)
The product candidate recently received Priority Medicines (PRIME) designation by the European Medicines Agency (EMA) for the third- or later-line treatment of testicular germ cell tumors. (pipelinereview.com)
The designation was granted based on the encouraging initial data particularly in patients with testicular cancer which is the most common type of germ cell tumors. (pipelinereview.com)
Whether this represents a secondary event in response to cell injury and the generation of neo-antigens, or an initiating event inducing immunopathology, remains controversial. (acgtfoundation.org)
We have developed a genetically modified tumor cell vaccine for the treatment of myeloid malignancies. (acgtfoundation.org)
This improved efficacy was associated with higher tumor T-cell infiltration and overexpression of PD-1/PD-L1. (unav.edu)
A Ludwig Cancer Research study has shown that combining adoptive T cell therapy (ACT) with an innovative, personalized cancer vaccine under development at the Lausanne Branch of the Ludwig Institute for Cancer Research can benefit patients with late-stage, drug-resistant ovarian cancer. (bionewscentral.com)
The personalized dendritic cell vaccine, developed over the past dozen years under the leadership of Kandalaft and Coukos, is one of them. (bionewscentral.com)
CDX-527 induces greater T cell stimulation, PD-1/PD-L1 axis checkpoint blockade, and potentiate anti-tumor immune activity. (cancer.gov)
This results in DC internalization, processing, MHC antigen presentation and antigen specific T-cell activation. (dc4u-technologies.nl)
In this way our dendritic cell targeting technology enables opportunities for both immune stimulation and suppression by selection of the right combination of glycan and antigen / allergen. (dc4u-technologies.nl)
Experimental treatment approaches include vaccines and nonmyeloablative allogeneic peripheral blood stem cell transplantation. (medscape.com)

Hepatocellular carcinoma (HCC) is a moderately mutated tumor, where the neoantigen repertoire has not been investigated. (unav.edu)

The field of Lymphocyte Surface Antigens and Activation Mechanisms is examined in two chapters. (scielo.br)
In addition to discovering and studying specific molecular and cellular mechanisms, we also address how and why the immune response (to tumors, pathogens or self) varies so dramatically across individuals. (massgeneral.org)

This early phase trial will inform a subsequent larger trial, potentially combining the P30-EPS multi antigen vaccine with a clinically available bi-specific antibody (CDX-527) that combines a CD27 agonist antibody (αCD27) with an anti-PD-L1 antibody (αPD-L1). (cancer.gov)

The Food and Drug Administration of the USA has approved both prophylactic and therapeutic vaccines for cancer in the last few years. (biomedcentral.com)

The findings evidence the possible administration of DC-based vaccines as an adjuvant treatment in AML following initial therapy. (bvsalud.org)
In a series of studies our laboratory demonstrated the therapeutic efficacy of SA- 4-1BBL as an adjuvant component of subunit cancer vaccines in various preclinical rodent cancer models. (louisville.edu)

They should also be considered as potential targets or at least as key players in any effort intended to generate therapeutic vaccines. (aacrjournals.org)

The trial is also the first to compare an investigational multi-antigenic COVID-19 vaccine to the current Food and Drug Administration (FDA)-approved mRNA vaccine from Pfizer/BioNTech in people who are immunocompromised. (geovax.com)
GEO-CM04S1 as a Booster Vaccine - In December 2021, patient enrollment began for the Phase 2 portion of a Phase 1/2 trial (NCT04639466) of GEO-CM04S1, evaluating its use as a universal booster vaccine to current FDA-approved two-shot mRNA vaccines from Pfizer/BioNTech and Moderna. (geovax.com)
9, 2021-- Moderna, Inc . (Nasdaq: MRNA), a biotechnology company pioneering messenger RNA (mRNA) therapeutics and vaccines, today announced significant advances across its portfolio of mRNA pipeline programs being presented at the Company's fifth annual R&D Day today. (modernatx.com)

While cancer immunology has been deeply studied in animal models, there remain many open questions in human tumor immunology. (massgeneral.org)

First, OVs are tumor-selective, thus in situ cancer vaccines, providing higher cancer specificity and better safety margin. (biomedcentral.com)
Additional efforts are needed to improve the response rates and tumor antigen specificity of ICI, and address the incidence of immune-related adverse events. (patent-art.com)

Sensitivity to PARP-inhibitors requires tumors to have mutations that disable effective repair of damaged DNA. (pcf.org)

Anatomy20

Organisms17

Diseases36

Chemicals and Drugs114

Analytical, Diagnostic and Therapeutic Techniques and Equipment36

Phenomena and Processes36

Disciplines and Occupations1

Information Science3

Health Care6

Immunity34

Immunotherapy35

Documented efficacy1

Microenvironment10

Chimeric antigen receptor5

Responses38

TAAs5

Vaccination13

Immunogenic7

Melanoma6

Peptide7

Peptides6

Cells66

Lymphocytes2

Receptor4

Solid tumors2

Clinical11

Dendritic cell vaccines1

Metastatic3

Antibodies6

Induce3

Oncolytic1

Therapies5

Receptors5

Neoantigens3

Self-antigens1

Synergistic1

Immunotherapies3

Immunization1

20221

Vivo2

Immunogenicity2

Promote cell proliferation1

Cell23

Neoantigen1

Mechanisms2

Clinically1

Prophylactic and therapeutic1

Adjuvant2

Targets1

MRNA3

Immunology1

Specificity2

Mutations1