Tumor angiogenesis metastasis adenocarcinoma. Medical search. Frequent questions

G55-dependent secreted proteins enhanced the proliferative and invasive activities of TP53-deficient LUAD cells and promoted angiogenesis and CD8+ T cell exhaustion in the tumor microenvironment. (jci.org)
Cancer cells depart their normal microenvironment from the primary tumor site through complicated and multistep processes disseminate and colonize distant organs [ 1 ]. (intechopen.com)
By contrast, normalization, instead of depletion, of the stroma in combination with chemotherapy or immunotherapy to kill tumor cells within the stromal microenvironment is a promising strategy for PDAC therapy. (hhs.gov)
Simple Summary: The poor prognosis outcome of patients with KRAS mutations (KRASmut) was correlated with an immunosuppressive tumor microenvironment (TME). (nanostring.com)
The authors point out that while clinical studies that target components of the tumor microenvironment in this setting are still limited, the integration of preclinical findings described here may help facilitate novel clinical strategies for the prevention and treatment of brain metastases. (aacr.org)
The pancreatic tumor microenvironment (TME) mainly consists of extracellular matrix, resident and recruited cells, and cancer-associated fibroblasts (CAFs), which play a crucial role in tumor progression and metastasis, metabolism, angiogenesis, and treatment resistance (such as immunosuppression and chemoresistance). (alfaoncology.com)
In the tumor microenvironment, tumor-associated macrophages (TAMs) display an array of phenotypes beyond the M1/M2 paradigm, ranging from antitumoral to immunosuppressive, proangiogenic, immunomodulatory and tissue-remodeling phenotypes ( 7 - 9 ). (frontiersin.org)
Another myeloid population in the tumor microenvironment (TME) are DCs, that originate from different precursors and display various phenotypes, ranging from immunosuppressive monocyte-derived DCs (Mo-DCs) to immunocompetent cDC1 and cDC2 subsets ( 22 ). (frontiersin.org)
We are also learning that much of the behavior of tumors depends on cancer stem cells and stromal cells within the tumor microenvironment, which participate in extensive, dynamic crosstalk known to affect tumor behavior. (surgicalneurologyint.com)
In a number of studies, it has been shown that while only a select number of cells are actually infected with the virus, numerous viral proteins are released into the cancer and stromal cells in the microenvironment and these viral proteins are known to affect tumor behavior and aggressiveness. (surgicalneurologyint.com)
Oncomodulation is a process, whereby tumor behavior is affected by virally induced mechanisms acting on cancer cells as well as stromal cells within the tumor microenvironment, including suppression of cancer cell apoptosis mechanisms, altering tumor metabolism, suppressing antitumor immunity, triggering tumor microenvironment inflammation, initiating angiogenesis, stimulating tumor cell proliferation, increasing tumor invasion, and enhancing tumor cell migration (metastasis) [ Figures 1 and 2 ]. (surgicalneurologyint.com)
Tumor cell proliferation, angiogenesis, and suppression of antitumor immune activity are enhanced in the face of tumor microenvironment inflammation. (surgicalneurologyint.com)
Activation of this factor occurs in the stromal cells, tumor cells, and invading immune cells within the tumor microenvironment. (surgicalneurologyint.com)
Cancer-associated fibroblasts (CAFs) are one major type of component identified in the tumor microenvironment. (spandidos-publications.com)
EGFRvIII impacts both cell-intrinsic and non-cell autonomous aspects of GBM progression, including cell invasion, angiogenesis and modulation of the tumor microenvironment. (cancer-genetics.org)
γδ T cells recruited into the tumor microenvironment can act as effector cells to mediate cancer immune surveillance. (explorationpub.com)
Therefore, an in-depth understanding of γδ T cells that play conflicting roles in the tumor microenvironment is necessary. (explorationpub.com)
In addition, obesity is associated with progression (but not incidence) of tumour microenvironment through prostate cancer. (who.int)

Here we show that nicotine significantly promotes the progression and metastasis of tumors in mouse models of lung cancer. (nih.gov)
These results suggest that while nicotine has only limited capacity to initiate tumor formation, it can facilitate the progression and metastasis of tumors pre-initiated by tobacco carcinogens. (nih.gov)
A growing number of data confirming an important role of the fibrinolytic system in tumor progression and metastasis has been reported. (czytelniamedyczna.pl)
In Dr. A.M. Shamsuddin's review of findings in Nutrition and Cancer vol. 55, he states that in addition to its role in cancer prevention and control of experimental tumor growth, progression and metastasis, IP6 possesses other significant benefits, such as the ability to enhance the immune system, function as a natural antioxidant, prevent calcification and kidney stone formation, lower elevated serum cholesterol, and reduce pathological platelet activity. (naturalnews.com)

Malignant transformation of cystic adenomas of the pancreas was first described in 1989 wherein the tumor showed invasion into surrounding structures and into the liver [ 4 ]. (hindawi.com)
Because local invasion and metastasis occurs early in the pathogenesis of esophageal adenocarcinoma, we hypothesized that EMT may be important in this disease. (aacrjournals.org)
Many molecular and phenotypic events underlie the development of invasion and metastases ( 3 ). (aacrjournals.org)
These include the loss of proliferative control, enhanced cellular migration and invasion, extracellular matrix degradation, angiogenesis, lymphangiogenesis, and vascular invasion followed by the distant seeding of tumor cells in specific tissues, such as the liver or lung. (aacrjournals.org)
SPARC (secreted protein, acidic and rich in cysteine) is closely related with the progress, invasion and metastasis of malignant tumor and angiogenesis. (nih.gov)
In recent years, emerging studies have highlighted the critical role of these pathways and their regulation by microRNAs (miRNAs) in cancer invasion and metastasis. (intechopen.com)
Cancer-associated fibroblasts (CAFs) influence many aspects of pancreatic adenocarcinoma (PAAD) carcinogenesis, including tumor cell proliferation, angiogenesis, invasion, and metastasis. (bvsalud.org)
The miR-3648/FRAT1-FRAT2/c-Myc negative feedback loop modulates the metastasis and invasion of gastric cancer cells. (nih.gov)
Breast cancer cells secrete a range of matrix metalloproteinases and lively plasminogen, which hydrolyses ECM and facilitates tumor invasion and metastasis. (mirnadatabase.com)
AQP1 knockout mouse models of human cancers showed marked inhibition of tumor-induced angiogenesis, and in pre-clinical studies of colon adenocarcinomas, forced over-expression of AQP1 was shown to increase angiogenesis, invasion and metastasis. (biomedcentral.com)
PGE2 activation of JAK2/STAT3 acting on genes controlling tumor invasion/migration, cell proliferation, angiogenesis, and initiating immune suppression is demonstrated. (surgicalneurologyint.com)
CAFs provide cancer cells with nutrition and promote the proliferation, invasion and metastasis of cells ( 6 - 9 ). (spandidos-publications.com)
During the metastasis, cancer cells in situ move to other tissues and organs from the blood circulation or the lymphatic system through proliferation, adhesion, invasion, and migration. (frontiersin.org)
This protein enhances cell motility, invasion and metastasis of cancer cells. (cancer-genetics.org)
The poor prognosis is generally related to loco-regional recurrence, regional lymphnode invasion, and distant metastases[ 8 , 9 ]. (ijpsonline.com)

A small molecule that blocks G55-G45 interactions impaired secretion and reduced TP53-deficient LUAD growth and metastasis. (jci.org)
We believe that exposure to nicotine either by tobacco smoke or nicotine supplements might facilitate increased tumor growth and metastasis. (nih.gov)
This study demonstrates for the first time that administration of nicotine either by i.p. injection or through over-the-counter dermal patches can promote tumor growth and metastasis in immunocompetent mice. (nih.gov)
Latest research demonstrate that the expression of TFPI two is down regulated in a few invasive tumor cell lines, including choriocarcinoma, glioma, prostate cancer, melanoma, fibrosarcoma, and pancreatic ductal adenocar cinoma, though exogenous expression of this gene in cancer cells can inhibit tumor growth and metastasis in vivo by modulating ECM remodeling and angiogenesis. (mirnadatabase.com)
G protein-coupled receptors (GPCRs) are among the most significant therapeutic targets and some of them promote the growth and metastasis of cancer. (oncotarget.com)

Some studies have pointed out that many biomarkers are closely related to the occurrence and development of tumors and can be used for early screening of tumors. (hindawi.com)
However, many biomarkers are highly expressed in various tumors without good specificity [ 4 ]. (hindawi.com)
Is Relative Quantification Dispensable for the Measurement of MicroRNAs as Serum Biomarkers in Germ Cell Tumors? (iiarjournals.org)

Pancreatic ductal adenocarcinoma (PDAC) is one of the leading causes of cancer-related mortality in the world. (hhs.gov)
Objective: Most patients with pancreatic ductal adenocarcinoma (PDAC) will experience recurrence after resection. (nanostring.com)
Treatment with VEGF inhibitors can delay progression in pancreatic ductal adenocarcinoma (PDA), however, many patients either do not respond to this treatment or eventually relapse. (aacr.org)
Pancreatic ductal adenocarcinoma (PDAC) possesses a dense and fibrotic desmoplastic stroma. (alfaoncology.com)
Cancer-Associated Fibroblasts in Pancreatic Ductal Adenocarcinoma: An Update on Heterogeneity and Therapeutic Targeting. (alfaoncology.com)
Combination Therapy with a Bispecific Antibody Targeting the hERG1/β1 Integrin Complex and Gemcitabine in Pancreatic Ductal Adenocarcinoma. (unifi.it)

The bioinformatics analysis of RIOX2 gene in lung adenocarcinoma and squamous cell carcinoma. (nih.gov)
To explore the pathologic significance of calponin 2 in esophageal squamous cell carcinoma, the expression level of calponin 2 proteins in the tumor tissue of 190 esophageal squamous cell carcinoma patients was examined with immunohistochemistry while the expression level of calponin 2 messenger ribonucleic acid was analyzed by using the data from The Cancer Genome Atlas database. (ijpsonline.com)
Both the calponin 2 messenger ribonucleic acid and protein level were increasingly expressed in the tumor tissues of esophageal squamous cell carcinoma patients compared with the adjacent non-tumor tissue and correlated negatively with the tumor grade. (ijpsonline.com)
Esophageal Squamous Cell Carcinoma (ESCC) and esophageal adenocarcinoma[ 2 , 3 ]. (ijpsonline.com)

To date, there have been a number of papers showing that downregulation of the miR-200 family can inhibit the epithelial-mesenchymal transition - a key step in the initiation of metastasis - and that its restoration can reverse the process. (genomeweb.com)
Ramucirumab is a fully human monoclonal antibody and angiogenesis inhibitor, also described as a VEGF receptor-2 antagonist that targets the VEGF-receptors to inhibit blood vessel structure, growth, and migration, thereby impeding sufficient blood flow necessary for tumor growth and survival. (southcarolinablues.com)
The primary focus of our research is to develop new therapies to inhibit lung cancer progression and prevent tumor cells from acquiring resistance to current treatments. (umn.edu)
Dopamine (DA) and dopamine D2 receptor (D2R) agonists inhibit VEGF-mediated blood vessel development (angiogenesis) and vascular permeability by inhibiting VEGF binding, VEGF receptor phosphorylation and subsequent downstream signaling. (umn.edu)
Our recent studies demonstrated D2R agonists, including FDA approved cabergoline, inhibit lung cancer growth in in vivo models by reducing angiogenesis and tumor infiltrating immune suppressor cells. (umn.edu)
PTEN can inhibit cell cycle progression and induce cell death to stimulate angiogenesis [ 6 ]. (aging-us.com)
The article also underscores the various possible mechanisms by which honey may inhibit growth and proliferation of tumors or cancers. (mdpi.com)
In anti-metastatic studies, lycopene has been found to inhibit the metastasis of human hepatoma SK-Hep-1 cells in athymic nude mice ( 17 ). (frontiersin.org)
They hypothesized that IP6 would inhibit the cell growth rate of Barrett's adenocarcinoma in vitro. (naturalnews.com)
Drs. Kim Vanderlinden and Ivana Vucenik describe what is presently known about how IP6 works to help normalize the rate of cell division, normalize cell physiology, enhance Natural Killer (NK) cells, increase tumor suppressor P53 gene activity, inhibit inflammation, and inhibit angiogenesis. (naturalnews.com)

In terms of colorectal cancers, Silibinin also inhibited angiogenesis through a decrease in expression and production of VEGF, HIF-1α، cyclooxygenase-II (COX2), and Inducible nitric oxide synthase (iNOS) (15). (researchsquare.com)
Adenocarcinoma is the most common histological subtype, accounting for about half of all lung cancers [ 1 ]. (hindawi.com)
Notably, miR-200's ability to do this was found to be dependent on tumor type, with its overexpression associated with poor clinical outcomes in certain cancers and positive outcomes in others - findings that have important translational implications for the development of miRNA-based therapeutics, according to the investigators. (genomeweb.com)
The team began by analyzing miR-200 expression data for four adenocarcinomas and found that low expression of a member of the miRNA family was significantly associated with worse overall survival for ovarian and renal cancers. (genomeweb.com)
At the same time, the cancer types in which miR-200 regulated angiogenesis - ovarian, lung, renal, and basal-like breast - were also found to have "markedly elevated" IL-8 and CXCL1 expression when compared with luminal breast cancers. (genomeweb.com)
Using microarray databases, the investigators found increased IL-8 expression in basal-like breast cancers was associated with significantly worse overall patient survival, relapse-free survival, and distant metastasis-free survival - relationships not noted in luminal subtypes of the disease. (genomeweb.com)
Over the past decade, the identification of stem-like cells as drivers of tumor initiation, recurrence, and metastasis spread in a variety of human cancers had a tremendous impact in basic and translational cancer research. (hindawi.com)
More recent studies have clearly shown that while not definitely causing these cancers, these viruses appear capable of affecting the biology of these tumors in such a way as to make them more aggressive and more resistant to conventional treatments. (surgicalneurologyint.com)
A newer concept is one that involves virally induced mechanisms that alter the biology and aggressiveness of a growing number of cancers including gliomas, medulloblastomas, breast adenocarcinomas, prostate adenocarcinomas, osteosarcomas, colon adenocarcinomas, and mucoepidermoid salivary carcinomas. (surgicalneurologyint.com)
This review article focuses on the role of honey in modulating the development and progression of tumors or cancers. (mdpi.com)

Patients in the report had a 5-year overall survival rate of 93.1%, although survival rates were lower in children who experienced symptoms, local recurrence, or metastasis or who did not undergo treatment with surgery or surgery plus radiotherapy. (medscape.com)
Cancer metastasis is a complicated process, which is one of the main causes of the recurrence and death of cancer patients. (frontiersin.org)

Although it is believed that anticancer properties of Silibinin are related to its effects on cell proliferation, apoptosis, inflammation, angiogenesis, and metabolism, its accurate biochemical anticancer mechanism is still under investigation (4-12). (researchsquare.com)
these oncomodulatory viruses can alter the pathology of these tumors by affecting cell signaling, cell metabolism, apoptosis mechanisms, cell-cell communication, inflammation, antitumor immunity suppression, and angiogenesis. (surgicalneurologyint.com)

These include regulation of cell cycle, activation of mitochondrial pathway, induction of mitochondrial outer membrane permeabilization, induction of apoptosis, modulation of oxidative stress, amelioration of inflammation, modulation of insulin signaling and inhibition of angiogenesis. (mdpi.com)
Apoptosis (necessary programmed cell death) of the adenocarcinoma cells was increased. (naturalnews.com)

Using immunohistochemistry in a well-characterized set of adenocarcinoma tissues, we showed down-regulation of epithelial markers (E-cadherin and cytokeratin 18) and up-regulation of mesenchymal markers (vimentin and α-smooth muscle actin) with concomitant transforming growth factor-β1 (TGF-β1) expression at the invasive margin compared with the central tumor. (aacrjournals.org)
Using human colon adenocarcinoma tissues (hereinafter referred to as colon cancer) and their corresponding non-diseased colon from 114 patients' biopsies, the expression of SPARC and vascular endothelial growth factor (VEGF) were investigated by immunohistochemistry staining to assessment the relationship between SPARC and VEGF, as well as their prognostic significance in patients. (nih.gov)
SPARC expression was mainly in the stromal cells surrounding the colon cancer, and was significant difference in those tissues with the lymph node metastasis and differentiation degree of tumor. (nih.gov)
The efficacy of every anticancer agent is usually assessed by its ability to kill tumor cells without damaging normal tissues. (researchsquare.com)
In this study, we found that HOXB-AS4 was markedly upregulated in tumor tissues compared to precancerous tissues. (bvsalud.org)
Histopathological analysis of over 60 lung adenocarcinoma patientderived tissues reveals t-DARPP protein overexpression positively correlates with tumor grade, suggesting upregulation of t-DARPP promotes lung adenocarcinoma progression. (umn.edu)

Researchers from the MD Anderson Cancer Center this month reported new data showing that the microRNA-200 family, which has previously been implicated in cancer metastasis, can regulate tumor angiogenesis. (genomeweb.com)
Moreover, Cav1 is also localized outside of caveolar regions in the cytoplasm, focal adhesions, the extracellular milieu, and the nucleus emphasizing its function in a variety of cell signalling and mechanotransduction phenomena that may regulate tumor cell behaviour. (diff.org)

these studies indicate that reciprocal interactions between tumor cells and brain stromal cells facilitate metastatic growth. (aacr.org)
Ramucirumab is considered MEDICALLY NECESSARY as a single agent or in combination with paclitaxel for the treatment of individuals with advanced (non-resectable) or metastatic esophageal, gastric, or gastroesophageal junction adenocarcinoma with disease progression that occurs during or after fluoropyrimidine- or platinum-containing chemotherapy. (southcarolinablues.com)
First-line treatment (in combination with erlotinib) of metastatic non-small cell lung cancer in patients whose tumors have epidermal growth factor receptor (EGFR) exon 19 deletions or exon 21 (L858R) substitution mutations. (southcarolinablues.com)
The results showed that lycopene reduced the number of metastatic tumors in the lungs, which was further suppressed by the combined treatment with sorafenib. (frontiersin.org)

Desmoplasia plays important roles in tumorigenesis and aggressiveness by promoting the proliferation and metastasis of tumor cells, enhancing angiogenesis, impeding drug penetration, and contributing to immune evasion. (hhs.gov)
Immune cells abundantly infiltrate tumors, creating a complex environment mediated by repetitive cycles of antitumor responses and immune evasion ( 1 ). (frontiersin.org)
Further, in esophageal cancer tumor tissue, calponin 2 gene was found to co-express with genes associated with tight junction and the expression level of calponin 2 was observed to correlate significantly with the number of infiltrating immune cells. (ijpsonline.com)

A common consensus is the fact that breast cancer metastasis is a multi gene involvement and multi step practice that result in the reduction of intercellular adhesion and degradation from the extracellular matrix, a pure barrier against tumor metastasis. (mirnadatabase.com)

Weis, S. M. & Cheresh, D. A. Tumor angiogenesis: molecular pathways and therapeutic targets. (nature.com)
These studies ultimately led the researchers to angiogenesis-related pathways that "all converged" onto the angiogenesis-promoting cytokines interleukin-8 and CXCL1, he said. (genomeweb.com)
Random set analysis was used to identify biological pathways enriched for genes differentially regulated in tumors (compared with 59 samples of normal mucosa). (biomedcentral.com)
Of the 880 canonical pathways we investigated, 112 displayed significant tumor-related upregulation or downregulation at one or more stages of tumorigenesis. (biomedcentral.com)
S transition in the cell cycle, upregulated expression of tumor-promoting microenvironmental factors, and profound dysregulation of metabolic pathways (e.g., increased aerobic glycolysis, downregulation of pathways that metabolize drugs and xenobiotics). (biomedcentral.com)
Our "Cancer Biology" research section studies the molecular mechanisms and signal transduction pathways involved in vascular permeability, cancer progression/metastasis, cancer drug resistance, and adverse effects of cancer therapy. (umn.edu)
GSEA analysis found STARD12 and STARD14 were associated with glycolysis, oxidative phosphorylation and tumor related signaling pathways. (medsci.org)

Desmoplasia is the most prominent characteristic of PDAC and comprises up to 80% of the tumor mass. (hhs.gov)
The stroma acts not only as a barrier to the penetration of drug and effector T cells, but also as a barrier to restrain the metastasis of PDAC tumors. (hhs.gov)

Similarly, pY14Cav1 was shown to stabilize FAK, focal adhesion kinase and other components within focal adhesions, and lead to enhanced focal adhesions turnover and tumor cell migration. (diff.org)
Recent work shows that pYCav1 in cooperation with the Mgat5/galectin-3 lattice, regulates FAK dynamics in focal adhesions and favours focal adhesion disassembly ad tumor cell migration. (diff.org)
Specific classes of AQP channels have been implicated in enhanced migration, angiogenesis and metastasis in a variety of cancer types [ 8 , 9 ], prompting the suggestion that inhibitors of AQP channels might provide new tools for cancer therapy [ 8 ]. (biomedcentral.com)

Metabolic reprogramming plays an important role in tumor progression and antitumor immunity. (medsci.org)

SPARC maybe involved in the regulation of anti-angiogenesis by which it may serve as a novel target for colon cancer treatment as well as a novel distinctive marker. (nih.gov)

Peripheral lung inflammation may cause a "spill-over" of cytokines, such as interlukin (IL)-6, IL-1β and tumour necrosis factor (TNF)-α, into the systemic circulation, which may increase acute-phase proteins such as C-reactive protein (CRP). (ersjournals.com)

1] This article focuses on cutaneous paraneoplastic syndromes caused by solid tumors. (medscape.com)
The presence of TAMs in most solid tumors is correlated with poor prognosis and overall survival of patients ( 10 ). (frontiersin.org)
In addition to TAMs, solid tumors are also infiltrated by immunosuppressive, immature myeloid progenitor cells, commonly referred to as monocytic or polymorphonuclear myeloid-derived suppressor cells (M/PMN-MDSC) ( 11 - 13 ). (frontiersin.org)

Lung cancer is one of the malignant tumors for which no effective cure has been found so far. (hindawi.com)
[ 4 , 5 ] ) Benign neoplasms occur more frequently in women than in men, but malignant tumors are distributed equally between the sexes. (medscape.com)

Although nicotine is generally thought to have limited ability to initiate cancer, it can induce cell proliferation and angiogenesis in a variety of systems. (nih.gov)
Depletion of GPR171 with an anti-GPR171 antibody decreased proliferation of lung carcinoma cells and attenuated tumor progression in a mouse xenograft model. (oncotarget.com)

In the past, the debate was centered on the idea that for a virus to have oncogenic effects, all of the cells in the tumor must be infected. (surgicalneurologyint.com)

However, the cellular and molecular machinery underlying metastasis is relatively poorly understood so far. (intechopen.com)
We used a molecular pathway-based approach to analyze transcriptomic profiles of 59 colorectal tumors representing early and late preinvasive stages and the invasive stage of tumorigenesis. (biomedcentral.com)

Although researchers have learned much from the study of this diverse group of tumors over the years, the diagnosis and treatment of salivary gland neoplasms remain complex and challenging problems for the head and neck surgeon. (medscape.com)
Salivary gland neoplasms make up 6% of all head and neck tumors. (medscape.com)
In children and adolescents, salivary gland tumors make up 0.5% of all malignancies. (medscape.com)
Almost half of all submandibular gland neoplasms and most sublingual and minor salivary gland tumors are malignant. (medscape.com)
Successful diagnosis and treatment of patients with salivary gland tumors require a thorough understanding of tumor etiology, biologic behavior of each tumor type, and salivary gland anatomy. (medscape.com)
An estimated 700 deaths (0.4 per 100,000 for males and 0.2 per 100,000 for females) related to salivary gland tumors occur annually. (medscape.com)
In the multicellular theory, each tumor type is associated with a specific differentiated cell of origin within the salivary gland unit. (medscape.com)

Others found that Silibinin targeted the onset of angiogenesis in prostate cancer and inhibited signalling originated by Hypoxia-inducible factor 1-alpha (HIF-1α) (13, 14). (researchsquare.com)
Most cases of paraneoplastic AN involve an adenocarcinoma,[5] most commonly one arising in the gastrointestinal tract (stomach or liver[3] ) and less commonly in the lungs, ovaries, uterus, breasts, kidneys, prostate or bladder. (medscape.com)

In this review, we discuss how rudimentary defense mechanisms deployed by myeloid cells can promote tumor progression. (frontiersin.org)

Microcystic adenoma of the pancreas is a tumor that is benign in nature. (hindawi.com)
Most tumors (65%) are benign, with hemangiomas being the most common, followed by pleomorphic adenomas. (medscape.com)

Enhanced immunity and antioxidant properties also contribute to tumor cell destruction. (naturalnews.com)
These results supported the idea that calponin 2 is involved in esophageal cancer and may function as a tumor inhibitor probably through modulating cancer cells tight junction and tumor immunity. (ijpsonline.com)

Here, we showed that TP53 loss initiated a pharmacologically actionable secretory process that drove lung adenocarcinoma (LUAD) progression. (jci.org)
Lung adenocarcinoma (LUAD) is one of the malignant lung tumors. (hindawi.com)
Despite the availability of various therapies including surgery, radiation, and targeted therapies, unfortunately, there are significant barriers to effective treatment of LUAD and an overall survival of less than five years in patients with lung adenocarcinoma [ 3 ]. (hindawi.com)
However, the underlying functions of STARDs in lung adenocarcinoma (LUAD) have not been clarified yet. (medsci.org)
Non-small cell lung cancer (NSCLC) accounts for 85-90% of cases, while lung adenocarcinoma (LUAD) is the most common subtype [ 2 ]. (medsci.org)

Acquisition of gemcitabine resistance enhances angiogenesis via upregulation of IL‑8 production in pancreatic cancer. (cancerindex.org)

of 152 evaluable patients, 39 (25.7 percent) developed hyperprogressive disease, all of which showed tumor infiltration by M2-like CD163 + CD33 + PD-L1 + clustered epitheloid macrophages in pretreatment samples. (aacr.org)
Tumor infiltration of CD8 T (P = 0.005) cells and naïve B cells (P = 0.001) was greater in the low-risk than in the high-risk group, with infiltration of these cells negatively correlated with risk score. (bvsalud.org)

Neutrophils also contribute to tumor progression, yet establishing the difference between PMN-MDSCs and tumor-associated neutrophils (TAN) remains challenging ( 11 , 15 , 16 ). (frontiersin.org)

This is not surprising considering the lack of knowledge of carcinogenesis, pathophysiology of metastases, and implications of tumor spread. (medscape.com)

About 29% to 35% of gastric cancer cases have regional spread to lymph nodes or metastasis to distant sites. (southcarolinablues.com)
The metastasizing cells penetrate the blood vessel wall by invasiveness, and migrate in the circulation, extravasate out of the blood vessels, colonize in the distant tissue, initiate angiogenesis, and finally grow at the new site ( 2 , 3 ). (frontiersin.org)

In the case of lung cancer, "delivery of miR-200a and -200b members resulted in a significant decrease in primary tumor burden as compared with control miRNA," they wrote. (genomeweb.com)

In preclinical models utilizing human lung cancer cells and specific NSCLC mutational subsets, the researchers found that tumor growth was enhanced by anti-PD-1 treatment but not by anti-PD-1 F(ab) 2 fragments, which lack the Fc portion of the antibody. (aacr.org)
Correspondingly, abrogation of DARPP-32 in human NSCLC cells reduces lung tumor growth in preclinical in vivo models. (umn.edu)
Evaluation of bioinformatics data corresponding to over 500 lung adenocarcinoma patients confirms elevated t-DARPP expression is associated with worsening tumor grade as well as demonstrates correlation between high t-DARPP levels and poor overall NSCLC patient survival. (umn.edu)

Additional in vitro and in vivo experiments confirmed that IL-8 and CXCL1 are direct targets of the miR-200 family, and that the miRNA family can directly affect angiogenesis in endothelial cells by targeting production of IL-8 and CXCL1. (genomeweb.com)

Complete depletion of the stroma, therefore, leads to a more aggressive tumor and a poor survival rate. (hhs.gov)
At the same time, low expression of several miR-200 isoforms was significantly associated with poor survival in lung adenocarcinomas. (genomeweb.com)
Our research aims to improve the dismal survival rate of lung cancer patients and seeks an innovative approach to combatting tumor drug resistance. (umn.edu)
Patients with higher calponin 2 in the tumor tissue were found to have longer overall survival time. (ijpsonline.com)

Collectively, our data suggested that HOXB-AS4 regulated the malignant tumor aggression of HT29 and SW480 cells through the miR-140-5p/HDAC7 axis and PI3K/AKT signaling pathway. (bvsalud.org)
Therefore, targeting drugs molecules in the PTEN signaling pathway may be another strategy to suppress tumor cells by inhibiting tumor activity [ 7 , 8 ]. (aging-us.com)

Recombinant Kinesin Family, Member 18A ( KIF18A ) belongs to Recombinant Kinesin Family [ 9 ], which is highly expressed in tumors and associated with poor prognosis [ 10 , 11 ]. (aging-us.com)

Expression of AQP1 in cell lines was assessed by quantitative (q) PCR, western blot and immunofluorescence, while expression of AQP1 in human colon tumour tissue was assessed by immunohistochemistry. (biomedcentral.com)

Understanding how cancer stem cells affect tumor heterogeneity, the contribution of resident stem and progenitor cells to the tumor niche, and the search for true cancer stem cell markers are other examples of scientific challenges in this fast-growing research area. (hindawi.com)

These cells may be a key factor ultimately mediating the deviation of the antagonistic response between tumor inhibition and tumor promotion. (explorationpub.com)

The mineral dust-induced gene, mdig, regulates angiogenesis and lymphangiogenesis in lung adenocarcinoma by modulating the expression of VEGF-A/C/D via EGFR and HIF-1α signaling. (nih.gov)

Esophageal adenocarcinoma is increasing in incidence ( 1 ). (aacrjournals.org)

The results of GO analysis showed that the downregulated genes were significantly enriched in matrix adhesion and angiogenesis and upregulated differential genes were significantly enriched in cell adhesion and vascular development. (hindawi.com)

Differentially expressed genes were obtained by comparing gene expression between lung adenocarcinoma samples and normal samples. (hindawi.com)

Rather, only a few cells need to be infected, with the release of viral proteins from the viruses, which occupy most if not all of the tumor cells, including stromal cells. (surgicalneurologyint.com)

these tumors also showed an increased expression of the alpha(7) nAChR subunit. (nih.gov)
However, while forced miR-200 expression can prevent the formation of metastasis in lung cancer, it has been found to enhance metastasis in certain breast cancer models. (genomeweb.com)
Pathological examination of human lung cancer tissue revealed a positive correlation between endothelial D2R expression levels and tumor stage as well as patient smoking history. (umn.edu)
To explore the possible pathological significance of calponin in ESCC, in this study, we first examined the expression of calponin isoforms in the tumor tissue of ESCC patients and further explored their association with the disease. (ijpsonline.com)

Studies have focused on the genetic and epigenetic status of CAFs, since they are critical in tumor progression and differ phenotypically and functionally from normal fibroblasts. (spandidos-publications.com)

Anatomy24

Organisms8

Diseases69

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Analytical, Diagnostic and Therapeutic Techniques and Equipment50

Phenomena and Processes36

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Information Science4

Health Care11

Microenvironment18

Progression and metastasis4

Invasion15

Growth and metastasis5

Biomarkers3

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Inhibit10

Cancers10

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LUAD5

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