Tumor angiogenesis. Medical search. Frequent questions

Researchers from the MD Anderson Cancer Center this month reported new data showing that the microRNA-200 family, which has previously been implicated in cancer metastasis, can regulate tumor angiogenesis. (genomeweb.com)
Myeloid cells are a heterogeneous population of bone marrow-derived cells that play a critical role during growth and metastasis of malignant tumors. (hindawi.com)
Myeloid cells promote tumor growth by stimulating tumor angiogenesis, suppressing tumor immunity, and promoting metastasis to distinct sites. (hindawi.com)
Angiogenesis, the growth of new blood vessels, occurs at different stages during embryonic development, physiological processes such as wound healing and reproduction, and numerous diseases, including inflammation, tumor progression, and metastasis [ 1 ]. (hindawi.com)
This suggested that EPCs are able to differentiate into endothelial cells and that such cells are incorporated into sites of active angiogenesis including ischemia, tumor angiogenesis, and metastasis in adult organisms [ 16 , 17 ]. (hindawi.com)
However, endocannabinoids are now emerging as suppressors of angiogenesis and tumor spreading since they have been reported to inhibit angiogenesis, cell migration and metastasis in different types of cancer, pointing to a potential role of the endocannabinoid system as a target for a therapeutic approach of such malignant diseases. (spandidos-publications.com)
Melanoma researchers have therefore been concentrating their efforts on learning more about angiogenesis, lymphangiogenesis and the nature of metastasis in order to better understand which types of melanomas have a tendency to metastasize. (dermatologytimes.com)
Spread can occur by local invasion into the surrounding tissue, by systemic metastasis via tumor-associated blood vessels to distant organs, or by lymphatic metastasis via tumor-associated lymphatic vessels to draining sentinel lymph nodes, then to distal lymph nodes and from there to distant organs. (dermatologytimes.com)
The elevated expression of several angiogenic factors, including vascular endothelial growth factor (VEGF), basic fibroblast growth factor (FGF) and interleukin-8, has been detected in primary cutaneous melanomas, and the importance of these mediators in promoting melanoma angiogenesis and metastasis has been confirmed in tumor xenotransplant models. (dermatologytimes.com)
Dr. Detmar set out to investigate whether the extent of tumor lymphangiogenesis can predict melanoma metastasis to sentinel lymph nodes. (dermatologytimes.com)
Dr. Detmar postulates that metastatic melanomas can therefore be characterized by increased lymphangiogenesis, as compared to non-metastatic tumors, and that the degree of tumor lymphangiogenesis can serve as a novel predictor of lymph node metastasis and overall patient survival, independent of tumor thickness. (dermatologytimes.com)
He explains that the extent of tumor lymphangiogenesis is a highly sensitive (83 percent) and specific (89 percent) prognostic marker of lymph node metastasis. (dermatologytimes.com)
In turn, de novo formed vessels enhance tumor invasion and metastasis through the production of MMP 2 and 9 and uPA, which further degrade ECM. (biomedcentral.com)
Administration of bacteria significantly enhanced survival rate, suppressed tumor progression and lowered expression levels of MMP-9, VEGFR2, CD31and Ki67 as potent markers for angiogenesis, tumor proliferation and metastasis. (authorea.com)
Conclusion Overall, administration of E. coli bearing cardiac hormone expression construct could effectively suppress tumor growth, angiogenesis, invasion and metastasis while enhancing survival rate in mice model of breast cancer. (authorea.com)
Tasquinimod targets the tumor microenvironment and counteracts cancer development by inhibiting angiogenesis and metastasis and by modulating the immune system. (wikipedia.org)
Over the past decade, the identification of stem-like cells as drivers of tumor initiation, recurrence, and metastasis spread in a variety of human cancers had a tremendous impact in basic and translational cancer research. (hindawi.com)
Tumor growth and metastasis depend on the establishment of tumor vasculature to provide oxygen, nutrients, and other essential factors. (biomedcentral.com)
The exploration of the underlying mechanisms of these alternative angiogenic approaches would not only widen our knowledge of tumor angiogenesis but also provide novel therapeutic targets for better controlling cancer growth and metastasis. (biomedcentral.com)
The overall 5-year survival rate of patients with esophageal cancer remains low at 10% to 40% due to late diagnosis, metastasis, and resistance of the tumor to radiotherapy and chemotherapy. (hku.hk)
More importantly, the results from tumor xenograft and experimental metastasis models showed that Bay11-7082 had significant antitumor effects on ESCC xenografts in nude mice by promoting apoptosis, and inhibiting proliferation and angiogenesis, as well as reduced the metastasis of ESCC cells to the lungs without significant toxic effects. (hku.hk)
TAZVERIK ® 's potential for broad applicability and favorable safety profile may provide further inhibition of tumor growth and metastasis when used in combination therapy. (businesswire.com)
Results: Following successive invasion of the extracellular matrix (ECM), new blood vessels penetrate and supply nutrients to tumor tissues for growth and metastasis. (edu.hk)
Chemokines have been implicated in many aspects of tumorigenesis cell biology, including tasks in the rules of malignancy cell growth, angiogenesis, metastasis, and sponsor immune response (5). (wwec2012.net)
Src activation by β-adrenoreceptors is a key switch for tumour metastasis. (mdanderson.org)
HIFs exert differential effects on tumor growth and affect important cancer hallmarks including cell proliferation, apoptosis, differentiation, vascularization/angiogenesis, genetic instability, tumor metabolism, tumor immune responses, and invasion and metastasis. (lu.se)
The prevalence and prognostic impact of lymph node metastasis in malignant germ cell tumors of the ovary. (cancercentrum.se)
Retroperitoneal nodal metastasis in primary and recurrent granulosa cell tumors of the ovary. (cancercentrum.se)
Patterns of metastasis in sex cord-stromal tumors of the ovary: can routine staging lymphadenectomy be omitted? (cancercentrum.se)

Subsequently, we demonstrated that in solid tumors, such as pediatric neuroblastoma and colon adenocarcinoma, deregulation of miR-17-92 leads to profound suppression of TGFβ signaling and diminished production of many anti-angiogenic TGFβ-inducible factors such as thrombospondin-1, CTGF, and clusterin. (chop.edu)
Ether-a-go-go-1 (Eag1) is a CNS-localized voltage-gated potassium channel that is found ectopically expressed in a majority of extracranial solid tumors. (mpg.de)
Tasquinimod (ABR-215050, CID 54682876) is an experimental drug currently being investigated for the treatment of solid tumors. (wikipedia.org)
In this article, we discuss the most recent findings and understanding on how solid tumors evade VEGF-targeted therapy, with a special focus on vessel co-option, vessel remodeling, and tumor cell-derived vasculature establishment. (biomedcentral.com)
This collaboration will accelerate the exploration of the clinical potential of EZH2 inhibition in multiple tumor types, including both hematological malignancies and solid tumors. (businesswire.com)
HUTCHMED plans to develop and seek approval for TAZVERIK ® in various hematological and solid tumors, including ES, FL and diffuse large b-cell lymphoma ("DLBCL") in its Territory. (businesswire.com)
In line with this observation, elevated extracellular lactate concentrations up to 40 mM and corresponding low extracellular pH (pH e ) have been found in solid tumors under hypoxic conditions [ 18 - 22 ]. (hindawi.com)
Researchers anticipate enrolling 130 participants with one of several solid tumors. (medscape.com)
Here we review the functions of HIFs in the progression and treatment of malignant solid tumors. (lu.se)

Tumors exhibit significant myeloid cell infiltrates, which are actively recruited to the tumor microenvironment. (hindawi.com)
Finally, we will comment on the mechanisms regulating myeloid cell recruitment to the tumor microenvironment and on the potential of myeloid cells as new targets for cancer therapy. (hindawi.com)
It is known that the inflammatory interleukin-3 (IL-3), released in the tumoral microenvironment, contributes to both angiogenesis and vasculogenic processes. (unito.it)
Tasquinimod is a novel small-molecule inhibitor that targets the tumor microenvironment by controlling the accumulation and immunosuppressive, pro-angiogenic and pro-metastatic functions of regulatory myeloid cells (also called myeloid-derived suppressor cells). (wikipedia.org)
It binds to and inhibits the interactions of S100A9, an immunomodulatory protein that promotes tumor development, influences suppressive and pro-angiogenic cells in the tumor microenvironment, and participates in the establishment of pre-metastatic niches. (wikipedia.org)
Tasquinimod may also target the tumor microenvironment by suppressing the tumor hypoxic response, in which genes involved in the adaptation and survival of cells during hypoxia are induced. (wikipedia.org)
Consequently, tumor vasculature is inefficient in carrying blood flow, resulting in a hypoxic tumor microenvironment, although the intra-tumoral microvessel density is commonly increased in contrast to the non-cancerous counterpart tissue. (biomedcentral.com)
These findings imply that HOXB9 overexpression may alter tumor-specific cell fates and the tumor stromal microenvironment, contributing to breast cancer progression. (elsevierpure.com)
The multiple tasks of CCL2 in the tumor microenvironment make it a good restorative target in metastatic prostate malignancy as well as with other cancers. (wwec2012.net)
In the metabolic symbiosis model, these cells have been proposed to overexpress MCT4 to release high amounts of lactate produced during anaerobic glycolysis into the tumor microenvironment. (hindawi.com)

Importantly, during tumor progression, myeloid cells are implicated in promoting tumor angiogenesis, causing resistance against antiangiogenic therapies in cancer, and suppressing the immune response during cancer [ 3 - 5 ]. (hindawi.com)
Neoangiogenesis, i.e. the formation of new blood vessels, is provided via the production of chemoattractans, which redirect endothelial cells into the tumor tissue to enable tumor progression. (biomedcentral.com)
While circumstantial evidence linking Eag1 to tumor biology has been well established, the mechanisms by which the channel contributes to tumor progression remain elusive. (mpg.de)
A mutation that eliminates ion permeation fails to completely abolish xenograft tumor formation by transfected cells, indicating that Eag1 contributes to tumor progression independently of its primary function as an ion channel. (mpg.de)
We provide new insight into the mechanisms of action regulating NRP-dependent tumor angiogenesis and signpost a novel approach to halt tumor progression. (figshare.com)
Silencing of circSDHC restrained cell malignant phenotypes and angiogenesis via reducing CEP55 expression by releasing miR-130a-3p in RCC, providing a new mechanism for understanding the progression of RCC. (bvsalud.org)
In fact, mTOR (the mammalian target of rapamycin) acts as a central regulator of many cellular activities involving growth and differentiation through regulation of cell cycle progression, cell size, cell migration and survival, including those in tumor cells. (edu.hk)
However, the mechanism of tumor progression in FAP/sporadic colorectal cancer and in colitis-associated colorectal cancer might differ as indicated by reduced tumor expression of COX-2 and reduced serum levels of PGE2 in the female double mutant (CysLT1R−/− ApcMin/+) mice, whereas AOM/DSS-treated female single mutant (CysLT1R−/−) mice demonstrated increased serum levels of PGE2. (lu.se)

Perfusion imaging of brain tumors has been performed by using various tracer and nontracer modalities and can provide additional physiologic and hemodynamic information, which is not available with routine morphologic imaging. (ajnr.org)
This article is an overview of the utility of PCT for assessment of brain tumors and describes the technique, its advantages, and limitations. (ajnr.org)
1 , 2 Malignant brain tumors are characterized by neovascularity and increased angiogenic activity, with a higher proportion of immature and highly permeable vessels. (ajnr.org)
Traditionally, perfusion imaging of brain tumors has been performed with MR imaging, by using various perfusion imaging techniques and estimating tumor blood volume, blood flow, and permeability. (ajnr.org)
In view of the wider availability, faster scanning times, and low cost compared with MR perfusion, PCT is potentially well-suited to study brain tumors 6 , 7 and could potentially be useful as an easy tool for quantitative estimates of perfusion parameters and their use as imaging biomarkers. (ajnr.org)
Osteosarcoma is the third most common cancer in adolescence-only lymphomas and brain tumors occur more frequently. (medscape.com)
Malignant gliomas are the most common primary malignant brain tumors with an increasing incidence of up to nine per 100,000 habitants over the last years [ 1 , 2 ]. (hindawi.com)
We provide proof-of-concept for extracellular vesicle (EV) profiling as a strategy for non-invasive, liquid biopsy of brain tumors. (lu.se)

Specific growth factors, such as vascular endothelial growth factor (VEGF) and basic fibroblast growth factor (bFGF), stimulate the proliferation and migration of naturally quiescent endothelial cells, resulting in the formation of new vessel structures during embryonic development and tumor growth [ 7 ]. (hindawi.com)
We propose a model of vascular tumour growth, which generalises the well recognised model formulated by Hahnfeldt et al. (impan.pl)
Fc4 in vivo inhibited the IL-3-mediated vasculogenic process, as well as inflammatory and tumour vascular growth. (unito.it)
Tumor vascular perfusion parameters obtained by using CT or MR perfusion have been used for tumor grading, prognosis, and treatment response in addition to differentiating treatment/radiation effects and non-neoplastic lesions from neoplasms. (ajnr.org)
High-grade gliomas can be highly invasive and extremely vascular tumors. (ajnr.org)
3 - 5 However, PCT, which has also been used recently for glioma grading, 6 , 7 provides a linear relationship between tissue attenuation and tissue concentration of a contrast agent, unlike perfusion MR imaging, and, hence, probably provides a more robust and less biased estimation of hemodynamic (tumor blood volume) and physiologic (tumor vascular leakiness) parameters. (ajnr.org)
The well-known vascular endothelial growth factor (VEGF) signaling is crucial for sprouting angiogenesis as well as recruitment of circulating progenitor endothelial cells to tumor vasculature, which has become therapeutic targets in clinical practice. (biomedcentral.com)
These factors could allow neoplastic tissues to survive and withstand the stress induced by hypoxia and/or disruption of the ECM, including vascular endothelial growth factor and matrix metalloproteinases that were found to be highly elevated in tumor tissues of colon cancer patients. (edu.hk)
CCL2 induces angiogenesis through multiple mechanisms including direct induction of vascular endothelial growth element A (54) and hypoxia-inducible element-1 (69). (wwec2012.net)
We investigated the impact on tumor malignancy in F98 glioma cells using in silico analysis, in vitro cell culture assays, and ex vivo vascular organotypic glioma impact model (VOGIM) [ 35 ] by implanting F98 cells into rat brain slices. (hindawi.com)
PSMA is a cell surface glycoprotein receptor present on tumor vascular endothelium of many types of cancer [6, 7]. (aiche.org)
The objective of this study was to evaluate clinical and microscopic features of squamous cell carcinomas using immunohistochemical analysis and assessing biological markers of angiogenesis and tumor vascular activity (anti-CD31, anti-CD34, Factor VIII), cell proliferation (Ki-67), and loss of cell suppression (p53). (bvsalud.org)

In vivo perfusion imaging techniques provide additional information regarding tumor physiology and hemodynamics, which may help in better characterizing glioma malignancy and may also overcome some of the limitations of histologic grading and conventional morphologic imaging. (ajnr.org)

Functionally, circSDHC silencing decreased xenograft tumor growth and induced RCC cell apoptosis , repressed RCC cell proliferation , angiogenesis, migration, and invasion in vitro . (bvsalud.org)

These observations stimulated an intensive search for the mechanisms regulating tumor angiogenesis. (hindawi.com)
Most work has focused on the role of endocannabinoids in regulating tumor cell growth and apoptosis and ongoing research is addressed to further dissect the precise mechanisms of cannabinoid antitumor action. (spandidos-publications.com)
Tumor cells utilize a complex set of molecular mechanisms in order to metastasize [ 2 ]. (biomedcentral.com)
However, the role of miR-874 in tumor angiogenesis and the mechanisms underlying its function in GC remained to be clarified. (oncotarget.com)
Figure 1: Classification of the different mechanisms of tumour vascularization. (nature.com)
Background: When tumor cells are under hypoxic condition or other forms of oxidative stress, one of the survival mechanisms is to undergo angiogenesis, involving dissemination of existing vessels or neovascularization to antagonize the apoptotic drive and to facilitate migration to secondary sites. (edu.hk)
The finding that continuously infused 5-FU is able to stimulate angiogenesis in the present rat model of angiogenesis warrants investigation of the mechanisms behind this unexpected finding. (unboundmedicine.com)
For this purpose, we designed an MCT4 overexpression and knockdown/inhibition model to explore the functional consequences of MCT4 expression on cancer cell metabolism, survival, proliferation, migration, invasion potential, and angiogenesis as well as on cell cycle profiles and cell death mechanisms. (hindawi.com)
Dufraine J, Funahashi Y, Kitajewski J. Notch signaling regulates tumor angiogenesis by diverse mechanisms. (medlineplus.gov)

Interestingly, brain endothelial cell (BEC) proliferation followed the same time-course, suggesting a mechanistic relationship, with the Fn-α5β1/αVβ3 integrin axis driving BEC proliferation and angiogenesis. (biomedcentral.com)
Immunohistochemical staining was performed to evaluate the expression of HOXB9, Ki-67, CD31, and CD34, and the association of tumor proliferation and angiogenesis with HOXB9 expression was analyzed. (elsevierpure.com)
HOXB9 expression, which promotes tumor proliferation and angiogenesis, is a significant prognostic factor in breast cancer. (elsevierpure.com)

In 1971, Dr. Judah Folkman observed that neovascularization occurs around tumors and proposed that new blood vessel growth is necessary to supply nutrients and oxygen to tumor cells during exponential tumor growth [ 6 ]. (hindawi.com)
Bone marrow-derived endothelial progenitor cells are a major determinant of nascent tumor neovascularization. (nature.com)
Studies have suggested that HOXB9 expression in breast cancer cells promotes cellular invasiveness, metastatic ability, and tumor neovascularization in the surrounding tissue in in vitro and in vivo assays. (elsevierpure.com)
It is a surrogate BIOMARKER used for many physiological and pathophysiological processes such as angiogenesis, neovascularization, disease and tumor progressions. (bvsalud.org)

Notably, miR-200's ability to do this was found to be dependent on tumor type, with its overexpression associated with poor clinical outcomes in certain cancers and positive outcomes in others - findings that have important translational implications for the development of miRNA-based therapeutics, according to the investigators. (genomeweb.com)
Thus, targeting microRNAs might be a viable anti-angiogenic strategy, especially in tumors without VEGF overexpression. (chop.edu)
Inhibition of MMPs has provided a significant increase in the survival rate in clinical trials, according to the frequent overexpression of MMPs in malignant tumors and the correlation with a highly aggressive phenotype and poor prognosis [ 8 - 10 ]. (biomedcentral.com)
Overexpression of STAT3 rescued the loss of tumor angiogenesis caused by miR-874. (oncotarget.com)
Furthermore, exogenetic expression of CEP55 counteracted miR-130a-3p overexpression-mediated effects on malignant phenotypes and angiogenesis of RCC cells . (bvsalud.org)
Since its finding, studies have shown the overexpression and resultant promotion of tumor growth of CCL2 in melanoma (35) and ovarian (36), BMS-986020 sodium breast (37C40), esophageal (41,42), gastric (43), renal cell (44), lung (45C47), colon (48), and papillary thyroid carcinomas (49) (Table 2). (wwec2012.net)

Histologic evaluation of tumor angiogenesis by using various markers such as MVD, MVCP, and TVA is also limited by this regional heterogeneity, and its confounding effect is worsened by its small size and a limited number of samples obtained with surgical biopsy. (ajnr.org)

Our model is based on the same idea that the carrying capacity for any solid tumour depends on its vessel density but it also incorporates vasculature quality which may be lost during angiogenesis as recognised by Jain in 2005. (impan.pl)
Using these quantum dots and the aforementioned imaging modalities, the angiogenic tumor vasculature was readily detected with the highest angiogenic activity occurring in the periphery of the tumor. (uu.nl)
Abnormal tumor vasculature typically lacks hierarchical structure and is composed of immature differentiated and undifferentiated vessels with increased permeability [ 1 , 2 ]. (biomedcentral.com)
When the concept of tumor vasculature normalization was first introduced, it was believed that along with the pruning of the immature and undifferentiated vessels in a solid tumor, the remaining vasculature would also undergo shrinkage and be eventually unable to support tumor growth. (biomedcentral.com)
In the present article, we discuss the origin of the remaining vessels after vasculature normalization treatment, as well as the alternative cellular origins of tumor vasculature, which are of great interest for improving the efficacy of antiangiogenic therapy. (biomedcentral.com)
Vessels co-option, a procedure of hijacking the blood vessels in surrounding normal tissue along with the invasion of a solid tumor, has been recognized as an important approach to establish tumor vasculature, especially in more aggressive tumors [ 2 , 15 ]. (biomedcentral.com)
HOXB9-positive tumors showed a significant increase in the number of vasculature and the Ki-67 ratio compared with HOXB9-negative tumors. (elsevierpure.com)
Furthermore, conditional silencing of FMOD in newly generated DGCs in vivo inhibits the growth of GSC-initiated tumors due to poorly developed vasculature and increases mouse survival. (tau.ac.il)
The objective of this study is to design a new class of liposomes that can target tumor vasculature via Prostate-Specific Membrane Antigen (PSMA) and rapidly and extensively release therapeutic agents intracellularly by using the pH-sensitive peptide GALA conjugated to lipid moieties to destabilize the integrity of intracellular endosomes and achieve better tumor killing outcomes. (aiche.org)
This study explores the mechanism of GALA anchored to gel-phase lipid vesicles in both clustered (pH and non-pH responsive) and uniform presentations with the goal of optimizing GALA presentation for improving therapeutic efficacy of tumor vasculature targeted liposome compositions. (aiche.org)
Therefore, tumor vasculature is directly and easily accessible to intravenously injected PSMA targeted treatments, whereas healthy vasculature and PSMA-expressing tissues are not expected to exhibit significant localization. (aiche.org)

The results of these studies will increase significantly our knowledge of the biological functions of proangiogenic monocytes in tumor development, and may improve cancer therapies by enlightening novel and yet unrecognized therapeutic targets and by providing proof-of-feasibility of a new gene therapy strategy. (europa.eu)
These novel findings could form a platform for future therapeutic strategies aimed at stimulating angiogenesis following cerebral ischemia. (biomedcentral.com)
Perfusion imaging has been used to assess tumor grade and prognosis and, recently, to assess treatment response, which has attracted more attention due to the advent of newer therapeutic options, including antiangiogenic agents. (ajnr.org)
Folkman, J. Tumor angiogenesis: therapeutic implications. (nature.com)
Weis, S. M. & Cheresh, D. A. Tumor angiogenesis: molecular pathways and therapeutic targets. (nature.com)
Collec-tively, these findings demonstrate that DGC-secreted FMOD promotes glioma tumor angiogenesis and growth through paracrine signaling in endothelial cells and identifies a DGC-produced protein as a potential therapeutic target in glioma. (tau.ac.il)

Bifulco M, Laezza C, Gazzerro P and Pentimalli F: Endocannabinoids as emerging suppressors of angiogenesis and tumor invasion (Review). (spandidos-publications.com)
Bacteria bearing constructs were then IV administered in mice bearing tumors and then tumor localization, as well as tumor proliferation, invasion and angiogenesis biomarkers (Ki-67, VEGFR, CD31and MMP9), changes in cytokine profile, suppression of tumor growth and survival were analyzed. (authorea.com)
al, angiogenesis, and invasion. (who.int)

It is now known that new blood vessels originate from preexisting vessels by activation, proliferation and migration of endothelial cells through a process named "angiogenesis" [ 4 ]. (hindawi.com)
Solid tumours need a blood supply, and a large body of evidence has previously suggested that they can grow only if they induce the development of new blood vessels, a process known as tumour angiogenesis. (nature.com)
Figure 2: Patterns of tumour growth in relation to blood vessels. (nature.com)
BACKGROUND: Angiogenesis is the development of new blood vessels from pre-existing ones. (ox.ac.uk)
This nutrient flow is critical to tumor growth and is facilitated in the host body by the growth of new blood vessels. (prnewswire.com)
In tumor angiogenesis, the blood vessels grow to support the growth of the tumor. (prnewswire.com)
This groundbreaking BCRI study has shown that angiogenesis or the proliferation of new blood vessels, in support of tumor growth, is retarded when high levels of vitamin C are present in the blood. (prnewswire.com)
This process enables tumor cells, including those within the core of the heterogeneous tumor mass to survive, despite being at a distance from blood vessels that supply their metabolic needs [ 16 , 17 ]. (hindawi.com)
The increased expression of the JAG1 gene may promote the development of new blood vessels that nourish a growing tumor. (medlineplus.gov)

Monocarboxylate transporter 4 (MCT4, SLC16A3 ) is elevated under hypoxic conditions in many malignant tumors including gliomas. (hindawi.com)

For VEGF, the target of current therapies, this correlation between hypoxia and higher cytokine levels was greater in primary breast and lung carcinoma cells than in ovarian carcinoma cells or tumor cell lines. (biomedcentral.com)
Methods: This paper reveals the pathogenesis of tumor angiogenesis, particularly during hypoxia and other forms of oxidative stress in cancer cells. (edu.hk)
Insufficient tissue oxygenation, or hypoxia, contributes to tumor aggressiveness and has a profound impact on clinical outcomes in cancer patients. (lu.se)

Likewise, the immunohistochemistry results showed significant decreases in tumor proliferation and vascularization in the treatment-group in comparison to the control-group of 26%(p≤0.05) and 32.2%(p≤0.05) respectively. (biomedcentral.com)
The triple-therapy is feasible and effective in reducing both tumor growth and vascularization. (biomedcentral.com)
Our data suggest that Eag1 interferes with the cellular mechanism for maintaining oxygen homeostasis, increasing HIF-1 activity, and thereby VEGF secretion and tumor vascularization. (mpg.de)

The inhibition of the tumor growth was accompanied with changes in proliferation and apoptosis as determined by reduced Ki-67 expression, increased expression of p21WAF/Cip1, cleaved caspase 3 and caspase-cleaved keratin 18. (lu.se)
At high concentrations, NSAIDs have anticarcinogenic properties operating through cyclooxygenase-2-dependent and -independent pathways to inhibit cellular proliferation, inhibit angiogenesis, and induce apoptosis. (medscape.com)

At the same time, the cancer types in which miR-200 regulated angiogenesis - ovarian, lung, renal, and basal-like breast - were also found to have "markedly elevated" IL-8 and CXCL1 expression when compared with luminal breast cancers. (genomeweb.com)
The reduced tumor volumes corresponded with significant reductions in tumor mass, and similar effects were observed in follow-on testing in models of ovarian and renal cancer. (genomeweb.com)
In the case of lung cancer, "delivery of miR-200a and -200b members resulted in a significant decrease in primary tumor burden as compared with control miRNA," they wrote. (genomeweb.com)
The potential use of cannabinoids to retard tumor growth and spreading is even more appealing considering that they show a good safety profile, regarding toxicity, and are already used in cancer patients as palliatives to stimulate appetite and to prevent devastating effects such as nausea, vomiting and pain. (spandidos-publications.com)
Dr. Detmar notes, 'It is tempting to speculate that the lymphangiogenic factors, in addition to increasing the mass of tumor-associated lymphatic vessels, might activate the lymphatic endothelium to express increased amounts of chemokines or adhesion molecules and receptors, which are involved in tumor cell-LEC interactions, thereby actively contributing to cancer dissemination. (dermatologytimes.com)
This proof-of-concept study demonstrates that high-frequency UMI is a low-cost, contrast-agent-free, easily applicable, accessible, and quantitative imaging tool for tumor characterization, which may be very useful for preclinical evaluation and longitudinal monitoring of anti-cancer treatment. (illinois.edu)
We developed here, for the first time, a novel spatiotemporal cancer targeted therapy applying engineered E. coli bacteria with capability of expressing cardiac peptides under hypoxic conditions of tumor. (authorea.com)
Advances in this field point to a more complex model of tumor development than previously envisioned, in which the stem-like phenotype may be dynamically acquired by cancer cells. (hindawi.com)
Understanding how cancer stem cells affect tumor heterogeneity, the contribution of resident stem and progenitor cells to the tumor niche, and the search for true cancer stem cell markers are other examples of scientific challenges in this fast-growing research area. (hindawi.com)
The interplay between stem cell and tumor biology offers an exceptional opportunity to advance our knowledge about cancer, one of the leading causes of death worldwide, with potential impacts in cancer diagnosis and therapy. (hindawi.com)
Novel cancer treatment strategies take advantage of tumor-induced vascularisation by combining standard chemotherapeutic agents with angiogenesis-inhibiting agents. (biomedcentral.com)
Cancer stem cells (CSCs) alone can initiate and maintain tumors, but the function of non-cancer stem cells (non-CSCs) that form the tumor bulk remains poorly understood. (tau.ac.il)
Besides, upregulated MCT4 has been linked to altered tumor metabolism as well as to increased growth and survival in breast and pancreatic cancer [ 33 , 34 ]. (hindawi.com)
Increased activity (expression) of the JAG1 gene has been linked to certain cancers, including breast cancer and head and neck tumors. (medlineplus.gov)
Ovarian granulosa cell tumor and increased risk of breast cancer. (cancercentrum.se)
In the mouse xenograft model of colon cancer, we were able to observe a reduced tumor growth in response to CysLT1R antagonist treatment. (lu.se)
[ 17-20 ] In vitro and in vivo research suggests that NSAIDs and selective cyclooxygenase-2 inhibitors hinder growth and survival of bladder cancer cells and nitrosamine-induced tumors. (medscape.com)
W e for the first time show that stress conditions modulate surfaceome turnover in cancer cells, providing opportunities for tumor specific drug delivery. (lu.se)

A linear correlation between normoxic and hypoxic growth conditions exists for expression levels of eight of eleven angiogenesis-related proteins tested including: VEGF, IL-8, PDGF-AA, PDGF-AA/BB, TGF-β1, TGF-β2, EGF, and IP-10. (biomedcentral.com)
Angiogenesis was induced in the mesenteric test tissue in adult male Sprague-Dawley rats by i.p. injection of VEGF-A, which is a key angiogenic factor in most tumors. (unboundmedicine.com)
Albertsson P, Lennernäs B, Norrby K. Low-dose continuous 5-fluorouracil infusion stimulates VEGF-A-mediated angiogenesis. (unboundmedicine.com)
TY - JOUR T1 - Low-dose continuous 5-fluorouracil infusion stimulates VEGF-A-mediated angiogenesis. (unboundmedicine.com)
Furthermore, lactate has been proposed to stimulate angiogenesis through HIF-1 α -dependent activation of the VEGF/VEGFR2 signaling pathway. (hindawi.com)
Notably, VEGF plays a crucial role in melanoma invasiveness, vasculogenic mimicry and tumor-associated angiogenesis. (cdc.gov)
An impaired tumor angiogenesis was also demonstrated by detection of increased levels of VEGF and reduced vessel size. (lu.se)

Additional in vitro and in vivo experiments confirmed that IL-8 and CXCL1 are direct targets of the miR-200 family, and that the miRNA family can directly affect angiogenesis in endothelial cells by targeting production of IL-8 and CXCL1. (genomeweb.com)
Here, gain- and loss-of-function assays demonstrated that miR-874 inhibited the tumor angiogenesis of GC cells in vitro and in vivo . (oncotarget.com)
Further studies should be performed to correlate in vitro protein expression levels of angiogenesis-related factors with in vivo patient response. (biomedcentral.com)
In vitro studies have shown that stromal cells cultured in hypoxic growth conditions secrete higher levels of critical angiogenesis-inducing factors than cells cultured in normoxic conditions [ 3 ]. (biomedcentral.com)

The current standard for tumor grading is histopathologic assessment of tissue, which has inherent limitations, such as sampling error, interobserver variation, and a wide variety of classification systems that are available, the most common of which is the WHO grading system. (ajnr.org)
As a tumor grows, the existing blood supply becomes inefficient at supporting the tissue, and areas of the tumor become hypoxic. (biomedcentral.com)
Tumor necrosis factor- mRNA was seen not been clearly established by immunohistochemical in lung tissue. (cdc.gov)
[ 15 , 16 ] Although not expressed in normal urothelial tissue, cyclooxygenase-2 has been shown to be overexpressed in both transitional cell and squamous cell urothelial tumor tissue. (medscape.com)

In this review, we discuss the role of myeloid cells in promoting tumor angiogenesis. (hindawi.com)
Although tumor cells were first thought to drive the cellular events underpinning tumor angiogenesis and growth, considerable evidence has now emerged for the central role of tumor infiltrating myeloid cells such as monocytes, macrophages, and neutrophils in this phenomenon [ 8 - 12 ]. (hindawi.com)
Recent data indicated that tumor-infiltrating myeloid cells promote tumor angiogenesis. (europa.eu)
Occult tumor cells that can lead to loco-regional recurrence and distant metastases are the main reason for the poor prognosis of patients suffering from squamous cell carcinoma of the head and neck [ 1 ]. (biomedcentral.com)
We found that a key translational regulator, eIF3i, is highly expressed in endothelial cells during embryonic and tumor angiogenesis. (temple.edu)
In zebrafish angiogenesis model, eIF3i mutant endothelial cells could not respond to induction signals from tumor mass. (temple.edu)
The differences between vessel-like structure and tubule-like structure formed by tumor cells are also introduced. (biomedcentral.com)
Also, miR-130a-3p silencing offset circSDHC knockdown-mediated impacts on malignant phenotypes and angiogenesis of RCC cells . (bvsalud.org)
CCL2 directly stimulates breast tumor cells to promote tumorigenesis (71C73). (wwec2012.net)
DGC-secreted FMOD promotes angiogenesis by activating integrin-dependent Notch signaling in endothelial cells. (tau.ac.il)
In a previous study (Sept, 2005) BCRI researchers found that intravenous infusions of vitamin C were selectively toxic to tumor cells. (prnewswire.com)
In summary, our data highlight MCT4 /SLC16A3 as a key gene for distinct hallmarks of tumor malignancy in glioma cells. (hindawi.com)
Antivascular therapy aims to kill tumor cells by cutting off blood flow, depriving tumors of nutrients they need to survive [2]. (aiche.org)
Intriguingly, perivascular tumor cells. (lu.se)
Intriguingly, perivascular tumor cells can also express HIF-2α, thereby forming a "pseudohypoxic" phenotype that further contributes to tumor aggressiveness. (lu.se)
These treatments target specific genetic characteristics of the tumor cells. (msdmanuals.com)

The technique was applied to a chicken embryo tumor model of renal cell carcinoma that was treated with two FDA-approved anti-angiogenic agents at clinically relevant dosages. (illinois.edu)
Vessel co-option in primary human tumors and metastases: an obstacle to effective anti-angiogenic treatment? (nature.com)

Taken together, these findings indicate that down-regulation of miR-874 contributes to tumor angiogenesis through STAT3 in GC, highlighting the potential of miR-874 as a target for human GC therapy. (oncotarget.com)

Conversely, the STAT3-shRNA attenuated the increased tumor angiogenesis caused by the miR-874-inhibitor. (oncotarget.com)
Here we investigate the biologic significance of Hsp90 inhibition in multiple myeloma (MM) and other hemato- logic tumors using an orally available novel small molecule inhibitor SNX-2112, which exhibits unique activities relative to 17- allyamino-17-demethoxy- geldanamycin (17- AAG). (kl.ac.at)
Domvanalimab (from Gilead Sciences) is an experimental immune checkpoint inhibitor, and zimberelimab (from Arcus Biosciences) is an investigational angiogenesis inhibitor. (medscape.com)

Scholars@Duke publication: Tumour suppressor genes and angiogenesis: the role of TP53 in fibroblasts. (duke.edu)
There appears to be a cluster of tumor suppressor genes on chromosome 3. (medscape.com)

Dr. Detmar and his team of researchers conducted a study consisting of 45 patients with primary cutaneous melanoma, where the extent of tumor lymphangiogenesis in the excised primary tumors and the presence of metastases in the sentinel lymph node biopsy samples were examined. (dermatologytimes.com)
Incidence and occurrence of second primary tumors. (cancercentrum.se)

The induction of angiogenesis is a critical point in the development of melanoma,' Dr. Detmar says. (dermatologytimes.com)
Finally, MCT4 inhibition mitigates the induction of angiogenesis, suggesting that MCT4 also plays a crucial role in tumor-related angiogenesis. (hindawi.com)

However, there has only been one previous functional study investigating MCT4 in glioblastoma (GBM) neurospheres, mainly focusing on tumor growth and survival dependent on the oxygen level [ 14 ]. (hindawi.com)

DGCs silenced for FMOD fail to cooperate with co-implanted GSCs to promote tumor growth. (tau.ac.il)

This is far from an isolated scenario, as non-angiogenic tumour growth has now been observed in tumours of many different organs in both humans and preclinical animal models. (nature.com)
A localized hypoxic environment occurs during tumor growth necessitating an angiogenic response or tumor necrosis results. (biomedcentral.com)

These studies ultimately led the researchers to angiogenesis-related pathways that "all converged" onto the angiogenesis-promoting cytokines interleukin-8 and CXCL1, he said. (genomeweb.com)
By exploiting state-of-the-art genetic strategies, including novel gene knockdown platforms and exogenously- and microRNA-regulated vectors, I will identify and validate molecular pathways that may be targeted to selectively inhibit TEMs activity in tumors. (europa.eu)
Growing tumors exist in metabolically compromised environments that require activation of multiple pathways to scavenge nutrients to support accelerated rates of growth. (jci.org)

Circular RNA circSDHC (hsa_circ_0015004) regulates tumor growth and angiogenesis via regulating centrosomal protein 55 expression in renal cell carcinoma. (bvsalud.org)

This brain tumor type is highly proliferative and shows an infiltrative growth pattern, accounting for the high recurrence rates in patients. (hindawi.com)
Patterns of spread and recurrence of sex cord-stromal tumors of the ovary. (cancercentrum.se)

miRNA-378 promotes tumor angiogenesis by targeting Sufu and Fus-1 [ 8 ]. (oncotarget.com)

Fc4 and Fc1.4 fragments prevented IL-3-mediated EPC expansion, arterial morphogenesis and tumour-derived EC migration, without affecting cell adhesion. (unito.it)

To grow, tumors rely on a high level of nutrients to flow to the tumor site. (prnewswire.com)

Indeed, the specific elimination of TEMs inhibits tumor angiogenesis and growth in several models. (europa.eu)
Our results indicate that blockade of Hsp90 by SNX-2112 not only inhibits MM cell growth but also acts in the bone marrow microenvi- ronment to block angiogenesis and oste- oclastogenesis. (kl.ac.at)

Children's Oncology Group's 2013 blueprint for research: bone tumors. (medscape.com)

Results IV Administered bacteria bearing constructs could specifically localize at tumor site and express cardiac peptides under hypoxic conditions. (authorea.com)
We postulated that the expression levels of angiogenesis-related proteins from various primary tumor cultures would be greater under hypoxic conditions than under normoxia. (biomedcentral.com)

CpG methylation of the FHIT, FANCF, cyclin-D2, BRCA2 and RUNX3 genes in Granulosa cell tumors (GCTs) of ovarian origin. (cancercentrum.se)
Conservative surgery to preserve ovarian function in patients with malignant ovarian germ cell tumors. (cancercentrum.se)

Those that received the combination of miR-200 family members showed a 72 percent reduction in tumor volume. (genomeweb.com)
In particular, compared with the placebo-group, the triple-therapy-group resulted in a reduction in tumor growth of 48.6% in size when assessed by CEUS and a significant reduction in the number of vessels in the tumor of 32% as assessed by immunohistochemistry. (biomedcentral.com)

Tumour angiogenesis regulation by the miR-200 family. (mdanderson.org)

second, after normalization, the remaining "normalized" vessels can undergo further remodeling and become more efficient in providing blood flow to support tumor growth. (biomedcentral.com)

Prognostic impact of lymphadenectomy in clinically early stage malignant germ cell tumour of the ovary. (cancercentrum.se)
Ayhan A, Salman MC, Velipasaoglu M, Sakinci M, Yuce K. Prognostic factors in adult granulosa cell tumors of the ovary: a retrospective analysis of 80 cases. (cancercentrum.se)

Upon intravenous injection of RGD-pQDs in tumor-bearing mice, intravital microscopy allowed the detection of angiogenically activated endothelium at cellular resolution with a small scanning window and limited penetration depth, while magnetic resonance imaging was used to visualize angiogenesis at anatomical resolution throughout the entire tumor. (uu.nl)
Hence, there is a need for noninvasive in vivo clinical imaging tools that can study perfusion in the entire tumor, can be used to assess much larger volumes than small biopsy samples, and can probably guide biopsy and excision sites for better results. (ajnr.org)

One was ex vivo and one in vivo and both illustrated the inhibition characteristics vitamin C has on new tumor blood vessel growth. (prnewswire.com)

Currently, tumor thickness is the main factor considered when determining prognosis, but a considerable number of patients with thin melanomas also go on to develop metastatic disease. (dermatologytimes.com)
Conclusion: This article highlights the importance of angiogenesis and oxidative stress on the development of advanced and metastatic colon cancers, and provides new insights on alternative and effective treatment options. (edu.hk)

We have recently reported that certain chemotherapeutics, including 5-fluorouracil (5-FU), may in fact stimulate angiogenesis in the tumor-free rat mesenteric window assay. (unboundmedicine.com)
Antioxidants stimulate BACH1-dependent tumor angiogenesis. (nih.gov)

Anatomy29

Organisms9

Diseases51

Chemicals and Drugs88

Analytical, Diagnostic and Therapeutic Techniques and Equipment39

Phenomena and Processes43

Disciplines and Occupations1

Information Science3

Health Care3

Metastasis29

Solid tumors9

Microenvironment10

Progression8

Brain tumors8

Vascular12

Characterizing glioma1

Cell proliferation1

Mechanisms9

Proliferation and angiogenesis3

Neovascularization4

Overexpression6

Evaluation of Tumor Angiogenesis1

Vasculature11

Therapeutic6

Invasion3

Blood vessels9

Malignant tumors1

Hypoxia3

Vascularization3

Apoptosis2

Cancer18

VEGF7

Vitro4

Tissue4

Cells16

Anti-angiogenic2

Contributes1

Inhibitor3

Suppressor genes2

Primary tumors2

Induction of angiogenesis2

Survival1

Promote tumor growth1

Angiogenic2

Pathways3

Regulates tumor1

Recurrence2

Promotes1

Migration1

Nutrients1

Inhibits2

Oncology1

Hypoxic conditions2

Ovarian2

Reduction in tumor2

Regulation1

Vessels1

Prognostic2

Entire tumor2

Vivo1

Metastatic2

Stimulate2