• yet, eggs null for the alpha6 integrin exhibit normal fertilization. (lu.se)
  • Allegra M, Gagnoux-Palacios L, Gache Y, Roques S, Lestringant G, Ortonne JP,Meneguzzi G. Rapid decay of alpha6 integrin caused by a mis-sense mutation in thepropeller domain results in severe junctional epidermolysis bullosa with pyloric atresia. (encyclopedia.pub)
  • Various beta1 integrins and alphav integrins are present on mouse eggs. (lu.se)
  • Oocyte-specific, beta1 integrin conditional knockout mice allowed us to obtain mature eggs lacking all beta1 integrins. (lu.se)
  • Thus, function of beta3 or alphav integrins does not seem to be involved in compensating for the absence of beta1 integrins. (lu.se)
  • Studies in osteoclast biology have led to the identification of factors responsible for the differentiation and activation of osteoclasts, the most important of which is the receptor activator of NF-kappa B ligand/osteoclast differentiation factor (RANKL/ODF), a tumor necrosis factor (TNF)-like protein. (umassmed.edu)
  • However, this mutant was targeted to focal contacts formed by GSK2118436A novel inhibtior other integrins, even when they had not bound ligand. (healthyconnectionsinc.com)
  • This encoded protein is a cell surface glycoprotein that is known to complex with integrins and other transmembrane 4 superfamily proteins. (wikipedia.org)
  • The ITGA6 gene provides instructions for making one part (the α6 subunit) of two proteins known as α6β4 integrin and α6β1 integrin. (encyclopedia.pub)
  • Integrins are a group of proteins that regulate the attachment of cells to one another (cell-cell adhesion) and to the surrounding network of proteins and other molecules (cell-matrix adhesion). (encyclopedia.pub)
  • As part of a complex network of proteins in hemidesmosomes, α6β4 integrin helps to hold the layers of skin together. (encyclopedia.pub)
  • The integrin proteins activate key signaling molecules, which trigger cancer cells to migrate through the body and invade other tissues. (encyclopedia.pub)
  • Based on the hypothesis that alpha6beta1 is necessary for the survival of these cells in the tumor microenvironment, we report here that hypoxia protects these cells from apoptosis induced by serum deprivation and that hypoxia-mediated protection requires alpha6beta1 expression. (umassmed.edu)
  • The results obtained indicate that alpha6beta1 is necessary for VEGF expression because the ability of hypoxia to activate HIF-1 and to stimulate VEGF transcription in MDA-MB-435 cells is dependent on alpha6beta1 expression by a mechanism that involves protein kinase C-alpha. (umassmed.edu)
  • Data indicate that S100 calcium binding protein P (S100P) increased lung cancer cell migration by binding integrin alpha7. (cusabio.com)
  • The α6β4 integrin protein is found primarily in epithelial cells, which are cells that line the surfaces and cavities of the body. (encyclopedia.pub)
  • The α6β1 integrin protein has not been as well studied as α6β4 integrin. (encyclopedia.pub)
  • Integrin alpha-7/beta-1 is the primary laminin receptor on skeletal myoblasts and adult myofibers. (cusabio.com)
  • Furthermore, neither anti-mouse beta3 integrin function-blocking monoclonal antibody (mAb) nor alphav integrin function-blocking mAb inhibited sperm binding to or fusion with beta1 integrin null eggs. (lu.se)
  • It is involved in cellular processes including cell adhesion and may regulate integrin trafficking and/or function. (wikipedia.org)
  • Integrins also transmit chemical signals that regulate cell growth and the activity of certain genes. (encyclopedia.pub)
  • Digenic mutational inheritance of the integrin alpha 7 and the myosin heavy chain 7B genes causes congenital myopathy with left ventricular non-compact cardiomyopathy. (cusabio.com)
  • The alpha6beta1 integrin has been implicated in breast carcinoma progression, but the mechanisms involved remain elusive. (umassmed.edu)
  • Researchers believe that both α6β1 integrin and α6β4 integrin may play critical roles in the progression of cancerous tumors called carcinomas. (encyclopedia.pub)
  • Changes in the location and activity of α6β1 integrin and α6β4 integrin within cancer cells are associated with the progression of carcinomas. (encyclopedia.pub)
  • Recent studies suggest that, in addition to their roles in the progression of existing carcinomas, α6β1 integrin and α6β4 integrin may be involved in the initial formation of these tumors. (encyclopedia.pub)
  • Alternative integrins may be involved in sperm-egg binding and fusion and could compensate for the absence of alpha6beta1. (lu.se)
  • The absence of either alpha7beta1 integrin or alpha6beta1 integrin impairs the ability of Schwann cells to spread and to bind laminin. (cusabio.com)
  • We found that the beta1 integrin null eggs were fully functional in fertilization both in vivo and in vitro. (lu.se)
  • The other integrin made with the α6 subunit, α6β1 integrin, functions during the formation of organs and tissues before birth. (encyclopedia.pub)
  • The ITGA6 gene mutations responsible for EB-PA lead to a loss of functional α6β4 integrin. (encyclopedia.pub)
  • The resulting shortage of functional α6β4 integrin causes cells in the epidermis to be fragile and easily damaged. (encyclopedia.pub)
  • This report provides a novel insight into the mechanism, involving interaction with high temperature requirement A2, by which ITGA7 acts as a tumor suppressor. (cusabio.com)
  • ILK interaction with MCM7 and MCM7 phosphorylation may be a critical event in ITGA7 signaling pathway, leading to tumor suppression. (cusabio.com)
  • These mutations alter the normal structure and function of the α6 integrin subunit or prevent cells from producing enough of this subunit. (encyclopedia.pub)
  • Bone metastasis occurs through a complex cascade of events that ultimately results in circulating tumor cells (CTCs) from the blood extravasating and invading the bone marrow - these cells within the bone marrow are referred to as disseminated tumor cells (DTCs) [ 4 ]. (oncotarget.com)
  • In addition, metastatic sites may re-seed primary tumors in a multi-directional fashion [ 8 ]. (oncotarget.com)
  • MDA-MB-435 cells engineered to be deficient in alpha6beta1 expression form primary tumors that are highly apoptotic and unable to metastasize, although they exhibit no increased apoptosis in vitro under standard culture conditions. (umassmed.edu)
  • The factors and cellular processes required for the induction of dormancy and subsequent tumor cell reactivation remain largely undefined [ 6 ]. (oncotarget.com)
  • As knockdown of Integrin alpha7 (ITGA7) can effectively reduce the stemness of oesophageal squamous cell carcinoma (OSCC) cells, ITGA7 could be a potential therapeutic target in OSCC treatment. (cusabio.com)
  • Due to the difficulty in sampling and detection, few techniques exist to efficiently and consistently detect and quantify disseminated tumor cells (DTCs) in the bone marrow of cancer patients. (oncotarget.com)
  • We investigated the influence of alpha6beta1 on vascular endothelial growth factor (VEGF) expression because autocrine VEGF is necessary for the survival of serum-deprived cells in hypoxia. (umassmed.edu)
  • Using alpha3 integrin null eggs, we found that the alpha3beta1 integrin was not essential for sperm-egg binding and fusion. (lu.se)
  • In contrast, deletion of the GSK2118436A novel inhibtior cytoplasmic domain of alpha6 C-terminal of AURKA the GFFKR motif resulted in a loss of responsiveness of alpha6beta1 to PMA stimulation and formation of focal contacts on laminin-1. (healthyconnectionsinc.com)
  • Data suggest that ITGA7 is an epigenetically regulated tumour suppressor gene and a prognostic factor in human malignant pleural mesothelioma. (cusabio.com)
  • Our previous work has shown that cleavage of the α6β1 integrin to produce the structural variant α6pβ1 on tumor cell surfaces is mediated by the serine protease urokinase plasminogen activator (uPA). (nih.gov)
  • 1. Ascites induces modulation of alpha6beta1 integrin and urokinase plasminogen activator receptor expression and associated functions in ovarian carcinoma. (nih.gov)
  • 2. Interleukin-1alpha enhances the aggressive behavior of pancreatic cancer cells by regulating the alpha6beta1-integrin and urokinase plasminogen activator receptor expression. (nih.gov)
  • 5. Downregulation of urokinase plasminogen activator receptor expression inhibits Erk signalling with concomitant suppression of invasiveness due to loss of uPAR-beta1 integrin complex in colon cancer cells. (nih.gov)
  • TAMs localize to solid tumors and contribute to increased tumor growth and the metastatic phenotype. (nih.gov)
  • Tetraspanin CD151, also known as PETA-3 or SFA-1, has been reported to predict prognosis in various solid tumors. (oncotarget.com)
  • Here, we performed this meta-analysis of relevant studies published on the topic to quantitatively evaluate the clinicopathological significance of CD151 in solid tumors. (oncotarget.com)
  • The pooled hazard ratios (HRs) and corresponding 95% confidence intervals (CI) of overall survival (OS) and disease-free survival (DFS) were calculated to evaluate the prognostic value of CD151 expression in patients with solid tumors. (oncotarget.com)
  • Taken together, the incorporative HR showed CD151 overexpression was associated with poor survival in human solid tumors. (oncotarget.com)
  • CD151 could be a valuable prognosis biomarker or a potential therapeutic target of solid tumors. (oncotarget.com)
  • Liver carcinogenesis is associated with striking changes in the integrin repertoire of hepatocytes, including the overexpression of the laminin and collagen receptors alpha1beta1 and the de novo induction of the laminin receptor alpha6beta1. (nih.gov)
  • The laminin-binding integrin α6β1 plays a major role in determining the aggressive phenotype of tumor cells during metastasis. (nih.gov)
  • 3. Role of integrin receptors for fibronectin, collagen and laminin in the regulation of ovarian carcinoma functions in response to a matrix microenvironment. (nih.gov)
  • This encoded protein is a cell surface glycoprotein that is known to complex with integrins and other transmembrane 4 superfamily proteins. (wikipedia.org)
  • It is involved in cell migration, embryonic development, leukocyte activation and tumor cell invasiveness. (reference.md)
  • Alternative splicing of the cytoplasmic domain of the alpha6 subunit (INTEGRIN ALPHA6) results in the formation of A and B isoforms of the heterodimer, which are expressed in a tissue-specific manner. (reference.md)
  • Allegra M, Gagnoux-Palacios L, Gache Y, Roques S, Lestringant G, Ortonne JP, Meneguzzi G. Rapid decay of alpha6 integrin caused by a mis-sense mutation in the propeller domain results in severe junctional epidermolysis bullosa with pyloric atresia. (medlineplus.gov)
  • Chung J, Mercurio AM. Contributions of the alpha6 integrins to breast carcinoma survival and progression. (medlineplus.gov)
  • 10. Overexpression of alpha(v)beta6 integrin in serous epithelial ovarian cancer regulates extracellular matrix degradation via the plasminogen activation cascade. (nih.gov)
  • The ITGA6 gene provides instructions for making one part (the α6 subunit) of two proteins known as α6β4 integrin and α6β1 integrin. (medlineplus.gov)
  • The other integrin made with the α6 subunit, α6β1 integrin, functions during the formation of organs and tissues before birth. (medlineplus.gov)
  • These mutations alter the normal structure and function of the α6 integrin subunit or prevent cells from producing enough of this subunit. (medlineplus.gov)
  • Cleavage of α6β1 increases tumor cell motility, invasion, and prostate cancer metastasis, and blockage of uPA inhibits α6pβ1 production. (nih.gov)
  • In this study, we utilized a coculture system of PC-3 prostate tumor cells and macrophages [12-O-tetradecanoylphorbol-13-acetate (TPA)-differentiated human leukemia HL-60 cells] to investigate the hypothesis that macrophages stimulate the production of the prometastatic variant α6pβ1 on human prostate cancer cells via the uPA/uPAR axis. (nih.gov)
  • The stimulation does not require macrophage/tumor cell contact because macrophage conditioned medium is sufficient for increased uPAR transcription and α6 cleavage-dependent PC-3 cell invasion. (nih.gov)
  • The ITGA6 gene mutations responsible for EB-PA lead to a loss of functional α6β4 integrin. (medlineplus.gov)
  • Researchers believe that both α6β1 integrin and α6β4 integrin may play critical roles in the progression of cancerous tumors called carcinomas. (medlineplus.gov)
  • Integrin expression was assessed by qualitative methods (immunocytochemistry, Western blotting) and semi-quantitative techniques (FACS, cellular ELISA), before and after stimulation by TNFalpha, IL1-beta, TGF-beta, FGF2, interferon gamma and interferon alpha-2b. (nih.gov)
  • Alpha 6 beta 4 integrin abnormalities in junctional epidermolysis bullosa with pyloric atresia. (medlineplus.gov)
  • Recent studies suggest that, in addition to their roles in the progression of existing carcinomas, α6β1 integrin and α6β4 integrin may be involved in the initial formation of these tumors. (medlineplus.gov)