Tumor alpha fetal proteins. Medical search. Frequent questions

Cachexia is thought to be caused by bioactive molecules produced by the tumor, such as alpha-lymphotoxin (tumor necrosis factor [TNF] alpha), peptides, and nucleotides, which are able to affect metabolism. (medscape.com)
We now show that during early apoptosis limited membrane permeabilization occurs in blebs and apoptotic bodies, which allows release of proteins that may affect the proximal microenvironment before the catastrophic loss of membrane integrity during secondary necrosis. (nature.com)
These results indicate that limited membrane permeabilization occurs in blebs and apoptotic bodies before secondary necrosis, leading to acute and localized release of immunomodulatory proteins during the early phase of active apoptotic membrane blebbing. (nature.com)
Some drugs (eg, hydralazine , procainamide , isoniazid , anti-tumor necrosis factor [TNF] drugs) cause a reversible lupus-like syndrome. (msdmanuals.com)
sis factor alpha (TNF-), tumor necrosis factor beta (TNF- ), interleukin (IL)-1, and IL-2 (11-14). (cdc.gov)
1) a reduction in inflammatory proteins including tumor necrosis factor α. (pharmacology2000.com)

In this situation, residual tumor is frequently nonviable. (medscape.com)

Tumor markers are soluble glycoproteins that are found in the blood, urine, or tissues of patients with certain types of cancer. (medscape.com)
Tumor markers are not elevated in all cancer patients, particularly patients with early-stage cancer. (medscape.com)
The various tumor markers differ in their usefulness for screening, diagnosis, prognosis, assessing therapeutic response, and detecting recurrence. (medscape.com)
Many new tumor markers have been discovered since the development of monoclonal antibodies, and most tumor markers are now detected with them. (medscape.com)
Ovarian cancer, uterine cervical cancer, endometrial cancer, and trophoblastic neoplasms are gynecologic malignancies for which tumor markers are in clinical use. (medscape.com)
Because pathologic diagnosis of ovarian cancer is difficult without laparotomy, tumor markers such as CA-125, in addition to diagnostic imaging, are useful in preoperative evaluation for ovarian cancer. (medscape.com)
No tumor markers with high sensitivity and high specificity for endometrial cancer are known at present, although CA-125 is often used in clinical practice. (medscape.com)
Beta-hCG and alpha-fetoprotein have proved to be useful markers for ovarian germ cell tumors. (medscape.com)
These tumor markers are most useful for monitoring response to therapy and detecting early relapse. (aafp.org)
With the exception of prostate-specific antigen (PSA), tumor markers do not have sufficient sensitivity or specificity for use in screening. (aafp.org)
Because family physicians are assuming a greater role in caring for patients with cancer, an understanding of tumor markers is becoming increasingly important. (aafp.org)
This article describes the use of common tumor markers in primary care practice. (aafp.org)
Nevertheless, tumor markers can play a crucial role in detecting disease and assessing response to therapy in selected groups of patients. (aafp.org)
This slide summarizes how AFP and hCG function as tumor markers. (aacc.org)
Serum tumor markers showed significant differences between primary hepatic SCC/ASC and HCC patients, especially for serum alpha fetal protein (AFP) level and carbohydrate antigen 19-9 (CA 19-9). (biomedcentral.com)

Alpha-fetoprotein (AFP), a marker for hepatocellular carcinoma, sometimes is used to screen highly selected populations and to assess hepatic masses in patients at particular risk for developing hepatic malignancy. (aafp.org)
Though the majority of the primary tumors are hepatocellular carcinoma (HCC), some rare diseases also could not be ignored by the reason of their characteristics. (biomedcentral.com)
Hepatocellular carcinoma (HCC), the sixth most malignant tumor worldwide, is the most common primary malignant tumor of the liver and the second leading cause of cancer-related death. (xiahepublishing.com)

Multiple endocrine neoplasia syndrome type 1 (MEN-1), loss-of-function germline mutations in the tumor suppressor gene MEN1 increase the risk of developing pituitary, parathyroid and pancreatic islet tumors, and less commonly thymic carcinoids, lipomas and benign adrenocortical tumors. (intechopen.com)
William Kaelin, Jr. was in 1995 engaged in the study of the von Hippel-Lindau tumor suppressor gene, and after isolation of the first full-length clone of the gene showed that it could suppress tumor growth in VHL mutant tumorigenic cell lines. (nobelprize.org)
In nearly all these complete situations, activation from the inactivation and proto-oncogene from the tumor suppressor gene have an effect on the advancement and development of epithelial malignancies. (diferencias-entre.org)
TP53 is a significant tumor suppressor gene, and its somatic mutations are one of the most frequent alterations in ~50% of all human cancers, including colorectal cancer ( 10 ). (spandidos-publications.com)

Some well known examples include: Alpha-fetoprotein (AFP), the predominant serum protein of the fetus which gives way to albumin in the adult. (wikipedia.org)
AFP was first found in human fetal serum in 1965 and determined to be the fetal version of albumin. (wikipedia.org)
This protein resembles albumin and is the main protein found in fetal serum. (wikipedia.org)
The serum concentration of AFP is loosely related to the size of HCC tumors. (aacc.org)
Trophoblastic tumors can produce very elevated concentrations of hCG in the serum that may exceed 1 million IU/L. The serum concentration of hCG is correlated with the size of the tumor, although hCG is not particularly specific to trophoblastic tumors. (aacc.org)
Such excellent special fetal bovine serum, how can anyone not know? (abbkine.com)
Detection of the Tau protein in human serum by a sensitive four-electrode electrochemical biosensor. (mdx.ac.uk)
found in embryonic and fetal serum [1,2]. (scirp.org)

In addition, beta-hCG serves as an ideal tumor marker for monitoring gestational trophoblastic disease and has set the standard with which other assays must be compared. (medscape.com)
A trophoblastic tumor is a proliferation of cells derived from the placenta. (aacc.org)
Recently, the use of metabolomics permitted to discover significant differences in 70 proteins within the trophoblastic cells of women with pre-eclampsia when compared with healthy control women. (peertechzpublications.com)
Gestational trophoblastic diseases (GTD) encompass a spectrum of interrelated conditions: Hydatidiform mole (HM) Invasive mole (IM) Choriocarcinoma (CC) Placental site trophoblastic tumour (PSTT) This article is available only as. (annals.edu.sg)

In the next few slides, we will review their functions in these different types of tumors. (aacc.org)

Combined AFP and β-hCG testing is an essential adjunct in the evaluation and treatment of nonseminomatous germ cell tumors, and in monitoring the response to therapy. (aafp.org)
In addition, younger women and teens tend to have certain ovarian growths, such as germ cell tumors. (momjunction.com)
Ovarian dysgerminoma, the commonest malignant tumor of germ cell origin, predominantly affects young women. (jpgo.org)
epithelial, germ cell and sex cord tumors. (jpgo.org)
Only 30 % of all ovarian neoplasms and 3 % of all ovarian malignancies are germ cell tumors (GCTs). (jpgo.org)
Ovarian germ cell tumors, derived from the primordial germ cells, are further divided into subgroups based on the histological features. (jpgo.org)
Mature teratoma being the commonest benign variety while dysgerminoma is the commonest malignant germ cell tumor. (jpgo.org)

Each tumor marker has a variable profile of usefulness for screening, determining diagnosis and prognosis, assessing response to therapy, and monitoring for cancer recurrence. (aafp.org)
In monitoring patients for disease recurrence, tumor marker levels should be determined only when there is a potential for meaningful treatment. (aafp.org)
The levels of TR3 expression in human hepatic cancer tissues correlates well with tumors that are at low/middle degree of tumor differentiation and have portal vein thrombosis, metastasis and recurrence, but not with age, gender, tumor number and Alpha-fetal protein (AFP) volume. (scitechnol.com)
ZIP4 expression was significantly associated with tumor recurrence ( P = 0.002), tumor node metastasis stage ( P = 0.044), Child-Turcotte-Pugh score ( P = 0.042), and tumor size ( P = 0.022). (ijbs.com)

In order to detect early stage or small tumors less than 5cm in size, the AFP cutoff is typically set at a concentration of 10 - 20 μg/L. (aacc.org)
Ungual fibromas, small tumors under the toenails or fingernails, may also be present. (uspharmacist.com)

The statistical analysis was used to assess the significance of TR3 expression in tumor tissues, paratumor tissues and normal tissues, and to investigate the correlation of TR3 expression and clincopathologic characteristics. (scitechnol.com)
Facial angiofibromas (benign tumors made up of blood vessels and fibrous tissues) are found in 75% of patients with TSC and are characterized by reddish spots or bumps on the face in a butterfly distribution. (uspharmacist.com)
Here, we identified the coding sequence of the EZH2 gene and characterized its expression pattern in fetal tissues of Duroc pigs at 65- and 90-day postcoitus (dpc). (hindawi.com)
EZH2 was ubiquitously expressed in the fetal tissues of two time points with different expression levels. (hindawi.com)
These results validated a different transcript in pigs and characterized its expression profile in fetal tissues of different gestation stages, which indicated that EZH2 played important roles during porcine embryonic development. (hindawi.com)
Considering the varieties of EZH2 splicing variant, identifying its transcript in porcine fetal tissues is the foundation to study its function. (hindawi.com)
Moreover, none of the EZH2 transcript variants have yet been identified in porcine fetal tissues. (hindawi.com)
In this study, we identified a transcript variant of EZH2 in porcine fetal tissues by cloning and sequencing. (hindawi.com)
Tumour the fetus via the maternal circulation utero, but when the reactive metab multiplicity rises to a maximum in must have crossed the placenta, and olites formed in maternal tissues are offspring exposed at approximate consequently are generally referred too unstable to circulate in the mater ly 21 days of gestation, a few days to as transplacental carcinogens. (who.int)
ENU during the final week of gestat the rapidly changing patterns of gene In both the fetus and the pregnant ion is approximately 50 times that of expression in fetal target tissues, female rat, the target organ for single the mother. (who.int)

and embryo-fetal toxicity. (epicos.com)

When a tumor arises, the body may produce antibodies to fight it by binding to and destroying tumor cells. (medscape.com)
[ 9 ] For example, antibodies or T cells directed against the tumor may mistakenly attack normal nerve cells. (medscape.com)
After a series of studies, we found that the possible etiology for left popliteal deep vein thrombosis and bilateral pulmonary embolism was VITT, which was confirmed by weakly positive anti-PF4 antibodies and protein S deficiency. (drpaulalexander.com)
But a disadvantage is that those who have been exposed to natural forms of the adenovirus have antibodies to the virus that will likely block the synthesis of the spike protein, and therefore not afford protection against SARS-CoV-2. (theepochtimes.com)
Just as in the case of antibiotic resistance, new strains evolve within an infected immune-compromised person's body that produce a version of the spike protein that no longer binds with the acquired antibodies. (theepochtimes.com)

In cases of pregnant patients with a history of pancreatic tumors, a multidisciplinary approach with maternal fetal medicine, medicine, and general surgery is appropriate and can result in a healthy mother and healthy term infant. (hindawi.com)
Recently, evidence that Zinc transporter ZRT/IRT-like protein 4 (ZIP4) is involved in invasiveness and apoptosis has emerged in pancreatic cancer and prostate cancer. (ijbs.com)

AFP3D- based conjugat es with vario us anti- tumor agents have shown specific anti -tumor activity. (scirp.org)
In recent years, multiple studies have reported that DIS has immunoregulation, anti‑fibrosis, anti‑inflammation, anti‑viral and anti‑tumor effects. (spandidos-publications.com)

Sometimes, the genes coding fetal isoforms occur adjacent to their adult homologues in the genome, and in those cases a locus control region often coordinates the transition from fetal to adult forms. (wikipedia.org)
The genes were involved in a number of processes, including protein degradation, mitochondria integrity, and α-synuclein aggregation. (bvsalud.org)
Then these extra genes instruct the cells to make too many HER2 receptors, which is called HER2 protein overexpression. (breastcancertalk.net)
TSC is characterized by autosomal-dominant mutations in the TSC1 or TSC2 genes (encoding for the protein Hamartin on chromosome 9q34 and Tuberin on chromosome 16q13 respectively) leading to overactivation of the mTOR (mechanistic target of rapamycin) pathway with increased cell proliferation and a range of other consequences. (uspharmacist.com)
Since identification of EZH2 in the research of protooncogene product Vav [ 3 ], studies have shown that EZH2 is highly expressed in tumorigenesis, which regulates the expression of tumor suppressor genes, such as in breast cancer, prostate cancer, and lung cancer [ 4 - 6 ]. (hindawi.com)
It consists of general approaches on molecules (such as genes, transcripts, proteins and metabolites) of which a cell, tissue or organism is made. (peertechzpublications.com)

However, the correlation of TR3 expression and clinical tumor progression has not been studied. (scitechnol.com)
Cancer‑associated fibroblasts (CAFs) are pivotal in tumor progression. (spandidos-publications.com)
The tumor microenvironment consists of various cell types and fibroblasts in the tumor tissue, called cancer-associated fibroblasts (CAFs), which play pivotal role in tumor progression ( 7 , 8 ). (spandidos-publications.com)

Several cancers produce proteins that are physiologically expressed in utero by embryonic and fetal cells but not expressed by normal adult cells. (medscape.com)
Subsequently, we detected the expression of EZH2 on mRNA level and protein level in two different embryonic development stages (65-dpc and 90-dpc) via qRT-PCR and western blots. (hindawi.com)

Persistently high AFP after surgery may indicate incomplete removal of the tumor or the presence of metastasis. (aacc.org)
A significant increase in AFP in post-surgery tumor-free patients may also indicate metastasis. (aacc.org)

They are typically produced by tumor cells, but in some cases they may be produced by the body in response to malignancy or to certain benign conditions. (medscape.com)

Solid pseudopapillary tumor of the pancreas is a rare tumor seen in predominately young women and carries a low malignant potential. (hindawi.com)
In addition to its rarity, pseudopapillary tumor of the pancreas is additionally associated with a relatively low malignant potential [ 2 ]. (hindawi.com)
The tumor is most commonly seen in young African American women and has a low malignant potential [ 1 , 2 ]. (hindawi.com)
These tumor components presented more malignant biological behavior, and that may be the common reason for the poor prognosis of the both [ 11 ]. (biomedcentral.com)

In the 1980s a study found that fetal size and gestational age affects the concentration of AFP and that maternal, venous, and cord arterial AFP are associated with each other. (wikipedia.org)
From the onset of presenting with her pregnancy, her care was managed with input from maternal fetal medicine, endocrinology, and general surgery. (hindawi.com)
Factors that cause a low incidence of tumours in offspring after birth, compared contribute to fetal susceptibility to near the end of gestation, in offspring with the incidence and multiplicity of these agents include maternal, pla that were exposed trans placental y. the same types of tumours in their cental, and fetal metabolism, the im This pattern can be seen in the directly exposed mothers. (who.int)

In other cases fetal isoforms can be produced by alternate splicing using fetal exons to produce proteins that differ in only a portion of their amino acid sequence. (wikipedia.org)

It is one of the oncofetal antigens produced during fetal life and has a high concentration in the sera of fetuses. (aacc.org)

Fetal hemoglobin has a main function to transfer oxygen from the pregnant person to the fetus during gestation. (wikipedia.org)
It is diagnosed based on the blood pressure of 140/90 mmHg or more in two stages with the urinary protein of 300 mg/day or higher, after 20 weeks of gestation (2). (ac.ir)

Filamin A is also involved in the organization of the extracellular matrix, which is the lattice of proteins and other molecules outside the cell. (medlineplus.gov)

The causes of hypertrophic osteoarthropathy remain unknown, although several hypotheses have been developed (eg, estrogen or growth hormone [GH] production by the tumor, vagal hyperactivity). (medscape.com)
As reported by previous studies, poor liver function and high tumor invasiveness lead to the rapid growth of HCC. (xiahepublishing.com)
9 Imaging findings also showed that poorly differentiated HCC had a shorter tumor volume doubling time, 10 suggesting that the growth rate before surgery can be used to determine the biological characteristics of HCC. (xiahepublishing.com)
Cancer is a complex genetic disease caused by abnormal alteration (mutations) in DNA sequences that leads to dyregulation of normal cellular processes thereby driving tumor growth. (intechopen.com)
Proteolysis of insulin-like growth factor binding protein-1 (IGFBP 1) in pregnancy.J Perinat Med. (mdx.ac.uk)
Tumor growth is dependent on angiogenesis. (pharmacology2000.com)
It is impossible to completely remove the tumour because of its growth. (biomedcentral.com)
In addition, xenografts of HCT116 cells with APJ‑suppressed fibroblasts showed accelerated tumor growth. (spandidos-publications.com)
The mutational inactivation of the TP53 gene in tumor cells has been reported to affect not only tumor cells but also the surrounding cells in the tumor microenvironment and to promote tumor-stromal activation and subsequent tumor growth ( 11 , 12 ). (spandidos-publications.com)

In other cases, paraneoplastic syndromes result from the production and release of physiologically active substances by the tumor. (medscape.com)

Primary hepatic ASC was defined as a liver tumor containing definite components of both adenocarcinoma and squamous cell carcinoma, and sometimes it was considered as a variant of cholangiocarcinoma [ 9 ]. (biomedcentral.com)
We investigated the role of Echinococcus multilocularis (Echinococcus genus) PSCs in hepatic fibrosis by examining structural changes and measuring hepatic fibrosis-related protein levels in cocultures of PSCs and human HSCs. (biomedcentral.com)
Structural changes were detected by transmission electron microscopy (TEM), and levels of the hepatic fibrosis-related proteins collagen I (Col-I), alpha-smooth muscle actin (α-SMA) and osteopontin (OPN) were measured by western blotting and enzyme-linked immunosorbent assay (ELISA). (biomedcentral.com)
Hepatic stellate cells (HSCs), which are the major cells responsible for the formation of extracellular matrix (ECM) proteins during cirrhosis, are found in the space of Disse and act as a major storage site for vitamin A [ 14 , 15 ]. (biomedcentral.com)

Filamin A binds to proteins called integrins, which span the cell membrane and anchor cells to the extracellular matrix. (medlineplus.gov)

α-FetoProtein (AFP) is part of the α1 globulin family of proteins. (wikipedia.org)
Alpha-fetoprotein or AFP is the major protein in fetal circulation and is closely related to albumin both genetically and structurally. (aacc.org)
The company's drug products use ACT's patented recombinant human alpha fetoprotein (AFP or ACT-101). (alpha-cancer.com)
ACT has exclusive worldwide rights to Alpha Fetoprotein (AFP) with over $100 million spent on the development of the in-licensed technology. (alpha-cancer.com)
Advancing proprietary Alpha Fetoprotein (AFP) platforms to treat cancer and auto-immune diseases. (alpha-cancer.com)
What is Alpha Fetoprotein? (alpha-cancer.com)

Previously, we have shown in a mouse model that exposure to hog dust extract (HDE) collected from a CAFO results in the activation of protein kinase C (PKC), elevated lavage fluid cytokines/chemokines including interleukin-6 (IL-6), and the development of significant lung pathology. (cdc.gov)

Even after successful resection of the tumor, attention needs to be paid to patients who subsequently become pregnant, secondary to any residual disease having a heightened sensitivity to increased levels of progesterone. (hindawi.com)

Fetal Hemoglobin is a member of erythrocytes called F-cells. (wikipedia.org)
However, tumor cell-derived AFP has various carbohydrate compositions depending on the saccharide transferase activity within the tumor cells. (aacc.org)
Dying cells have been defined as apoptotic by distinguishing features, including cell contraction, nuclear fragmentation, blebbing, apoptotic body formation and maintenance of intact cellular membranes to prevent massive protein release and consequent inflammation. (nature.com)
The FLNA gene provides instructions for producing the protein filamin A, which helps build cells' extensive internal network of protein filaments called the cytoskeleton. (medlineplus.gov)
The cytoskeleton is also important for certain processes inside the cells, such as the movement of proteins within the cell and the breakdown of unneeded proteins. (medlineplus.gov)
Filamin A can also bind to many other proteins in the cell to carry out various functions, including the attachment of cells to one another (cell adhesion), cell movement (migration), determination of cell shape, the relay of signals within cells, and cell survival. (medlineplus.gov)
which may render the genetic mate doses of NDMA is the kidney, but a Transplacental carcinogenesis rial of fetal cells highly accessible to much lower incidence of tumours is stu dies with ENU in nonhuman pri carcinogens. (who.int)
CheKine™ microquantitative test kits and recombinant proteins help you explore cells with ease! (abbkine.com)
to tumor cells. (scirp.org)

Fever may also be related to necrotic-inflammatory phenomena of the tumor and/or to alterations in liver function and consequent disorders of steroidogenesis. (medscape.com)
The most enriched proteins released were the nucleosomal histones, which have previously been identified as damage-associated molecular pattern proteins (DAMPs) that can initiate sterile inflammatory responses. (nature.com)
In addition to playing a role in mediating inflammatory allergic reactions, it also plays an important role in the treatment and research of tumors and autoimmune diseases. (abbkine.com)
The expressions of inflammatory factors and NF‑κB pathway proteins were detected by immunofluorescence, ELISA, western blotting and RT‑qPCR. (spandidos-publications.com)
Mechanistically, DIS not only decreased the expressions of inflammatory factors including IL‑1β, NOD‑like receptor thermal protein domain associated protein 3, monocyte chemotactic protein 1, IL‑6, TNF‑α and IL‑18 but also reduced the level of phosphorylation of NF‑κB p65 in vivo and in vitro , which was similar to the impact of Bay11‑7082. (spandidos-publications.com)

In this work, we investigated the effect of dexamethasone on NO production induced by the epidermal cytokine granulocyte / macrophage colony-stimulating factor (GM-CSF) in a mouse fetal skin dendritic cell line.Methods: NO production was assessed by the method of Griess. (pdffox.com)

Due to the prevalence of hepatitis and some other reasons, the morbidity of primary liver tumor is high in Asia, especially in China [ 1 ]. (biomedcentral.com)
A total of 75 liver tumor patients, who had received liver resection (LR) during the period from January 1998 to December 2011 in Eastern Hepatobiliary Surgery Hospital, were picked out and included in this study. (biomedcentral.com)
The prognosis of HCC patients is influenced by many factors, the most important of which lie in the tumor itself and the underlying liver condition. (xiahepublishing.com)

Recently were identified proteins in cervical-vaginal fluid that could be useful to predict preterm labor in asymptomatic women: thioredoxin and interleukin-1 receptor antagonist. (peertechzpublications.com)
It has been found that the use of interleukin in tumor treatment can achieve good results. (abbkine.com)

Thus, the APJ system in fibroblasts in the tumor microenvironment may be a promising therapeutic target. (spandidos-publications.com)

Filamin A primarily attaches (binds) to another protein called actin and helps it form the branching network of filaments that make up the cytoskeleton. (medlineplus.gov)
Activated HSCs differentiate into muscle fibroblasts, which express alpha-smooth muscle actin (α-SMA) and accelerate the process of cirrhosis. (biomedcentral.com)
CAFs with tumor-promoting effects were usually activated and exhibited myofibroblast-like properties such as the upregulation of alpha-smooth muscle actin (α-SMA) ( 9 ). (spandidos-publications.com)

Normalization of tumor marker values may indicate cure despite radiographic evidence of persistent disease. (medscape.com)
Sometimes, tumor marker values may rise after effective treatment (due to cell lysis), but the increase may not portend treatment failure. (medscape.com)
A consistent increase in a tumor marker value, combined with lack of clinical improvement, may indicate treatment failure. (medscape.com)
The usefulness of a tumor marker is in its sensitivity and specificity, as well as its influence on patient management decisions. (medscape.com)
Particular emphasis is given to when these tests should be ordered and to common factors that influence the interpretation of tumor marker levels. (aafp.org)
To date, no tumor marker has demonstrated a survival benefit in randomized controlled trials of screening in the general population. (aafp.org)
Following tumor marker response is particularly useful when other evidence of disease is not readily accessible. (aafp.org)
This session will focus on hCG's functions as a tumor marker. (aacc.org)

The other form was responsible for fetal abnormalities. (pharmacology2000.com)

The protein encoded by this gene isPPAR-gamma and is a regulator of adipocyte differentiation. (diferencias-entre.org)

Cases of the tumor in pregnancy can be devastating, since the tumor often has receptors which are responsive to progesterone. (hindawi.com)
Healthy HER2 receptors are the proteins that help manage how a breast cell grows, divides, and repairs itself. (breastcancertalk.net)

One of the other isoforms, a fetal cardiac TnT isoform, is also found in the fetal skeletal muscle. (wikipedia.org)
Expression of the inducible isoform of nitric oxide synthase (iNOS) protein was evaluated by western blot analysis and immunofluorescence microscopy. (pdffox.com)

In some situations the continuing expression of fetal forms can reveal the presence of a disease condition or serve as a treatment for diseases such as sickle cell anemia. (wikipedia.org)
Polycomb Group (PcG) proteins are a family of protein complex that regulate gene expression, especially repressing gene transcription [ 1 ]. (hindawi.com)
Proteomics analysis of biological samples has the potential to identify novel protein expression patterns and/or changes in protein expression patterns in different developmental or disease states. (peertechzpublications.com)
Often altered expression of a gene is not always causally related to a phenotype or a process and so a change in transcription is not always followed by protein synthesis. (peertechzpublications.com)
Dexamethasone also inhibited GM-CSF-induced NFkB activation by preventing a significant decrease on the IkB-a protein levels, thus blocking NF-kB migration to the nucleus.Conclusions : The corticosteroid dexamethasone inhibits GM-CSF-induced NF-kB activation, iNOS protein expression and NO production. (pdffox.com)
Univariate analysis showed that ZIP4 expression was significantly associated with overall survival ( P = 0.020) and tumor-free survival ( P = 0.049). (ijbs.com)

carcinoma, hepatocellular cancers, and breast cancer Clofarabine tumor [10C13]. (diferencias-entre.org)

Fetal hemoglobin is vital in this system because it has a high affinity for oxygen. (wikipedia.org)

Herein we selected a Mendelian genetics form of familial cancer such as hereditary tumor syndromic endocrine neoplasias caused by highly penetrant germline mutations leading to pheochromocytoma-paraganglioma syndromes. (intechopen.com)
In the case of multiple endocrine neoplasia type 2 (MEN 2), gain-of-function germline mutations clustered in specific codons of the RET proto-oncogene increase the risk of developing medullary thyroid carcinoma (MTC), phaeochromocytoma and parathyroid tumors. (intechopen.com)
All recognized mutations for AD are associated with increased deposition of amyloid-beta (Abeta), a peptide fragment comprising 39-43 amino acids that derive from the catabolism of the amyloid precursor protein (APP) molecule. (medscape.com)

Primary gastric choriocarcinoma (PGC) is an extremely rare and highly invasive tumor with rapid hematogenous spread. (edu.pe)

High HBV DNA level, low non-TLV/ICG, vascular invasion, and a poorly differentiated tumor were confirmed as independent risk factors for both OS and DFS. (xiahepublishing.com)

8 Understanding tumor occurrence and development is of great help in determining their prognosis. (xiahepublishing.com)

Common blood disorders with high levels of fetal hemoglobin show symptoms like anemia. (wikipedia.org)
In a broad sense, these syndromes are collections of symptoms that result from substances produced by the tumor, and they occur remotely from the tumor itself. (medscape.com)
Different variants in the FLNA gene appear to produce specific changes in the protein, resulting in particular signs and symptoms that are classified as individual FLNA -related disorders. (medlineplus.gov)
Researchers suspect that the variants involved in frontometaphyseal dysplasia may change the way the filamin A protein helps regulate processes involved in skeletal development, but it is not known how changes in the protein relate to the specific signs and symptoms of the condition. (medlineplus.gov)

On the pathologic performance, primary SCC/ASC tumor was rarely accompanied with tumor capsule. (biomedcentral.com)

Alternative splicing of gene can generate multiple transcripts and proteins to regulate tissue and organ development [ 17 ]. (hindawi.com)
human fetal lung, mouse embryo, mouse lung and rat lung tissue lysates. (abcam.com)

Anatomy15

Organisms11

Diseases66

Chemicals and Drugs84

Analytical, Diagnostic and Therapeutic Techniques and Equipment40

Phenomena and Processes44

Disciplines and Occupations1

Information Science4

Health Care5

Necrosis6

Residual tumor is frequently nonviable1

Markers15

Hepatocellular carcinoma3

Suppressor gene4

Serum8

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Types of tumors1

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Recurrence4

Small tumors2

Tissues10

Embryo-fetal1

Antibodies5

Pancreatic2

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Embryonic2

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Benign conditions1

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Oncofetal antigens1

Gestation2

Molecules1

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Paraneoplastic syndromes1

Hepatic4

Extracellular matrix1

Fetoprotein6

Cytokines1

Subsequently1

Cells9

Inflammatory5

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Interleukin2

Microenvironment1

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