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  • patients
  • Tekmira has enrolled a total of 36 patients in a population of advanced cancer patients with solid tumors. (globenewswire.com)
  • Of the 36 patients enrolled, three out of the four ACC patients (75%) treated with TKM-PLK1 achieved stable disease, including one patient who saw a 19.3% reduction in tumor size and is still on study receiving TKM-PLK1. (globenewswire.com)
  • Of the two GI-NET patients enrolled, both experienced clinical benefit: one patient had a partial response based on RECIST criteria, and the other GI-NET patient achieved stable disease and showed a greater than 50% reduction in Chromogranin-A (CgA) levels, a key biomarker used to predict clinical outcome and tumor response. (globenewswire.com)
  • The ongoing TKM-PLK1 Phase I/II clinical trial, which is currently targeting GI-NET and ACC patients for enrollment, is a multi-center, single arm, open label study designed to measure efficacy using RECIST and tumor biomarkers for GI-NET patients, as well as to evaluate TKM-PLK1's safety, tolerability and pharmacokinetics. (globenewswire.com)
  • It is expected that approximately 20 patients with advanced GI-NET or ACC tumors will be enrolled in this trial, with a minimum of 10 GI-NET patients to be enrolled. (globenewswire.com)
  • liver
  • In an exploratory laparotomy, a 15 cm-size hepatic tumor was located in the right lobe with multiple satellite lesions in both lobes of the liver. (nagasaki-u.ac.jp)
  • genetic
  • Although the gene that causes tumors in people with the MEN1 syndrome has been found, genetic testing for MEN1 is not widely available. (cancer.org)
  • small
  • Smoking may increase the risk of getting a carcinoid tumor of the small intestine, according to some research. (cancer.org)
  • risk
  • People with this syndrome have a very high risk of getting tumors of 3 glands: the pituitary, parathyroid, and pancreas. (cancer.org)
  • patient
  • After surgery for operable colon carcinoma, the patient received chemotherapy and biological therapy for both tumors. (diva-portal.org)
  • cancer
  • People with von Hippel Lindau disease have an inherited tendency to develop blood vessel tumors of the brain, spinal cord, or retina, as well as kidney cancer. (cancer.org)
  • disease
  • This disease often runs in families and is characterized by many neurofibromas (benign tumors that form in nerves under the skin and in other parts of the body). (cancer.org)
  • feed tumors in mice
  • A team of researchers at the National Cancer Institute (NCI), part of the National Institutes of Health (NIH), has uncovered a set of genes that are turned on, or expressed, at high levels only in the blood vessels that feed tumors in mice and humans. (nih.gov)
  • metastatic
  • This treatment can be tailored to the particular tumor of the spine, either metastatic or primary. (wikipedia.org)
  • The significant efforts put into understanding the CTCs biological properties have demonstrated the critical role circulating tumor cells play in the metastatic spread of carcinoma . (wikipedia.org)
  • Reliable and valid statistics on the incidence, prevalence, and mortality of malignant bone tumors are difficult to come by, particularly in the oldest (those over 75 years of age), because carcinomas that are widely metastatic to bone are rarely ever curable, biopsies to determine the origin of the tumor in cases like this are rarely done. (wikipedia.org)
  • solid tumors
  • By contrast, analysis of solid tumors necessitates invasive procedures that might limit patient compliance. (wikipedia.org)
  • While angiogenesis can reduce this affect, the partial pressure of oxygen is below 5 mm Hg (venous blood has a partial pressure of oxygen at 40 mm Hg) in more than 50% of locally advanced solid tumors. (wikipedia.org)
  • occur
  • Normally benign, these slow-growing tumors can occur in various structures of the skull, spine and brain when normal developmental cells are trapped within the growing brain. (ucla.edu)
  • about one third of the cases of multiple tumors occur in those younger than 20 years. (wikipedia.org)
  • A few other cases of malignant glomus tumors have been reported in the literature usually occur in the older age group, and have been described at several locations, primarily the soft tissues and gastrointestinal tracts. (wikipedia.org)
  • The conversion of glucose to lactate rather than metabolizing it in the mitochondria through oxidative phosphorylation, (which can also occur in hypoxic normal cells) persists in malignant tumor despite the presence of oxygen. (wikipedia.org)
  • Bowel intussusception can occur with various benign colonic tumors. (wikipedia.org)
  • citation needed] Despite the personality and behavior changes that occur in people with brain tumors, little research on such changes has been done. (wikipedia.org)
  • hormones
  • Tumors of endocrine tissues may overproduce certain hormones, especially when the cells are well differentiated. (wikipedia.org)
  • Some tumors also produce hormones that can lead to life-threatening situations. (wikipedia.org)
  • adrenal
  • Neuroblastoma and pheochromocytoma are the two most important tumors which arise from the adrenal medulla. (wikipedia.org)
  • Both tumors may also arise from extra-adrenal sites, specifically, in the paraganglia of the sympathetic chain. (wikipedia.org)
  • neoplasm
  • A mammary tumor is a neoplasm originating in the mammary gland . (wikipedia.org)
  • A glomus tumor (also known as a "solitary glomus tumor," "solid glomus tumor," or glomangioma) is a rare neoplasm arising from the glomus body and mainly found under the nail, on the fingertip or in the foot. (wikipedia.org)
  • surgery
  • For this reason and other possible negative health effects, some benign tumors are removed by surgery. (wikipedia.org)
  • Radiation treatment after breast-conserving surgery with negative margins may significantly reduce the local recurrence rate for borderline and malignant tumors. (wikipedia.org)
  • The authors of a 2012 study have derived a risk calculator for relapse risk of phyllodes tumors after surgery. (wikipedia.org)
  • tissues
  • Although benign tumors will not metastasize or locally invade tissues, some types may still produce negative health effects. (wikipedia.org)
  • The growth of benign tumors produces a "mass effect" that can compress tissues and may cause nerve damage, reduction of blood to an area of the body (ischaemia), tissue death (necrosis) and organ damage. (wikipedia.org)
  • The primary tumor instead established a microenvironment that is functionally analogous to that of certain normal tissues, such as the eye. (wikipedia.org)
  • A Tumor Bank, A Tumor Bank is sometimes also referred to as a Tissue Bank, since normal tissues for research are also often collected. (wikipedia.org)
  • Germ
  • Germ cell tumors, including teratoma, often present and originate in the midline of the sacrum, coccyx, or both. (wikipedia.org)
  • arise
  • Glomus tumors do not arise from glomus cells, but paragangliomas do. (wikipedia.org)
  • On gross pathological examination, the tumor is cystic and may be solid and some arise in cystic endometriosis. (wikipedia.org)
  • Genetic
  • Your doctor may ask about your family history of tumors or other problems to see if you might have an inherited genetic syndrome , such as multiple endocrine neoplasia, type I (MEN1). (cancer.org)
  • There are several hypotheses on the molecular mechanisms involved in the development of canine mammary tumors but a specific genetic mutation has not been identified. (wikipedia.org)
  • lesions
  • As stated above, these lesions should not be confused with paragangliomas, which were formerly also called glomus tumors in now-antiquated clinical usage. (wikipedia.org)
  • Glomus tumors are usually solitary and small lesions. (wikipedia.org)
  • Sex Solitary glomus tumors, particularly subungual lesions, are more common in females than in males. (wikipedia.org)
  • behavior
  • The World Health Organization (WHO) classification scheme places neuroendocrine tumors into three main categories, which emphasize the tumor grade rather than the anatomical origin: well-differentiated neuroendocrine tumours, further subdivided into tumors with benign and those with uncertain behavior well-differentiated (low grade) neuroendocrine carcinomas with low-grade malignant behavior poorly differentiated (high grade) neuroendocrine carcinomas, which are the large cell neuroendocrine and small cell carcinomas. (wikipedia.org)
  • While a lack of oxygen can cause glycolytic behavior in cells, tumor cells also undergo aerobic glycolysis, in which they preferentially produce lactate from glucose even given abundant oxygen, called the Warburg effect. (wikipedia.org)
  • Frontal lobe tumors may contribute to poor reasoning, inappropriate social behavior, personality changes, poor planning, lower inhibition, and decreased production of speech (Broca's area). (wikipedia.org)
  • parathyroid
  • This is a hereditary condition in which people have a very high risk of developing tumors of 3 glands: the pituitary, parathyroid, and pancreas. (cancer.org)
  • Tumors with similar cellular characteristics in the pituitary, parathyroid, and adrenomedullary glands are sometimes included or excluded. (wikipedia.org)
  • pathology
  • The role of endovascular therapy in tumor management has significantly increased over the past decade as a result of improved technology, better understanding of tumor pathology, and evolution of chemotherapy regimens. (springer.com)
  • vascular
  • Through knowledge of intracranial and extracranial anastomotic pathways, understanding of vascular anatomy, identification of high-flow shunts within the tumor, and awareness of personal and procedural limitations all help to minimize adverse outcomes. (springer.com)
  • Sekhar LN, Biswas A, Hallam D, Kim LJ, Douglas J, Ghodke B. Neuroendovascular management of tumors and vascular malformations of the head and neck. (springer.com)
  • Vascular tumors can bleed, which in some cases can be substantial, leading to anemia. (wikipedia.org)
  • carcinomas
  • Malignant mammary tumors are divided into sarcomas , carcinosarcomas , inflammatory carcinomas (usually anaplastic carcinomas ), and carcinomas (including adenocarcinomas ), which are the most common. (wikipedia.org)
  • Inflammatory carcinomas describe tumors that are fast growing and have bruising, edema , and pain, and can also cause disseminated intravascular coagulation . (wikipedia.org)
  • adults
  • Age Solitary glomus tumors are more frequent in adults than in others. (wikipedia.org)
  • The most common types of primary tumors in adults are meningiomas (usually benign), and astrocytomas such as glioblastomas. (wikipedia.org)
  • The protocol with the best reported survival in children and adults is an intra-arterial protocol where tumor response is tracked by serial arteriogram. (wikipedia.org)
  • bone
  • The tumor microenvironment (TME) is the cellular environment in which the tumor exists, including surrounding blood vessels, immune cells, fibroblasts, bone marrow-derived inflammatory cells, lymphocytes, signaling molecules and the extracellular matrix (ECM). (wikipedia.org)
  • The brown tumor is a bone lesion that arises in settings of excess osteoclast activity, such as hyperparathyroidism. (wikipedia.org)
  • it may also be seen in giant cell tumors of the bone. (wikipedia.org)
  • A bone tumor (also spelled bone tumour) is a neoplastic growth of tissue in bone. (wikipedia.org)
  • The most common symptom of bone tumors is pain, which will gradually increase over time. (wikipedia.org)
  • Some bone tumors may weaken the structure of the bone, causing pathologic fractures. (wikipedia.org)
  • There is a variety of chemotherapy treatment protocols for bone tumors. (wikipedia.org)
  • blood vessels
  • In addition, the protein was also found to be frequently overexpressed by the tumor cells themselves, indicating that a suitable inhibitory molecule might be able to deliver a double blow -- one to the tumor cells themselves and the other to the blood vessels that feed them. (nih.gov)
  • This tissue is not vascularized, which prevents tumors from growing greater than 2mm in diameter without inducing new blood vessels. (wikipedia.org)
  • citation needed
  • citation needed] Parietal lobe: Tumors here may result in poor interpretation of languages, decreased sense of touch and pain, and poor spatial and visual perception. (wikipedia.org)
  • citation needed] Cerebellum: Tumors in this area may cause poor balance, muscle movement, and posture. (wikipedia.org)
  • 2017
  • In April 2017, Springer announced it was retracting 107 papers that had been published in Tumor Biology while they were publishing it. (wikipedia.org)
  • often
  • The tumors are often multiple. (wikipedia.org)
  • Even though Wilms tumors often are large when found, most have not spread to other areas of the body. (kidshealth.org)
  • Neuroblastic tumors often produce elevated levels of catecholamine hormone precursors, such as vanillylmandelic acid (VMA) and homovanillic acid, and may produce severe watery diarrhea through production of vasoactive intestinal peptide. (wikipedia.org)
  • The enhanced permeability and retention effect (EPR effect) is the observation that the vasculature of tumors is often leaky and accumulates molecules in the blood stream to a greater extent than in normal tissue. (wikipedia.org)
  • include
  • This may include exams to look for vision or nervous system problems that could be caused by a tumor. (cancer.org)
  • NETs include certain tumors of the gastrointestinal tract and of the pancreatic islet cells, certain thymus and lung tumors, and medullary carcinoma of the parafollicular cells of the thyroid. (wikipedia.org)
  • Common examples of benign tumors include moles and uterine fibroids. (wikipedia.org)
  • Related, but less aggressive tumors composed of more mature neural cells include ganglioneuroblastoma and ganglioneuroma. (wikipedia.org)
  • primary
  • Circulating tumor cells ( CTCs ) are cells that have shed into the vasculature or lymphatics from a primary tumor and are carried around the body in the blood circulation . (wikipedia.org)
  • The multifaceted role of tumor embolization ranges from adjuvant treatment in meningiomas and diffuse pontine gliomas to primary treatment in retinoblastoma, with selective ophthalmic artery chemosurgery. (springer.com)
  • This immune response did not however affect the primary tumor. (wikipedia.org)
  • adenoma
  • Overweight, obesity and height as risk factors for meningioma, glioma, pituitary adenoma and nerve sheath tumor: a large population-based prospective cohort study. (cancer.org)
  • chemotherapy
  • With the developments in technology for early tumor detection and radio isotope labeling of target tumor cells based on angioneogenesis and tumor-specific characteristics, IA chemotherapy is evolving as a promising selective target tumor treatment. (springer.com)
  • glycolytic
  • In the PI3K/AKT/mTOR pathway, AKT1 (also known as Protein Kinase B or PKB), is an important driver of the tumor glycolytic phenotype and stimulates ATP generation. (wikipedia.org)