• A member of the genus Francisella , F. tularensis is the causative agent of tularemia or rabbit fever. (loinc.org)
  • Medical care in tularemia is directed primarily toward antibiotic eradication of F tularensis , with streptomycin being the drug of choice (DOC) for this treatment. (medscape.com)
  • Francisella tularensis is a gram-negative, intracellular, coccobacillus zoonotic bacteria which is the cause of the disease tularemia. (picmonic.com)
  • Francisella tularensis is a small pathogenic gram-negative bacterium that causes tularemia. (ximbio.com)
  • Francisella tularensis can cause the zoonotic disease tularemia and is partitioned into subspecies due to differences in chromosomal organization and virulence. (nebraska.edu)
  • Francisella tularensis, the etiologic agent of tularemia and a Class A Select Agent, is divided into three subspecies and multiple subpopulations that differ in virulence and geographic distribution. (nau.edu)
  • Francisella tularensis is the etiological agent of tularemia, a serious disease in several Northern hemisphere countries. (bibbase.org)
  • article{karlsson_sequencing_2000, title = {Sequencing of the {Francisella} tularensis {Strain} {Schu} 4 {Genome} {Reveals} the {Shikimate} and {Purine} {Metabolic} {Pathways}, {Targets} for the {Construction} of a {Rationally} {Attenuated} {Auxotrophic} {Vaccine}}, volume = {5}, issn = {1090-6592}, url = {https://www.liebertpub.com/doi/10.1089/10906590050145249}, doi = {10.1089/10906590050145249}, abstract = {Francisella tularensis is the etiological agent of tularemia, a serious disease in several Northern hemisphere countries. (bibbase.org)
  • F. tularensis can cause a fatal, febrile illness, although these natural tularemia infections are rare in the United States. (fda.gov)
  • This research provides guidance to federal action agencies for UV-C control of F. tularensis and will help food processors protect their workers and consumers from tularemia. (usda.gov)
  • Francisella tularensis is the causative agent of tularemia, a plague-like illness that affects animals and humans, and has caused large illness pandemics in the last century. (usda.gov)
  • Tularemia, sometimes referred to as "rabbit fever" after its most common reservoir, is a relatively rare zoonotic disease caused by the bacterium Francisella tularensis. (cdc.gov)
  • Subspecies Virulence Region Francisella tularensis subsp. (umd.edu)
  • tularensis (Type A) high North America, Francisella tularensis subsp. (umd.edu)
  • holarctica (Type B) moderate North America,Europe, Asia Francisella tularensis subsp. (umd.edu)
  • 5HVN: 3.0 Angstrom Crystal Structure of 3-dehydroquinate Synthase (AroB) from Francisella tularensis in Complex with NAD. (rcsb.org)
  • Francisella tularensis is a pathogenic species of gram-negative bacteria. (loinc.org)
  • What the clinician didn't know was that the patient had been exposed to a bacterium called Francisella tularensis (F. tularensis), which can cause a life-threatening illness. (cdc.gov)
  • Pediatrics Central , peds.unboundmedicine.com/pedscentral/view/Johns_Hopkins_ABX_Guide/540233/all/Francisella_tularensis. (unboundmedicine.com)
  • Fabre V. Francisella tularensis. (unboundmedicine.com)
  • Francisella tularensis is an intracellular pathogen that can survive and replicate within host macrophages, but may also infect many other cell types. (picmonic.com)
  • Francisella tularensis is a facultative intracellular bacterium in the family Francisellaceae that causes the acute zoonosis tularaemia.F. tularensis. (cabi.org)
  • Francisella tularensis infection-derived monoclonal antibodies provide detection, protection, and therapy. (ximbio.com)
  • View of Role of LpnA in Francisella tularensis Susceptibility to Resazurin. (pwvas.org)
  • Francisella tularensis, Bartonella bacilliformis, Bacteroides species, Vibrio cholerae and Campylobacte fetus, Brucella species (in conjunction with streptomycin). (rxlist.com)
  • This is important for highly pathogenic bacteria such as Bacillus anthracis, Brucella species, and Francisella tularensis. (rki.de)
  • Treatment of murine pneumonic Francisella tularensis infection with gatifloxacin, moxifloxacin or ciprofloxacin. (ox.ac.uk)
  • Dermacentor andersoni transmission of Francisella tularensis subsp. (usda.gov)
  • Sequence comparison of Francisella tularensis LVS, LVS-G, and LVS-R. (fda.gov)
  • Francisella tularensis is a gram-negative organism found in many regions of the world. (fda.gov)
  • World Health Organization (WHO) estimates hypothesize that if 50 kg of 'weaponized' or highly virulent bacterium Francisella tularensis was dispersed in aerosol form over a large city, depending on weather and exposure patterns, there could be as many as 250,000 infections resulting in a projected 19,000 deaths. (faqs.org)
  • Both the Japanese and Western armies experimented with Francisella tularensis during World War II. (faqs.org)
  • The causative bacterium, Francisella tularensis is a Gram-negative bacterium that, even though it does not form a spore, can survive for protracted periods of time in environments such as cold water, moist hay, soil, and decomposing carcasses. (faqs.org)
  • An especially severe pneumonia develops from the inhalation of one type of the organism, which is designated as Francisella tularensis biovar tularensis (type A). The pneumonia can progress to respiratory failure and death. (faqs.org)
  • Francisella tularensis causes a plague-like illness which can be contracted through consumption of contaminated food and water as well as the processing of diseased animals. (usda.gov)
  • In this study we investigated the ability of UV-C to inactivate Francisella tularensis Utah-112(a rodent pathogen)on agar plates, stainless steel, plastic, and foods. (usda.gov)
  • Francisella tularensis Transmission by Solid Organ Transplantation, 2017 1 . (bvsalud.org)
  • La produce FRANCISELLA TULARENSIS y se caracteriza por fiebre, escalofríos, cefalea, lumbalgia y decaimiento. (bvsalud.org)
  • F. tularensis subsp. (unboundmedicine.com)
  • tularensis often are worse than those caused by F. tularensis subsp. (unboundmedicine.com)
  • However, the development of F. tularensis as a potential weapon of bioterrorism during the Cold War spurred the development of a live attenuated vaccine, LVS, from F. tularensis subsp. (fda.gov)
  • To better understand the impact of these mutations on LVS' immunogenicity, we sequenced the genomes of LVS-G and LVS-R as well as our parental laboratory stock of LVS, originally obtained from ATCC, and compared these to the F. tularensis subsp. (fda.gov)
  • 4 Until now, all cases reported in Spain were caused by F. tularensis subsp. (elsevier.es)
  • Given these differences, there is a need to rapidly and accurately determine if a strain is F. tularensis and, if it is, assign it to subspecies and subpopulation. (nau.edu)
  • The remaining nine assays classify F. tularensis-confirmed isolates into F. tularensis subspecies and subpopulations. (nau.edu)
  • Altogether, these eleven TaqMan real-time PCR assays represent a highly accurate, rapid, and sensitive means of identifying the species, subspecies, and subpopulation of any F. tularensis isolate if used in a step-wise hierarchical scheme. (nau.edu)
  • This mouse IgG2a monoclonal antibody is reactive against both F. tularensis LVS and F. tularensis SchuS4 protein LpnA/Tul4 (does not react with F. novicida). (ximbio.com)
  • One assay differentiates F. tularensis, F. novicida, and F. hispaniensis from the more genetically distant F. philomiragia and Francisella-like endosymbionts. (nau.edu)
  • A. tularensis is listed as an endangered species on the California state level, but not on the federal level. (wikipedia.org)
  • type species of the genus F.. SYN: Pasteurella tularensis. (theodora.com)
  • Due to its ease of spread by aerosol and its high virulence, F. tularensis is classified as a Class A agent by the U.S. government. (loinc.org)
  • Genes located on plasmids pOM1 and pNFL10, which had been previously isolated from low virulence strains of F. tularensis, were absent but all of the other known F. tularensis genes were represented in the assembled data. (bibbase.org)
  • [5] Known as one of the most infectious pathogens, only a few F. tularensis organisms may cause infection. (qmrawiki.org)
  • A set of classical dose-response data for F. tularensis infection via oral exposure by Quan et al were used in investigating the effects of inoculation route on the response. (qmrawiki.org)
  • If antibodies are found, it means you either have a current or past infection with F tularensis . (medlineplus.gov)
  • In some cases, a single high level of antibodies that are specific to F tularensis means you have an infection. (medlineplus.gov)
  • Title : A new organism resembling P. tularensis isolated from water Personal Author(s) : Larson, Carl L.;Wicht, William;Jellison, William L. (cdc.gov)
  • 1955). A new organism resembling P. tularensis isolated from water. (cdc.gov)
  • F. tularensis Schu4 was able to grow in the absence of aromatic amino acids and orthologues of genes which could encode enzymes in the shikimate pathway in other bacteria were identified in the assembled data. (bibbase.org)
  • In this study the use of a U.S. Food and Drug Administration approved technology, 254 nm ultraviolet light (UV-C), to inactivate F. tularensis Utah-112 (a rodent pathogen) on food and food contact surfaces was investigated. (usda.gov)
  • Day and Berendt exposed 4-5 kg monkeys to aerosol particles of SCHU S-4 strain of F. tularensis . (qmrawiki.org)
  • A random library of DNA fragments from a highly virulent strain (Schu 4) of F. tularensis was constructed and the nucleotide sequences of 13,904 cloned fragments were determined and assembled into 353 contigs. (bibbase.org)
  • This data will be used to develop defined rationally attenuated mutants of F. tularensis, which could be used as replacements for the existing genetically undefined live vaccine strain. (bibbase.org)
  • These assays would be very useful in clinical, epidemiological, and/or forensic investigations involving F. tularensis. (nau.edu)
  • We designed TaqMan real-time PCR genotyping assays using eleven single nucleotide polymorphisms (SNPs) that were potentially specific to closely related groups within the genus Francisella, including numerous subpopulations within F. tularensis species. (nau.edu)
  • This characteristic differentiates A. tularensis from Atriplex cordulata, which is otherwise very similar in appearance. (wikipedia.org)
  • Another assay differentiates F. tularensis isolates from near neighbors. (nau.edu)
  • [ 1 ] F tularensis is one of the most infectious bacterial species known. (medscape.com)
  • The genotyping accuracy of these nine assays diminished when tested on outgroup isolates (i.e. non F. tularensis), therefore a hierarchical approach of assay usage is recommended wherein the F. tularensis-specific assay is used before the nine downstream assays. (nau.edu)
  • For F. tularensis, high-resolution genotyping using core-genome MLST (cgMLST) and core-genome Single-Nucleotide-Polymorphism (cgSNP) typing produced highly comparable results between data from Illumina and both ONT flow cell versions. (rki.de)
  • This method checks if your body has produced substances called antibodies to a specific foreign substance ( antigen ), in this case F tularensis . (medlineplus.gov)
  • [6] [7] The U.S. Centers for Disease Control and Prevention have classified F. tularensis as a Category A bioterrorism agent for public health preparedness. (qmrawiki.org)
  • Atriplex tularensis is endemic to Kern County, California, where it is known only from a few individuals at Kern Lake, a usually dry ephemeral lake bed just north of the Interstate 5 and Highway 99 split. (wikipedia.org)
  • anthracis and F. tularensis as well as multilocus sequence types for Br. (rki.de)
  • If antibodies are detected, there has been exposure to F tularensis . (medlineplus.gov)
  • b) Western blots of whole-cell lysates from F. tularensis strains with antiserum against F. tularensis 43-kDa protein (2). (nih.gov)
  • In this study, using highly virulent F. tularensis strains and the closely related species F. novicida, IglG was characterized as a protein featuring a unique α-helical N-terminal extension and a domain of unknown function (DUF4280), present in more than 250 bacterial species. (canada.ca)
  • The geographical distribution of erythromycin-resistant F. tularensis strains was further investigated by literature search. (nau.edu)
  • Background: Bacillus anthracis, Francisella tularensis, and Yersinia pestis are bacterial pathogens that can cause anthrax, lethal acute pneumonic disease, and bubonic plague, respectively, and are listed as NIAID Category A priority pathogens for possible use as biological weapons. (vt.edu)
  • Francisella tularensis is a Gram-negative coccobacillus, which means that shape-wise, it's somewhere between a spherical coccus and a rod-like bacillus. (osmosis.org)
  • Francisella tularensis DNA was found in the skin biopsy and the serology showed titres consistent with tularaemia. (medscape.com)
  • Francisella tularensis DNA extractions and isolates from the emerge seasonally from August-March ( 7 ). (cdc.gov)
  • These studies demonstrate for the first time that: 1) FcR-targeted immunogen enhances immunogen-specific IgA production and protection against subsequent infection in an IgA-dependent manner, 2) FcgammaR and neonatal FcR are crucial to this protection, and 3) inactivated F. tularensis, when targeted to FcRs, enhances protection against the highly virulent SchuS4 strain of F. tularensis, a category A biothreat agent. (umassmed.edu)
  • This method checks if your body has produced substances called antibodies to a specific foreign substance ( antigen ), in this case F tularensis . (medlineplus.gov)
  • Alright, now Francisella tularensis is non-motile, non-spore forming, facultative intracellular which means it can survive both outside and inside the cell and aerobic which means it can survive only in the presence of oxygen. (osmosis.org)
  • An IgM monoclonal antibody (mAb) recognized surface antigens specific to Francisella tularensis wild-type (Schu4) and live vaccine strain (LVS), and reacted with both in ELISA and slide agglutination tests. (psu.edu)
  • We hypothesized that protection against mucosal infection with F. tularensis would be significantly enhanced by targeting inactivated F. tularensis live vaccine strain (iFt) to FcRs at mucosal sites, via intranasal immunization with mAb-iFt complexes. (umassmed.edu)
  • Francisella tularensis outcomes tularaemia in man and sure small mammals, resembling rabbits, hares, beavers and a number of other rodent species. (keiseronlineuniversity.com)
  • Serum from instances of F. tularensis could cross-react with brucellosis and vice versa, often to comparatively low titre. (keiseronlineuniversity.com)
  • A normal result is no antibodies specific for F tularensis are found in the serum. (medlineplus.gov)
  • From more than 250,000 screens performed, we identified 3,073 human-B. anthracis, 1,383 human-F. tularensis, and 4,059 human-Y. pestis protein-protein interactions including interactions involving 304 B. anthracis, 52 F. tularensis, and 330 Y. pestis proteins that are uncharacterized. (vt.edu)
  • Francisella tularensis is highly infectious when grown in culture, and laboratory-acquired infections have been documented. (cdc.gov)
  • F tularensis is one of the most infectious bacterial species known. (medscape.com)
  • We report herein the first case of bacteremic F. tularensis pneumonia in an immunocompetent individual in southern Europe. (nih.gov)
  • holarctica , which is found widely throughout the known vectors of F. tularensis ( 1 , 4 ). (cdc.gov)
  • a) PCR products of the F. tularensis 17-kDa lipoprotein gene (250 bp) (27). (nih.gov)
  • Introducing 2059C into an rrl gene of an erythromycin-susceptible F. tularensis strain resulted in resistance. (nau.edu)
  • Conclusions: Erythromycin resistance in F. tularensis is caused by an A2059C rrl gene mutation, which exhibits a strictly clonal inheritance pattern found only in phylogenetic group B.12. (nau.edu)
  • The phylogeography of F. tularensis in Asia is poorly insights into F. tularensis transmission from environmental understood because of undersampling in many regions, sources to humans. (cdc.gov)
  • Although F tularensis has been cultured from sputum, pleural fluid, wounds, blood, lymph node biopsy samples, and gastric washings, the yield is extremely low and culturing poses a danger to laboratory personnel. (medscape.com)
  • F. tularensis has been developed as a organic warfare agent and has potential software in bioterrorism. (keiseronlineuniversity.com)
  • If antibodies are found, it means you either have a current or past infection with F tularensis . (medlineplus.gov)
  • F. tularensis is extraordinarily harmful to deal with within the laboratory and Class 3 containment is required for all manipulations and animal work. (keiseronlineuniversity.com)
  • In some cases, a single high level of antibodies that are specific to F tularensis means you have an infection. (medlineplus.gov)