Reliable, digital, automated detection of interstitial fibrosis and tubular atrophy (IFTA) has not yet been developed. (ufl.edu)
The primary endpoint was moderate-to-severe interstitial fibrosis and tubular atrophy assessed by protocol biopsy at 3 years evaluated by a single pathologist blinded to the study group. (biomedcentral.com)
Valganciclovir prophylaxis, as compared with valacyclovir, was associated with a reduced risk of moderate-to-severe interstitial fibrosis and tubular atrophy in patients after renal transplantation. (biomedcentral.com)
Treatment was initiated late (6 weeks of age) in mice with elevated serum creatinine and albuminuria and in presence of glomerulosclerosis, interstitial fibrosis and tubular atrophy. (asn-online.org)
Results for CKD biomarkers in blood (BUN, creatinine, phosphorus, and SDMA concentrations) and urine (protein concentration, urine protein-to-creatinine ratio, and urine specific gravity) were evaluated for correlation with histologic kidney damage scored with an objective grading scale defined by percentage of inflammation, fibrosis, and tubular atrophy. (avma.org)
Development and Validation of a Deep Learning Model to Quantify Interstitial Fibrosis and Tubular Atrophy From Kidney Ultrasonography Images. (ucsd.edu)
The aging kidneys undergo a wide range of macrostructural changes, such as decreased cortical volume, increased surface roughness, and augmented numbers and sizes of cysts [ 11 ], which correspond to the typical microstructural features of glomerulosclerosis, tubular atrophy, interstitial fibrosis, and nephron loss [ 12 ]. (hindawi.com)
What we see histopathologically is interstitial inflammation, tubular atrophy, fibrosis, and then also secondary glomerulosclerosis that forms as the disease progresses. (hstalks.com)
She underwent renal biopsy which showed diffuse global glomerulosclerosis with prominent subcapsular fibrosis, tubular atrophy, severe interstitial fibrosis involving 60% of the cortex ( figure 1 ) and calcium oxalate deposition ( figure 2 ) on light microscopy. (bmj.com)
Microscopic changes consist of dilation of the tubular lumen and flattening of the tubular epithelium. (medscape.com)
Renal failure2
It can lead to tubular damage, interstitial inflammation and fibrosis that can cause acute or chronic renal failure, and may progress to end-stage renal disease. (bmj.com)
Although Jeune syndrome may be associated with bilateral microcystic renal disease, which may gradually progress to tubular atrophy and renal failure, the most common and prominent clinical presentation is alveolar hypoventilation. (medscape.com)
Nephron loss1
More chronic disruptions lead to profound tubular atrophy and permanent nephron loss. (medscape.com)
Kidney5
Our previous cell and animal experiments confirmed that zinc supplementation could activate Nrf2 and up-regulate its downstream antioxidant factors, thus reducing oxidative damage to renal tubular epithelial cells and kidney tissues [ 11 ]. (nature.com)
Interstitial fibrosis would be the end stage result of the inflammation and tubular death that's happening within the kidney. (hstalks.com)
For the first time to our knowledge, we demonstrate that CRELD2 can serve as a sensitive urinary biomarker for detecting ER stress in podocytes or renal tubular cells in murine models of podocyte ER stress-induced nephrotic syndrome and tunicamycin- or ischemia-reperfusion-induced acute kidney injury (AKI), respectively. (jci.org)
Most importantly, urinary CRELD2 elevation occurs in patients with autosomal dominant tubulointerstitial kidney disease caused by UMOD mutations, a prototypical tubular ER stress disease. (jci.org)
A 75-year-old woman with fever, cough, and myalgia developed kidney dysfunction with inflammatory reactions and tubular-type proteinuria, without glomerular hematuria. (bvsalud.org)
Podocytes1
Other reports also show that DN is highly associated with accelerated aging in various types of cells such as tubular cells, podocytes, mesangial cells, and endothelial cells [ 21 - 23 ]. (hindawi.com)
Proximal2
80-100 μg/dL) disrupts both proximal tubular structure and function. (medscape.com)
Lead is absorbed by the proximal tubular cells of the renal tubules, where it binds to specific lead-binding proteins. (medscape.com)
Sclerosis3
Chronic lead poisoning may also result in lead nephropathy, which is characterized by tubulointerstitial fibrosis, tubular atrophy, glomerular sclerosis, and ultimately diminished glomerular filtration rate (GFR). (medscape.com)
In all documented biopsied cases, there is a significant decline in germ cell development and an increase in tubular sclerosis by puberty. (medscape.com)
Pathology generally shows mesangial and endocapillary hypercellularity, segmental sclerosis, and/or cellular crescents as well as presence of interstitial fibrosis and/or tubular atrophy. (medscape.com)
Acute1
2-5 The majority of these studies provide evidence that systemic administration of bone marrow-derived or adipose-tissue derived MSC can help preserve renal function in the face of acute insults and can also help reduce tubular injury and fibrosis. (vin.com)
Dysfunction1
Chronic tubulointerstitial nephritis (CTIN) arises when chronic tubular insults cause gradual interstitial infiltration and fibrosis, tubular atrophy and dysfunction, and a gradual deterioration of renal function, usually over years. (merckmanuals.com)
Thin basement membrane nephropathy biopsy results demonstrate cystic dilatation of the Bowman's capsule and atrophy of the glomerular tuft, with a thin glomerular basement membrane. (medscape.com)
Cortical1
Eventually, cortical atrophy progresses to the point at which only a thin rim of parenchyma is present. (medscape.com)
Deposition1
The frameshift mutation results in the formation of a truncated protein which cannot fold properly, promoting aggregation, and subsequent deposition in tubular cells. (medscape.com)
Cells2
Gyrate atrophy may also cause disturbances in the nerves connecting the brain and spinal cord to muscles and sensory cells (peripheral nervous system). (medlineplus.gov)
4,6,7 It has been proposed that some of these MSC may actually differentiate into functional renal tubular epithelial cells, though this theory remains controversial. (vin.com)
Clinically1
Overview of Tubulointerstitial Diseases Tubulointerstitial diseases are clinically heterogeneous disorders that share similar features of tubular and interstitial injury. (merckmanuals.com)
Gyrate atrophy of the choroid and retina, which is often shortened to gyrate atrophy, is an inherited disorder characterized by progressive vision loss. (medlineplus.gov)
Most people with gyrate atrophy have no symptoms other than vision loss, but some have additional features of the disorder. (medlineplus.gov)
Disease1
An autosomal recessive disorder that causes premature aging in adults, characterized by sclerodermal skin changes, cataracts, subcutaneous calcification, muscular atrophy, a tendency to diabetes mellitus, aged appearance of the face, baldness, and a high incidence of neoplastic disease. (bvsalud.org)
Amount1
Variable amount of tubular atrophy and interstitial fibrosis depending on the point in the natural history of the condition that the biopsy is performed. (medscape.com)
Lead1
Occasionally, newborns with gyrate atrophy develop excess ammonia in the blood (hyperammonemia), which may lead to poor feeding, vomiting, seizures, or coma. (medlineplus.gov)
Generally1
Neonatal hyperammonemia associated with gyrate atrophy generally responds quickly to treatment and does not recur after the newborn period. (medlineplus.gov)
Transport1
In addition, renal tubular ability to transport sodium, potassium, and protons and concentrate and to dilute the urine is severely impaired. (medscape.com)