These small currents were linked to ACh release since anticholinesterases (neostigmine) increased their effects, while cholinergic receptor antagonist (tubocurarine, a nicotinic receptor blocker) blocked. (pharmacology2000.com)
Interactions1
We previously found that blockade of nerve-induced activity by d-Tubocurarine perturbed muscle cell interactions, resulting in a failure of myotubes to separate. (rupress.org)
Lithium1
Non-depolarizing muscle relaxants, such as Tubocurarine, can also be problematic with greater risks of lithium toxicity. (ntpills.com)
Alkaloid2
Tubocurarine (also known as d-tubocurarine or DTC) is a toxic benzylisoquinoline alkaloid historically known for its use as an arrow poison. (wikipedia.org)
Tubocurarine is a naturally occurring mono-quaternary alkaloid obtained from the bark of the Menispermaceous South American plant Chondrodendron tomentosum, a climbing vine known to the European world since the Spanish conquest of South America. (wikipedia.org)
Adults1
When the effect of d-tubocurarine is determined by twitch response, infants and children are more resistant to d-tubocurarine and recover faster than adults from similar levels of neuromuscular depression. (cornell.edu)
Muscle3
Regardless, all in all some 30,000 patients had been given tubocurarine by 1941, although it was Griffith and Johnson's 1942 publication that provided the impetus to the standard use of neuromuscular blocking agents in clinical anesthetic practice - a revolution that rapidly metamorphosized into the standard practice of "balanced" anesthesia: the triad of barbiturate hypnosis, light inhalational anesthesia and muscle relaxation. (wikipedia.org)
Tubocurarine): Possible increased responsiveness to the muscle relaxant may result. (pediatriconcall.com)
In the mid-1900s, doctors also used tubocurarine with anaesthesia to induce muscle relaxation so patients wouldn't move. (labonline.com.au)
Drugs1
This provides a useful way to terminate paralysis produced by tubocurarine or similar drugs at the end of surgical procedures. (britannica.com)
Plant2
Tubocurarine is so-called because some of the plant extracts designated curare were stored, and subsequently shipped to Europe, in bamboo tubes. (wikipedia.org)
The Chondrodendron tomentosum plant produces tubocurarine, a potent toxin used to create poisoned arrows. (labonline.com.au)
Action2
Thus, tubocurarine is effective only if given parenterally, as demonstrated by Bernard, who also showed that the site of its action was at the neuromuscular junction. (wikipedia.org)
Re-evaluation of dosage and duration of action of d-tubocurarine in the pediatric age group. (cornell.edu)
Group1
The additional methyl group is transferred to form tubocurarine, with its single quaternary N,N-dimethylamino group. (wikipedia.org)
Agent1
In this sense, tubocurarine is the prototypical adjunctive neuromuscular non-depolarizing agent. (wikipedia.org)
Effects1
Curare had been used as a source of arrow poison by South American natives to hunt animals, and they were able to eat the animals' contaminated flesh subsequently without any adverse effects because tubocurarine cannot easily cross mucous membranes. (wikipedia.org)
Children1
A cumulative dose-response curve for d-tubocurarine based on body weight was determined for 44 infants and children 1 day to 7 years of age during halothane, nitrous oxide and oxygen anesthesia. (cornell.edu)
Receptors1
Strychnine and d-tubocurarine (d-TC) are neurotoxins that have been highly instrumental in decades of research on glycine receptors (GlyR) and nicotinic acetylcholine receptors (nAChR), respectively. (nih.gov)
Neuromuscular Junction1
Thus, tubocurarine is effective only if given parenterally, as demonstrated by Bernard, who also showed that the site of its action was at the neuromuscular junction. (wikipedia.org)
Muscle2
Regardless, all in all some 30,000 patients had been given tubocurarine by 1941, although it was Griffith and Johnson's 1942 publication that provided the impetus to the standard use of neuromuscular blocking agents in clinical anesthetic practice - a revolution that rapidly metamorphosized into the standard practice of "balanced" anesthesia: the triad of barbiturate hypnosis, light inhalational anesthesia and muscle relaxation. (wikipedia.org)
A cholinesterase inhibitor used in the treatment of myasthenia gravis and to reverse the effects of muscle relaxants such as gallamine and tubocurarine . (lookformedical.com)
Pharmacology1
We found that two distinct components underlying the biphasic curve differed in their ionic permeability and pharmacology (one being sensitive to d -tubocurarine, and the other affected only by mecamylamine and α-conotoxin ImI). (aspetjournals.org)
The injection of either d-tubocurarine (350 micrograms/kg) or alpha-bungarotoxin (alpha-Butx) (1 mg/kg) resulted in a flaccid paralysis. (nih.gov)
Extracts2
Tubocurarine is so-called because some of the plant extracts designated curare were stored, and subsequently shipped to Europe, in bamboo tubes. (wikipedia.org)
29.6% (mean value) of the total 125I-alpha-bungarotoxin (alpha-BuTx) binding sites in the TE671 extracts was not inhibited by d-tubocurarine (dTC). (nih.gov)