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  • Biological
  • Results: Cross-matching of literature and in silico-derived data, in conjunction with the prioritization scheme and biological rationale, allowed for selection of 189 putative vaccine candidates from the entire genome. (www.gov.uk)
  • Adults
  • The BCG vaccine is the only available prevention against TB, yet it elicits inconsistent protection when given to infants, fails to provide consistent protection in adults against pulmonary disease, and is unsafe for use in immunocompromised patients. (www.gov.uk)
  • Mtb72F/AS02A is a candidate TB vaccine under development for two indications: prevention of primary TB infection in young children in highly endemic areas and as an adjunct to treatment for TB in adolescents and adults. (clinicaltrials.gov)
  • infection
  • Current approved prophylactic TB vaccines (BCG and derivatives thereof) are of variable efficiency in adult protection against pulmonary TB (0%-80%), and directed essentially against early phase infection. (www.gov.uk)
  • efficacious
  • These new TB vaccines are hoped to provide a safe, efficacious replacement, or addition to, the nearly century-old BCG and provide protection against TB disease beyond childhood. (www.gov.uk)
  • candidates
  • A new crop of TB vaccine candidates has entered into clinical trials, with a second generation following shortly. (www.gov.uk)
  • This review details the status of the most promising TB vaccine candidates in development, as one of these candidates may play a key role in defending against an ominous health threat. (www.gov.uk)
  • Conclusion: The comprehensive literature and in silico-based analyses allowed for the selection of a repertoire of 189 vaccine candidates, out of the whole-genome 3989 ORF products. (www.gov.uk)
  • Adverse
  • We monitored them over six months, observing for clinical, haematological and biochemical adverse events, together with assessment of the vaccine induced cellular immune response using ELISPOT and flow cytometry. (www.gov.uk)
  • humans
  • Despite plaguing humans for thousands of years, tuberculosis remains a widespread and lethal public health problem throughout the world today. (www.gov.uk)