MycobacteriumPulmonaryIsoniazid2023RifampicinSusceptibilityMultidrugInfectionAntibioticLinezolidRegimensActive tuberculosisPrognosis of MDR tuberculosisUncle revealed MDR tuberculosisPretomanidMoxifloxacin and clofazimineNature of childhood tuberculosisMutationsDelamanidTreatmentMulti-drug ResistaPrimary drug-resistant tuPeople worldwide had tuberculosisSputumLeprosy2019Report 2020Burden of tuberculosis20212020ExtrapulmonaryAntitubercular drugsIsolatesDrugsAdultsClinicalAssayRv0678AbstractPatientsDetectionIncidenceGenome
Mycobacterium23
- Methods: We isolated 96 mutants of Mycobacterium tuberculosis resistant to clofazimine and performed WGS and Sanger sequencing to identify possible mutations associated with clofazimine resistance. (johnshopkins.edu)
- Tuberculosis (TB) is caused by a slow-growing bacterium (germ) called Mycobacterium tuberculosis . (bccdc.ca)
- Tuberculosis is caused by infection with the bacterium Mycobacterium tuberculosis. (wikipedia.org)
- Mycobacterium tuberculosis and SARS-CoV-2 Coinfections: A Review. (nih.gov)
- Tuberculosis (TB) is one of the major causes of death related to antimicrobial resistance worldwide because of the spread of Mycobacterium tuberculosis multi- and extensively drug resistant (multi-drug resistant (MDR) and extensively drug-resistant (XDR), respectively) clinical isolates. (frontiersin.org)
- According to the World Health Organization (WHO) report, in 2018, tuberculosis (TB), caused by Mycobacterium tuberculosis , was one of the major causes of death related to antimicrobial resistance ( World Health Organization [WHO], 2019a ). (frontiersin.org)
- Individuals aged ≥15 years with a pulmonary infection by Mycobacterium tuberculosis , confirmed by culture-based drug susceptibility tests or molecular tests, were included. (news-medical.net)
- the complete genome sequence of Mycobacterium tuberculosis continues to provide an invaluable resource to understand tuberculosis (TB), the leading cause of global infectious disease mortality. (jci.org)
- It is a disease caused by strains of Mycobacterium tuberculosis that are resistant to at least isoniazid and rifampicin, the 2 most powerful first-line anti-tuberculosis drugs (1-3). (who.int)
- In every case, the results show approximately ≥80% success rates against MDR-TB caused by Mycobacterium tuberculosis strains without known resistance to the drugs in the regimen (with the only exception of isoniazid), similar to outcomes with conventional longer regimens. (ersjournals.com)
- CRyPTIC Consortium 2022, 'High fluoroquinolone resistance proportions among multidrug-resistant tuberculosis driven by dominant L2 Mycobacterium tuberculosis clones in the Mumbai Metropolitan Region', Genome medicine , Jg. (fz-borstel.de)
- The role of mutations in genes associated with phenotypic resistance to bedaquiline (BDQ) and delamanid (DLM) in Mycobacterium tuberculosis complex (MTBc) strains is poorly characterized. (itg.be)
- Bedaquiline and clofazimine resistance in Mycobacterium tuberculosis: an in-vitro and in-silico data analysis. (ox.ac.uk)
- Mycobacterium tuberculosis causes a contagious pulmonary disease with a high mortality rate in developing countries. (eurekaselect.com)
- TB infection occurs when a person inhales droplet nuclei containing Mycobacterium tuberculosis organisms. (hiv.gov)
- It is a disease caused by strains The patient had not recovered despite vealed multiple lymph nodes located of Mycobacterium tuberculosis that previous antibiotic therapies. (who.int)
- However, the culture of Mycobacterium tuberculosis ( M. tuberculosis ) complex strains from stool perform poorly. (biomedcentral.com)
- There is an urgent need for rapid, comprehensive detection of drug resistance of Mycobacterium tuberculosis ( M. tuberculosis) complex strains to guide appropriate treatment regimens [ 5 ]. (biomedcentral.com)
- However, Mycobacterium tuberculosis (MTB) that independent resistance and cross-resistance to bedaquiline and clofazimine gradually increased in recent years. (rsghb.cn)
- The aim of this review is to provide a reference for the study on resistance mechanism of Mycobacterium tuberculosis to bedaquiline and clofazimine and for their further application on tuberculosis treatment. (rsghb.cn)
- 10] Hartkoorn RC, Uplekar S, Cole ST.Cross-resistance between clofazimine and bedaquiline through upregulation of MmpL5 in Mycobacterium tuberculosis [J]. Antimicrob Agents Chemother, 2014, 58(5): 2979-2981. (rsghb.cn)
- In tests with 18 drug-susceptible strains of Mycobacterium tuberculosis, the MIC at which 50% of the strains are inhibited by levofloxacin (LVFX) was one dilution less than that at which 50% of the strains are inhibited by ofloxacin (OFLO), but the MICs at which 90% of the strains are inhibited were similar. (eurekamag.com)
- Dr Kunota's PhD research focused on understanding one of the mechanisms that Mycobacterium tuberculosis ( Mtb ) - the bacterium which causes tuberculosis - uses to counteract TB drugs. (ahri.org)
Pulmonary6
- Extrapulmonary tuberculosis should be managed according to the principles and with the drug regimens outlined for pulmonary tuberculosis, except for children who have miliary tuberculosis, bone/joint tuberculosis, or tuberculous meningitis who should receive a minimum of 12 mo of therapy. (cdc.gov)
- In a recent study published in The Lancet Respiratory Medicine , researchers reported the TB-PRACTECAL clinical trial outcomes, which evaluated the efficacy and safety of oral bedaquiline, linezolid, and pretomanid (BPaL)-based regimens for pulmonary tuberculosis resistant to rifampicin. (news-medical.net)
- The BPaLM regimen showed the most promising results, and the World Health Organization (WHO) suggested a six-month BPaLM course for rifampicin-resistant TB without fluoroquinolone resistance in 2022 and a BPaL regimen for pulmonary tuberculosis resistant to rifampicin with further resistance in 2022. (news-medical.net)
- The study included individuals aged ≥15 years with pulmonary tuberculosis resistant to rifampicin at seven community locations and hospitals in South Africa, Belarus, and Uzbekistan. (news-medical.net)
- thus, procedures such as sputum induction or gastric aspiration are required to collect diagnostic specimens for pulmonary tuberculosis [ 8 ]. (biomedcentral.com)
- "BPaMZ" is an all-oral TB treatment regimen consisting of bedaquiline (B) , pretomanid (Pa) , moxifloxacin (M) and pyrazinamide (Z) . BPaMZ is currently being tested in those with drug-sensitive (DS-) as well as those with drug-resistant (MDR-) pulmonary tuberculosis (specifically multidrug-resistant TB and mono-resistance to isoniazid and rifampicin) in the pivotal SimpliciTB trial . (tballiance.org)
Isoniazid9
- Multiple-drug-resistant tuberculosis (i.e., resistance to at least isoniazid and rifampin) presents difficult treatment problems. (cdc.gov)
- A 4-mo regimen of isoniazid and rifampin is acceptable therapy for adults who have active tuberculosis and who are sputum-smear and culture negative, if there is little possibility of drug resistance (see Section 1 above). (cdc.gov)
- Multidrug-resistant tuberculosis (MDR-TB) is a form of tuberculosis (TB) infection caused by bacteria that are resistant to treatment with at least two of the most powerful first-line anti-TB medications (drugs): isoniazid and rifampin. (wikipedia.org)
- On the 7th day of hospitalization, combined anti-tuberculosis therapy with isoniazid (10 mg/kg/day), rifampicin (15 mg/kg/day), pyrazinamide (30 mg/kg/day) and ethambutol (20 mg/kg/day) was started, pending culture and drug susceptibility testing. (who.int)
- Drug susceptibility testing of the uncle revealed MDR tuberculosis (isoniazid, rifampicin, ethambutol and streptomycin resistant). (who.int)
- On the 20th day of admission, therefore, rifampicin and ethambutol treatments of the girl were stopped, and anti-tuberculosis treatment was readjusted to high doses of isoniazid (15 mg/kg once daily), pyrazinamide (30 mg/kg/day), amikacin (15 mg/kg/day), levofloxacin (10 mg/kg twice daily), linezolid (10 mg/kg twice daily), cycloserine (15 mg/kg once daily) and clofazimine (5 mg/kg once daily) (8). (who.int)
- MDR tuberculosis in children is often A draining lesion on her right forearm with isoniazid (10 mg/kg/day), ri- undetected. (who.int)
- Therefore, tuberculostatic therapy was individualized because of resistance against rifampicin, isoniazid, bedaquiline, and clofazimine and pre-existing liver cirrhosis and neuropathy. (touchinfectiousdiseases.com)
- The in vivo activity of LVFX against M. tuberculosis was compared with the activities of isoniazid, OFLO, and sparfloxacin (SPFX). (eurekamag.com)
20231
- Development of Low-Cost, Weight-Adjustable Clofazimine Mini-Tablets for Treatment of Tuberculosis in Pediatrics Published in the European Journal of Pharmaceutical Sciences on May 18, 2023 Check out MCIDT Affiliate Dr. Ashlee Brunaugh's research on developing. (umich.edu)
Rifampicin5
- The TB-PRACTECAL clinical trial investigated novel anti-tubercular medicinal performances in delivering efficient 24-week therapeutic regimens for tuberculosis infection resistant to rifampicin. (news-medical.net)
- The 2018 World Health Organization (WHO) treatment guidelines for multidrug-/rifampicin-resistant tuberculosis (MDR/RR-TB) give preference to all-oral long regimens lasting for 18-20 months. (tmu.edu.tw)
- Characteristics of rifampicin-resistant tuberculosis detection in China, 2015-2019. (chinacdc.cn)
- In 2016 by WHO declared that person with tuberculosis resistant to rifampicin, with or without resistance to other drugs, should be treated with an MDR-TB treatment regimen. (boneandspine.com)
- PK, safety and acceptability data and practical guidance on the optimal dosing of new more child-friendly formulations of moxifloxacin and clofazimine in children are urgently needed to inform their current and future use in children with Rifampicin-Resistant TB (RR-TB). (hopkinscidi.org)
Susceptibility6
- Antimycobacterial Susceptibility Testing Group 2022, 'Updating the approaches to define susceptibility and resistance to anti-tuberculosis agents: implications for diagnosis and treatment', The European respiratory journal , Jg. (fz-borstel.de)
- Genomic Sequencing from Sputum for Tuberculosis Disease Diagnosis, Lineage Determination, and Drug Susceptibility Prediction. (ox.ac.uk)
- Drug susceptibility testing of the with disseminated MDR tuberculosis. (who.int)
- In contrast, stool culture of M. tuberculosis complex strains has a sensitivity of under 30% against respiratory culture, limiting the utility of phenotypic drug susceptibility testing (pDST) from stool specimens [ 14 ]. (biomedcentral.com)
- 7) Susceptibility to Thiopen-2-Carboxylic Acid Hydrazide (TCH): The addition of 10 µg / ml TCH will not inhibit the growth of M. tuberculosis, but the growth of South Indian strains of M. tuberculosis and M. bovis are inhibited by this TCH. (vint.cz)
- Along with his colleagues their findings conclusively demonstrated, for the first time, that Mtb is an avid producer of a gas called hydrogen sulfide (H 2 S). The project went on to show that this H2S modulates processes that govern Mtb respiration, central metabolism, oxidative stress, and ultimately susceptibility to the anti-TB drug, clofazimine. (ahri.org)
Multidrug12
- Multidrug-resistant tuberculosis has a variety of causes, but resistance usually due to treatment failure, drug combinations, coinfections, prior use of anti-TB medications, inadequate absorption of medication, underlying disease, and noncompliance with anti-TB drugs. (wikipedia.org)
- Therapeutic drug management: is it the future of multidrug-resistant tuberculosis treatment? (ersjournals.com)
- Multidrug-resistant tuberculosis (MDR) is an emerging problem in the world. (who.int)
- With three new and three recently repurposed drugs, treatment of multidrug-resistant tuberculosis (MDR-TB) is more hopeful today than at any time since it emerged in the 1980s and 1990s [ 1 - 3 ]. (ersjournals.com)
- Time to sputum culture conversion and treatment outcome of patients with multidrug-resistant tuberculosis: a prospective cohort study from urban China. (chinacdc.cn)
- In spite of the flatlined infectious diseases research agenda at the U.S. National Institutes of Health (NIH), the White House issued an (unfunded) National Action Plan for Combatting Multidrug-Resistant Tuberculosis last December [7]. (i-base.info)
- Multidrug-resistant tuberculosis Swelling on the left side of her neck in and consolidation on the right lung. (who.int)
- Early identification of patients with multidrug-resistant tuberculosis, rapid molecular drug resistance testing (mDST), and linkage to care is paramount to decreasing transmission of MDR M. tuberculosis complex strains. (biomedcentral.com)
- 6] Diacon AH, Pym A, Grobusch M, et al.The diarylquinoline TMC207 for multidrug-resistant tuberculosis[J]. N Engl J Med, 2009, 360(23): 2397-2405. (rsghb.cn)
- In this case study, we present a 53-year-old Ukrainian refugee with reactivation of multidrug-resistant tuberculosis, which was treated in Ukraine 4 years before he fled the country following the Russian invasion of Ukraine. (touchinfectiousdiseases.com)
- Multidrug-resistant tuberculosis (MDR-TB) is an increasing problem worldwide, and 24% occurs in India. (hopkinscidi.org)
- The use of bedaquiline in the treatment of multidrug-resistant tuberculosis: interim policy guidance. (bvsalud.org)
Infection6
- Tuberculosis (TB) is an infection caused by a slow-growing germ most often in the lungs. (bccdc.ca)
- This is a pyrazine analog of nicotinamide that is either bacteriostatic or bactericidal against M tuberculosis , depending on the concentration of drug attained at the site of infection. (medscape.com)
- Last year the WHO released its first-ever Guidelines on the Management of Latent Tuberculosis Infection [5]. (i-base.info)
- TB disease (defined as clinically active disease, often with positive smears and cultures) can develop soon after exposure to M. tuberculosis organisms (primary disease) or after reactivation of latent infection. (hiv.gov)
- The two current diagnostics available for detection of M. tuberculosis infection in the United States, IGRA and TST, help differentiate those with and without TB infection. (hiv.gov)
- This tuberculosis doses in the addition of various problems in the gravis deforming later on to Congenital and 21-hydroxylase infection. (shotglass.org)
Antibiotic3
- Clofazimine: A useful antibiotic for drug-resistant tuberculosis. (nih.gov)
- Nguyen, L. Antibiotic resistance mechanisms in M. tuberculosis: An update. (eurekaselect.com)
- It turns out all these images were taken by one lab and they all have a single antibiotic, clofazimine (CFZ). (bashthebug.net)
Linezolid5
- Rajjab Alikhan, an Ola driver from Wadala, has visited more than 100 chemists across Mumbai Metropolitan Region (MMR) region in search of four anti-TB medications, including Linezolid, Clofazimine, Cycloserine and Moxifloxacin, so that his wife's MDR-TB treatment can continue. (freepressjournal.in)
- A 27-year-old woman registered at the Parel health post said she spends ₹1,700 per week on Linezolid, Clofazimine and Cycloserine. (freepressjournal.in)
- The guidelines strongly recommend combining bedaquiline, levofloxacin (or moxifloxacin) and linezolid, supplemented by cycloserine and/or clofazimine. (tmu.edu.tw)
- For multi drug resistant TB (MDR-TB), initial regimens should include Levofloxacin AND Bedaquiline AND Linezolid AND Clofazimine AND Cycloserine. (thereviewcourse.com)
- Extensively drug-resistant TB is defined as when pre-extensively drug-resistant strains of M. tuberculosis exhibit additional drug resistance to linezolid (Lzd) and/or bedaquiline (Bdq). (touchinfectiousdiseases.com)
Regimens2
- The trial had three potential regimens: BPaL with or without clofazimine (BPaLC) or moxifloxacin (BPaLM). (news-medical.net)
- Regimens that could treat both rifampin-resistant (RR) and rifampin-susceptible tuberculosis (TB) while shortening the treatment duration have reached late-stage clinical trials. (biomedcentral.com)
Active tuberculosis3
- The radiograph shows a classic posterior segment right upper lobe density consistent with active tuberculosis. (medscape.com)
- Auld SC, Lee SH, Click ES, Miramontes R, Day CL, Gandhi NR, Heilig CM. IFN-γ Release Assay Result Is Associated with Disease Site and Death in Active Tuberculosis. (cdc.gov)
- Treatment of Active Tuberculosis in Chicago, 2008-2011: The Role of Public Health Departments. (cdc.gov)
Prognosis of MDR tuberculosis2
- Moreover, little is known about the clinical profile, treatment and prognosis of MDR tuberculosis in children (2,4-7). (who.int)
- She had been vaccinated mide (30 mg/kg/day) and ethambutol prognosis of MDR tuberculosis in chil- with bacillus Calmette-Guérin when (20 mg/kg/day) was started, pending dren ( 2 , 4 - 7 ). (who.int)
Uncle revealed MDR tuberculosis1
- ted to our hospital, was positive, with uncle revealed MDR tuberculosis an induration of 23 mm. (who.int)
Pretomanid1
- To fight MDR and XDR tuberculosis, three new antitubercular drugs, bedaquiline (BDQ), delamanid, and pretomanid were approved for use in clinical setting. (frontiersin.org)
Moxifloxacin and clofazimine2
- The combination of bedaquiline, moxifloxacin and clofazimine in the same regimen may excessively increase the QT interval. (tmu.edu.tw)
- This is an open-label multisite trial to study the PK, safety, tolerability, and acceptability of new child-friendly formulations of moxifloxacin and clofazimine (hereafter referred to as "study drugs") given at current WHO-recommend weight-based doses, where these drugs are included in an optimized RR-TB treatment regimen, in HIV-infected and -uninfected children treated for RR-TB. (hopkinscidi.org)
Nature of childhood tuberculosis2
- However, because of the paucibacillary nature of childhood tuberculosis, a microbiological diagnosis is made in only 20-40% of cases. (who.int)
- However, because of the paucibacillary with a weight of 8.8 kg and height of 70 was performed on the right forearm, nature of childhood tuberculosis, a mi- cm. (who.int)
Mutations6
- We discovered two new genes (rv1979c and rv2535c) associated with clofazimine resistance in mutants without rv0678 mutations. (johnshopkins.edu)
- Conclusions: Mutations in rv0678 are a major mechanism of clofazimine resistance. (johnshopkins.edu)
- The two M. tuberculosis MDR clinical isolates were firstly characterized by whole genome sequencing, finding the main mutations responsible for their MDR phenotype. (frontiersin.org)
- Furthermore, several M. tuberculosis BDQ resistant mutants were isolated by both MDR strains, harboring mutations in both atpE and Rv0678 genes. (frontiersin.org)
- The most common mutations linked to low-level of BDQ resistance are present in Rv0678 gene coding for the M. tuberculosis repressor of MmpS5-MmpL5 efflux system. (frontiersin.org)
- In this work, we analyzed all mutations in candidate genomic regions associated with BDQ- and DLM-resistant phenotypes using a whole-genome sequencing (WGS) data set from a collection of 4,795 MTBc clinical isolates from six countries with a high burden of tuberculosis (TB). (itg.be)
Delamanid1
- Current or past use of clofazimine, bedaquiline or delamanid. (who.int)
Treatment11
- This Statement is one of a series of four Statements on diagnosis, treatment, and control of tuberculosis. (cdc.gov)
- Objectives: Although clofazimine has been traditionally used to treat leprosy, there is recent interest in using clofazimine for the treatment of MDR-TB and drug-susceptible TB. (johnshopkins.edu)
- At 72 weeks post-randomization, the primary study outcome was the unfavorable status of either treatment cessation, treatment failure, tuberculosis recurrence, loss to follow-up, or death. (news-medical.net)
- Here we report the clinical picture and treatment of an infant with disseminated MDR tuberculosis. (who.int)
- This optimism contrasts starkly with dismal global treatment success rates of 48-56% as reported by the World Health Organization (WHO) in its annual Global Tuberculosis Reports from 2014 to 2019 [ 4 , 5 ]. (ersjournals.com)
- Tuberculosis treatment monitoring and outcome measures: new interest and new strategies. (chinacdc.cn)
- Dheda, K. Drug-resistant tuberculosis: An update on disease burden, diagnosis and treatment. (eurekaselect.com)
- Basaraba, R.J. Experimental tuberculosis: The role of comparative pathology in the discovery of improved tuberculosis treatment strategies. (eurekaselect.com)
- Bedaquiline and clofazimine are core anti-tuberculosis drugs belong to group A and B respectively, and are recommended by World Health Organization (WHO) for the treatment of multi-drug resistant tuberculosis with a good effect. (rsghb.cn)
- 3] World Health Organization.WHO consolidated guidelines on drug-resistant tuberculosis treatment[M]. Geneva: World Health Organization, 2019. (rsghb.cn)
- The latter was a sequela of a former tuberculosis treatment taken 4 years earlier. (touchinfectiousdiseases.com)
Multi-drug Resista2
- Multi-drug resistant tuberculosis (MDR-TB) is a critical global public health problem. (chinacdc.cn)
- 7] Lakshmanan M, Xavier AS.Bedaquiline-The first ATP synthase inhibitor against multi-drug resistant tuberculosis[J]. J Young Pharmacist, 2013, 5(4): 112-115. (rsghb.cn)
Primary drug-resistant tu2
- Children usually acquire primary drug-resistant tuberculosis from adults with MDR tuberculosis. (who.int)
- Transmitted or primary drug-resistant tuberculosis results from the direct transmission of drug-resistant tuberculosis from one person to another. (boneandspine.com)
People worldwide had tuberculosis2
- The World Health Organization (WHO) in 2013 reported that an estimated 12 million people worldwide had tuberculosis, with about 630 000 (5.3%) of these people having MDR tuberculosis (1). (who.int)
- 2013 reported that an estimated 12 mil- his military service and stayed at their tissue heterogeneity extending to the lion people worldwide had tuberculosis, home during his medical examination skin surrounding the bone (Figure 1). (who.int)
Sputum2
- This woman was admitted to isolation and started empirically on a 4-drug regimen in the ED. Tuberculosis was confirmed on sputum testing. (medscape.com)
- Stool is an important diagnostic specimen for tuberculosis in populations who struggle to provide sputum, such as children or people living with HIV. (biomedcentral.com)
Leprosy1
- Atypical mycobacteria (MAC) diseases are caused by species of mycobacteria that do not cause tuberculosis or leprosy. (vint.cz)
20191
- Only 7.1 million (71%) of the estimated 10 million individuals with tuberculosis (TB) accessed care in 2019 [ 1 ]. (biomedcentral.com)
Report 20202
- WHO G.. Global tuberculosis report 2020. (eurekaselect.com)
- 2] World Health Organization.Global tuberculosis report 2020[R]. Geneva: World Health Organization, 2020. (rsghb.cn)
Burden of tuberculosis1
- Dye, C. The growing burden of tuberculosis: Global trends and interactions with the HIV epidemic. (eurekaselect.com)
20211
- Largest ever global study of tuberculosis identifies genetic causes of drug resistance (press release) Univ of Oxford, Oct 19, 2021. (cdc.gov)
20201
- 4] World Health Organization.Meeting report of the WHO expert consultation on the definition of extensively drug-resistant tuberculosis[R]. Geneva: World Health Organization, 2020. (rsghb.cn)
Extrapulmonary1
- Medina, F.J. Extrapulmonary tuberculosis: Pathophysiology and imaging findings. (eurekaselect.com)
Antitubercular drugs1
- A person is said to have drug-resistant tuberculosis if the tuberculous bacteria that the person is infected with, will not respond to, and are resistant to, at least one of the main antitubercular drugs. (boneandspine.com)
Isolates1
- To this aim, in this work an in vitro generation of M. tuberculosis mutants resistant to BDQ was performed starting from two MDR clinical isolates as parental cultures. (frontiersin.org)
Drugs5
- Some mechanisms of drug resistance include: Cell wall: The cell wall of M. tuberculosis (TB) contains complex lipid molecules which act as a barrier to stop drugs from entering the cell. (wikipedia.org)
- Drug-resistant tuberculosis occurs when bacteria become resistant to the drugs used to treat TB. (boneandspine.com)
- However, the recommendation of DOTS (approved by WHO) was effective in treating tuberculosis, but nowadays, resistance from the first line (MDR-TB) and the second line (XDR-TB) drugs is highly common. (eurekaselect.com)
- X-ray assay of the right line anti-tuberculosis drugs ( 1 - 3 ). (who.int)
- New anti-tuberculosis drugs are urgently needed to prevent the increase of drug resistant tuberculosis. (rsghb.cn)
Adults2
- sis from adults with MDR tuberculosis. (who.int)
- Identification of M. tuberculosis complex in stool specimens by polymerase chain reaction (PCR), typically with the GeneXpert® MTB/RIF (Xpert), has demonstrated sensitivity between 60 and 70% against culture on respiratory specimens in children and adults [ 9 , 10 ]. (biomedcentral.com)
Clinical2
- At the 25-year anniversary of this accomplishment, we describe how insights gleaned from the M. tuberculosis genome have led to vital tools for TB research, epidemiology, and clinical practice. (jci.org)
- The M. tuberculosis genome has ushered in a quarter century of substantial clinical and public health advancements. (jci.org)
Assay2
- Cranial magnetic resonance imaging assay was performed to evaluate the disseminated tuberculosis. (who.int)
- assay was performed to evaluate the MDR tuberculosis can affect people There were no other cases of tuberculo- disseminated tuberculosis. (who.int)
Rv06781
- Results:We found that 97% (93/96) of clofazimine-resistant mutants had a mutation in rv0678 encoding a transcription repressor for efflux pump MmpL5. (johnshopkins.edu)
Abstract1
- Abstract :At present, the drug resistant tuberculosis is relatively high worldwide and has become a serious public health issue. (rsghb.cn)
Patients8
- Multi-drug tuberculosis (MDR-TB) patients across Mumbai are being forced to run from pillar to post in search of medicines that are not available at DOT centres and chemists. (freepressjournal.in)
- For three decades, drug-resistant tuberculosis (TB) has posed grave challenges to patients, communities and global TB control efforts. (cdc.gov)
- tNGS can identify drug resistance from stool provided by tuberculosis patients. (biomedcentral.com)
- This affords the opportunity to obtain critical diagnostic information for tuberculosis patients who struggle to provide respiratory specimens. (biomedcentral.com)
- A large case detection gap exists for people living with HIV (PLHIV), children, and patients with drug-resistant tuberculosis [ 1 ]. (biomedcentral.com)
- A growing body of evidence demonstrates that M. tuberculosis can be found in the stool of patients with tuberculosis. (biomedcentral.com)
- Cultures from 80 out of 1667 patients (4.8%) admitted consecutively to a tuberculosis hospital grew atypical mycobacteria. (vint.cz)
- Because LVFX displayed powerful bactericidal activity, promising effects against human tuberculosis may be achieved if patients are treated with the maximal clinically tolerated dosage of LVFX. (eurekamag.com)
Detection2
- Our findings provide useful information for the design of new molecular tests for rapid detection of clofazimine resistance. (johnshopkins.edu)
- National tuberculosis programmes should also strengthen their capacity in the detection and management of fluoroquinolone-resistant MDR-TB following the WHO guidelines. (tmu.edu.tw)
Incidence1
- The overall incidence of tuberculosis (TB) remains low, but foreign-born individuals and Canadian Indigenous people are disproportionately affected. (thereviewcourse.com)
Genome1
- Whole-genome sequencing (WGS) of M. tuberculosis and related mycobacteria is now routine, allowing comparisons across time and space. (jci.org)