ProteinSynthaseSynthetasesArginyl-tRNA SynthetaseBiosynthesisSynthetase classInterproscanMethionineDiphosphateParticipatesMetabolismTryptophanylEnzymeProteinsClassDOMAINBacteriaCompoundHumanSiteSynthetaseCytoplasmicUbiquitinGenesPhenylalanineActivates tryptophanAmino acid2019Bonds2000RibosomeProtein synthesisNuclearTransferTranslationPresenceExpand
Protein2
- 42520) hypothetical protein CP001857 tRNA Arcpr_R0002 complement(42639. (go.jp)
- Click on the protein counts, or double click on taxonomic names to display all proteins containing Arg_tRNA_synt_N domain in the selected taxonomic class. (embl-heidelberg.de)
Synthase1
- Other names in common use include tryptophanyl-tRNA synthetase, L-tryptophan-tRNATrp ligase (AMP-forming), tryptophanyl-transfer ribonucleate synthetase, tryptophanyl-transfer ribonucleic acid synthetase, tryptophanyl-transfer RNA synthetase, tryptophanyl ribonucleic synthetase, tryptophanyl-transfer ribonucleic synthetase, tryptophanyl-tRNA synthase, tryptophan translase, and TrpRS. (wikipedia.org)
Synthetases3
- The 20 aminoacyl-tRNA synthetases are divided into two classes, I and II. (embl-heidelberg.de)
- However, tRNA binding involves an alpha-helical structure that is conserved between class I and class II synthetases. (embl-heidelberg.de)
- In reactions catalysed by the class I aminoacyl-tRNA synthetases, the aminoacyl group is coupled to the 2'-hydroxyl of the tRNA, while, in class II reactions, the 3'-hydroxyl site is preferred. (embl-heidelberg.de)
Arginyl-tRNA Synthetase2
- This domain is found at the amino terminus of Arginyl tRNA synthetase, also called additional domain 1 (Add-1). (embl-heidelberg.de)
- Crystal structure of arginyl-tRNA synthetase from Klebsiella pneumoniae subsp. (embl-heidelberg.de)
Biosynthesis1
- This enzyme participates in tryptophan metabolism and aminoacyl-trna biosynthesis. (wikipedia.org)
Synthetase class2
- Aminoacyl-tRNA synthetase, class II (D/K/N) [Interproscan]. (ntu.edu.sg)
- tRNA synthetase class II core domain (G, Seryl-tRNA synthetase N-terminal domain [Interproscan]. (ntu.edu.sg)
Interproscan6
- Glycine-tRNA ligase, alpha subunit [Interproscan]. (ntu.edu.sg)
- Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase, anticodon-binding [Interproscan]. (ntu.edu.sg)
- Serine-tRNA synthetase, type1, N-terminal [Interproscan]. (ntu.edu.sg)
- Pantoate-beta-alanine ligase [Interproscan]. (ntu.edu.sg)
- D-ala D-ala ligase C-terminus, D-ala D-ala ligase N-terminus [Interproscan]. (ntu.edu.sg)
- Glutamate-cysteine ligase family 2(GCS2) [Interproscan]. (ntu.edu.sg)
Methionine1
- aromatic amino acids (AAA)-tyrosine, tryptophan and phenylalanine, as well as methionine-are increased in these conditions. (selfdecode.com)
Diphosphate1
- In enzymology, a tryptophan-tRNA ligase (EC 6.1.1.2) is an enzyme that catalyzes the chemical reaction ATP + L-tryptophan + tRNATrp ⇌ {\displaystyle \rightleftharpoons } AMP + diphosphate + L-tryptophyl-tRNATrp The 3 substrates of this enzyme are ATP, L-tryptophan, and tRNA(Trp), whereas its 3 products are AMP, diphosphate, and L-tryptophyl-tRNATrp. (wikipedia.org)
Participates1
- Within humans, L-tryptophan participates in a number of enzymatic reactions. (foodb.ca)
Metabolism1
- In humans, L-tryptophan is involved in tryptophan metabolism. (foodb.ca)
Tryptophanyl3
- Description: Enzyme-linked immunosorbent assay based on the Double-antibody Sandwich method for detection of Human Tryptophanyl tRNA Synthetase (WARS) in samples from tissue homogenates, cell lysates and other biological fluids with no significant corss-reactivity with analogues from other species. (unicoupi.com)
- Description: A sandwich ELISA kit for detection of Tryptophanyl tRNA Synthetase from Human in samples from blood, serum, plasma, cell culture fluid and other biological fluids. (unicoupi.com)
- Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Mouse Tryptophanyl tRNA Synthetase (WARS) in Tissue homogenates, cell lysates and other biological fluids. (unicoupi.com)
Enzyme4
- This enzyme belongs to the family of ligases, to be specific those forming carbon-oxygen bonds in aminoacyl-tRNA and related compounds. (wikipedia.org)
- The systematic name of this enzyme class is L-tryptophan:tRNATrp ligase (AMP-forming). (wikipedia.org)
- In particular, L-tryptophan can be converted into n'-formylkynurenine through the action of the enzyme tryptophan 2,3-dioxygenase. (foodb.ca)
- In addition, L-tryptophan and tetrahydrobiopterin can be converted into 5-hydroxy-L-tryptophan and 4a-hydroxytetrahydrobiopterin through its interaction with the enzyme tryptophan 5-hydroxylase 1. (foodb.ca)
Proteins4
- There are 26085 Arg_tRNA_synt_N domains in 26083 proteins in SMART's nrdb database. (embl-heidelberg.de)
- Taxonomic distribution of proteins containing Arg_tRNA_synt_N domain. (embl-heidelberg.de)
- The complete taxonomic breakdown of all proteins with Arg_tRNA_synt_N domain is also avaliable . (embl-heidelberg.de)
- Natalie Krahn Assistant Professor, Biochemistry & Molecular Biology Department Engineering tRNA technology to build novel proteins with selenocysteine. (uga.edu)
Class1
- L-Tryptophan, also known as Trp or W, belongs to the class of organic compounds known as indolyl carboxylic acids and derivatives. (foodb.ca)
DOMAIN1
- It is about 140 residues long and it has been suggested that this domain will be involved in tRNA recognition. (embl-heidelberg.de)
Bacteria2
Compound1
- L-Tryptophan is a very strong basic compound (based on its pKa). (foodb.ca)
Human1
- Outside of the human body, L-Tryptophan is found, on average, in the highest concentration within a few different foods, such as caseins, steller sea lions, and evening primroses and in a lower concentration in thunnus, kefirs, and garden onions. (foodb.ca)
Site1
- Some viruses hijack cellular machinery to translate some of their mRNAs through a noncanonical initiation pathway using internal ribosome entry site (IRES), a highly structured RNAs which can directly recruit the ribosome with a restricted set of initiation factors, and in some cases even without cap and initiator tRNA. (cnrs.fr)
Synthetase21
- Other names in common use include tryptophanyl-tRNA synthetase, L-tryptophan-tRNATrp ligase (AMP-forming), tryptophanyl-transfer ribonucleate synthetase, tryptophanyl-transfer ribonucleic acid synthetase, tryptophanyl-transfer RNA synthetase, tryptophanyl ribonucleic synthetase, tryptophanyl-transfer ribonucleic synthetase, tryptophanyl-tRNA synthase, tryptophan translase, and TrpRS. (wikipedia.org)
- 3. Tryptamine induces tryptophanyl-tRNA synthetase-mediated neurodegeneration with neurofibrillary tangles in human cell and mouse models. (nih.gov)
- 5. Tryptamine-mediated stabilization of tryptophanyl-tRNA synthetase in human cervical carcinoma cell line. (nih.gov)
- 6. Mapping and molecular characterization of novel monoclonal antibodies to conformational epitopes on NH2 and COOH termini of mammalian tryptophanyl-tRNA synthetase reveal link of the epitopes to aggregation and Alzheimer's disease. (nih.gov)
- 7. Tryptophanyl-tRNA synthetase mediates high-affinity tryptophan uptake into human cells. (nih.gov)
- 8. Human tryptophanyl-tRNA synthetase binds with heme to enhance its aminoacylation activity. (nih.gov)
- 9. The prognostic significance of tryptophanyl-tRNA synthetase in colorectal cancer. (nih.gov)
- 11. [Karyological and morphological analysis of bovine kidney cells resistant to tryptophan analogs--inhibitors of tryptophanyl-tRNA synthetase]. (nih.gov)
- 12. An unusual tryptophanyl tRNA synthetase interacts with nitric oxide synthase in Deinococcus radiodurans. (nih.gov)
- 13. A concerted tryptophanyl-adenylate-dependent conformational change in Bacillus subtilis tryptophanyl-tRNA synthetase revealed by the fluorescence of Trp92. (nih.gov)
- 15. Identification and characterization of human mitochondrial tryptophanyl-tRNA synthetase. (nih.gov)
- 16. Hypoxia signature of splice forms of tryptophanyl-tRNA synthetase marks pancreatic cancer cells with distinct metastatic abilities. (nih.gov)
- 18. Oxidative stress-responsive intracellular regulation specific for the angiostatic form of human tryptophanyl-tRNA synthetase. (nih.gov)
- 20. A short peptide insertion crucial for angiostatic activity of human tryptophanyl-tRNA synthetase. (nih.gov)
- Two forms of tryptophanyl-tRNA synthetase exist, a cytoplasmic form, named WARS, and a mitochondrial form, named WARS2. (nih.gov)
- Tryptophanyl-tRNA synthetase (WARS) catalyzes the aminoacylation of tRNA(trp) with tryptophan and is induced by interferon. (nih.gov)
- Tryptophanyl-tRNA synthetase belongs to the class I tRNA synthetase family. (nih.gov)
- Tryptophanyl-tRNA synthetase (WARS) gene polymorphisms have been associated with the patho-physiology of vascular angiogenesis and homeostasis. (nih.gov)
- We describe here the use of protein design to show experimentally that a minimal class I aminoacyl-tRNA synthetase active site might have functioned in the distant past. (nyu.edu)
- We deleted the anticodon binding domain from tryptophanyl-tRNA synthetase and fused the discontinuous segments comprising its active site. (nyu.edu)
- 3. Manickam Y, Chaturvedi R, Babbar P, Malhotra N, Jain V, Sharma A. (2018) Drug targeting of one or more aminoacyl-tRNA synthetase in the malaria parasite Plasmodium falciparum. (guidetoimmunopharmacology.org)
Cytoplasmic1
- Translation reactions contained 60 μg of cytoplasmic extract 100 μm amino acids 16 mm Hepes pH 7.6 2 mm Mg(CH3CO2)2 60 mm KCH3CO2 80 μg/ml tRNA 0.8 mm ATP 0.1 mm GTP 40 μg/ml creatine kinase 20 mm creatine phosphate and 100 fmol of bicistronic 200 fmol of monocistronic or 50 fmol of 5′-cap-Luc mRNA. (tam-receptor.com)
Ubiquitin2
Genes1
- encode only 45 nuclear tRNA genes, many codons are necessarily decoded by wobble pairings. (cancer-pictures.org)
Phenylalanine4
- The purified recombinant Tdc1 protein decarboxylated tyrosine and 2,3-dihydroxy-l-phenylalanine (l-DOPA), but not tryptophan and phenylalanine. (bvsalud.org)
- In contrast, the purified Tdc2 was capable of decarboxylating tryptophan but not l-DOPA, tyrosine, or phenylalanine. (bvsalud.org)
- The presence of PAHs has also created an CXCR1 Compound increase in L-alanine, L-tryptophan, L-(-)-tyrosine and D-(+)- Glycopeptide manufacturer Phenylalanine content in plant cell tissues [56,57]. (piminhibitor.com)
- That is doable a consequence in the stimulation of phenylalanine ammonia-lyase (PAL) activity, and also of the boost in the concentration of the precursors phenylalanine, tyrosine and tryptophan. (piminhibitor.com)
Activates tryptophan2
- The resulting 130 residue minimal catalytic domain activates tryptophan. (nyu.edu)
- An enzyme that activates tryptophan with its specific transfer RNA. (nih.gov)
Amino acid2
- With the exception of methionine and tryptophan, any amino acid can be decoded by two to six synonymous codons (two C six fold degeneracy). (cancer-pictures.org)
- covelantely attach the proper amino acid to a specific tRNA molecule by recognizing specific bases in the acceptor stem, anticodon stem, or anticodon of tRNAs. (flashcardmachine.com)
20191
- and several tRNA-mRNA complexes by Zhang (2019, 2020). (nih.gov)
Bonds3
- Link to all annotated objects annotated to ligase activity, forming carbon-nitrogen bonds. (planteome.org)
- Link to all direct and indirect annotations to ligase activity, forming carbon-nitrogen bonds. (planteome.org)
- Ligase catalyzes the formation of covalent bonds between the Okazaki fragments. (notesforshs.com)
20001
- 2. Ibba M, Soll D. (2000) Aminoacyl-tRNA synthesis. (guidetoimmunopharmacology.org)
Ribosome2
- The E.coli ribosome has how many binding sites for tRNA? (flashcardmachine.com)
- peptidyl-tRNA hydrolase, ribosome-attached [Ensembl]. (ntu.edu.sg)
Protein synthesis1
- 17. Diet-Related Metabolic Perturbations of Gut Microbial Shikimate Pathway-Tryptamine-tRNA Aminoacylation-Protein Synthesis in Human Health and Disease. (nih.gov)
Nuclear1
- Despite being unicellular organisms, all species only harbor a set of 45 non-redundant, nuclear-encoded tRNA isoacceptors, and there is no correlation between tRNA gene copy numbers and codon usages. (cancer-pictures.org)
Transfer4
- Sequence analysis of a 44 kb DNA fragment of yeast chromosome XV including the Tyl-H3 retrotransposon, the suf1(+) frameshift suppressor gene for tRNA-Gly, the yeast transfer RNA-Thr-1a and a delta element. (ymdb.ca)
- During translation, codons are read by transfer RNAs (tRNA) that bear the matching anticodons. (cancer-pictures.org)
- The expression of your enzymes involved within the glutathione cycle-glutamate cysteine ligase (synthesis), glutathione reductase (recycling) and glutathione-S-transferase (the transfer to xenobiotics)-is upregulated within the presence of PAHs [57]. (piminhibitor.com)
- transfer RNA (tRNA), messenger RNA (mRNA), and ribosomal RNA (rRNA). (notesforshs.com)
Translation1
- The cooperative nature of codons and anticodons during translation imparts possible influence wielded by tRNAs on codon usage. (cancer-pictures.org)
Presence1
- Both enter a stimulated tRNA presence for the acid p110 cycle but may forward be a neutral significant Methylation( 6th et al. (evakoch.com)
Expand1
- Wobble position on a Ro 90-7501 manufacture tRNA can be modified to expand pairing capacity. (cancer-pictures.org)