Tryptophan Hydroxylase" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (harvard.edu)
This graph shows the total number of publications written about "Tryptophan Hydroxylase" by people in Harvard Catalyst Profiles by year, and whether "Tryptophan Hydroxylase" was a major or minor topic of these publication. (harvard.edu)
Below are the most recent publications written about "Tryptophan Hydroxylase" by people in Profiles. (harvard.edu)
Identification of New Non-BBB Permeable Tryptophan Hydroxylase Inhibitors for Treating Obesity and Fatty Liver Disease. (harvard.edu)
Peripartum dietary supplementation of a small-molecule inhibitor of tryptophan hydroxylase 1 compromises infant, but not maternal, bone. (harvard.edu)
We have searched for association between 119 SNPs in genes implicated in monoaminergic pathways [tryptophan hydroxylase 1 (TPH1), TPH2, tyrosine hydroxylase (TH), DOPA decarboxylase (DDC), dopamine beta-hydroxylase (DBH), catechol-O-methyltransferase (COMT), monoamine oxidase A (MAOA) and MAOB] and monoamine metabolite concentrations in CSF in 74 patients with psychotic disorder. (scilifelab.se)
COMT2
In humans, catechol- O -methyltransferase protein is encoded by the COMT gene . (en-academic.com)
Any compound having a catechol structure, like catecholestrogens and catechol-containing flavonoids, are substrates of COMT. (en-academic.com)
The two enzymes were identified to be a part of two separate catechol dioxygenase families: 1,2-CTD was classified as an intradiol dioxygenase while 2,3-CTD was classified as an extradiol dioxygenase. (wikipedia.org)
The catalytic mechanism of catechol 1,2-dioxygenase was elucidated using a combination of O18 labeling experiments and crystallography. (wikipedia.org)
Comment: In MetaCyc pathway anthranilate degradation I ( link ), a dioxygenase cleaves off carbon dioxide and ammonia, leaving catechol. (lbl.gov)
Comment: In MetaCyc pathway catechol degradation to HPD I (meta-cleavage, link ), dioxygenase xylE converts catechol to (2Z,4E)-2-hydroxy-6-oxohexa-2,4-dienoate (also known as 2-hydroxymuconate 6-semialdehyde). (lbl.gov)
In MetaCyc pathway catechol degradation III (ortho-cleavage, link ), the 1,2-dioxygenase catA forms cis,cis-muconate, a cycloisomerase forms (+)-muconolactone, an isomerase converts this to (4,5-dihydro-5-oxofuran-2-yl)-acetate (also known as 3-oxoadipate enol lactone), and a hydrolase cleaves this to 3-oxoadipate. (lbl.gov)
Tyrosine2
The discussed metabolic pathways take advantage of key metabolites in the shikimic acid pathway, which is responsible for the production of the aromatic amino acidsphenylalanine, tyrosine, and tryptophan. (asu.edu)
Catecholamines are any of a group of amines (nitrogen-contain organic compounds) derived from the amino acid tyrosine and containing a catechol group (aromatic chemical compound consisting of a benzene ring with two hydroxyl groups). (newworldencyclopedia.org)
An enzyme that catalyzes the oxidation of catechol to muconic acid with the use of Fe3+ as a cofactor. (nih.gov)
Dopamine1
Catechol- O -methyltransferase is involved in the inactivation of the catecholamine neurotransmitters ( dopamine , epinephrine , and norepinephrine ). (en-academic.com)
Protocatechuate2
This series of steps is part of protocatechuate para-cleavage, link , or catechol degradation II, link . (lbl.gov)
In addition, a novel alternative pathway for the production of protocatechuate (PCA) and catechol from the endogenous metabolite chorismate is demonstrated. (asu.edu)
Substrates1
From the model, stoichiometric optimums maximizing both product-to-substrate and biomass-to-substrate yields were discovered in a co-fed model using glycerol and D-xylose as the carbon substrates for the biosynthetic production of catechol. (asu.edu)
Carbon3
1,2-CTD uses Fe3+ as a cofactor to cleave the carbon-carbon bond between the phenolic hydroxyl groups of catechol, thus yielding muconic acid as its product. (wikipedia.org)
In contrast, 2,3-CTD utilizes Fe2+ as a cofactor to cleave the carbon-carbon bond adjacent to the phenolic hydroxyl groups of catechol, thus yielding 2-hydroxymuconaldehye as its product. (wikipedia.org)
The second catechol hydroxyl group on carbon 3 (C3) is coordinated to Fe3+ after its deprotonation by the Tyr200 ligand. (wikipedia.org)
Presence1
All isolates produced IAA in vitro in presence of very low amounts of tryptophan. (scielo.br)
Activity1
Phenol (108952), catechol (154234) and pyrogallol (87661) exhibited some activity. (cdc.gov)
BENZOATE1
Catalyzes the oxidation of catechol to 2-hydroxymuconate semialdehyde in the carbazole and BENZOATE degradation via HYDROXYLATION pathways. (nih.gov)
Influence of the catechol-O-methyltransferase val158met genotype on amygdala and prefrontal cortex emotional processing in panic disorder. (cdc.gov)
Asymmetry of prefrontal cortex activities and catechol-O-methyltransferase Val158Met genotype in patients with panic disorder during a verbal fluency task: near-infrared spectroscopy study. (cdc.gov)
Oxidation1
However, there is other evidence to indicate that the most probable pathway for the oxidation is: l-tryptophan d-tryptophan l-kynurenin d-kynurenin kynurenic acid and hence the adaptation to both isomers after exposure to the d-~iromer alone appears to represent a case of non-specific activation. (nih.gov)
Enzymes1
The two enzymes were identified to be a part of two separate catechol dioxygenase families: 1,2-CTD was classified as an intradiol dioxygenase while 2,3-CTD was classified as an extradiol dioxygenase. (wikipedia.org)
Normative Data on Serum and Plasma Tryptophan and Kynurenine Concentrations from 8,089 Individuals Across 120 Studies: A Systematic Review and Meta-Analysis. (gensteiner.com)
Side1
Catecholamines are molecules that have a catechol nucleus consisting of benzene with two hydroxyl side groups and a side-chain amine. (absoluteastronomy.com)