• It is metabolized primarily by the cyclo-oxygenase or 5-lipoxygenase pathways to produce prostaglandins and leukotrienes, which are important mediators of inflammation. (unboundmedicine.com)
  • The kynurenine pathway (KP) is a major route for the metabolism of an essential amino acid, tryptophan which results in the production of biologically active molecules, kynurenines. (ukessays.com)
  • The levels of KYNA and ratio of KYNA/TRP (theoretical index of kynurenine pathway activity) was found to be increased in the amygdale and hippocampus of kindled animals whereas concentration of tryptophan in the prefrontal cortex and hippocampus was found to be decreased (Szyndler et al. (ukessays.com)
  • A study by Szyndler and co-workers demonstrated that during the electrically induced kindling of seizures, the seizures development is associated with significant alterations in the levels of KYNA and its precursor, tryptophan (TRP). (ukessays.com)
  • Rather tryptophan and cysteine mutagenesis scans recognized residues lining a single face of the M4 section that interact specifically with the M1 and M3 transmembrane segments of an adjacent subunit (22). (perlierusa.com)
  • Abe F, Horikoshi K (2000) Tryptophan permease gene TAT2 confers high-pressure growth in Saccharomyces cerevisiae. (univ-amu.fr)
  • 5-methoxyindole metabolites of L-tryptophan represent a new class of compounds that control COX-2 expression at the transcriptional level. (biomedcentral.com)
  • In addition, an important role for the haem oxygenase-1 isotype has been demonstrated in experimental cerebral malaria and in clinical cases. (bvsalud.org)
  • Previously, a ribulose 1,5-bisphosphate carboxylase/oxygenase (RubisCO)-deficient strain (strain SBI/II) was found to show enhanced levels of cbb(I) and cbb(II) promoter activities during photoheterotrophic growth in the presence of dimethyl sulfoxide. (statescale.ml)
  • Analysis of tryptophan fluorescence quenching during the interaction of PGG with BSA suggests that binding of PGG leads to some conformational changes that are energetically closer to the unfolded state of the BSA structure, because small red shifts in the resulting emission spectra were observed. (reading.ac.uk)
  • Moreover, the authors identified a tryptophan residue within a specific monoclonal FLC that was required for optimal H2O2 production and downstream signaling. (jci.org)
  • On the other hand, 5-methoxyindole metabolites of tryptophan are valuable lead compounds for development of new anti-inflammatory drugs and cancer chemoprevention. (biomedcentral.com)
  • A B6 deficiency has been proven in long-term OCP use and is often linked to pre-menstrual depression and appears to be related to the role that B6 plays in facilitating in the tryptophan to niacinamide pathway. (monarchnaturalhealth.co.nz)
  • Therefore, the present work aims to determine the influence of haem oxygenase in thrombocytopaenia and acute pulmonary injury during infection with Plasmodium berghei strain NK65. (bvsalud.org)