inhibitor
- Finally, mice were given the 5-HT precursor l -tryptophan (TRP) or the 5-HT synthesis inhibitor p -chlorophenylalanine (PCPA) ( Koe and Weissman, 1966 ) to assess how treatments that boost or lower 5-HT synthesis affect the citalopram response. (jneurosci.org)
- LP-533401 hydrochloride is a tryptophan hydroxylase 1 inhibitor that regulates serotonin production in the gut. (medchemexpress.com)
- LP-533401 hydrochloride is a tryptophan hydroxylase 1 inhibitor. (medchemexpress.com)
- Telotristat (LP-778902) is a potent tryptophan hydroxylase inhibitor with an in vivo IC 50 of 0.028 μM. (medchemexpress.com)
- LX-1031 is a potent, orally available tryptophan 5-hydroxylase (TPH) inhibitor that reduces serotonin (5-HT) synthesis peripherally. (medchemexpress.com)
- Telotristat ethyl (LX1606) is a novel, orally-delivered inhibitor of tryptophan hydroxylase that reduces serotonin production. (medchemexpress.com)
- LX-1031, a tryptophan 5-hydroxylase inhibitor, and its potential in chronic diarrhea associated with increased serotonin. (nih.gov)
- LX-1031 is an oral, small molecule tryptophan 5-hydroxylase (TPH) inhibitor that reduces serotonin (5-HT) synthesis peripherally. (nih.gov)
- Treatment with p-chlorophenylalanine (PCPA), a tryptophan hydroxylase inhibitor, for 3 days significantly increased plasma FGF21 levels, and decreased body weight and hyperglycemia in db/db mice while having no significant effect on plasma insulin levels. (jneuropsychiatry.org)
- These findings suggest that hepatic FGF21 production is decreased in db/db mice, and that a tryptophan hydroxylase inhibitor increases expression of hepatic FGF21 production and decreases hepatic gluconeogenesis and hyperglycemia independently of insulin in db/db mice. (jneuropsychiatry.org)
gene
- Tryptophan hydroxylase 1 gene (TPH1) is a gene . (dtu.dk)
- TPH1 expression is limited to a few specialized tissues: raphe neurons, pinealocytes, mast cells, mononuclear leukocytes, beta-cells of the islets of Langerhans, and intestinal and pancreatic enterochromaffin cells.The tryptophan hydroxylase 1 (TPH1) gene is also reported to be associated with suicidal behavior. (sinobiological.com)
- The tryptophan hydroxylase gene ( TPH ), which codes for the enzyme catalyzing the rate-limiting step in serotonin biosynthetic pathway, is one of the leading candidate genes for psychiatric and behavioral disorders. (biomedcentral.com)
- This gene encodes a member of the pterin-dependent aromatic acid hydroxylase family. (nih.gov)
- Interaction of tryptophan hydroxylase 2 gene and life events in susceptibility to major depression in a Chinese Han population. (nih.gov)
- Genetic variability in tryptophan hydroxylase 2 gene in alcohol dependence and alcohol-related psychopathological symptoms. (nih.gov)
- Tryptophan hydroxylase 2 gene is associated with cognition in late-onset depression in a Chinese Han population. (nih.gov)
- Serotonin Transporter and Tryptophan Hydroxylase Gene Variations Mediate Working Memory Deficits of Cocaine Users. (nih.gov)
- Methylation of the tryptophan hydroxylase?2 gene is associated with mRNA expression in patients with major depression with suicide attempts. (nih.gov)
- Targeted disruption of the tryptophan hydroxylase 1 ( tph1 ) gene resulted in levels of circulating serotonin that are only 3-15% of those of normal mice. (pnas.org)
- Numerous meta-analyses of case-control studies have shown significant associations of SB with variants in the serotonin transporter gene (5-HTT or SLC6A4) and the tryptophan hydroxylase 1 gene (TPH1), but others report contradictory results. (frontiersin.org)
aromatic amino acid hydro
- TPH a three-domain, iron-containing enzyme which belongs to the aromatic amino acid hydroxylase (AAAH) family. (dtu.dk)
- Tryptophan 5-hydroxylase 1, also known as Tryptophan 5-monooxygenase 1, Tryptophan hydroxylase 1, TPH1, TPH and TPRH, is an enzyme which belongs to the biopterin-dependent aromatic amino acid hydroxylase family. (sinobiological.com)
Polymorphism
- Polymorphism of tryptophan hydroxylase, the rate-limiting enzyme in the synthesis of brain serotonin (5-HT), is associated with less synthesis of brain 5-HT in DBA/2J and BALB/c than in C57BL/6J and 129/Sv mice. (jneurosci.org)
genes
- 1,25-Dihydroxyvitamin D regulates expression of the tryptophan hydroxylase 2 and leptin genes: implication for behavioral influences of vitamin D. (nih.gov)
- Various studies on genetic associations have tended to suggest that a number of genes [e.g., tryptophan hydroxylase, serotonin receptors and transporters, or brain-derived neurotrophic factors (BDNFs)] are linked to SBs, but these findings are not consistently supported by the results obtained. (frontiersin.org)
Tyrosine
- Previously determined crystal coordinates of two highly homologous proteins, phenylalanine hydroxylase and tyrosine hydroxylase, were used as templates. (semanticscholar.org)
Behavioral
- Exposure of male rats to the SSRI citalopram at the later end of this critical window (P8-P21) decreases dorsal raphe tryptophan hydroxylase (TPH) immunoreactivity and elicits behavioral changes consistent with depression [ 15 ]. (hindawi.com)
synthesis
- Eighteen social anxiety disorder patients and six healthy controls were scanned during 60 minutes in a resting state using positron emission tomography and 5-hydroxy-L-[β -(11)C]tryptophan, [(11)C]5-HTP, a substrate of the second enzymatic step in serotonin synthesis. (diva-portal.org)
- Tryptophan hydroxylase-1 (TPH1) is a key enzyme in the synthesis of serotonin. (mdpi.com)
catalyzes
- Tryptophan hydroxylase catalyzes the biopterin-dependent monooxygenation of tryptophan to 5-hydroxytryptophan (5HT), which is subsequently decarboxylated to form the neurotransmitter serotonin. (sinobiological.com)
activity
- Enhancement of L-tryptophan 5-hydroxylation activity by structure-based modification of L-phenylalanine 4-hydroxylase from Chromobacterium violaceum. (semanticscholar.org)
- The activity of tryptophan hydroxylase was measured in the rat brainstem and cortex by the rate of in vivo accumulation of 5-hydroxytryptophan after inhibition of aromatic amino acid decarboxylase with 3-hydroxybenzyl-hydrazine. (ac.ke)