- Tyrosine hydroxylase, phenylalanine hydroxylase, and tryptophan hydroxylase together constitute the family of biopterin-dependent aromatic amino acid hydroxylases. (wikipedia.org)
- Tryptophan hydroxylase (TPH), tyrosine hydroxylase (TH) and phenylalanine hydroxylase (PAH) are members of a superfamily of aromatic amino acid hydroxylases, catalyzing key steps in important metabolic pathways. (wikipedia.org)
- Analogously to phenylalanine hydroxylase and tyrosine hydroxylase, this enzyme uses (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin (BH4) and dioxygen as cofactors. (wikipedia.org)
- Tryptophan hydroxylase (TPH) is an enzyme (EC 1.14.16.4) involved in the synthesis of the neurotransmitter serotonin. (wikipedia.org)
- Aromatic L -amino acid decarboxylase ( AADC or AAAD ), also known as DOPA decarboxylase ( DDC ), tryptophan decarboxylase , and 5-hydroxytryptophan decarboxylase , is a lyase enzyme ( EC 4.1.1.28 ). (wikidoc.org)
- The activity of tryptophan hydroxylase (i.e. the rate at which it converts L-tryptophan into the serotonin precursor L-5-hydroxytryptophan) can be increased when it undergoes phosphorylation. (wikipedia.org)
- In humans, the stimulation of serotonin production by administration of tryptophan has an antidepressant effect[citation needed] and inhibition of tryptophan hydroxylase (e.g. by p-Chlorophenylalanine) may precipitate depression. (wikipedia.org)
- Hiripi, L & Stefano, GB 1980, ' Dopamine inhibition of tryptophan hydroxylase in molluscan nervous tissue homogenates: Evidence for intracellular site of action ', Life Sciences , vol. 27, no. 13, pp. 1205-1209. (elsevier.com)
- Plasma levels of tryptophan, kynurenine, and QUIN did not differ between patients and controls. (biomedcentral.com)
- The pathway for the synthesis of serotonin from tryptophan Metabolic pathway from tryptophan to serotonin Molecular and Cellular Biology portal McKinney J, Teigen K, Frøystein NA, Salaün C, Knappskog PM, Haavik J, Martínez A (Dec 2001). (wikipedia.org)
- The aim of the present study is to investigate the peripheral concentration of cytokines and tryptophan and kynurenine metabolites in patients with unipolar treatment-resistant depression before and after electroconvulsive therapy (ECT), the most effective treatment for depression. (biomedcentral.com)
- Tryptophan and kynurenine metabolites were detected with high-performance liquid chromatography (HPLC) and LC/MS. KYNA was analyzed in a second healthy control cohort ( n = 22). (biomedcentral.com)
- TPH catalyzes the following chemical reaction L-tryptophan + tetrahydrobiopterin + O2 ⇌ {\displaystyle \rightleftharpoons } 5-Hydroxytryptophan + dihydrobiopterin + H2O It employs one additional cofactor, iron. (wikipedia.org)
- Conformation of the substrate and pterin cofactor bound to human tryptophan hydroxylase. (wikipedia.org)
- Magyar, K & Knoll, J 1977, ' Effect of para-substituted amphetamine derivatives on tryptophan hydroxylase activity ', Acta physiologica Academiae Scientiarum Hungaricae , vol. 49, no. 3-4. (elsevier.com)
- Key inflammatory markers as well as kynurenic acid (KYNA) and quinolinic acid (QUIN), both tryptophan metabolites, have been associated with depressive symptoms and suicidality. (biomedcentral.com)
- PCPA, dopamine and the dopamine agonist epinine inhibited trytophan hydroxylase activity in nervous tissue homogenates of Anodonta cygnea and Mytilus edulis (Bivalvia). (elsevier.com)
- Haloperidol did not affect tryptophan hydroxylase activity in the homogenates nor did it antagonize dopamine action. (elsevier.com)
