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  • amino acids
  • Groups of rats were deprived of food overnight and then given free access to diets designed to raise (carbohydrate) or lower (carbohydrate and large neutral amino acids) brain tryptophan concentrations. (biochemj.org)
  • Correlations were made between brain tryptophan and (1) free serum tryptophan, (2) the ratio of free serum tryptophan to the sum of the other large neutral amino acids in serum that compete with it for uptake into the brain, (3) total serum tryptophan or (4) the ratio of total serum tryptophan to the sum of its circulating competitors. (biochemj.org)
  • biosynthetic
  • Niacin is synthesized from tryptophan via kynurenine and quinolinic acids as key biosynthetic intermediates. (wellnesscenter.net)
  • The industrial production of tryptophan is also biosynthetic and is based on the fermentation of serine and indole using either wild-type or genetically modified bacteria such as B. amyloliquefaciens, B. subtilis, C. glutamicum or E. coli. (wikipedia.org)
  • The (tryptophan) repressor is a 25 kD protein homodimer which regulates transcription of the tryptophan biosynthetic pathway in bacteria. (wikipedia.org)
  • proteins
  • The aromatic portion of tryptophan also serves as an ultraviolet marker for detection of this amino acid either separately, or incorporated into proteins and enzymes, via ultraviolet spectrophotometry. (fsu.edu)
  • Tryptophan is incorporated into proteins and enzymes at the molar rate of 1.1 percent compared to other amino acids making it the rarest amino acid found in proteins. (fsu.edu)
  • L-Tryptophan is naturally found in animal and plant proteins. (wellnesscenter.net)
  • Only the L-stereoisomer of tryptophan is used in structural or enzyme proteins, but the D-stereoisomer is occasionally found in naturally produced peptides (for example, the marine venom peptide contryphan). (wellnesscenter.net)
  • Tryptophan is among the less common amino acids found in proteins, but it plays important structural or functional roles whenever it occurs. (wikipedia.org)
  • Tryptophan is present in most protein-based foods or dietary proteins. (wikipedia.org)
  • When this occurs, transcription of the DNA is prevented, suppressing the products of the gene - proteins which make more tryptophan. (wikipedia.org)
  • protein
  • Tryptophan 7-halogenase is a 538-residue, 61-kDa protein. (wikipedia.org)
  • When the amino acid tryptophan is plentiful in the cell, it binds to the protein, which causes a conformational change in the protein. (wikipedia.org)
  • One of the genes regulated by trp repressor, trpR, codes for the tryptophan repressor protein itself. (wikipedia.org)
  • If there isn't enough tryptophan, the repressor protein breaks off from the operator (where the repressor is normally bound) and RNA polymerase can complete its reading of the strand of DNA. (wikipedia.org)
  • TRAP protein forms an oligomer of 11 subunits, in the presence of tryptophan this binds to section of RNA containing 11 (G/U)AG repeats. (wikipedia.org)
  • Tryptophan RNA-binding attenuator protein inhibitory protein (Anti-TRAP protein or AT) is a short protein encoded by the rtpA in Bacillus. (wikipedia.org)
  • mood
  • L-tryptophan has been used in alternative medicine as a possibly effective aid in treating symptoms of premenstrual dysphoric disorder syndrome (such as mood swings and irritability), and to help people quit smoking. (cigna.com)
  • Tryptophan obviously plays a role in mood balancing created by brain chemistry. (psyweb.com)
  • 2001
  • L-Tryptophan was banned by the FDA in the 1990s because of contamination in the production process, but was re-released onto the U.S. market in 2001 after the FDA published a revised estimate of the risks. (erowid.org)
  • histidine
  • Histidine-tryptophan-ketoglutarate, or Servator HTK solution is a high-flow, low-potassium preservation solution used for organ transplantation. (wikipedia.org)
  • The osmolarity of HTK is 310 mOsm/L. Sodium: 15 mmol/L Potassium: 9 mmol/L Magnesium: 4 mmol/L Calcium: 0.015 mmol/L Ketoglutarate/glutamic acid: 1 mmol/L Histidine: 198 mmol/L Mannitol: 30 mmol/L Tryptophan: 2 mmol/L Biostasis Organ transplant 1. (wikipedia.org)
  • Follow-up experience using histidine-tryptophan-ketoglutarate solution in clinical pancreas transplantation Transplant Proc. (wikipedia.org)
  • Histidine-tryptophan-ketoglutarate solution for organ preservation in human liver transplantation - a prospective multi-centre observation study. (wikipedia.org)
  • Hepatic preservation with histidine-tryptophan-ketoglutarate solution in living related and cadaveric liver transplantation. (wikipedia.org)