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  • inhibitors
  • Among the endogenous TRP-channel sensitizers, activators and inhibitors, more than 50 arachidonic acid- and linoleic acid-metabolites from the COX-, LOX- and CYP-pathways, as well as lysophospholipids and isoprenoids can be found. (ox.ac.uk)
  • TRPM7
  • Charge screening by internal pH and polyvalent cations as a mechanism for activation, inhibition, and rundown of TRPM7/MIC channels. (nih.gov)
  • and they can be reactivated by PIP2 following rundown in inside-out patches.We propose that MIC (TRPM7) channels are regulated by a charge screening mechanism and may function as sensors of intracellular pH. (nih.gov)
  • The Mg2+-inhibited cation (MIC) current, believed to represent activity of TRPM7 channels, is found in lymphocytes and mast cells, cardiac and smooth muscle, and several other eukaryotic cell types. (nih.gov)
  • We propose that MIC (TRPM7) channels are regulated by a charge screening mechanism and may function as sensors of intracellular pH. (nih.gov)
  • We are currently investigating the mechanisms which mediate the functional roles of TRPM7 and TRPM8 and attempting to develop these ion channels as clinical biomarkers and therapeutic targets for achieving the goal of personalized therapy in pancreatic cancer. (hindawi.com)
  • The aim of this study was to clarify the role for TRPM7 channels and the effect of waixenicin A on the pacemaking activity of interstitial cells of Cajal (ICCs) and on the cell viability of the human gastric and breast adenocarcinoma cell lines, AGS and MCF-7, respectively. (isharonline.org)
  • Stress hormone potentiates Zn(2+)-induced neurotoxicity via TRPM7 channel in dopaminergic neuron. (gopubmed.org)
  • TRPM7 channels are discussed regarding hypoxia-sensing function in ischemic cell death. (gopubmed.org)
  • Mibefradil represents a new class of benzimidazole TRPM7 channel agonists. (gopubmed.org)
  • Here, we investigated the function of hepatocystin during Xenopus laevis embryogenesis and identified hepatocystin as a binding partner of the TRPM7 ion channel, whose function is required for vertebrate gastrulation. (gopubmed.org)
  • The Different Roles of The Channel-Kinases TRPM6 and TRPM7 . (gopubmed.org)
  • Recent studies have continued to add to the growing number of Mg (2+)transporters and ion channels involved in Mg (2+)homeostasis, including TRPM6 and TRPM7, members of the transient receptor potential (TRP) ion channel family. (gopubmed.org)
  • TRPM7 is a ubiquitous ion channel and kinase, a unique 'chanzyme,' required for proper early embryonic development. (gopubmed.org)
  • Here we review what is known of the function of Mg 2+ in early development and summarize recent findings regarding the function of the TRPM6 and TRPM7 ion channels during embryogenesis. (ehu.es)
  • sensory
  • As a consequence, these lipids represent the vast majority of endogenous TRP-channel modulators in sensory neurons. (ox.ac.uk)
  • Fluorescence-activated cell sorting (FACS) and subsequent microarray analysis of sensory neurons activated at 4 °C identified an enriched repertoire of ion channels, which include the Trp channel Trpm8 and potassium channel Kcnk9, that are potentially required for cold sensing above freezing temperatures in mouse DRG neurons. (nih.gov)
  • A subset of transient receptor potential (TRP) channels mediates thermosensation and is expressed in sensory tissues, such as nociceptors and skin. (nih.gov)
  • Two members of the TRPM family function in sensory perception and three TRPM proteins are chanzymes, which contain C-terminal enzyme domains. (sciencemag.org)
  • roles
  • Growing evidence has revealed that TRP ion channels play important roles in a wide range of human diseases, including malignancies. (hindawi.com)
  • sensors
  • Thus, TRP-channels seem to be key sensors for lipids, integrating and interpreting incoming signals from the different metabolic lipid pathways. (ox.ac.uk)
  • pathway
  • Caterina MJ, Schumacher MA, Tominaga M, Rosen TA, Levine JD, Julius D. The capsaicin receptor: a heat-activated ion channel in the pain pathway. (springer.com)
  • characterize
  • The objectives of this study are to characterize the exchange interactions of Tyl with common soil cations in subsoil horizons that contain smectite and to investigate the interactions using in situ Fourier transform infrared (FTIR) spectroscopy. (bioportfolio.com)
  • modulators
  • Here, we discuss the specific properties of the currently known endogenous lipid-derived TRP-channel modulators concerning their ability to activate or inhibit TRP-channels, the molecular mechanisms of lipid/TRP-channel interactions and specific TRP-regulatory characteristics of the individual lipid families. (ox.ac.uk)
  • Accumulating evidence has implicated that ion channels are important modulators of the pathogenic mechanisms underlying many human diseases such as cancer [ 4 ]. (hindawi.com)
  • mechanisms
  • Collectively, our results indicate that heteromultimerization of TRPML channels plays a role in various TRPML-regulated mechanisms. (nih.gov)
  • In this regard, understanding the function of Transient Receptor Potential (TRP) channels, which are fundamental determinants of Ca 2+ signaling, is critical to uncovering mechanisms of mechanotransduction during cell migration and, consequently, in pathologies closely linked to it, such as cancer. (frontiersin.org)
  • effects
  • Dominant-negative TRPML(P-KK)s attenuate the cytotoxic effects of constitutively active TRPML(P) channels. (nih.gov)
  • cells
  • C) Maximal current densities with control (1 mM, n = 5 cells) or 10 mM EDTA (n = 3) solutions and with solutions containing inhibitory cations. (nih.gov)
  • In some experiments, confocal immunolabeling of wholemount preparations was used to examine the localization of specific mechanosensitive TRP channels in retinal vascular smooth muscle cells (VSMCs). (arvojournals.org)
  • activity
  • Under pathophysiological conditions, excessive activity of TRP-channels leads to mechanical allodynia and thermal hyperalgesia. (ox.ac.uk)
  • Direct plasma membrane stretch triggered cation current activity that was blocked by tranilast and specific TRPV2 pore-blocking antibodies and mimicked by the TRPV2 activator, Δ9-tetrahydrocannabinol. (arvojournals.org)
  • vascular
  • Our results suggest that retinal VSMCs express a range of mechanosensitive TRP channels, but only TRPV2 appears to contribute to myogenic signaling in this vascular bed. (arvojournals.org)
  • Current
  • Paralogous current-modulating mutations in all three TRPML channels affect cell viability in a similar manner. (nih.gov)
  • transporters
  • Although the concentration of Mg 2+ in the extracellular environment can vary significantly, the total intracellular Mg 2+ concentration is actively maintained within a relatively narrow range (14 - 20 mM) via tight, yet poorly understood, regulation of intracellular Mg 2+ by Mg 2+ transporters and Mg 2+ -permeant ion channels. (ehu.es)
  • pathophysiological
  • Here, we review recent studies on the association between TRP channels and migration-related mechanotransduction events, as well as in the involvement of TRP channels in the migration-dependent pathophysiological process of metastasis. (frontiersin.org)
  • Here, we discuss the role of TRP channels in cell migration from a mechanostransduction perspective, and the specific role they play in the migration-dependent pathophysiological phenomenon of cancer metastasis. (frontiersin.org)
  • role
  • Heteromultimeric TRPML channel assemblies play a crucial role in the regulation of cell viability models and starvation-induced autophagy. (nih.gov)
  • Since ADP (adenosine 5'-diphosphate) alone did not activate or antagonize the channel, we used a chemical biology approach employing synthetic analogues to focus on the role of the ADPR terminal ribose. (ox.ac.uk)
  • There is a paucity of knowledge about the role of ion channels in normal pancreatic development and during malignant transformation. (hindawi.com)
  • In the present study we sought to determine the potential role of various mechanosensitive TRP channels to myogenic signaling in arterioles of the rat retina. (arvojournals.org)
  • activation
  • TRP channels in mechanosensation: direct or indirect activation? (springer.com)
  • The nature of divalent inhibition and the mechanism of channel activation in an intact cell remain unknown. (nih.gov)
  • TFEB increases the pool of lysosomes in the proximity of the PM and promotes their fusion with PM by raising intracellular Ca²⁺ levels through the activation of the lysosomal Ca²⁺ channel MCOLN1. (nih.gov)
  • By mutating amino acid residues of the NUDT9H domain, predicted by modelling and docking to interact with the terminal ribose, we demonstrate that abrogating hydrogen bonding of the amino acids Arg1433 and Tyr1349 interferes with activation of the channel by ADPR. (ox.ac.uk)
  • homeostasis
  • In this review, we discuss the evidence for an array of microglia ion channels and their importance in modulating microglial homeostasis and how this process could be disrupted in Alzheimer's disease. (frontiersin.org)
  • involvement
  • In support of this, there is a growing body of evidence pointing to the involvement of microglial ion channels contributing to neurodegenerative diseases such as Alzheimer's disease. (frontiersin.org)