AnatomyOrganismsDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPhenomena and ProcessesHealth Care
TroponinTroponin TTroponin ITroponin CCardiac Imaging TechniquesBiological MarkersMyocardial InfarctionElectrocardiographyPrognosisTropomyosinRisk FactorsMyocardiumMyofibrilsCalciumCreatine Kinase, MB FormRabbitsMusclesCreatine KinaseActin CytoskeletonMuscle ProteinsChest PainActomyosinSarcomeresMyosinsMyocardial ContractionHeart InjuriesCa(2+) Mg(2+)-ATPaseActinsChickensCardiomyopathy, HypertrophicPsoas MusclesMuscle, SkeletalMuscle ContractionNaphthalenesulfonatesAngina, UnstablePeptide FragmentsThiadiazinesMyoglobinHeartAdenosine Triphosphatases
AssaysAssayBiomarkersSensitivity cardiac troponinBiomarkerCTnTConcentrationsElevationSerum troponinMyoglobinSkeletal muscleMyocardial ischemiaIndicator of myocardialProteinPatientsDetectCardiovascular eventsBaselineAssociated with elevatedHomocysteineMeasurementTropomyosinSubclinicalNecrosisActin99th percentileBindsLactate dehydrogenaseClinicalSignificantlyIschemiaDetectableEnzyme levelsAcute MyocardialChestSymptomsCTnI levelsDamageSubstancesNormalMoleculesProteinsMuscularMeasurementsClinicallyBlood
Assays18
  • Even when cardiac troponin levels detected by high-sensitivity assays are within the normal range, elevations are associated with incident cardiovascular events in people without overt disease, a meta-analysis confirms. (tctmd.com)
  • Adding information from high-sensitivity troponin assays to models that included conventional risk factors improved prediction of cardiovascular events, particularly fatal ones, suggesting a possible role for the tests in a primary prevention setting, the researchers say. (tctmd.com)
  • Although cardiac troponins have been measured for years for diagnosing acute MI, the introduction of high-sensitivity assays-including just recently in the United States -has allowed for detection of very low levels, even in people without obvious signs of myocardial damage or cardiovascular disease. (tctmd.com)
  • With the introduction of high-sensitivity cardiac troponin (hs-cTn) assays, the time it takes to detect signs of myocyte necrosis has shortened considerably. (bmj.com)
  • Recent approvals of high sensitivity cardiac troponin (hs-cTn) assays by the U.S. Food and Drug Administration (FDA) and international regulatory bodies have enabled clinical labs to develop more sophisticated diagnostic protocols based on utilization of low cTn measurements at or near the assays' limit of detection (LoD) to expediate and improve the accuracy of acute myocardial infarction diagnosis. (clpmag.com)
  • The following is a concise review of assay sensitivity as it relates to hs-cTn testing, it's relevance to clinical labs for subsequent diagnosis of cardiac events, and conclude with high level considerations for cTn target concentrations for quality controls intended to monitor the performance of hs-cTn assays. (clpmag.com)
  • Non-high sensitivity cardiac troponin assays lack the analytical sensitivity to reliably measure small cTn concentrations and their subsequent changes below the 99th percentile upper reference limit (URL). (clpmag.com)
  • Assays for hs-cTnI and hs-cTnT have allowed clinical labs to shift emphasis from using cardiac troponin as binary tests (in which the 99th percentile URL of a healthy reference population was used as a cut-off for defining normal vs increased cTn values) to more complex diagnostic protocols utilizing cTn values below the 99th percentiles' URLs. (clpmag.com)
  • New high-sensitivity troponin assays will reduce the threshold for the diagnosis of myocardial infarction (MI), as specified in the 2012 third Universal Definition of MI. (bjcardio.co.uk)
  • At the 2012 European Society of Cardiology (ESC) meeting the Universal Definition of MI was updated for the third time in a decade, 3 and a major inclusion was the introduction of high-sensitivity cardiac troponin assays, which are again likely to change the rate of MI diagnosis. (bjcardio.co.uk)
  • Troponin assays have developed with successive generations such that they can detect increasingly low levels of troponin. (bjcardio.co.uk)
  • 4 This has incrementally reduced the diagnostic cut-offs for the rule-out of MI from 0.5 µg/L in the first generation assays to the currently used levels of 0.05-0.1 µg/L (3rd generation), which are in widespread use today. (bjcardio.co.uk)
  • 6 This is as expected for a more sensitive assay, as it is simply detecting the same troponin release at an earlier time than conventional assays. (bjcardio.co.uk)
  • Singulex has received the CE mark for its Sgx Clarity cTnI assay, an ultra-sensitive test that measures cardiac troponin at lower levels than most existing assays. (aacc.org)
  • Troponins are generally undetectable in healthy patients, although this may eventually change as more sensitive assays become available. (medscape.com)
  • The 99th percentile of a reference decision limit (medical decision cutoff) for cardiac troponin (cTn) assays should be determined in each local laboratory with internal studies using the specific assay that is used in clinical practice or validating a reference interval that is based on findings in the literature. (medscape.com)
  • Table 1 shows the calculated 99th upper reference limit values for some of the available troponin assays. (medscape.com)
  • When measured with older generation assays, elevated troponin levels can be detected 6-12 hours after onset of myocardial injury, peaking at about 24 hours, followed by a gradual decline over several days (up to 2 weeks). (medscape.com)
Assay9
  • So, it can be concluded that the human kit of chemiluminescence assay can be used to measure CKMB and cTnI level in dogs. (vin.com)
  • With the increased clinical utility of sub-99th percentile hs-cTn measurements, quality controls with lower cardiac troponin concentrations are needed to monitor and validate hs-cTn assay performance. (clpmag.com)
  • 99thpercentiles for cardiac troponin assay methods addressed in this article are greater than their respective assay methods' LoB, LoD, and LoQ. (clpmag.com)
  • Circulating Cardiac Troponin I Levels Measured by a Novel Highly Sensitive Assay in Acute Decompensated Heart Failure: Insights from the ASCEND-HF Trial. (dataemia.com)
  • The US Food and Drug Administration (FDA) has approved the Architect Stat (Abbott Laboratories) high-sensitivity troponin-I assay, which can detect myocardial infarction (MI) faster and more accurately than other troponin tests, according to the company. (medscape.com)
  • The addition of Abbott's high sensitivity troponin-I assay to the laboratory's diagnostic testing menu is a great step forward to help laboratory scientists and clinicians better evaluate patients suspected of having a heart attack," Fred Apple, PhD, professor of laboratory medicine and pathology at the University of Minnesota in Minneapolis, said in the release. (medscape.com)
  • Hs-cTnI levels were measured using the ARCHITECT STAT High-Sensitivity Troponin-I assay in blood samples collected pre-angiogram. (acc.org)
  • The levels of nonspecific inflammatory marker C-reactive protein (CRP) and proinflammatory cytokine interleukin-6 (IL-6) in serum were measured by enzyme-linked immunosorbent assay (ELISA). (cdc.gov)
  • The 99th percentile cutoff point for cardiac troponin T (cTnT) is well-known at 0.01 ng/mL (with 10% coefficient of variance value at the 99th percentile of 0.03 ng/mL), as only one cTnT assay exists. (medscape.com)
Biomarkers4
  • Cardiac troponin I and troponin T are sensitive biomarkers. (uhhospitals.org)
  • For PCI in patients with normal baseline troponin values, elevations of cardiac biomarkers above the 99th percentile upper reference limit indicate periprocedural myocardial necrosis. (medscape.com)
  • Levels of cardiac and thromboembolic biomarkers, taken within 14 days from symptom onset, were compared between patients diagnosed with AF (n=74) during monitoring and those without AF (n=185). (lu.se)
  • and release of BIOMARKERS of myocardial NECROSIS (e.g., elevated TROPONIN levels). (bvsalud.org)
Sensitivity cardiac troponin10
  • Rapid rule-out of acute myocardial infarction with a single high-sensitivity cardiac troponin T measurement below the limit of detection. (bmj.com)
  • The high-sensitivity cardiac troponin test can detect very small levels of troponin T in the bloodstream. (netlify.app)
  • The normal range (value) for high-sensitivity cardiac troponin T test (hs-cTnT) is 14 ng/l. (netlify.app)
  • titeln "Taking the congestion out of heart failure" av professor Lynne Warner Stevenson Investigations and follow-up in patients with chest pain and elevated high- sensitivity cardiac troponin T levels but no myocardial infarction vs patients. (netlify.app)
  • Importance Elevated high- sensitivity cardiac troponin T (hscTnT) and N-terminal pro- B-type natriuretic peptide (NTproBNP) levels are associated with risk of heart failure (HF) and mortality among individuals in the general population . (bvsalud.org)
  • sensitivity cardiac troponin T and NTproBNP levels were measured from stored specimens collected at enrollment, with elevated levels defined as 14 ng/L or more for hscTnT (to convert to micrograms per liter, multiply by 0.001) and 125 pg/mL or more for NTproBNP (to convert to nanograms per liter, multiply by 1.0). (bvsalud.org)
  • High-Sensitivity Cardiac Troponin for Risk Assessment in Patients With Chronic Coronary Artery Disease. (acc.org)
  • The purpose of this study was to evaluate whether high-sensitivity cardiac troponin I (hs-cTnI) in patients with undergoing angiography for suspected CAD is associated with MI or CV death. (acc.org)
  • In patients undergoing coronary angiography for suspected coronary artery disease (CAD), do high-sensitivity cardiac troponin I (hs-cTnI) levels improve risk stratification for the primary outcome of myocardial infarction (MI) or cardiovascular (CV) death at follow-up? (acc.org)
  • RESULTS: B-type natriuretic peptide (BNP), N-terminal pro-brain natriuretic peptide (NT-proBNP), creatine kinase, D-dimer, high-sensitivity cardiac Troponin I and T were significantly higher in the AF than non-AF group. (lu.se)
Biomarker2
  • The elevation of the level of this specific biomarker may be indicative of sufficient chest trauma to result in the heart being injured, independent of the presence of cardiac decompensation or shock from other causes. (qxmd.com)
  • Currently, CABG-related MI is defined as (1) biomarker level elevations more than 5 times the upper reference limit plus either new pathological Q waves or new left bundle branch block (LBBB), (2) angiographically documented new graft or native coronary artery occlusion, or (3) imaging evidence of new loss of viable myocardium. (medscape.com)
CTnT2
Concentrations3
  • Serum cardiac troponin I and cardiac troponin T concentrations in dogs with gastric dilatation-volvulus. (vin.com)
  • Patients with hs-cTnI levels above the 99% URL were four times more likely to experience MI or CV death compared to those with troponin concentrations below 5 ng/L, and improved risk discrimination. (acc.org)
  • Hs-cTnI levels were higher in patients with CAD (3.4 ng/L) compared to those without (1.9 ng/L), and in the majority of CAD patients, these concentrations were above the detection limit. (acc.org)
Elevation5
  • This report is the first to document elevation of CTnI levels in cases of thoracic NAT. (qxmd.com)
  • Troponin elevation in ischemic heart disease Not specific for acute thrombotic occlusion of coronary artery. (netlify.app)
  • 0.10 ng/ml) and borderline (0.10 to 1.49 ng/ml) troponin elevation levels in critically ill patients without acute coronary syndrome. (wustl.edu)
  • however, elevation of troponin levels can occur in myriad conditions other than ischemic damage. (medscape.com)
  • An initial small elevation occurs when troponins are released from the cytosolic pool, when troponin molecules in the cytosol of cardiac muscle diffuse across the sarcolemma into the surrounding lymphatics and blood vessels, becoming detectable in blood. (medscape.com)
Serum troponin3
Myoglobin2
  • During the past decade a number of new analysis have been studied and their respective performance have been documented which include myoglobin, CK isoform, myosin light chain, troponin T and troponin I. Sensitivity is not a major concern but specificity is a problem because the standard markers are not restricted to heart. (edu.pk)
  • This study was conducted to investigate the effect of cold water immersion applied after exercise on cardiac troponin T and myoglobin levels. (gazi.edu.tr)
Skeletal muscle6
Myocardial ischemia1
  • We conclude that troponin I may be used as a reliable marker to diagnose myocardial ischemia in postpartum women. (elsevierpure.com)
Indicator of myocardial2
  • Troponin T is an early indicator of myocardial infarction and is superior to CKMB in diagnosis of myocardial injury. (edu.pk)
  • Evaluation with serum cardiac troponin I (CTnI), a specific indicator of myocardial injury, could improve the comprehensive evaluation of patients with suspected NAT. (qxmd.com)
Protein6
  • Troponin is a protein found in all muscles. (netlify.app)
  • 2019-04-29 · Higher levels of the protein were associated with a greater chance of developing cardiovascular disease, particularly heart failure. (netlify.app)
  • Troponin is attached to the protein tropomyosin and lies within the groove between actin filaments in muscle tissue. (wikipedia.org)
  • citation needed] Troponin is a component of thin filaments (along with actin and tropomyosin), and is the protein complex to which calcium binds to trigger the production of muscular force. (wikipedia.org)
  • It has been demonstrated that stability of cTnI in native complex is significantly better than stability of the purified form of the protein or the stability of cTnI in artificial troponin complexes combined from purified proteins. (wikipedia.org)
  • Your body releases high levels of a protein called troponin. (medicinenet.com)
Patients24
  • First, there are no primary prevention trials similar to those done for statins to show that targeting patients with elevated troponin levels can improve outcomes. (tctmd.com)
  • Cardiac troponin I level was elevated in 7 (70%) of 10 patients with levels between 2 and 50 times the upper limit of normal. (qxmd.com)
  • Objective: The aim of this investigation was to determine if the presence of ischemic electrocardiographic (ECG) changes in patients undergoing vascular surgery provides incremental prognostic information about the long-term risk of death compared with a single peak troponin level within 48 hours after surgery. (umn.edu)
  • Most patients who have had a heart attack have increased troponin levels within 6 hours. (medlineplus.gov)
  • The aim of this study is to investigate myocardial damage in recovering coronavirus disease 2019 (COVID-19) patients with high-sensitivity troponin levels (hsTnT) and echocardiography. (go.jp)
  • Demographic characteristics, hsTnT levels, and echocardiography data were collected for 209 patients, after excluding those without serum samples or good-quality echocardiographic images. (go.jp)
  • Our objective was to describe the change in the level of troponin I in patients who undergo a vaginal or cesarean delivery. (elsevierpure.com)
  • The current study aims to establish the association between elevated homocysteine level and the extent of myocardial injury measured by cardiac troponin-I and ejection fraction in patients admitted with acute coronary syndrome. (biomedjournal.com)
  • Serum homocysteine is associated with increased myocardial injury which has been quantified in the current study by serum cardiac troponin-I levels and ejection fraction, which are independent markers of the extent of myocardial damage in patients of acute coronary syndrome. (biomedjournal.com)
  • 2262 of 8828 patients (25.6%) had elevated hscTnT levels, 3371 of 8836 patients (38.2%) had elevated NTproBNP, and 1411 of 8828 patients (16.0%) had both levels elevated. (bvsalud.org)
  • Borderline increase of troponin I (cTnI) is associated with higher rates of cardiovascular events compared with normal levels in the setting of acute coronary syndrome (ACS), but the significance of borderline cTnI levels in patients without chest pain may differ. (wustl.edu)
  • The aim of this study was to determine the prognostic implications of intermediate serum cTnI levels in patients without ACS in the intensive care unit (ICU). (wustl.edu)
  • In conclusion, an intermediate level of cTnI in patients without ACS in the ICU is an independent prognostic marker predicting in-hospital mortality and length of ICU stay. (wustl.edu)
  • Patients with intermediate cTnI levels who survive to discharge have equivalent out-of-hospital courses for up to 6 months compared with patients with normal cTnI levels. (wustl.edu)
  • A short-cut review was carried out to establish whether troponin levels are useful for evaluating the presence of coronary artery disease (CAD) in patients presenting with supraventricular tachycardia (SVT). (bmj.com)
  • The adoption of a troponin standard for the definition of MI in 2000 increased the incidence of MI by approximately 15%, 2 and undoubtedly identified more high-risk patients for whom aggressive management would be beneficial. (bjcardio.co.uk)
  • It also means that the concept of a 'negative' troponin becomes relatively meaningless as troponin at some level can almost always be detected even in healthy patients. (bjcardio.co.uk)
  • The Architect Stat test detects very low levels of troponin, allowing clinicians to assess patients with suspected MI within 2 to 4 hours of admission, the company said. (medscape.com)
  • In the HiSTORIC study, for example, of more than 30,000 consecutive patients, a single cardiac troponin measurement using the test safely and effectively ruled out MI at presentation. (medscape.com)
  • An hs-cTnI level >10 ng/L identified patients with a 50% increase in the risk of MI or CV death. (acc.org)
  • In patients with CAD, hs-cTnI levels are associated with risk of MI or CV death independent of severity of CAD or risk factors. (acc.org)
  • The risk discrimination power of hs-cTnI levels surpassing the upper reference limit of normal (URL) is compelling, suggesting a possible role in directing treatment strategies for stable patients following diagnosis. (acc.org)
  • In contrast, there is significant variability in how patients with a nonischemic ECG and normal troponin levels are managed. (medscape.com)
  • Low-risk" patients were defined by nonischemic ECGs, two negative serial troponin tests, and stable vital signs. (medscape.com)
Detect1
Cardiovascular events3
  • Numerous studies have identified a relationship between troponin levels and first-ever cardiovascular events in the general population, so Willeit and colleagues set out to provide an overall estimate of the association. (tctmd.com)
  • When asked about the most likely mechanisms to explain the link between modestly elevated troponins and cardiovascular events, Willeit pointed to subclinical coronary atherosclerosis, cardiac stress, and cardiac abnormalities that have not yet been detected. (tctmd.com)
  • The study found that highly sensitive troponin tests were especially good at predicting cardiovascular events when added to the results of a special equation commonly used to calculate a person's 10-year risk of having a heart attack or stroke. (netlify.app)
Baseline1
  • Indeed, 80% of the participants in this meta-analysis, all of whom had no history of cardiovascular disease, had detectable levels at baseline. (tctmd.com)
Associated with elevated2
  • They were significantly associated with elevated hsTnT levels. (go.jp)
  • 30 years) were associated with elevated troponins. (nih.gov)
Homocysteine4
  • Elevated level of plasma homocysteine has been demonstrated to be an independent risk factor for the development of coronary artery disease. (biomedjournal.com)
  • Also, a positive correlation was found between serum homocysteine levels and ejection fraction. (biomedjournal.com)
  • Homocysteine, troponin, acute coronary syndrome. (biomedjournal.com)
  • Evaluation of the levels of homocysteine. (yyu.edu.tr)
Measurement1
  • Blood troponin levels may be used as a diagnostic marker for stroke or other myocardial injury that is ongoing, although the sensitivity of this measurement is low. (wikipedia.org)
Tropomyosin3
  • Under resting intracellular levels of calcium, tropomyosin covers the active actin sites to which myosin (a molecular motor organized in muscle thick filaments) binds in order to generate force. (wikipedia.org)
  • citation needed] Individual subunits serve different functions:[citation needed] Troponin C binds to calcium ions to produce a conformational change in TnI Troponin T binds to tropomyosin, interlocking them to form a troponin-tropomyosin complex Troponin I binds to actin in thin myofilaments to hold the actin-tropomyosin complex in place Smooth muscle does not have troponin. (wikipedia.org)
  • Three types of troponins exist-troponin I, troponin T, and troponin C. Each subunit has a unique function: Troponin T binds the troponin components to tropomyosin, troponin I inhibits the interaction of myosin with actin, and troponin C contains the binding sites for Ca 2+ that helps initiate contraction. (medscape.com)
Subclinical1
  • The hope is that a marker like troponin could be used to identify people who have subclinical disease and it could help target preventive interventions," Willeit told TCTMD. (tctmd.com)
Necrosis3
  • There was also an increase in cardiac tissues and serum levels of the pro-inflammatory cytokines interleukin-6 (IL-6) and tumor necrosis factor- α (TNF- α ) [ 1 , 4 ]. (hindawi.com)
  • If the injury persists and necrosis progresses, further troponins are released from the muscular pool. (medscape.com)
  • Síndrome clínico caracterizado por síntomas de ISQUEMIA MIOCÁRDICA, elevación persistente de los segmentos ST en la ELECTROCARDIOGRAFÍA, y elevación de los BIOMARCADORES de NECROSIS miocárdica (por ej. (bvsalud.org)
Actin1
  • Some of this calcium attaches to troponin, which causes it to change shape, exposing binding sites for myosin (active sites) on the actin filaments. (wikipedia.org)
99th percentile2
  • The 99th percentile represents the analyte concentration (for which only 1% of the population has higher levels in a healthy reference population. (clpmag.com)
  • A laboratory's strategy to reduce the time from "order to result" of high-sensitivity troponin, defined as an imprecision level (%CV) of ?10% at the 99th percentile of normal by the joint ESC/ACC committee, is discussed. (clpmag.com)
Binds1
Lactate dehydrogenase1
  • Creatine kinase, aspartate amino-transferase, lactate dehydrogenase and Troponin T were determined by kit methods. (edu.pk)
Clinical7
  • Even though we see this very strong association of troponin levels with cardiovascular risk, it still is unclear and remains unknown how we would potentially modify that risk and how we would change our approach based on having a troponin laboratory value as part of your usual clinical assessment," she said. (tctmd.com)
  • National Heart, Lung, and Blood Institute PETAL Clinical Trials Network, Ginde AA, troponin levels high no heart attack /07/06 · The level of troponin that indicates a heart attack is the level above the reference range. (netlify.app)
  • Associations of High-Sensitivity Troponin and Natriuretic Peptide Levels With Outcomes After Intensive Blood Pressure Lowering: Findings From the SPRINT Randomized Clinical Trial. (bvsalud.org)
  • BACKGROUND: Circulating cardiac troponin levels (cTn), representative of myocardial injury, are commonly elevated in heart failure (HF) and related to adverse clinical events. (dataemia.com)
  • CONCLUSIONS: Circulating cTnI level was associated with clinical outcomes in ADHF, but these observations diminished with additional adjustment for NT-proBNP. (dataemia.com)
  • The clinical bottom line is that there has not been enough research to date to support the routine use of troponin levels in the evaluation of SVT. (bmj.com)
  • Interpretation of troponin results must be in combination with a full assessment of the clinical context. (bjcardio.co.uk)
Significantly1
  • Phosphorylation levels of cTnI in the left ventricle were significantly lower at d 1 postexposure. (cdc.gov)
Ischemia1
  • think of a heart attack as an event that causes disabling chest pain, it is not always so level of troponin in the blood is a sign that you've l Demand ischemia. (netlify.app)
Detectable2
  • That more than three-quarters of participants without obvious cardiovascular disease have detectable troponin is "pretty striking," she added. (tctmd.com)
  • Serum levels of IL-6 were not detectable in both groups. (cdc.gov)
Enzyme levels1
  • Up to half of the people in the hospital for COVID-19 have enzyme levels in their blood that signal liver damage. (medicinenet.com)
Acute Myocardial1
  • Troponin increases were relatively common among marathon finishers and can reach levels typically diagnostic for acute myocardial infarction. (nih.gov)
Chest2
  • Having normal troponin levels 12 hours after chest pain has started means a heart attack is unlikely. (medlineplus.gov)
  • specific high-conductance channel (called the mi- ure or a serum creatinine level of 120 μmol per the following reasons: onset of chest pain more. (netlify.app)
Symptoms3
  • Since you had cardiac symptoms, an elevated troponin would usually lead to an invasive evaluation to include angiography of your coronary arteries. (netlify.app)
  • Cardiac troponin- I (cTI) was measured after 10 to 12 hours of onset of symptoms. (biomedjournal.com)
  • Data collected included demographic and training history, symptoms experienced during the run, and postrace troponin T and I levels. (nih.gov)
CTnI levels2
  • Although they likely represent a spectrum of risk in ADHF, these findings question the implications of changing cTnI levels during treatment. (dataemia.com)
  • 0.1 ng/ml) or intermediate (0.1 to 1.49 ng/ml) cTnI levels. (wustl.edu)
Damage5
Substances1
Normal2
  • The CK MB and cTnI serum level of healthy dogs were used as pattern of normal values, which were compared to those obtained from dogs that had ST segment deviation. (vin.com)
  • Serum values of cardiac troponin T in normal and cardiomyopathic dogs, Vet. (vin.com)
Molecules1
  • Inside the cardiac troponin complex the strongest interaction between molecules has been demonstrated for cTnI - TnC binary complex especially in the presence of Ca2+ ( KA = 1.5 × 10−8 M−1). (wikipedia.org)
Proteins2
Muscular1
  • It is proposed that there is a small cytosolic pool and a larger muscular pool of troponins. (medscape.com)
Measurements2
  • Some labs use different measurements (for example, "high sensitivity troponin test") or test different samples. (medlineplus.gov)
  • Measurements of cardiac-specific troponins I and T are extensively used as diagnostic and prognostic indicators in the management of myocardial infarction and acute coronary syndrome. (wikipedia.org)
Clinically2
  • This study is important, and it certainly underscores the importance of knowing more, but I think we're still very far from knowing clinically how to use this information to better prevent cardiovascular disease on a population level. (tctmd.com)
  • There's also uncertainty about the source of the raised troponin levels in people without clinically apparent disease. (tctmd.com)
Blood4
  • Cardiac troponin levels are normally so low they cannot be detected with most blood tests. (medlineplus.gov)
  • When the heart is working well, there are low levels of BNP in the blood. (uhhospitals.org)
  • To test the hypothesis that elevated hscTnT and NTproBNP levels would identify individuals with the greatest risk for mortality and HF and the largest benefit associated with intensive systolic blood pressure (SBP) lowering. (bvsalud.org)
  • Oxygen levels in your blood get dangerously low, and you'll probably need a ventilator to help you breathe. (medicinenet.com)