AnatomyOrganismsDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPhenomena and ProcessesInformation ScienceHealth Care
Troponin ITroponinTroponin TTroponin CTropomyosinMyocardiumMyofibrilsBiological MarkersCreatine KinaseActin CytoskeletonCalciumRabbitsMusclesMyocardial ContractionChest PainMuscle ProteinsSarcomeresMyocardial InfarctionActomyosinMyosinsMyoglobinCardiomyopathy, RestrictiveHeartCreatine Kinase, MB FormActinsCa(2+) Mg(2+)-ATPaseCardiomyopathy, HypertrophicElectrocardiographyPeptide FragmentsMuscle, SkeletalChickensAngina, UnstablePsoas MusclesThiadiazinesAmino Acid SequenceMuscle, StriatedMyocytes, CardiacImmunoassayCardiac MyosinsCardiomyopathy, Hypertrophic, FamilialAcute Coronary SyndromePhosphorylationSensitivity and SpecificityPredictive Value of TestsMuscle ContractionNaphthalenesulfonatesMyocardial IschemiaNatriuretic Peptide, BrainMolecular Sequence DataAdenosine TriphosphatasesProtein IsoformsCyclic AMP-Dependent Protein KinasesCardiomyopathiesProspective StudiesElectrophoresis, Polyacrylamide GelROC CurveCardiotonic AgentsCalcium-Binding ProteinsBinding SitesSalmineHeart DiseasesPrognosisProtein BindingBepridilAcute DiseaseMuscle Fibers, Slow-TwitchClinical Chemistry TestsFluoroimmunoassayTime FactorsProtein ConformationIsoenzymesSpectrometry, FluorescenceMyosin SubfragmentsHeart InjuriesMyocardial StunningHeart VentriclesMutationCattleIsotachophoresisCardiomyopathy, DilatedMyocardial Reperfusion InjuryCalmodulinIsometric ContractionMyocarditisKineticsVentricular MyosinsIsoproterenolMyosin Heavy ChainsMyosin Light ChainsPhosphorylase KinasePulmonary EmbolismMice, TransgenicMuscle Fibers, SkeletalStrontiumMuscle Fibers, Fast-TwitchContusionsRecombinant ProteinsHeart FailurePericarditisHydrazones
AssaysIncreased troponin levelsAssayCTnICTnTAcuteHigh sensitivity troponin testConcentrationsSubunit of troponinBindsElevationHYPERTROPHIC CARDIOMYOPATHYNecrosisNormal troponinSerumLevelsElevationsDiagnostic99th percentileSkeletal typeNatriuretic peptideClinicalProteinUnderwentCardiovascular diseaseCardiac muscleSensitivity cardiacIschemicPatientsTropomyosinImmunoassaysChestAntibodyPulmonary EmbolismRisk stratificationActinCoronaryPrognosticLevel
Assays24
  • Since the initial 1st-generation assays, 5th-generation high-sensitivity cardiac troponin (hs-cTn) assays have been developed, and are now widely used. (nih.gov)
  • Singulex has received the CE mark for its Sgx Clarity cTnI assay, an ultra-sensitive test that measures cardiac troponin at lower levels than most existing assays. (aacc.org)
  • The very recent commercialization of methods with further improved analytical sensitivity (i.e., "ultra-sensitive" assays), which allow to measure cardiac troponin values in the vast majority of healthy subjects, is now challenging the diagnostic paradigm based on early rule-out of subjects with cardiac troponin values comprised between the 99th percentile and LoD. (srce.hr)
  • Scheitz JF, Nolte CH, Laufs U, Endres M. Application and interpretation of high-sensitivity cardiac troponin assays in patients with acute ischemic stroke. (eso-stroke.org)
  • New high-sensitivity troponin assays will reduce the threshold for the diagnosis of myocardial infarction (MI), as specified in the 2012 third Universal Definition of MI. (bjcardio.co.uk)
  • At the 2012 European Society of Cardiology (ESC) meeting the Universal Definition of MI was updated for the third time in a decade, 3 and a major inclusion was the introduction of high-sensitivity cardiac troponin assays, which are again likely to change the rate of MI diagnosis. (bjcardio.co.uk)
  • Troponin assays have developed with successive generations such that they can detect increasingly low levels of troponin. (bjcardio.co.uk)
  • 6 This is as expected for a more sensitive assay, as it is simply detecting the same troponin release at an earlier time than conventional assays. (bjcardio.co.uk)
  • Recent approvals of high sensitivity cardiac troponin (hs-cTn) assays by the U.S. Food and Drug Administration (FDA) and international regulatory bodies have enabled clinical labs to develop more sophisticated diagnostic protocols based on utilization of low cTn measurements at or near the assays' limit of detection (LoD) to expediate and improve the accuracy of acute myocardial infarction diagnosis. (clpmag.com)
  • Non-high sensitivity cardiac troponin assays lack the analytical sensitivity to reliably measure small cTn concentrations and their subsequent changes below the 99th percentile upper reference limit (URL). (clpmag.com)
  • Assays for hs-cTnI and hs-cTnT have allowed clinical labs to shift emphasis from using cardiac troponin as binary tests (in which the 99th percentile URL of a healthy reference population was used as a cut-off for defining normal vs increased cTn values) to more complex diagnostic protocols utilizing cTn values below the 99th percentiles' URLs. (clpmag.com)
  • Siemens Healthineers offers proven, true high-sensitivity troponin I assays that provide fast, actionable, and reliable results you can count on. (siemens-healthineers.com)
  • Even when cardiac troponin levels detected by high-sensitivity assays are within the normal range, elevations are associated with incident cardiovascular events in people without overt disease, a meta-analysis confirms. (tctmd.com)
  • Adding information from high-sensitivity troponin assays to models that included conventional risk factors improved prediction of cardiovascular events, particularly fatal ones, suggesting a possible role for the tests in a primary prevention setting, the researchers say. (tctmd.com)
  • Although cardiac troponins have been measured for years for diagnosing acute MI, the introduction of high-sensitivity assays-including just recently in the United States -has allowed for detection of very low levels, even in people without obvious signs of myocardial damage or cardiovascular disease. (tctmd.com)
  • With the introduction of high-sensitivity cardiac troponin (hs-cTn) assays, the time it takes to detect signs of myocyte necrosis has shortened considerably. (bmj.com)
  • We report analytical data from a fully automated digital immunoassay for cardiac troponin I (cTnI) based on Single Molecule Array (Simoa) technology with a limit of detection 2 logs lower than contemporary high sensitivity troponin assays. (quanterix.com)
  • Ninety-Minute vs 3-h Performance of High-Sensitivity Cardiac Troponin Assays for Predicting Hospitalization for Acute Coronary Syndrome. (lifelabs.com)
  • These changes were instituted following the introduction of increasingly sensitive and precise troponin assays. (medscape.com)
  • Two different reference ranges are used in troponin assays. (medscape.com)
  • Troponins are generally undetectable in healthy patients, although this may eventually change as more sensitive assays become available. (medscape.com)
  • The 99th percentile of a reference decision limit (medical decision cutoff) for cardiac troponin (cTn) assays should be determined in each local laboratory with internal studies using the specific assay that is used in clinical practice or validating a reference interval that is based on findings in the literature. (medscape.com)
  • Table 1 shows the calculated 99th upper reference limit values for some of the available troponin assays. (medscape.com)
  • When measured with older generation assays, elevated troponin levels can be detected 6-12 hours after onset of myocardial injury, peaking at about 24 hours, followed by a gradual decline over several days (up to 2 weeks). (medscape.com)
Increased troponin levels1
Assay16
  • The US Food and Drug Administration (FDA) has approved the Architect Stat (Abbott Laboratories) high-sensitivity troponin-I assay, which can detect myocardial infarction (MI) faster and more accurately than other troponin tests, according to the company. (medscape.com)
  • The addition of Abbott's high sensitivity troponin-I assay to the laboratory's diagnostic testing menu is a great step forward to help laboratory scientists and clinicians better evaluate patients suspected of having a heart attack," Fred Apple, PhD, professor of laboratory medicine and pathology at the University of Minnesota in Minneapolis, said in the release. (medscape.com)
  • A recent publication has shown that cardiac troponin T (TnT) concentrations measured with a highly sensitive assay were significantly associated with the incidence of cardiovascular death and heart failure in stable coronary artery disease after adjustment for other independent prognostic indicators [ 13 ]. (hindawi.com)
  • Hs-cTnI levels were measured using the ARCHITECT STAT High-Sensitivity Troponin-I assay in blood samples collected pre-angiogram. (acc.org)
  • With the increased clinical utility of sub-99th percentile hs-cTn measurements, quality controls with lower cardiac troponin concentrations are needed to monitor and validate hs-cTn assay performance. (clpmag.com)
  • 99thpercentiles for cardiac troponin assay methods addressed in this article are greater than their respective assay methods' LoB, LoD, and LoQ. (clpmag.com)
  • Hear the results of their studies, how transitioning to a high-sensitivity troponin I assay impacted their labs, and the realized benefits to patients and hospitals. (siemens-healthineers.com)
  • Discover how a study in Italy has validated the high-sensitivity troponin I assay as an essential tool for one diagnostic laboratory. (siemens-healthineers.com)
  • Dr. Antonio Buno, La Paz University Hospital, has been working to transform the delivery of cardiac care by implementing a high-sensitivity Troponin I assay. (siemens-healthineers.com)
  • These videos are part of a series of educational videos focusing on the clinical utility of high-sensitivity troponin I. Hear other leaders in the area of cardiovascular disease and laboratory diagnostics discuss implementing a high-sensitivity troponin I assay into their facility. (siemens-healthineers.com)
  • It is unclear if a high-sensitivity troponin assay will have enough discriminative power to become a decision support in primary care. (altmetric.com)
  • The aim of this study was to evaluate a high-sensitivity troponin T assay performed in three primary health care centres in southeast Sweden and to compare the outcome with a point-of-care troponin T test. (altmetric.com)
  • With growing interest in exploring as an early indicator of adverse heart health trends, the ability to quantitate troponin in healthy control populations is emerging as a highly desirable assay capability. (quanterix.com)
  • The 99th percentile cutoff point for cardiac troponin T (cTnT) is well-known at 0.01 ng/mL (with 10% coefficient of variance value at the 99th percentile of 0.03 ng/mL), as only one cTnT assay exists. (medscape.com)
  • Hs-troponin I (Siemens), TNIH assay, was measured using the Siemens Centaur XP. (cdc.gov)
  • For hs-troponin T (Roche) and hs-troponin I (Ortho), low values were initially blinded for each assay. (cdc.gov)
CTnI8
  • Inside the cardiac troponin complex the strongest interaction between molecules has been demonstrated for cTnI - TnC binary complex especially in the presence of Ca2+ ( KA = 1.5 × 10−8 M−1). (wikipedia.org)
  • It has been demonstrated that stability of cTnI in native complex is significantly better than stability of the purified form of the protein or the stability of cTnI in artificial troponin complexes combined from purified proteins. (wikipedia.org)
  • The purpose of this study was to evaluate whether high-sensitivity cardiac troponin I (hs-cTnI) in patients with undergoing angiography for suspected CAD is associated with MI or CV death. (acc.org)
  • Patients with hs-cTnI levels above the 99% URL were four times more likely to experience MI or CV death compared to those with troponin concentrations below 5 ng/L, and improved risk discrimination. (acc.org)
  • In patients undergoing coronary angiography for suspected coronary artery disease (CAD), do high-sensitivity cardiac troponin I (hs-cTnI) levels improve risk stratification for the primary outcome of myocardial infarction (MI) or cardiovascular (CV) death at follow-up? (acc.org)
  • Cardiac troponins (cTn), cardiac troponin I (cTnI) and cardiac troponin T (cTnT), are important analytes for acute myocardial infarction diagnosis and are used to guide treatment and patient management decisions. (clpmag.com)
  • Under 2020 och 21 införs inom Region Skåne en ny högkänslig blodprovsanalys för troponin I (hs-cTnI) som kan avslöja hjärtskada eller hjärtinfarkt. (lu.se)
  • Phosphorylation levels of cardiac troponin I (cTnI) were determined by Western blot. (cdc.gov)
CTnT3
  • We aimed to assess the relationship between LAP burden and circulating levels of high-sensitivity cardiac troponin T (hs-cTnT), and to explore the potential underlying etiology in patients undergoing clinically indicated coronary CT angiography (CCTA). (physiciansweekly.com)
  • The primary aim of this study was to determine optimal thresholds of preoperative and perioperative changes in high-sensitivity cardiac troponin T (hs-cTnT) to predict MACCE and mortality. (lu.se)
  • The use of troponin T (cTnT) and N-terminal Pro-BNP (NTpBNP) in combination with echocardiography assessment may facilitate the development of a superior predictive model. (bmj.com)
Acute25
  • Measurements of cardiac-specific troponins I and T are extensively used as diagnostic and prognostic indicators in the management of myocardial infarction and acute coronary syndrome. (wikipedia.org)
  • The role of cardiac troponins as diagnostic biomarkers of myocardial injury in the context of acute coronary syndrome (ACS) is well established. (nih.gov)
  • The measurement of cardiac troponins, either cardiac troponin I or T, has become the culprit of clinical decision making in patients with suspected acute coronary syndrome (ACS), especially in those with non-ST elevation myocardial infarction (NSTEMI). (srce.hr)
  • Elevated troponin in acute ischemic stroke - a matter of debate? (eso-stroke.org)
  • With respect to high prognostic relevance, 1 international guidelines recommend the measurement of troponin in all patients presenting with acute ischemic stroke. (eso-stroke.org)
  • 2 However, high-sensitivity troponin is elevated in 20-55% of acute stroke patients, 3 many of whom without thrombotic acute coronary syndrome (ACS). (eso-stroke.org)
  • Why is troponin elevated in so many acute stroke patients? (eso-stroke.org)
  • This question was addressed by the Troponin Elevation in Acute Ischemic Stroke (TRELAS) study, which included 2123 consecutive patients presenting with acute ischemic stroke, who did not have ST-segment-elevation myocardial infarction (STEMI). (eso-stroke.org)
  • 5 Nonetheless, coronary culprit lesions were identified in 24% of stroke patients with elevated troponin, thus demonstrating that elevated troponin should not be ignored in acute stroke patients. (eso-stroke.org)
  • The recently launched Prediction of Acute Coronary Syndrome in Acute Ischemic Stroke (PRAISE) study aims to develop a diagnostic algorithm that allows the prediction of acute coronary syndrome in stroke patients with elevated troponin. (eso-stroke.org)
  • For the time being, a clear recommendation for acute stroke patients with elevated troponin is lacking. (eso-stroke.org)
  • So, elevated troponin in acute ischemic stroke remains a matter of debate! (eso-stroke.org)
  • Jensen JK, Atar D, Mickley H. Mechanism of troponin elevations in patients with acute ischemic stroke. (eso-stroke.org)
  • Coronary Angiographic Findings in Acute Ischemic Stroke Patients With Elevated Cardiac Troponin: The Troponin Elevation in Acute Ischemic Stroke (TRELAS) Study. (eso-stroke.org)
  • By employing a high-sensitivity Troponin I test, laboratory scientists led by Dr. Katell Peoc'h from Paris Diderot University Hospital have been able to more rapidly and accurately diagnose those suffering from acute cardiac events. (siemens-healthineers.com)
  • Troponin T - contemporary approach towards diagnosing acute myocardial ischemia. (medline.ru)
  • We have researched a possibility to apply the Enzyme Multiplied Immunoassay Technique (EMIT-test) for Troponin T to diagnose death resulting from the acute myocardial ischemia in the biological laboratory of the Leningrad Regional Bureau of Forensic Medical Examination. (medline.ru)
  • It means that Troponin T lends itself most widely for a diagnosis uniting the advantages of the quick and slow markers with the acute myocardial ischemia. (medline.ru)
  • Background Patients presenting with acute chest pain without a rise in cardiac troponins are considered to be at low risk of adverse cardiac events and are often considered for early discharge without further inpatient investigation. (bmj.com)
  • However, the further risk stratification of patients presenting with acute chest pain without a rise in cardiac troponin is inconsistent. (bmj.com)
  • Rapid rule-out of acute myocardial infarction with a single high-sensitivity cardiac troponin T measurement below the limit of detection. (bmj.com)
  • The value of high-sensitivity troponin I in the assessment of patients with suspected acute coronary syndrome (ACS) has been well established in clinical practice guidelines. (siemens-healthineers.com)
  • See also Acute coronary syndromes Two subtypes of troponin (cardiac troponin I and T) are very sensitive and specific indicators of damage to the heart muscle ( myocardium ). (wikidoc.org)
  • Up to 80% of patients with acute MI will have an elevated troponin level within 2-3 hours of emergency department (ED) arrival, versus 6-9 hours or more with CK-MB and other cardiac markers. (medscape.com)
  • Recognizing that cardiac troponin measurements may be elevated in disease states not primarily related to myocardial ischemia, a fourth universal definition of acute MI was developed by the American College of Cardiology (ACC), European Society of Cardiology (ESC), American Hospital Association (AHA), and World Health Federation (WHF) in 2018. (medscape.com)
High sensitivity troponin test2
  • Some labs use different measurements (for example, "high sensitivity troponin test") or test different samples. (medlineplus.gov)
  • Cite this: FDA Clears Architect Stat High-Sensitivity Troponin Test for MI - Medscape - Oct 02, 2019. (medscape.com)
Concentrations2
  • Serum cardiac troponin I and cardiac troponin T concentrations in dogs with gastric dilatation-volvulus. (vin.com)
  • Very low concentrations of hs-troponin are associated with greater variability and are not routinely reported for clinical use. (cdc.gov)
Subunit of troponin2
  • The main difference is that the TnC subunit of troponin in skeletal muscle has four calcium ion-binding sites, whereas in cardiac muscle there are only three. (wikipedia.org)
  • The TnT subunit of troponin binds to tropomyosin-t form, a troponin-tropomyosin complex, anchored in place by the binding of TnI to actin, within muscle thin filaments. (thermofisher.com)
Binds6
Elevation6
  • Serum troponin (Tn) elevation is a specific and well-established necrosis biomarker in ACS, being the only biomarker currently used for risk stratification and guided invasive management decision in non-STEACS [ 8 , 9 ]. (hindawi.com)
  • It has been shown that even very small elevation in the troponin concentration is associated with increased risk of adverse outcomes in patients with ACS [ 12 ]. (hindawi.com)
  • The level of troponin is measured in the bloodstream and it is used to differentiate between unstable angina (no elevation of troponin, the myocardium is not irreversibly damaged) versus either non ST elevation MI or ST elevation MI (heart attack) in patients with chest pain . (wikidoc.org)
  • For example, patients with elevated troponin levels but negative CK-MB values who were formerly diagnosed with unstable angina or minor myocardial injury are now reclassified as non-ST-segment elevation MI (NSTEMI), even in the absence of diagnostic electrocardiographic (ECG) changes. (medscape.com)
  • however, elevation of troponin levels can occur in myriad conditions other than ischemic damage. (medscape.com)
  • An initial small elevation occurs when troponins are released from the cytosolic pool, when troponin molecules in the cytosol of cardiac muscle diffuse across the sarcolemma into the surrounding lymphatics and blood vessels, becoming detectable in blood. (medscape.com)
HYPERTROPHIC CARDIOMYOPATHY3
  • Troponin C1 is a BIOMARKER for damaged or injured CARDIAC MYOCYTES and mutations in troponin C1 gene are associated with FAMILIAL HYPERTROPHIC CARDIOMYOPATHY. (nih.gov)
  • The aim of this study was to evaluate the potential utility of genetic diagnosis in clinical management of families with hypertrophic cardiomyopathy (HCM) caused by mutations in the gene for cardiac troponin I (TNNI3). (nih.gov)
  • Mutations in the Cardiac Troponin I gene cause familial hypertrophic cardiomyopathy type 7 (CMH7) and familial restrictive cardiomyopathy (RCM). (thermofisher.com)
Necrosis3
  • Cardiac troponins are components of the contractile apparatus of cardiomyocytes and are released during myocardial necrosis in patients with ACS [ 7 ]. (hindawi.com)
  • For PCI in patients with normal baseline troponin values, elevations of cardiac biomarkers above the 99th percentile upper reference limit indicate periprocedural myocardial necrosis. (medscape.com)
  • If the injury persists and necrosis progresses, further troponins are released from the muscular pool. (medscape.com)
Normal troponin1
Serum3
  • The purpose of this study was to examine whether the combination of two simple tests, electrocardiography (ECG) and serum troponin I (TnI) level, may serve as reliable predictors of BCI or the absence of it. (unboundmedicine.com)
  • Cardiac Troponin-I was measured in serum by ELISA. (bmj.com)
  • Serum values of cardiac troponin T in normal and cardiomyopathic dogs, Vet. (vin.com)
Levels17
  • Blood troponin levels may be used as a diagnostic marker for stroke or other myocardial injury that is ongoing, although the sensitivity of this measurement is low. (wikipedia.org)
  • A troponin test measures the levels of troponin T or troponin I proteins in the blood. (medlineplus.gov)
  • Cardiac troponin levels are normally so low they cannot be detected with most blood tests. (medlineplus.gov)
  • Very high levels of troponin are a sign that a heart attack has occurred. (medlineplus.gov)
  • Troponin levels may remain high for 1 to 2 weeks after a heart attack. (medlineplus.gov)
  • The Architect Stat test detects very low levels of troponin, allowing clinicians to assess patients with suspected MI within 2 to 4 hours of admission, the company said. (medscape.com)
  • Women may particularly benefit from this technology as they often have lower levels of troponin than men, which could lead to an undiagnosed heart attack with contemporary troponin tests," they add in a news release . (medscape.com)
  • The aim of this study is to investigate myocardial damage in recovering coronavirus disease 2019 (COVID-19) patients with high-sensitivity troponin levels (hsTnT) and echocardiography. (go.jp)
  • Numerous studies have identified a relationship between troponin levels and first-ever cardiovascular events in the general population, so Willeit and colleagues set out to provide an overall estimate of the association. (tctmd.com)
  • Even though we see this very strong association of troponin levels with cardiovascular risk, it still is unclear and remains unknown how we would potentially modify that risk and how we would change our approach based on having a troponin laboratory value as part of your usual clinical assessment," she said. (tctmd.com)
  • First, there are no primary prevention trials similar to those done for statins to show that targeting patients with elevated troponin levels can improve outcomes. (tctmd.com)
  • There's also uncertainty about the source of the raised troponin levels in people without clinically apparent disease. (tctmd.com)
  • Violin plots show distribution of expression levels for Troponin I (SMED30021982) in cells (dots) of each of the 12 neoblast clusters. (stowers.org)
  • Violin plots show distribution of expression levels for Troponin I (SMED30021982) in cells (dots) of each of the 10 clusters of sub-leathally irradiated X1 and X2 cells. (stowers.org)
  • Associations of High-Sensitivity Troponin and Natriuretic Peptide Levels With Outcomes After Intensive Blood Pressure Lowering: Findings From the SPRINT Randomized Clinical Trial. (bvsalud.org)
  • Importance Elevated high- sensitivity cardiac troponin T (hscTnT) and N-terminal pro- B-type natriuretic peptide (NTproBNP) levels are associated with risk of heart failure (HF) and mortality among individuals in the general population . (bvsalud.org)
  • sensitivity cardiac troponin T and NTproBNP levels were measured from stored specimens collected at enrollment, with elevated levels defined as 14 ng/L or more for hscTnT (to convert to micrograms per liter, multiply by 0.001) and 125 pg/mL or more for NTproBNP (to convert to nanograms per liter, multiply by 1.0). (bvsalud.org)
Elevations1
  • N-terminal B-type natriuretic peptide or troponin elevations, or the Background use of inotropes during admission, are much more powerful and Risk stratification and prediction is an integral part of clinical accurate predictors than admission to hospital alone. (who.int)
Diagnostic7
  • They note that the current diagnostic criteria for perioperative myocardial infarction /injury "need to be updated with these high-sensitivity cardiac troponin data. (medscape.com)
  • The aim of this article is to provide an update on commercially available HS and "ultra"-sensitive techniques for measuring cardiac troponins, along with possible implications of increasingly enhanced analytical sensitivity on diagnostic algorithms for evaluating patients with suspected ACS. (srce.hr)
  • 5 Of all included patients, a subset of 29 of 291 patients with elevated troponin underwent diagnostic coronary angiography. (eso-stroke.org)
  • The total level and the dynamic of the troponin increase may help to predict myocardial infarction, 6 but eventually, the diagnostic work up and treatment of individual patients remains a matter of debate between neurologists and cardiologists. (eso-stroke.org)
  • The EMIT-test for Troponin T - a protein of the myocardial troponin complex - is nowadays of the great diagnostic value. (medline.ru)
  • Conclusions The use of troponin as a diagnostic test and risk stratification tool appears to be used universally in England. (bmj.com)
  • Discussions of troponin often pertain to its functional characteristics and/or to its usefulness as a diagnostic marker for various heart disorders. (wikidoc.org)
99th percentile1
  • A laboratory's strategy to reduce the time from "order to result" of high-sensitivity troponin, defined as an imprecision level (%CV) of ?10% at the 99th percentile of normal by the joint ESC/ACC committee, is discussed. (clpmag.com)
Skeletal type1
  • Troponin C1 is skeletal and cardiac type whereas troponin C2 is skeletal type. (nih.gov)
Natriuretic peptide3
  • Troponin T was analysed by a point-of-care test and a high-sensitivity method together with N-terminal pro-B-type natriuretic peptide (NT-proBNP) and creatinine. (altmetric.com)
  • Cardiovascular and non‐cardiovascular death distinction: the utility of troponin beyond N‐terminal pro‐B‐type natriuretic peptide. (gla.ac.uk)
  • The best model to predict CV death included low blood pressure, estimated glomerular filtration rate ≤ 60 mL/min, peripheral oedema, previous HF hospitalization, ischaemic HF, chronic obstructive pulmonary disease, elevated N‐terminal pro‐B‐type natriuretic peptide (NT‐proBNP), and troponin (c‐index = 0.73). (gla.ac.uk)
Clinical3
  • Interpretation of troponin results must be in combination with a full assessment of the clinical context. (bjcardio.co.uk)
  • Univariate and multivariate logistic regression was carried out to examine possible connections between troponin T ≥ 15 ng/L, clinical variables and laboratory findings at baseline. (altmetric.com)
  • The cardiac troponins, in particular, have become the cardiac markers of choice for patients with ACS, eclipsing CK-MB and myoglobin in terms of clinical value. (medscape.com)
Protein4
  • Troponin is attached to the protein tropomyosin and lies within the groove between actin filaments in muscle tissue. (wikipedia.org)
  • Cardiac Troponin I (Cardiac-specific troponin I, TnI, Troponin I) is an integral inhibitory protein in cardiac muscle that exists as part of a complex with troponin C (TnC) and troponin T (TnT). (thermofisher.com)
  • The gene for the sarcomeric thin-filament protein, slow skeletal muscle troponin T (TNNT1), maps to this interval and was sequenced. (clinicforspecialchildren.org)
  • Troponins are protein molecules that are part of cardiac and skeletal muscle. (medscape.com)
Underwent1
  • The meta-analysis included 28 prospective studies with a total of 154,052 participants free from cardiovascular disease who underwent high-sensitivity troponin testing. (tctmd.com)
Cardiovascular disease2
  • That more than three-quarters of participants without obvious cardiovascular disease have detectable troponin is "pretty striking," she added. (tctmd.com)
  • Ultra-sensitive cardiac troponin measurement offers a promising new tool for early detection and monitoring of cardiovascular disease. (quanterix.com)
Cardiac muscle3
  • Troponin, or the troponin complex, is a complex of three regulatory proteins (troponin C, troponin I, and troponin T) that are integral to muscle contraction in skeletal muscle and cardiac muscle, but not smooth muscle. (wikipedia.org)
  • Troponin is found in both skeletal muscle and cardiac muscle, but the specific versions of troponin differ between types of muscle. (wikipedia.org)
  • The troponins are regulatory proteins found in skeletal and cardiac muscle. (medscape.com)
Sensitivity cardiac6
  • Perioperative myocardial injury, reflected by release of high-sensitivity cardiac troponin T, is associated with 30-day mortality after various cardiac surgeries at postoperative prognostic cutoffs higher than proposed in current definitions, new research suggests. (medscape.com)
  • High-sensitivity cardiac troponin. (nih.gov)
  • High-Sensitivity Cardiac Troponin for Risk Assessment in Patients With Chronic Coronary Artery Disease. (acc.org)
  • High-sensitivity cardiac troponin at 3 hours: is the cat among the pigeons? (whiterose.ac.uk)
  • This webinar will cover the utilization of high-sensitivity cardiac troponin (cTn) in the emergency department (ED) and its impact when delivered via a rapid point of care device or core laboratory. (siemens-healthineers.com)
  • The results for high-sensitivity cardiac troponin in this data release are reported in nanograms per liter (ng/L). (cdc.gov)
Ischemic1
  • If a patient is troponin positive, and has signs and symptoms of ischemic heart disease (substernal chest pain or pressure, electrocardiographic EKG changes), then an early invasive strategy is warranted. (wikidoc.org)
Patients9
  • In the HiSTORIC study, for example, of more than 30,000 consecutive patients, a single cardiac troponin measurement using the test safely and effectively ruled out MI at presentation. (medscape.com)
  • Therefore, the management of stroke patients with elevated troponin is a common matter of debate between neurologists and cardiologists in emergency rooms. (eso-stroke.org)
  • 4 Beyond, elevated troponin in stroke patients might be attributable to nonischemic myocyte injury due to catecholamine-mediated myocardial toxicity, cytokine-mediated myocardial injury, endothelial dysfunction and microvascular spasms. (eso-stroke.org)
  • Is troponin suitable to predict ACS in stroke patients? (eso-stroke.org)
  • What's the ideal management of stroke patients with elevated troponin? (eso-stroke.org)
  • The adoption of a troponin standard for the definition of MI in 2000 increased the incidence of MI by approximately 15%, 2 and undoubtedly identified more high-risk patients for whom aggressive management would be beneficial. (bjcardio.co.uk)
  • It also means that the concept of a 'negative' troponin becomes relatively meaningless as troponin at some level can almost always be detected even in healthy patients. (bjcardio.co.uk)
  • In addition, 21 patients with troponin T ≥ 15 ng/L and no signs of AMI or UA were followed up for 2-3 years. (altmetric.com)
  • Fourteen of the 21 patients, without signs of AMI or UA at baseline, still had increased troponin T at follow-up after 2-3 years. (altmetric.com)
Tropomyosin1
Immunoassays1
  • However, the skeletal and cardiac subforms for TnI and troponin TnT are distinct, and immunoassays have been designed to differentiate between them. (medscape.com)
Chest1
  • One of the more common uses of troponin is to determine if a patient with chest pain has sustained death of the myocytes (heart muscle cells) as a result of thrombotic (blood clot related) occlusion of a coronary artery which would warrant urgent medical or interventional therapy. (wikidoc.org)
Antibody1
  • The following product was used in this experiment: Cardiac Troponin I Monoclonal Antibody (1D5D6), CoraLite®Plus 488 from Thermo Fisher Scientific, catalog # CL488-66376. (thermofisher.com)
Pulmonary Embolism1
Risk stratification1
  • Troponin is a simple yet potent tool for risk stratification. (wikidoc.org)
Actin1
Coronary2
  • When asked about the most likely mechanisms to explain the link between modestly elevated troponins and cardiovascular events, Willeit pointed to subclinical coronary atherosclerosis, cardiac stress, and cardiac abnormalities that have not yet been detected. (tctmd.com)
  • Low-attenuation coronary plaque burden and troponin release in chronic coronary syndrome: A mediation analysis. (physiciansweekly.com)
Prognostic1
  • Canine Cardiac Troponin I Significantly Complements Established Prognostic Composite Score In Dogs With Systemic Inflammation. (ku.dk)
Level4
  • Even a slight increase in the troponin level will often mean there has been some damage to the heart. (medlineplus.gov)
  • Willeit agreed, saying more research, including meta-analyses with patient-level rather than study-level data, needs to be performed before making any recommendations regarding expansive troponin testing. (tctmd.com)
  • Troponin T appears in blood a little earlier that CK-MB, two and a half hours after the onset of the heart attack, reaches its maximum in 8-10 hours (the first peak) and in 3-4 days (the second peak), and its level becomes standard in 10-14 days. (medline.ru)
  • The standard level of Troponin T must be close to zero because it should not get into the blood flow with healthy people. (medline.ru)