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  • isoforms
  • We used differential scanning calorimetry (DSC) and circular dichroism (CD) to investigate thermal unfolding of recombinant fibroblast isoforms of alpha-tropomyosin (Tm) in comparison with that of smooth muscle Tm. (kent.ac.uk)
  • TPM3
  • We find that mice in which the 9D exon from the TPM3/γTm tropomyosin gene is deleted (γ9D -/-) exhibit a more rapid wound-healing response 7 days after wounding compared with wild-type mice. (edu.au)
  • Mouse
  • We have therefore analyzed the requirement for tropomyosin isoform expression in a mouse model of cutaneous wound healing. (edu.au)
  • gene mutation
  • 4 5 We therefore have studied the proband with the Asp175Asn mutation, along r with all available family members (family DB), to determine whether the α-tropomyosin gene mutation arose de novo. (ahajournals.org)
  • filament
  • In each state, the radial distance of tropomyosin from the filament axis is indicated by yellow. (nih.gov)
  • In the activated state, the azimuthal angle change of tropomyosin around the filament axis is denoted by an arrow. (nih.gov)
  • peptides
  • modified peptides were then captured and identified by LC/MS/MS. The analysis revealed sites of modification on tropomyosin (Cys 190) and actin (Cys 257) that were specific to NCA treatment (n=3). (ahajournals.org)
  • azimuthal
  • Tropomyosin shows considerable azimuthal movement away from the open state toward the surrounds of a more energetically favorable blocked B-state position over F-actin. (rupress.org)
  • TPM2
  • Deletion of regions 2-3 in tropomyosin (zeige TPM2 Antikörper ) alpha resulted in an 60 % decrease in both isometric tension and stiffness of tropomyosin (zeige TPM2 Antikörper )-reconstituted myocardium. (antikoerper-online.de)
  • Tropomyosin (zeige TPM2 Antikörper ) is primarily responsible for the change in the kinetic constants of the elementary steps of the cross bridge cycle. (antikoerper-online.de)
  • Reactivity
  • The terminal and middle fragments of tropomyosin had the highest IgE reactivity, but overall no clear immunodominant region was observed in this study. (figshare.com)
  • studies showed
  • X-ray studies showed that whole caldesmon bound to tropomyosin in several places. (rice.edu)
  • Skin prick test studies showed positive responses to the terminal and middle fragments and increased responses to the fragment mixture compared to whole tropomyosin. (figshare.com)
  • molecular weight
  • Western blot analysis of NCA-treated samples on non-reducing gels revealed higher molecular weight forms of tropomyosin and actin that were intermediate to their homodimeric forms which were lost with DTT treatment, indicating a heterodimer formation via disulphide bond. (ahajournals.org)
  • shrimp
  • Our aim was to map the immunodominant regions of shrimp tropomyosin by both IgE-binding and IgE-receptor crosslinking studies. (figshare.com)
  • Conclusions
  • Conclusions De novo mutations in the α-tropomyosin gene can result in hypertrophic cardiomyopathy that may appear to be sporadic but in subsequent generations gives rise to familial disease. (ahajournals.org)
  • species
  • The species specificity of S. mansoni tropomyosin suggests that further study of its potential as an immunodiagnostic reagent is warranted. (ajtmh.org)
  • genes
  • However, some features of the mutations in the α-tropomyosin gene contrast with those of mutations in the other disease genes for hypertrophic cardiomyopathy. (ahajournals.org)