AnatomyOrganismsDiseasesChemicals and DrugsPhenomena and ProcessesInformation Science
Trophoblastic NeoplasmsTrophoblastic Tumor, Placental SiteGestational Trophoblastic DiseaseUterine NeoplasmsHydatidiform Mole, InvasiveChoriocarcinomaEpithelioid CellsHydatidiform MoleGenes, Y-LinkedPregnancyChorionic GonadotropinEncyclopedias as TopicMedlinePlusKeratinsHoof and ClawPerissodactylaIntermediate FilamentsReptilesKeratins, Type II
PlacentalChoriocarcinomaMetastaticMyeloproliferative NeoplasmsCancerMalignant neoplasmUterusPregnancyTesticularSolid TumorsEtiologyGerm cell tAbnormalEpithelialMucinous neoplasmCancersMetastasisClinicalLiverChorionic gonadotropinStromal TumorsOvaryRecurrenceBenignEpithelioid trophoblastic tumorHuman chorionic goPSTTRenalGroup of neoplasmsNeoplasticChemotherapyCHORIONIC VILLIOvarian TumorsMetastasisGestational and non-gestationalEmbryonalMarkersBrain TumorsDiseaseGonadsClassificationEmbryonicNecrosisMalignant tumorPrognosisClinical
Placental16
  • [ 2 ] The modified WHO prognostic scoring system is not applicable to patients with placental-site trophoblastic disease (PSTT) or epithelioid trophoblastic tumor (ETT). (medscape.com)
  • Benign lesions include placental site nodule and hydatidiform moles while malignant lesions have four subtypes including invasive mole, gestational choriocarcinoma, placental site trophoblastic tumor (PSTT) and epithelioid trophoblastic tumor (ETT). (wikipedia.org)
  • Placental side trophoblastic tumor (PSTT) is differentiated by low β-hCG levels because it is a neoplastic proliferation of intermediate trophoblastic cells. (wikipedia.org)
  • Microscopically, hemorrheage and necrosis are found, and tumor cells resemble placental trophoblastic cells: cytotrophoblast (CT), intermediate trophoblast (IT), and syncytiotrophoblast (ST). The CT and IT tend to grow in clusters and sheets separated by ST. The typical pattern of choriocarcinoma has been called two cell pattern, biphasic-terms that reflect the relatively regular, alternating arrangement of CT and ST in the tumor interspread with intermediate trophoblast. (atlasgeneticsoncology.org)
  • Gestational trophoblastic neoplasms (GTNs) are a rare group of neoplastic diseases composed of choriocarcinomas, placental site trophoblastic tumors (PSTTs) and epithelioid trophoblastic tumors (ETTs). (johnshopkins.edu)
  • Tumors arising from the placental tissue include two distinct histological types: the benign vascular tumor, chorangioma, and very rarely, choriocarcinoma. (biomedcentral.com)
  • This case is possibly the first report on this kind of a placental tumor which has been examined using both immunohistochemistry and chromosome analysis. (biomedcentral.com)
  • A rare benign smooth muscle neoplasm involving the placental parenchyma is presented. (biomedcentral.com)
  • This case report is of interest to the clinical specialty of obstetrics and gynecology and will advance our knowledge of the etiology of placental tumors. (biomedcentral.com)
  • whether the tumor is a primary placental or uterine neoplasm. (biomedcentral.com)
  • A patient with a placental smooth muscle tumor that appears to be a uterine leiomyoma entrapped entirely in the placenta during its growth is presented. (biomedcentral.com)
  • Tru-cut placental site trophoblastic tumor biopsy: A novel way for diagnosis. (peertechzpublications.org)
  • A Placental Site Trophoblastic Tumor (PSTT) is a rare form of gestational trophoblastic disease and usually manifests itself with abnormal uterine bleeding and elevated β-hCG serum levels even months or years after any antecedent pregnancy event. (peertechzpublications.org)
  • The patient performed a hysteroscopy with simultaneous tru-cut biopsy of the lesion under US guidance and a placental site trophoblastic tumor was diagnosed by histological examination. (peertechzpublications.org)
  • Placental Site Trophoblastic Tumor (PSTT) is a rare form of gestational trophoblastic disease accounting for about 1% - 2% of all trophoblastic tumors [1]. (peertechzpublications.org)
  • Gestational trophoblastic diseases (GTD) encompass a spectrum of interrelated conditions: Hydatidiform mole (HM) Invasive mole (IM) Choriocarcinoma (CC) Placental site trophoblastic tumour (PSTT) This article is available only as. (annals.edu.sg)
Choriocarcinoma6
Metastatic7
  • Stage I - Disease confined to the uterus Stage II - GTN extends outside of the uterus, but is limited to the genital structures (adnexa, vagina, broad ligament) Stage III - GTN extends to the lungs, with or without known genital tract involvement Stage IV - All other metastatic sites All types of gestational trophoblastic neoplasia originate from the placenta. (wikipedia.org)
  • This proposed Phase I clinical trial of SON-DP is an FIH, open-label, Phase Ia/Ib dose escalation and expansion study to evaluate the safety, tolerability, PK, and PD of SON-DP in participants with relapsed/refractory/intolerant to standard of care therapies, for advanced/ metastatic solid tumors. (policylab.us)
  • A malignant metastatic form of trophoblastic tumors. (umassmed.edu)
  • 5-day methotrexate for women with metastatic gestational trophoblastic disease. (medscape.com)
  • What is the best protocol of single-agent methotrexate chemotherapy in nonmetastatic or low-risk metastatic gestational trophoblastic tumors? (medscape.com)
  • Roberts JP, Lurain JR. Treatment of low-risk metastatic gestational trophoblastic tumors with single-agent chemotherapy. (medscape.com)
  • The response to treatment is generally favourable but the associated complications of HIV, comorbidities, poor performance status and extent of metastatic disease in gestational trophoblastic neoplasm patients receiving chemotherapy, compromises the outcome and survival. (sun.ac.za)
Myeloproliferative Neoplasms1
  • Myeloproliferative neoplasms (MPNs) are a group of complex blood diseases that often baffle medical professionals due to their intricacy. (lawsuitlegit.com)
Cancer18
  • Gestational trophoblastic neoplasia (GTN) is staged by the American Joint Committee on Cancer (AJCC) and the Féderation Internationale de Gynécologie et d'Obstétrique (FIGO) systems, based on the criteria below (see Table 1). (medscape.com)
  • Current FIGO staging for cancer of the vagina, fallopian tube, ovary, and gestational trophoblastic neoplasia. (medscape.com)
  • Tumors or cancer of the LIVER. (lookformedical.com)
  • Tumors or cancer of the PANCREAS. (lookformedical.com)
  • Tumors or cancer of the SKIN. (lookformedical.com)
  • This study elucidates the effects of the intravenous (IV) lidocaine infusion on the biology of pancreatic circulating tumor cells (CTCs) isolated from patients undergoing robotic pancreatectomy for all types of pancreatic cancer. (policylab.us)
  • Circulating and disseminated tumor cell (CTC/DTC) and circulating cell-free (cf) DNA isolation from the blood, urine and bone marrow will increase understanding of cancer spread and advance knowledge to develop individualized the. (policylab.us)
  • Tumor markers are soluble glycoproteins that are found in the blood, urine, or tissues of patients with certain types of cancer. (medscape.com)
  • Tumor markers are not elevated in all cancer patients, particularly patients with early-stage cancer. (medscape.com)
  • Ovarian cancer, uterine cervical cancer, endometrial cancer, and trophoblastic neoplasms are gynecologic malignancies for which tumor markers are in clinical use. (medscape.com)
  • Because pathologic diagnosis of ovarian cancer is difficult without laparotomy, tumor markers such as CA-125, in addition to diagnostic imaging, are useful in preoperative evaluation for ovarian cancer. (medscape.com)
  • No tumor markers with high sensitivity and high specificity for endometrial cancer are known at present, although CA-125 is often used in clinical practice. (medscape.com)
  • To describe the prevalence of inadequate nutritional status of children and adolescents with malignant neoplasm at hospital admission in childhood cancer reference centers in Brazil. (bvsalud.org)
  • This article focuses on the latest advancements in kidney cancer treatment, providing an insightful perspective on renal cell cancer, transitional cell cancer, and Wilms tumor. (lawsuitlegit.com)
  • Testicular cancer represents 1% of adult neoplasms and 5% of urological tumours, with three to ten new cases per 100,000 males/per year in Western societies [ 6 ]. (uroweb.org)
  • The CAP Cancer Protocols provide guidelines for collecting the essential data elements for complete reporting of malignant tumors and optimal patient care. (cap.org)
  • Three new hematology cancer protocols including Precursor and Mature Lymphoid Malignancies, Myeloid and Mixed / Ambiguous Neoplasms, and Plasma Cell Malignancies. (cap.org)
  • Pancreatic cancer (PC) is a highly aggressive tumor, often difficult to diagnose and treat. (bjbms.org)
Malignant neoplasm2
  • A primary malignant neoplasm of epithelial liver cells. (lookformedical.com)
  • A benign or malignant neoplasm arising from tissues that do not include fluid areas. (mycancergenome.org)
Uterus3
  • Gestational trophoblastic neoplasia (GTN) is group of rare diseases related to pregnancy and included in gestational trophoblastic disease (GTD) in which abnormal trophoblast cells grow in the uterus. (wikipedia.org)
  • Chest x-ray: It may be done if the tumor has spread outside of the uterus. (wikipedia.org)
  • Typically, tumors are confined into the uterus and secrete lower levels of β-hCG compared with other Gestational Trophoblastic Neoplasia (GTN). (peertechzpublications.org)
Pregnancy4
  • Serum tumor marker test: For GTN, the blood is checked for the level of β-hCG, a hormone that is made by the body during pregnancy. (wikipedia.org)
  • Although the most common cause of an elevated HCG level in females is pregnancy, occasionally, a HCG-secreting tumor is suspected and other conditions such as gestational trophoblastic disease (GTD), nontrophoblastic neoplasms, or a pituitary source of HCG, must be considered. (sheppard-arts.com)
  • The co-occurrence of pregnancy and NEOPLASMS. (nih.gov)
  • Gestational trophoblastic neoplasm (GTN) is a rare pregnancy-related disorder with an incidence ranging from 0.12-0.7/1000 pregnancies in Western nations. (sun.ac.za)
Testicular2
  • Suppressed follicle stimulating hormone in men with chorionic gonadotropin secreting testicular tumors. (umassmed.edu)
  • Additional risk factors include a family history of TC among first-degree relatives and the presence of a contralateral testicular tumour or GCNIS [ 15-22 ]. (uroweb.org)
Solid Tumors1
  • Neoplasms originating from the blood or bone marrow (leukemias and myeloproliferative disorders) are not considered solid tumors. (mycancergenome.org)
Etiology1
Germ cell t2
  • This article reports a case of an ovarian mixed germ cell tumour, which presented with bleomycin-associated pulmonary toxicity. (sun.ac.za)
  • The peak incidence is in the third decade of life for non-seminomatous germ cell tumour (NSGCT) and mixed GCT patients, and in the fourth decade for seminoma testis (ST) patients. (uroweb.org)
Abnormal1
  • Abnormal growths of tissue that follow a previous neoplasm but are not metastases of the latter. (lookformedical.com)
Epithelial2
  • It ranges from a well-differentiated tumor with EPITHELIAL CELLS indistinguishable from normal HEPATOCYTES to a poorly differentiated neoplasm. (lookformedical.com)
  • Representative examples include epithelial neoplasms (e.g. lung carcinoma, prostate carcinoma, breast carcinoma, colon carcinoma), and neoplasms arising from the soft tissues and bones (e.g. leiomyosarcoma, liposarcoma, chondrosarcoma, osteosarcoma). (mycancergenome.org)
Mucinous neoplasm1
  • A case report of effusion cytology of a mucinous neoplasm is illustrated. (sun.ac.za)
Cancers1
Metastasis4
  • Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms. (lookformedical.com)
  • Clinical characteristics and treatment of gestational trophoblastic tumor with vaginal metastasis. (medscape.com)
  • Management of liver metastasis from gestational trophoblastic neoplasia. (medscape.com)
  • ASPH appears to be involved in the regulation of proliferation, invasion and metastasis of PC cells through multiple signaling pathways, suggesting its role as a tumor biomarker and therapeutic target. (bjbms.org)
Clinical5
  • There are 5 clinical trials for solid neoplasm, of which 1 is open and 4 are completed or closed. (mycancergenome.org)
  • BRAF is the most frequent gene inclusion criterion for solid neoplasm clinical trials [ 3 ]. (mycancergenome.org)
  • Cbl0137, cudc-907, and allogeneic hematopoietic stem cell transplantation are the most common interventions in solid neoplasm clinical trials. (mycancergenome.org)
  • ABL1 is an inclusion eligibility criterion in 1 clinical trial for solid neoplasm, of which 0 are open and 1 is closed. (mycancergenome.org)
  • A consistent increase in a tumor marker value, combined with lack of clinical improvement, may indicate treatment failure. (medscape.com)
Liver3
  • It has been used to treat hepatic metastases of gastrointestinal adenocarcinomas and for palliation in malignant neoplasms of the liver and gastrointestinal tract. (curehunter.com)
  • Liver neoplasms. (lookformedical.com)
  • Experimentally induced tumors of the LIVER. (lookformedical.com)
Chorionic gonadotropin1
Stromal Tumors2
  • Sex cord-stromal tumors of the ovary are a heterogenous group of relatively rare neoplasms arising from hormone-producing cells of ovarian cortical stroma . (webpathology.com)
  • Mixed sex cord-stromal tumors include Sertoli-Leydig cell tumor, sex cord-stromal tumor, NOS, and gynandroblastoma. (webpathology.com)
Ovary7
  • Current FIGO staging for cancer of the vagina, fallopian tube, ovary, and gestational trophoblastic neoplasia. (medscape.com)
  • 39. Tumor markers in the human ovary and its neoplasms. (nih.gov)
  • Based on their location, germ cell tumors can be classified into intragonadal ( ovary and testis ) or extragonadal ( mediastinum , brain , retroperitoneum , coccyx ). (wikidoc.org)
  • Germ cell tumors develop due to the abnormal growth of the germ cells in the ovary , testis , brain , mediastinum , coccyx , or pelvis . (wikidoc.org)
  • A rare tumor of the female genital tract, most often the ovary, formerly considered to be derived from mesonephric rests. (sdsu.edu)
  • Pure ovarian choriocarcinomas are extremely rare, but represents a component encountered in up to 20% of mixed germ cell tumors of ovary. (surgpath4u.com)
  • The vast majority of the tumors are uilateral, therefore, unilateral salpingo-oopherectomy is usually sufficient if the contralateral ovary and uterus is not involved. (surgpath4u.com)
Recurrence3
  • However, approximately 75% of childhood cancer survivors develop late effects, including problems with growth and development, vital organ function, reproduction, and psychological health, as well as serious complications of secondary neoplasms and recurrence. (medscape.com)
  • Common complications of germ cell tumors include recurrence, lymph node metastasis , distant metastasis , and secondary malignancies . (wikidoc.org)
  • Due to re-recurrence of the tumor, the following decisions had been made: total abdominal hysterectomy, bilateral salpingectomy, right-sided inguinal lymph node biopsy. (hindawi.com)
Benign1
  • Dysembryoplastic neuroepithelial tumor (DNT) is a rare, benign tumor encountered in the cortex. (lookfordiagnosis.com)
Epithelioid trophoblastic tumor1
  • [ 2 ] The modified WHO prognostic scoring system is not applicable to patients with placental-site trophoblastic disease (PSTT) or epithelioid trophoblastic tumor (ETT). (medscape.com)
Human chorionic go3
  • The cause of this disease is unknown but the identification of the tumor based on total beta-human chorionic gonadotropin (β-hCG) in the serum. (wikipedia.org)
  • 38. Tumor-associated antigen levels (carcinoembryonic antigen, human chorionic gonadotropin, and alpha-fetoprotein) antedating the diagnosis of cancer in the Framingham study. (nih.gov)
  • Lab findings include abnormal serum tumor marker levels such as LDH , HCG ( seminoma ), lactate dehydrogenase ( LDH ), human chorionic gonadotropin ( HCG ), CA-125 , and alpha-fetoprotein ( AFP ) ( ovarian germ cell tumors ), alpha fetoprotein ( AFP ) greater than 100 ng/ml ( Endodermal sinus tumor) . (wikidoc.org)
PSTT1
  • Placental side trophoblastic tumor (PSTT) is differentiated by low β-hCG levels because it is a neoplastic proliferation of intermediate trophoblastic cells. (wikipedia.org)
Renal1
  • Two varieties are recognized: (1) clear cell carcinoma, so called because of its histologic resemblance to renal cell carcinoma, and now considered to be of muellerian duct derivation and (2) an embryonal tumor (called also ENDODERMAL SINUS TUMOR and yolk sac tumor), occurring chiefly in children. (sdsu.edu)
Group of neoplasms1
  • Amongst them, pediatric cancers and rare hematologic neoplasms are often covered by dedicated educational events, while rare adult solid cancers are hardly grouped together and approached as a collective group of neoplasms. (eso.net)
Neoplastic1
  • 8. "Inappropriate" secretion of TSH, which may be present either in patients with TSH- producing pituitary tumors (TSHomas) or from a non-neoplastic cause, i.e. pituitary resistance to the action of thyroid hormone (3,4). (nih.gov)
Chemotherapy7
  • Although this group of diseases are highly susceptible to chemotherapy, prognosis depends on the type of GTN and whether the tumor has spread to other areas of the body. (wikipedia.org)
  • Surgery along with chemotherapy are the mainstay of treatment depending on the staging of the tumor . (wikidoc.org)
  • The tumor recurred despite the patient undergoing chemotherapy. (hindawi.com)
  • BEP regimen (bleomycin, etoposide, cisplatin) used in the manner described for germ cell tumors is preferred by some as an alternative chemotherapy protocol(Corakç). (surgpath4u.com)
  • Phase II and Phase III clinical trials are conducted evaluating primary surgery, irradiation chemotherapy and immunotherapy in virtually every gynecologic tumor by site, stage and grade of disease. (arizona.edu)
  • Braly, PS, Rettenmaier MA, DiSaia PJ: Depressed natural killer cell activity in tumor bearing rats: Effect of immunotherapy and cytoreductive chemotherapy. (scgynoncology.com)
  • 3. Stratton JA, Rettenmaier MA, Berman ML, DiSaia PJ: The response of gynecologic tumors to chemotherapy: Correlation of the chemosensitivity predicted by the subrenal capsule implant assay with the clinical response of the patients. (scgynoncology.com)
CHORIONIC VILLI2
  • As a contrast, CC is a malignant tumor without chorionic villi, abnormal syncytiotrophoblast and cytotrophoblast, necrosis, and hemorrhage [ 9 ]. (hindawi.com)
  • Definition: Focal hydropic swelling of chorionic villi with trophoblastic hyperplasia and identifiable embryonic or fetal tissues. (ibis-birthdefects.org)
Ovarian Tumors1
  • They make up approximately 8% of all ovarian tumors and are the most common ovarian tumors with endocrine manifestations . (webpathology.com)
Metastasis1
  • Evaluation of surgical resection of pulmonary metastasis of trophoblastic tumour]. (nih.gov)
Gestational and non-gestational2
  • Gestational and Non-gestational Trophoblastic Disease. (thieme-connect.de)
  • The aim was to standardize diagnostic procedures and the management of gestational and non-gestational trophoblastic disease in accordance with the principles of evidence-based medicine, drawing on the current literature and the experience of the colleagues involved in compiling the guideline. (thieme-connect.de)
Embryonal4
  • A dermoid cyst is an ovarian tumor of undefined origin that consists of undifferentiated embryonal cells. (rnpedia.com)
  • Neoplasms, Germ Cell and Embryonal" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (sdsu.edu)
  • This graph shows the total number of publications written about "Neoplasms, Germ Cell and Embryonal" by people in this website by year, and whether "Neoplasms, Germ Cell and Embryonal" was a major or minor topic of these publications. (sdsu.edu)
  • Below are the most recent publications written about "Neoplasms, Germ Cell and Embryonal" by people in Profiles. (sdsu.edu)
Markers8
  • 25. Tumour markers in gynaecologic oncology. (nih.gov)
  • 26. Tumor markers: how useful are they? (nih.gov)
  • 28. The role of tumor markers in gynecologic oncology. (nih.gov)
  • 29. Clinical use of gynaecologic tumour markers. (nih.gov)
  • 36. [The place of tumor markers in breast and gynecologic neoplasms]. (nih.gov)
  • 40. [Diagnostic significance of tumor markers for gynecologic malignancies]. (nih.gov)
  • Whereas, in gestational trophoblastic neoplasm (GTD) only few markers have been studied, and some correlated with progression. (bmj.com)
  • Angiogenesis factors may have a prognostic role to play in patients with gynecological cancers and should continue to be investigated as clinically useful tumor markers. (bmj.com)
Brain Tumors1
  • Due to its mixed nature (glial-neuronal), WHO histological classification of brain tumors included it into the group of neuronal and glial-neuronal mixed tumors. (lookfordiagnosis.com)
Disease7
  • Gestational Trophoblastic Disease: Current Evaluation and Management. (medscape.com)
  • Although risk factors may impact on the development of the tumor, most do not directly cause of disease. (wikipedia.org)
  • Gestational trophoblastic disease: treatment results at the Brewer Trophoblastic Disease Center. (nih.gov)
  • C138190 CTS-API Disease Main Type Terminology C3088 Angiosarcoma A malignant tumor arising from the endothelial cells of the blood vessels. (nih.gov)
  • Dr. Diaz diagnoses gestational trophoblastic disease and orders ultrasonography. (rnpedia.com)
  • In a client with gestational trophoblastic disease, an ultrasound performed after the 3rd month shows grapelike clusters of transparent vesicles rather than a fetus. (rnpedia.com)
  • The group is currently expanding its efforts to study such questions as the impact of hormonal vs. barrier contraception in gestational trophoblastic disease. (arizona.edu)
Gonads2
  • Neoplasms composed of primordial GERM CELLS of embryonic GONADS or of elements of the germ layers of the EMBRYO, MAMMALIAN. (sdsu.edu)
  • The concept does not refer to neoplasms located in the gonads or present in an embryo or FETUS. (sdsu.edu)
Classification2
  • 2. WHO Classification of Tumors. (webpathology.com)
  • The pattern-based (Silva) classification of invasive HPV-associated endocervical adenocarcinomas (HPVA) is an established and reproducible method to predict outcomes for this otherwise stage-dependent group of tumors. (stanford.edu)
Embryonic1
  • and nongermminomatous/ differentiated which include embryonic and extra-embryonic germ cell tumors. (wikidoc.org)
Necrosis1
  • Moreover, the tumor cells had polygonal nuclei with moderate nuclear pleomorphism and were surrounded by extensive necrosis. (hindawi.com)
Malignant tumor1
  • Malignant Epithelioma A malignant tumor arising from epithelial cells. (nih.gov)
Prognosis1
  • Depending on the type, location, and the extent of the tumor at the time of diagnosis , the prognosis may vary. (wikidoc.org)
Clinical5
  • This Course is aimed at dealing with them on an annual basis, to provide the community of clinical oncologists specialising in these tumors with a regular update of recent advances in this specific area. (eso.net)
  • For this reason, the European Faculty of this Course is asked to focus on most recent advances always trying to put them into the context of state-of-the-art treatment of these tumors, with a special view to ESMO Clinical Practice Guidelines. (eso.net)
  • The two neoplasms are histologically identical, thus, one must review the clinical history. (surgpath4u.com)
  • Basing on clinical manifestation and histopathological findings dysembryoplastic neuroepithelial tumor was diagnosed. (lookfordiagnosis.com)
  • Dr. Howitt is a gynecologic and sarcoma pathologist, with academic interests in gynecologic mesenchymal tumors and morphologic and clinical correlates of molecular alterations in gynecologic neoplasia. (stanford.edu)