Trophoblastic tumor placental site. Medical search. Frequent questions

26. Ki-67 labeling index in the differential diagnosis of exaggerated placental site, placental site trophoblastic tumor, and choriocarcinoma: a double immunohistochemical staining technique using Ki-67 and Mel-CAM antibodies. (nih.gov)
Embryonic germ cell tumors include teratoma , and extraembryonic germ cell tumors include Choriocarcinoma and Yolk sac tumor . (wikidoc.org)
These tumors include postmolar gestational trophoblastic neoplasia (gestational trophoblastic neoplasia that develops after a molar pregnancy), placental-site trophoblastic tumor, epithelioid trophoblastic tumor, choriocarcinoma, and invasive mole. (msdmanuals.com)
Yes, there are different subtypes of GTN: invasive mole, choriocarcinoma, placental site trophoblastic tumor (PSTT) and epithelioid trophoblastic tumor (ETT). (isuog.org)
We present a complicated case of recurrence of gestational trophoblastic neoplasms (GTN), mixed ETT and choriocarcinoma at an abdominal cesarean scar. (hindawi.com)
This tumor consisted of typical morphologic and immunophenotypic features of ETT and choriocarcinoma. (hindawi.com)
Gestational trophoblastic neoplasms (GTN) are a group of neoplasms from fetal trophoblastic cells including choriocarcinoma (CC), epithelioid trophoblastic tumors (ETT), and placental site trophoblastic tumors (PSTT) [ 1 ]. (hindawi.com)
GTDs encompass hydatidiform mole (HM) (complete and partial), invasive mole, gestational choriocarcinoma, placental-site trophoblastic tumor, and epithelioid trophoblastic tumor. (nih.gov)
It includes hydatidiform mole, invasive mole, choriocarcinoma and placental site trophoblastic tumor. (unime.it)
Gestational trophoblastic neoplasia (GTN) refers to the subgroup of these trophoblastic or placental tumors with malignant behavior and includes postmolar GTN, invasive mole, gestational choriocarcinoma, placental-site trophoblastic tumor (PSTT), and epithelioid trophoblastic tumor. (medscape.com)
The dataset has been developed for the pathology reporting of resection specimens for primary uterine gestational trophoblastic neoplasia which includes invasive hydatidiform mole of either complete or partial type, gestational choriocarcinoma, placental site trophoblastic tumour and epithelioid trophoblastic tumour. (iccr-cancer.org)
These can range from traumas suffered by the mother, such as those from car accidents or falls ( 7,8) , to obstetrical procedures (such as antepartum umbilical cord blood sampling, external cephalic version, amniocentesis or chorionic villus biopsy) or obstetrical complications (placental abruption, placenta praevia , vasa praevia , choriocarcinoma, fetal death). (medichub.ro)
These tumors appear to arise from a pluripotent germ cell capable of differentiating into embryonic structures (teratoma and embryonal carcinoma), placental structures (yolk-sac tumor and choriocarcinoma) or seminoma (the most primitive germ cell tumor). (health.am)

Introduction: The placental site trophoblastic tumor (PSTT), is a rare tumor in the gestational trophoblastic diseases (GTD) group, a heterogeneous group of interrelated lesions with a common factor: the abnormal proliferation of the trophoblast epithelium of the placenta. (sogr.ro)
27. Placental site trophoblastic tumor (PSTT): a case report and review of the literature. (nih.gov)
1) GTD: Gestational trophoblastic disease, (2) GTT: Gestational trophoblastic tumor, (3) GTN: Gestational trophoblastic neoplasia, (4) PSTT: Placental site trophoblastic tumor. (wjols.com)
Curability rate 100% was achieved in stage I & II and all placental site trophoblastic tumours (PSTT), 98.3% in stage III and 50% stage IV. (cs-gynekologie.cz)
The incidence of other gestational trophoblastic neoplasia in the same years was for PSTT one in 533 753 pregnancies and one in 372 422 deliveries, invasive mole one in 145 611 pregnancies and one in 101 569 deliveries, and persistent GTN one in 40 043 pregnancies and one in 27 932 deliveries. (cs-gynekologie.cz)

Gestational trophoblastic disease (GTD) is a group of conditions that originate from the abnormal hyperproliferation of trophoblastic cells, which derive from the trophectoderm, the outer layer of the blastocyst that would normally develop into the placenta during pregnancy. (nih.gov)
GTD tumors originate in the trophoblast, the cells surrounding the embryo that develop into a placenta during a pregnancy. (cumedicine.us)
Trophoblastic tissue is responsible for formation of the placenta during pregnancy. (medscape.com)
Placental studies have shown a higher risk of high-volume hemorrhages associated with a less favorable clinical outcome for the fetus if the placenta presented villous edema, if nucleated red blood cells were found in the fetal vessels (nucleated erythrocytes can be found in fetal circulation normally, but are identified especially in growth restriction and fetal hypoxemia), and in the case of villous immaturity ( 4-6) . (medichub.ro)
Human placental proteins are proteins derived from the placenta, an organ that develops during pregnancy to support the growth and development of the fetus. (imarcgroup.com)
I have now exploited these peptides to create novel nanocarriers for targeted delivery of drugs to the placenta, and novel placental-specific therapeutics. (manchester.ac.uk)

An invasive mole is a hydatidiform mole which is invasive and has excessive trophoblastic proliferation. (greek.doctor)
Invasive implants and postoperative residual tumors were significantly associated with shorter disease-free survival. (bvsalud.org)
Successful laparoscopic bipolar coagulation of a large arteriovenous malformation due to invasive trophoblastic disease: A case report. (wjols.com)
Secondly, we showed that the HTR-8/SVneo trophoblastic cell line's invasive ability was low in the presence of conditioned media from ESCs cultured with sPIF. (biomedcentral.com)

Germ cell tumors develop due to the abnormal growth of the germ cells in the ovary , testis , brain , mediastinum , coccyx , or pelvis . (wikidoc.org)
Lab findings include abnormal serum tumor marker levels such as LDH , HCG ( seminoma ), lactate dehydrogenase ( LDH ), human chorionic gonadotropin ( HCG ), CA-125 , and alpha-fetoprotein ( AFP ) ( ovarian germ cell tumors ), alpha fetoprotein ( AFP ) greater than 100 ng/ml ( Endodermal sinus tumor) . (wikidoc.org)
Abnormal serum tumor marker levels ( LDH , HCG ). (wikidoc.org)
The placental tissue is abnormal, and fetal tissue does not form. (msdmanuals.com)
A partial molar pregnancy may contain normal placental tissue with abnormal placental tissue. (msdmanuals.com)
As a contrast, CC is a malignant tumor without chorionic villi, abnormal syncytiotrophoblast and cytotrophoblast, necrosis, and hemorrhage [ 9 ]. (hindawi.com)
Gestational trophoblastic disease (GTD) is a group of diseases in which abnormal growths of tissue or tumors occur in the uterus, specifically in the layer of cells surrounding an embryo called the trophoblast that joins the sperm and the egg. (cumedicine.us)
Gestational trophoblastic disease (GTD) is a collection of abnormal cell growths and tumors within the cells of a woman's uterus. (cumedicine.us)
Gestational trophoblastic disease (GTD), a group comprising benign (hydatidiform moles) and malignant tumors, occurs when gestational trophoblastic tissue behaves in an abnormal manner. (medscape.com)
The placental tissue grows but is abnormal and contains fluid-filled cysts (or tumors). (clevelandclinic.org)
Abnormal extrauterinre sites: implantation takes place outside the uterus, resulting in extrauterine pregnancy, or ectopic pregnancy. (slideshare.net)

39. Diagnosis and management of gestational trophoblastic disease: 2021 update. (nih.gov)
The aim was to standardize diagnostic procedures and the management of gestational and non-gestational trophoblastic disease in accordance with the principles of evidence-based medicine, drawing on the current literature and the experience of the colleagues involved in compiling the guideline. (thieme-connect.de)
The aim of this study is to evaluate the role of minimal access surgical procedures like laparoscopy, hysteroscopy and robotic surgery in the management of gestational trophoblastic tumors. (wjols.com)
Place of surgery in the management of gestational trophoblastic tumours. (wjols.com)
The role of adjuvant surgery in the management of gestational trophoblastic neoplasia. (wjols.com)

21. Clinical characteristics and outcomes of extrauterine epithelioid trophoblastic tumors. (nih.gov)
37. A Case Series of Five Patients With Pure or Mixed Gestational Epithelioid Trophoblastic Tumors and a Literature Review on Mixed Tumors. (nih.gov)

After a complete hydatidiform mole, approximately 15 to 20% of patients are treated for gestational trophoblastic neoplasia. (msdmanuals.com)
Nica A, Bouchard-Fortier G, Covens A. Gestational trophoblastic disease: hydatidiform mole, nonmetastatic and metastatic gestational trophoblastic tumor: diagnosis and management. (medlineplus.gov)
A molar pregnancy (also known as a hydatidiform mole) is a type of gestational trophoblastic disease (GTD). (tobago-bay.de)

Gestational trophoblastic disease is proliferation of trophoblastic tissue in pregnant or recently pregnant women. (msdmanuals.com)
General references Gestational trophoblastic disease is proliferation of trophoblastic tissue in pregnant or recently pregnant women. (msdmanuals.com)
Gestational Trophoblastic Neoplasia (GTN) is a malignant tumor originating from placental tissue from a previous pregnancy. (isuog.org)
GTN develops from trophoblastic tissue, made of trophoblast cells that normally surround the fertilized egg in the uterus. (isuog.org)
In most cases, only placental tissue forms with gestational trophoblastic disease. (medlineplus.gov)
Due to an imbalance in the number of chromosomes supplied from the mother and the father, the placental tissue grows abnormally and forms a tumour, leading to a malignant cancer in approximately 15 to 20 per cent of cases. (rimuhc.ca)
The diagnosis of germ cell tumor of the testis requires histopathologic examination of tissue obtained from an orchiectomy specimen. (health.am)

Our study aimed to analyze the prognosis and reproductive outcomes of patients with advanced-stage serous borderline ovarian tumors (SBOTs) who underwent fertility-sparing surgery (FSS). (bvsalud.org)
The cytokeratin 17 expression in primary ovarian tumors has diagnostic but not prognostic significance. (patologia.ro)

Based on their location, germ cell tumors can be classified into intragonadal ( ovary and testis ) or extragonadal ( mediastinum , brain , retroperitoneum , coccyx ). (wikidoc.org)
Histologically , Germ cell tumors can be classified as germinomatous/ undifferentiated germ cell tumors which include, dysgerminoma and seminoma . (wikidoc.org)
and nongermminomatous/ differentiated which include embryonic and extra-embryonic germ cell tumors. (wikidoc.org)
The name of a germ cell tumor came from the word (germinate), which means to begin to grow. (wikidoc.org)
World health organization (WHO) classified germ cell tumors into 7 types based on histology . (wikidoc.org)
The cause of germ cell tumors development is not fully understood but some causes include, genetic mutations , cryptorchidism , undescended testes , trauma , mumps , maternal estrogen exposure. (wikidoc.org)
Common risk factors include Caucasian race , Family history or personal history of germ cell tumor, Klinefelter syndrome . (wikidoc.org)
Symptoms and signs of germ cell tumors depend on the type and location of the tumor . (wikidoc.org)
Common complications of germ cell tumors include recurrence, lymph node metastasis , distant metastasis , and secondary malignancies . (wikidoc.org)
CT , MRI , and ultrasound are used in combination with biopsy to distinguish between the types and subtypes of germ cell tumors and for diagnosis confirmation. (wikidoc.org)
Non-gestational trophoblastic tumours (germ cell or somatic origin) and metastatic tumours are excluded from this dataset. (iccr-cancer.org)
Germ cell tumors of the testis are the most common cancer in young men between the ages of 15 and 35 years. (health.am)
Germ cell tumors of the testis represent greater than 90% of all tumors of the testis. (health.am)
Other malignancies of the testis include lymphoma (the most common non-germ cell cause of testicular malignancy in elderly men), metastatic cancer or leukemia, tumors of the testicular stroma, and other rare tumors. (health.am)
Because the tumor may contain histologic mixtures of several germ cell elements, it is essential that a total orchiectomy specimen plus a generous margin of spermatic cord be provided the pathologist. (health.am)
Occasionally extragonadal germ cell tumors may present within the mediastinum or retroperitoneum without an identifiable testicular tumor. (health.am)
Ultrasonography of the testes should be performed in the event that there is doubt about which testis may harbor the tumor, that bilateral tumors are suspected, or that there is an extragonadal presentation of a germ cell tumor. (health.am)
The availability of sensitive serum assays for α fetoprotein (AFP) and for the β-subunit of human chorionic gonadotropin (β-HCG) has markedly enhanced the accurate and aggressive management of patients with germ cell tumors. (health.am)

Advances in management of high-risk gestational trophoblastic tumors. (wjols.com)
According to prognostic scoring and staging system FIGO/WHO 56 (75%) patients had low-risk gestational trophoblastic neoplasia and 19 (25%) of patients had high-risk gestational trophoblastic neoplasia. (cs-gynekologie.cz)

Gestational trophoblastic neoplasias are malignant placental tumors. (msdmanuals.com)

A placental site trophoblastic tumor is a monophasic neoplasm of the implantation site intermediate trophoblast, and usually a benign lesion, which comprises less than 2% of all gestational trophoblastic proliferations. (wikipedia.org)
It is important to differentiate from the benign placental-site nodule, which is also composed of intermediate trophoblast cells. (medscape.com)
Hydatiform moles are benign placental tumors with malignant potential. (msdmanuals.com)

Sampling and Definitions of Placental Lesions: Amsterdam Placental Workshop Group Consensus Statement. (nih.gov)

Matherials and Methods: The authors of this article are reporting a case of placental site trophoblastic tumor in 39 year old woman, complaining of vaginal bleeding. (sogr.ro)

Tumors are removed by suction curettage. (msdmanuals.com)

40. Linear regression of postevacuation serum human chorionic gonadotropin concentrations predicts postmolar gestational trophoblastic neoplasia. (nih.gov)

24. Coexisting epithelioid trophoblastic tumor and placental site trophoblastic tumor of the uterus following a term pregnancy: report of a case and review of literature. (nih.gov)
31. A malignant placental site trophoblastic tumor of the uterus with multiple metastases: A case report of a rare tumor showing an aggressive behavior. (nih.gov)
GTD often involves a tumor forming in the uterus rather than a fetus. (cumedicine.us)
Placental-site trophoblastic tumor is a rare form of GTD caused by placental attachment to the lining of the uterus. (cumedicine.us)
Gestational trophoblastic disease (GTD) is a group of conditions that cause tumors to grow in your uterus . (clevelandclinic.org)
Gestational trophoblastic disease (GTD) is a group of pregnancy-related conditions that develop inside a woman's uterus (womb). (medlineplus.gov)

Most women with gestational trophoblastic neoplasia (GTN) receive their diagnosis during their reproductive years. (medscape.com)
Conclusions:Considering these results, the diagnosis of placental site trophoblastic tumor has been established. (sogr.ro)
Depending on the type, location, and the extent of the tumor at the time of diagnosis , the prognosis may vary. (wikidoc.org)
Placental site trophoblastic tumour presenting as an intramural mass with negative markers: An opportunity for novel diagnosis and treatment with robotic hysterectomy. (wjols.com)
Value of hysteroscopy and laparoscopy in differential diagnosis of gestational trophoblastic neoplasia. (wjols.com)
Squamous and Glandular Epithelial Tumors of the Cervix: A Pragmatical Review Emphasizing Emerging Issues in Classification, Diagnosis, and Staging. (patologia.ro)

Hysteroscopy provides proof of trophoblastic tumours in three cases with negative color Doppler images. (wjols.com)
A review of the management of hysterectomy of 25 cases of gestational trophoblastic tumours from March 1993 to january 2006. (wjols.com)

Current WHO/International Federation of Gynecology and Obstetrics prognostic scoring system for gestational trophoblastic disease. (medscape.com)
Prior Charing Cross prognostic scoring system for gestational trophoblastic disease. (medscape.com)
38. Placental site trophoblastic tumor and epithelioid trophoblastic tumor: Clinical and pathological features, prognostic variables and treatment strategy. (nih.gov)
Horizontal tumor extent (HZTE) has limited prognostic significance in 2018 FIGO stage I endocervical adenocarcinoma (ECA): a retrospective study of 416 cases. (patologia.ro)
Retrospective analysis results of gestational trophoblastic neoplasia treatment according to prognostic scoring and staging system FIGO/WHO in Centre for gestational trophoblastic disease Ministry of Health the Slovak Republic Bratislava in the years 1993-2012. (cs-gynekologie.cz)

My postdoctoral research focused on how placental-derived trophoblast cells and uterine natural killer cells interact with and remodel the uterine spiral arteries during pregnancy. (manchester.ac.uk)

Surgery along with chemotherapy are the mainstay of treatment depending on the staging of the tumor . (wikidoc.org)
The tumor recurred despite the patient undergoing chemotherapy. (hindawi.com)
METHODS: This study recruited premenopausal women aged 15 to 45 with a newly diagnosed low-risk gestational trophoblastic neoplasia needing actinomycin D. AMH was measured at baseline, during chemotherapy, and 1, 3, and 6 months after the last chemotherapy. (bvsalud.org)
Background: Synergistic antitumor effects of immunotherapy and chemotherapy have been demonstrated in several solid tumors. (bvsalud.org)
Braly, PS, Rettenmaier MA, DiSaia PJ: Depressed natural killer cell activity in tumor bearing rats: Effect of immunotherapy and cytoreductive chemotherapy. (scgynoncology.com)
3. Stratton JA, Rettenmaier MA, Berman ML, DiSaia PJ: The response of gynecologic tumors to chemotherapy: Correlation of the chemosensitivity predicted by the subrenal capsule implant assay with the clinical response of the patients. (scgynoncology.com)

20-38% of women with unexplained high MS-AFP (ie, in the absence of fetal abnormality) suffer adverse pregnancy outcomes (premature birth, preeclampsia, 2-4 x IUGR, 10 x perinatal mortality, 10 x placental abruption)! (radiologykey.com)
Spontaneous fetomaternal hemorrhage is defined as the transfer of fetal blood into the maternal circulation that occurs without any trauma history and in the absence of clinical or histopathological evidence of placental abruption. (medichub.ro)

Women with GTN after a non-molar pregnancy usually experience vaginal bleeding or more rarely symptoms from metastatic sites, such as cough or headache. (isuog.org)

These tumors may be found on the uterine fundus, lower uterine segment, endocervix, and the broad ligament [ 1 ]. (hindawi.com)
The tumour appears as an irregular haemorrhagic growth in the uterine walls. (greek.doctor)

Mutants of Ras are found in 25-30% of human tumors. (embl.de)

These technologies have facilitated the discovery of novel placental proteins with therapeutic potential, providing an impetus for the market growth. (imarcgroup.com)
I spent 2011 working as a Visiting Fellow in the laboratory of Professor Erkki Ruoslahti at The Sanford Burnham Institute, UC Santa Barbara USA, where I identified a series of novel placental homing peptides. (manchester.ac.uk)

The tumor may secrete human placental lactogen, and result in a false-positive pregnancy test. (wikipedia.org)
Gestational trophoblastic disease can occur during or after an intrauterine or ectopic pregnancy. (msdmanuals.com)
Women with GTN are classified into low-risk and high-risk groups based on pre-treatment variables including tumor volume and activity, age, and type of antecedent pregnancy. (isuog.org)
A molar pregnancy occurs when an egg and sperm join incorrectly at fertilization and create a noncancerous tumor. (clevelandclinic.org)
The tumor can't support a developing embryo and the pregnancy ends. (clevelandclinic.org)
Molar pregnancy is the most common form of all placental diseases (or trophoblastic diseases). (rimuhc.ca)
This Special Issue of the International Journal of Molecular Sciences aims at providing novel insights into the mechanisms of embryo implantation and placental development as well as at giving an overview of our current knowledge on the different signaling pathways regulating the early steps of implantation and placentation and on the pathological alterations which may impair the establishment of a physiological pregnancy. (mdpi.com)

Gestational trophoblastic disease begins in the layer of cells surrounding an embryo called the trophoblast that joins the sperm and the egg. (cumedicine.us)
Human embryo implantation is a multistep process that begins with the apposition of trophoblastic cells from a competent blastocyst against the maternal endometrium. (biomedcentral.com)

Although about 90% of early-stage patients can be cured by surgery, advanced-stage patients still need new treatment methods to improve their efficacy, especially for those with recurrence and metastasis tumors. (bvsalud.org)

Due to histologic examination, tumour cells have been observed, that were large with polygonal or rounded shape, infiltrative into the myometrium in clusters or singly. (sogr.ro)

Due to re-recurrence of the tumor, the following decisions had been made: total abdominal hysterectomy, bilateral salpingectomy, right-sided inguinal lymph node biopsy. (hindawi.com)
Laparoscopic hysterectomy for persistent gestational trophoblastic noeplasia. (wjols.com)

Definition: Focal hydropic swelling of chorionic villi with trophoblastic hyperplasia and identifiable embryonic or fetal tissues. (ibis-birthdefects.org)

Gestational trophoblast neoplasia (GTN) is a malignant type of gestational trophoblastic disease, a condition caused by pathological proliferation of trophoblasts. (greek.doctor)

As a consequence, representative incisional biopsy rather than wholesale excision of these frequently bulky tumors is sufficient to guide therapeutic recommendations. (health.am)

Non-villous forms of gestational trophoblastic disease]. (nih.gov)

This is a rare, slow-growing form of GTD that has been proposed to arise from the intermediate trophoblasts at the implantation site. (medscape.com)

Analysis and epidemiology of gestational trophoblastic neoplasia treatment in the Slovak Republic in the years 1993-2012. (cs-gynekologie.cz)

This occurs when there is a discontinuity in the placental barrier, and there are multiple possible causes implicated. (medichub.ro)

A mouse homologue of the Drosophila tumor suppressor l(2)tid gene defines a novel Ras GTPase-activating protein (RasGAP)-binding protein. (embl.de)
Here we report the cloning and characterization of a novel GAP-binding protein, mTid-1, a DnaJ chaperone protein that represents the murine homolog of the Drosophila tumor suppressor l(2)tid gene. (embl.de)

Instead they form a tumor that looks like a cluster of grapes. (cumedicine.us)
The tumor looks like tiny water-filled sacs, similar to a cluster of grapes. (clevelandclinic.org)

Anatomy3

Diseases8

Chemicals and Drugs3

Analytical, Diagnostic and Therapeutic Techniques and Equipment3

Phenomena and Processes2

Choriocarcinoma13

PSTT5

Placenta6

Invasive4

Abnormal11

Management of gestational5

Epithelioid Trophoblastic Tumors2

Hydatidiform3

Tissue7

Ovarian tumors2

Germ18

High-risk gestational2

Gestational trophoblastic neoplasias1

Benign3

Lesions1

Case of placental1

Curettage1

Postmolar gestational1

Uterus6

Diagnosis6

Tumours2

Prognostic5

Trophoblast cells1

Chemotherapy6

Abruption2

Metastatic1

Uterine2

Human Tumors1

Novel placental2

Pregnancy7

Embryo2

Metastasis1

Histologic1

Hysterectomy2

Chorionic villi1

Pathological1

Biopsy1

Villous1

Implantation1

Epidemiology1

Occurs1

Suppressor2

Cluster of grapes2