Trophoblast glycoprotein. Medical search. Frequent questions

CD146 is a 118 kDa transmembrane glycoprotein also known as MCAM, MUC18, or Mel-CAM. (bdbiosciences.com)
TROP2 (trophoblast cell-surface antigen 2) is a transmembrane glycoprotein that is highly expressed on several types of solid tumors. (adcreview.com)
Background: Trophoblast cell surface antigen 2 (Trop2) is a transmembrane glycoprotein and promising biomarker for diagnosis and prognosis and a potential target for treatment. (clinicsinsurgery.com)
CD62L antibody, clone DREG56, recognizes CD62L, also known as L-selectin or LECAM-1, a 74-95 kDa type I transmembrane glycoprotein and cell adhesion molecule expressed on most circulating leukocytes1. (assaygenie.com)
The transmembrane glycoprotein, nicastrin, is associated with presinilins and has been found to bind to the carboxyl-terminus of beta APP and helps to modulate the production of the amyloid beta peptide. (thermofisher.com)

The human trophoblast cell surface antigen 2 (TROP2), which is also called tumor-associated calcium signal transduction-2 (TACSTD-2), is a surface glycoprotein encoded by TACSTD. (nanoworld.com)
Evidence for a novel HLA antigen found on human extravillous trophoblast and a choriocarcinoma cell line. (ox.ac.uk)
This antigen is an electrophoretically non-polymorphic glycoprotein of approximately 40,000 molecular weight, which is found in association with beta 2 microglobulin, and which is detected by monoclonal antibodies recognizing monomorphic determinants of HLA Class I. Elucidation of the nature and origin of this molecule may provide valuable information regarding the immune barrier that exists between mother and fetus. (ox.ac.uk)
Controversy and debate surround the role of the non-classic human lymphocyte antigen (HLA) class I molecule HLA-G. 1, 2 Initially, the expression of HLA-G was reported to occur only in a limited subset of trophoblast cells at the fetal-maternal interface. (bmj.com)

To determine whether trophoblast can facilitate invasion of the uterus by degrading components of normal uterine extracellular matrix, mouse blastocysts were cultured on a radio-labeled extracellular matrix that contained glycoproteins, elastin, and collagen. (rupress.org)
In mammals, the egg is protected by a layer of extracellular matrix consisting mainly of glycoproteins called the zona pellucida . (opentextbc.ca)

hCG is a 36.7kDa glycoprotein produced by the trophoblast tissue of the placenta in pregnancy and at a number of other sites in malignant conditions. (ibms.org)
Human chorionic gonadotropin is a glycoprotein secreted by trophoblast cells of placenta. (kangyuan.com.cn)
These antibodies interfere with uterine blood flow, more specifically the development of the trophoblast, which are the cells that form the placenta. (toronto-fertility.com)
Microarray-based global gene expression analyses on bovine placenta and trophoblast cells suggest that the expression profiles of specific genes depend on the cells and tissues in which they are expressed as well as the time of the gestation period. (bioone.org)
Specifically, the shallow invasion of the placenta is an important factor in PE, as it causes long-term ischemia and hypoxia in trophoblasts. (hindawi.com)

Human chorionic gonadotropin (HCG) has great reference value in the diagnosis and differentiation of pregnancy, trophoblast cell tumor and other diseases. (kangyuan.com.cn)
Pregnancy-specific glycoprotein 1 (PSG1) is a recently identified gal-1 ligand at the maternal-fetal interface, which may facilitate a successful pregnancy. (bvsalud.org)
This custom-made microarray revealed that trophoblast-specific genes such as placental lactogen, pregnancy-associated glycoproteins, prolactin-related proteins, and those of the sulfotransferase family were mainly expressed in the trophoblast giant cells and that their expression increased as gestation progressed. (bioone.org)
The PAG (Pregnancy-Associated Glycoproteins) gene family and chorionic expressions of their products suggest an important role(s) of this glycoprotein family throughout pregnancy in various mammals (pig, cattle, sheep, goat, hourse, zebra, cat and mouse). (edu.pl)

Notably, differential placental glycosylation through the Sda-capped N-glycans dominates the invasive trophoblast capacity triggered by maternal-derived gal-1. (bvsalud.org)
These factors include lopinavir plasma protein binding and uptake, cellular binding, and efflux of lopinavir in the placental trophoblast cells. (vcu.edu)

The aCL antibodies bind to b2GPI, or a complex formed by this b2GPI is a platelet adhesin glycoprotein and cardiolipin. (medscape.com)

During implantation the embryo attaches to the endometrial surface and trophoblast traverses the uterine epithelium, anchoring in the uterine connective tissue. (rupress.org)
Background 5T4, also known as trophoblast glycoprotein, is expressed in many solid cancers, including non-small cell lung cancer, triple-negative breast cancer, bladder, esophageal, prostate, uterine and head and neck squamous cell carcinomas (HNSCCs). (bmj.com)

Four transcript variants encoding three different isoforms (a proteoglycan, glycoprotein and cell surface protein) [2] have been found for this gene. (meddic.jp)

CD146 is also expressed by angioblasts, mesenchymal stem cells, melanoma cells, intermediate trophoblasts and a subpopulation of activated T cells. (bdbiosciences.com)
By day 7 there were areas where individual trophoblast cells had separated from one another, revealing the underlying substratum that was cleared of matrix. (rupress.org)
When trophoblast cells were lysed with NH(4)OH on day 8, it was apparent that the area underneath the trophoblast outgrowth had been cleared of matrix. (rupress.org)
Here the cells in the blastula arrange themselves in two layers: the inner cell mass , and an outer layer called the trophoblast . (opentextbc.ca)
The expression patterns of two genes only expressed in ESCd >40 and ESCd >70 cells (GABRP and VTCN1), one gene expressed strongly in PHTd cells (PSG4), and a fourth (KRT7) expressed more generally in trophoblast were confirmed by quantitative PCR (qPCR) (SI Appendix, Fig. S8). (ack1inhibitor.com)
Despite thefact that ESCd >70 and PHTd cells express a host of gene markers consistent with a trophoblast identity and lack gene signatures for the three main germ-line lineages, they are clearly distinct sorts of cell. (ack1inhibitor.com)
www.pnas.org/cgi/doi/10.1073/pnas.Discussion In this paper, we describe a characterization of the syncytial areas that emerge when human pluripotent stem cells differentiate along the trophoblast lineage. (ack1inhibitor.com)

Next, we examined lopinavir uptake, binding and efflux using the BeWo human trophoblast cell culture model. (vcu.edu)

In addition, proteome profiles had been in comparison with gene expression profiles previously generated from isolated EVT and CTB primary trophoblast populations [38]. (nrtisinhibitor.com)

The composition of human chorionic gonadotropin is composed of two glycoproteins, which are alpha and beta dimers respectively. (kangyuan.com.cn)
First, we determined the unbound fraction of lopinavir in cord blood and characterized the binding of lopinavir to α1-acid glycoprotein (AAG) and human serum albumin (HSA), and displacement by ritonavir. (vcu.edu)
CD62L is also expressed on human embryo trophoblasts and has been proposed to play a role in human embryo implantation4. (assaygenie.com)

Anti-phospholipid antibodies include: lupus anticoagulant, anticardiolipin antibody, and anti-B2 glycoprotein. (toronto-fertility.com)

The sharp boundaries of degredation observed may be due to localized proteinase secretion by trophoblast, to membrane proteinases on the surface of trophoblast, or to endocytosis. (rupress.org)
Identification of P-glycoprotein at the membrane of mast cell secretoty granules. (uniud.it)

Without adequate blood supply, the trophoblasts release inflammatory factors into maternal blood, leading to an increase in maternal blood pressure and causing damage to certain organs [ 6 ]. (hindawi.com)

INTERVENTION(S): Wound-healing experiments were conducted to study trophoblast migration. (bvsalud.org)

alpha-1-B glycoprotein [Source:HG. (gsea-msigdb.org)

The embryos attached to the matrix, and trophoblast spread over the surface. (rupress.org)

Scanning electron microscopy and time-lapse cinemicrography confirmed that the digestion of matrix was highly localized, taking place only underneath the trophoblast, with no evidence of digestion of the matrix beyond the periphery of the trophoblast outgrowth. (rupress.org)
b) Acrosomal reactions help the sperm degrade the glycoprotein matrix protecting the egg and allow the sperm to transfer its nucleus. (opentextbc.ca)

It is an N-glycosylated transmembrane 72 kDa glycoprotein containing eight leucine-rich repeats. (wikipedia.org)
This gene encodes a leucine-rich transmembrane glycoprotein that may be involved in cell adhesion. (nih.gov)
Trophoblast antigen 2 (Trop2) is a transmembrane glycoprotein upregulated in multiple solid tumours. (bvsalud.org)
CD49f is a ~150 kDa type I transmembrane glycoprotein that belongs to the integrin alpha chain family of extracellular matrix and cell adhesion receptors. (bdbiosciences.com)
CD19 antigen is a type I transmembrane glycoprotein belonging to the immunoglobulin Ig superfamily. (musechem.com)
CD22 is a 130 kDa type I transmembrane glycoprotein, normally expressed on B-lineage cells from the pre-B-cell stage and is also expressed on most malignant mature B cells, including follicular NHL, marginal zone lymphoma (MZL), MCL, DLBCL, small lymphocytic lymphoma (SLL), and CLL. (musechem.com)
TROP2 is a transmembrane glycoprotein with both extracellular and intracellular components and has been implicated in several cell signaling pathways including intracellular calcium transduction, MAPK signaling pathway, RAF, NF-κB and Cyclin D/E among others. (adcreview.com)

Trophoblast glycoprotein, also known as TPBG, 5T4, Wnt-Activated Inhibitory Factor 1 or WAIF1, is a human protein encoded by a TPBG gene. (wikipedia.org)
These autoantibodies are directed against beta2-glycoprotein antigens, a plasmatic protein that displays an intense tropism for endothelial cell membrane phospholipids [ 10 , 15 - 17 ]. (hindawi.com)
B2GP1 is a 326-amino acid protein synthesized by hepatocytes, endothelial cells, and trophoblast cells. (testcatalog.org)
Snake venoms contain disintegrin protein that bind integrins and disrupt cell - extracellular matrix connections or bloodstream clotting systems and analogously we among others possess hypothesised that PSGs may work as secreted integrin ligands that disrupt integrin function and thus facilitate invasion of maternal tissue by fetal trophoblast or disrupt various other integrin mediated features in maternal tissue [6] [24]. (biotech-angels.com)
Gal-1 is a β-galactoside binding protein implicated in myeloma and interestingly already implicated in trophoblast and myoblast fusion. (bone-abstracts.org)

It is generally accepted that the major autoantigen for aPL Abs is beta (2) glycoprotein I, which mediates the binding of aPL Abs to target cells (i.e., endothelial cells, monocytes, platelets, trophoblasts, etc.) leading to thrombosis and fetal loss. (nih.gov)
Our aim is to investigate a possible association of circulating anti-beta2-glycoprotein I antibodies (ABGPI) with the endothelial dysfunction, nitric oxide bioactivity dysregulation, and the inflammatory status that surrounds peripheral arterial disease. (hindawi.com)
C1q is also synthesized by decidual endothelial cells, thus acting as a link between decidual cells and trophoblasts, as well as contributing to the remodelling of spiral arteries. (explorationpub.com)

In extravillous trophoblasts, 5T4 might function in epithelial-to-mesenchymal changeover during placentation. (imacst.com)
Furthermore, C1q is produced by the extravillous trophoblasts (EVTs) invading the decidua. (explorationpub.com)
It is synthesized by extravillous trophoblasts (EVTs) to help their connection with the matrix of the maternal decidua, thus easing their invasive capacity towards the inner layer of myometrium and migration next to the spiral arteries [ 6 ]. (explorationpub.com)

The human pregnancy-specific glycoproteins (PSGs) are a family of proteins that are synthesized in large amounts by placental trophoblasts and released into the maternal circulation during pregnancy. (antibodies-online.com)
Human chorionic gonadotrophin (hCG), placental alkaline phosphatase (PLAP), and pregnancy-specific glycoprotein (PSG) are three major proteins produced by the trophoblast of the human placenta. (imingo.net)
Launch Pregnancy-specific glycoproteins (PSGs) are portrayed throughout individual being pregnant and so are one of the most abundant fetal proteins secreted with the placental syncytiotrophoblast in to the maternal blood stream in middle to late being pregnant (～200 - 400 μg/ml) [1]-[3]. (biotech-angels.com)
Pregnancy-associated glycoproteins (PAGs) are a large grouping of placental proteins that belong to the aspartic peptidase gene family. (umsystem.edu)

The objective of the proposed studies is to examine the developmentally regulated interaction of trophoblast cells with components of the uterine extracellular matrix (ECM), focusing on fibronectin which is a major component of the endometrial ECM that is infiltrated by differentiated trophoblasts early during interstitial implantation. (grantome.com)

This molecule has been widely studied in tissue culture cells, generating much information about its structure-function relationships and its binding to a specific cell surface receptor glycoprotein, integrin. (grantome.com)
We will therefore be able to generate biochemical and immunological probes to test the hypothesis 1) that trophoblast binding to fibronectin is mediated by a fibronectin-specific integrin, and 2) that integrin is developmentally regulated during the onset of attachment competence of the mouse blastocyst. (grantome.com)

Little is known about the biochemical basis for the invasive activity of the trophoblasts during early implantation because of the complexity of the uterine endometrium, its inaccessibility to experimental study and the paucity of material comprising the embryo itself. (grantome.com)
Non visualized pregnancy loss includes biochemical pregnancy loss and resolved and treated pregnancies of unknown location which occurs after 6 weeks of gestation, where an ultrasound examination is done only after complete expulsion of the embryo and trophoblast or else no ultrasound was done after heavy bleeding. (fortunejournals.com)
The function of trophoblast cells in the embryo is to invade the endometrium to build maternal connection with an embryo. (revivaivf.com)

Our results claim that in types with haemochorial placentation where maternal blood is within direct connection with fetal trophoblast INO-1001 the high appearance degree of PSGs shows a necessity to antagonise abundant (3 mg/ml) fibrinogen in the maternal flow which might be essential to prevent platelet aggregation and thrombosis in the prothrombotic maternal environment of being pregnant. (biotech-angels.com)

Isolation of a cDNA encoding 5T4 oncofetal trophoblast glycoprotein. (wikipedia.org)

B. endoderm The amnion stems from the extra-embryonic somatic mesoderm on the outer side and the extra-embryonic ectoderm or trophoblast on the inner side. (imingo.net)
Implantation marks the initial physical connection between mother and the conceptus during pregnancy, and its success is greatly dependent upon the function of the embryonic cells, the trophoblast, that establish themselves in the uterine wall and give rise to the placenta. (grantome.com)

Human chorionic gonadotropin (hCG) is a glycoprotein hormone composed of two dissimilar subunits and a tumor marker to make a diagnosis and monitor therapeutic effect in GTN. (elsevierpure.com)
The hormone itself is a glycoprotein composed of two subunits, the alpha and beta subunits. (anabolexshop.com)
LH is a glycoprotein dimer composed of 2 glycosylated noncovalently-linked subunits designated alpha and beta. (medscape.com)
HCG is a glycoprotein hormone that consists of two subunits: the alpha subunit, which is structurally similar to other glycoprotein hormones (e.g., follicle-stimulating hormone), and the unique beta subunit, which confers specificity to HCG. (newsarms.com)

In vitro studies have demonstrated that HCG promotes trophoblast cell invasion, angiogenesis, and the production of other hormones necessary for successful implantation and placental development [ 4 ]. (newsarms.com)

With regard to the pathological consequences, C1q deposition is associated with the activation of the classical pathway of the C. Excessive C activation can cause angiogenetic factor imbalance and an impaired invasion of the decidua by trophoblasts, thus leading to incorrect placentation [ 5 , 9 ]. (explorationpub.com)

Given the role of EGFR in trophoblast proliferation and differentiation during placental development, this study suggests that exposures to BPS at environmentally relevant concentrations may result in placenta dysfunction, affecting fetal growth and development. (nih.gov)

Syncytin-1 mediated trophoblast fusion is essential for normal placental development. (wikipedia.org)

In this context, circulating anti-beta2-glycoprotein I antibodies (ABGPI) have been associated with peripheral arterial disease (PAD) and coronary arterial disease [ 12 - 14 ]. (hindawi.com)
Diagnostic criteria for antiphospholipid syndrome include the presence of at least one of the following: lupus anticoagulant, anticardiolipin, and anti-beta-2 glycoprotein 1 IgG or IgM antibodies. (testcatalog.org)
Based on the 2006 revised Sapporo consensus classification criteria, the laboratory requirements for diagnosing APS include the presence of at least one of the following: lupus anticoagulant (LAC), anticardiolipin (aCL), and anti-beta-2 glycoprotein 1 (B2GP1) IgG or IgM antibodies. (testcatalog.org)
Animals immunized with aCL or with the cofactor beta-2 glycoprotein I (b2GPI) develop clinical manifestations of APS, including fetal loss, thrombocytopenia, and neurologic and behavioral dysfunction, along with elevated levels of aPL antibodies. (medscape.com)
beta(2) glycoprotein I (beta(2)GPI)-dependent aPL, the most important subset of these antibodies, mediate several-not necessarily alternative-thrombogenic mechanisms, mainly on the basis of their reactivity with beta(2)GPI expressed on the membrane of cells that participate in the coagulation cascade. (unimi.it)

Finally, the findings of the in vitro studies will be tested in a newly developed culture system wherein embryos are co-cultured with an acellular preparation of ECM isolated from the receptive endometrium to determine the relative role of trophoblast-fibronectin interactions within the complex ECM encountered in utero. (grantome.com)
Lectin glycoprotein interactions have been implicated in osteoclast formation. (bone-abstracts.org)

The uterine epithelium cells have glycoprotein on its surface which acts as a barrier between blastocyst and endometrium. (revivaivf.com)

Due to enzymatic breakage of glycoprotein, the adhesion molecules (includes cadherins, intergrins, glycan, & lectin etc.) in blastocyst and endometrium have free accesses to each other. (revivaivf.com)

4. Trophoblast glycoprotein promotes pancreatic ductal adenocarcinoma cell metastasis through Wnt/planar cell polarity signaling. (nih.gov)

The lacunar networks begin to form in the Syncytiotrophoblast & by the 12th day the lacunar networks stops growing .The uterine blood vessels in the endometrium comes in contact with lacunar networks which directs the placental trophoblast to maternal blood circulation. (revivaivf.com)

The tumors are composed mainly of intermediate trophoblast derived from cytotrophoblast, and so produce little hCG. (medscape.com)
The growth of trophoblast forms Cytotrophoblast & Syncytiotrophoblast becomes quiker at this stage. (revivaivf.com)

Its sequence is very similar to the glycoprotein hormones secreted by the pituitary gland, such as follicle stimulating hormone (FSH) and luteinizing hormone (LH). (kangyuan.com.cn)

This is a rare, slow-growing form of GTD that has been proposed to arise from the intermediate trophoblasts at the implantation site. (medscape.com)

Previous studies revealed that the NNS sucralose (Sucr) altered P-glycoprotein (PGP) expression in rat colon. (mdpi.com)
Genome-wide gene expression analysis was performed on the RNA extracted from the trophoblast of GDM and obese and normal placentae. (ox.ac.uk)

Two major signs of placental disease are chronic hypoxia and trophoblast invasions. (wmcresearch.org)

The blastocyst consists of two main components - The trophoblast & the Inner Cell Mass (ICM). (revivaivf.com)

Results are reported in standard IgG anti-beta 2 glycoprotein 1 units (SGU). (testcatalog.org)

HCG is a glycoprotein, which is secreted in large quantities by normal trophoblasts. (neobiotechnologies.com)

Anatomy19

Organisms10

Diseases10

Chemicals and Drugs63

Analytical, Diagnostic and Therapeutic Techniques and Equipment16

Phenomena and Processes35

Disciplines and Occupations1

Information Science4

Transmembrane glycoprotein5

Antigen4

Extracellular matrix2

Placenta5

Pregnancy4

Placental2

Platelet1

Uterine2

Protein1

Cells7

BeWo1

Gene1

Human3

Antibody1

Membrane2

Maternal1

Migration1

Alpha1

Surface1

Matrix2

Transmembrane7

Protein5

Endothelial3

Extravillous trophoblasts3

Proteins4

Extracellular1

Integrin2

Embryo3

PSGs1

Oncofetal1

Embryonic2

Subunits4

Angiogenesis1

Invasion1

Proliferation1

Placental development1

Antibodies5

Interactions2

Epithelium1

Lectin1

Metastasis1

Maternal blood1

Cytotrophoblast2

Hormone1

Implantation1

Expression2

Disease1

Cell1

Beta1

Large1