• The tropane alkaloids atropine, scopolamine, and hyoscyamine are highly anticholinergic compounds found in a number of plants. (medscape.com)
  • A subgroup of the alkaloids is the alkaloid amines, which include three major pharmacologic groups: the hallucinogenic alkaloid amines, the stimulant alkaloid amines, and the tropane alkaloids (also called the belladonna alkaloids or bicyclic alkaloids). (medscape.com)
  • Chinese herbal medicines containing tropane alkaloids have been used to treat asthma, chronic bronchitis, pain, and flu symptoms. (medscape.com)
  • Many cultures worldwide add plants with tropane alkaloids (particularly Datura species) to alcoholic beverages to increase intoxication. (medscape.com)
  • The cereal was found to have been contaminated with tropane alkaloids from seeds of Datura stramonium that had invaded grain fields. (medscape.com)
  • Although most tropane alkaloids cause an anticholinergic syndrome, a case report indicates that the tropane alkaloid-containing medicinal herb Erycibe henri Prain ("Ting Kung Teng") contains a tropane alkaloid that may cause a cholinergic syndrome, as well as kidney, liver, and erythrocyte toxicity. (medscape.com)
  • [ 14 ] This is considered atypical for the tropane alkaloids, which are predominantly strongly anticholinergic. (medscape.com)
  • Toxicity from plants containing tropane alkaloids manifests as classic anticholinergic poisoning. (medscape.com)
  • Symptoms usually occur 30-60 minutes after ingestion and may continue for 24-48 hours because tropane alkaloids delay gastric emptying and absorption. (medscape.com)
  • Category 2 Food Alert for Information: Independent Irish Health Foods is recalling some batches of Organic Millet Pops due to the possible presence of tropane alkaloids. (fsai.ie)
  • The biosynthesis of tropane and tobacco alkaloids has been extensively studied since the 1950's. (gla.ac.uk)
  • The introduction of this thesis contains descriptions of tropane alkaloid structure and occurrence, tobacco alkaloid structure and occurrence, pharmacology of tropane alkaloids, pharmacology of tobacco alkaloids and finally, the aims of the project. (gla.ac.uk)
  • A critical review of the biosynthesis of the tropane and tobacco alkaloids is presented in conjunction with a simplified description of the production and manipulation of transformed root cultures. (gla.ac.uk)
  • Tropane alkaloids (TAs) are secondary metabolites which naturally occur in plants of several families including Brassicaceae, Solanaceae (e.g. mandrake, henbane, deadly nightshade, Jimson weed) and Erythroxylaceae (including coca). (fsai.ie)
  • Tropane alkaloids (TA) including anisodamine, anisodine, hyoscyamine and scopolamine are a group of important anticholinergic drugs with rapidly increasing market demand, so it is significant to improve TA production by biotechnological approaches. (biomedcentral.com)
  • The alkaloids 5-(2-oxopropyl)-hygrine (8) and phygrine (20) are new for this species and 3-(hydroxyacetoxy)tropane (9), 6,7-dehydro-3-phenylacetoxytropane (15), 3-(2'-phenylpropionyloxy) tropane (17), 6,7-dehydro-3-apotropoyloxytropane (18), 3-(3'-methoxytropoyloxy)tropane (23), and aponorscopolamine (25) are described for the first time for the genus Hyoscyamus. (degruyter.com)
  • An example of this is the occurrence of pyrrolizidine or tropane alkaloids in (herbal) teas or spices. (bund.de)
  • All parts of the plant contain tropane alkaloids[254]. (pfaf.org)
  • the manufacturer is immediately recalling Amaizin tortilla chips due to containing tropane alkaloids. (planetorganic.com)
  • This unfortunately resulted in the presence of tropane alkaloids in the chips. (planetorganic.com)
  • Chemical & Engineering News - Tropane alkaloids, a broad class of natural products from plants, have been used as medicines for more than a century. (ttu.edu)
  • Cocaine is extracted from coca leaves whose major chemical constituents are a complex mixture of tropane alkaloids, mainly cocaine and other ecgonine esters. (who.int)
  • Nearly 20% of plant species accumulate alkaloids, which mainly include terpenoid indole alkaloids, tropane alkaloids and purine alkaloids 3 . (scialert.net)
  • In addition the selectivity of the enzymes involved in tropane and tobacco alkaloid biosynthesis was studied. (gla.ac.uk)
  • Plant tropane alkaloid biosynthesis evolved independently in the Solanaceae and Erythroxylaceae. (mpg.de)
  • The reaction is investigated in the field of piperidine, piperazine, and tropane derivatives. (heterocycles.jp)
  • The toxic berry of Atropa belladonna which contains the tropane deliriants scopolamine , atropine , and hyoscyamine . (wikipedia.org)
  • I had began reading all about the datura and nightshade families and had become increasingly interested in tropane-containing plants. (erowid.org)
  • 123 I]β-CIT (2β-carbomethoxy-3β-(4-iodophenyl)tropane) is a cocaine derivative radioligand which binds to dopamine transporters with substantial striatal specificity at 24 hours postinjection. (bmj.com)
  • I explained to her the plant I had picked and boiled into a tea contained several psychoactive tropanes and was poisonous. (erowid.org)
  • Tropane is a nitrogenous bicyclic organic compound. (wikipedia.org)
  • Synthesis, Fluorine-18 Radiolabeling, and Biological Evaluation of N-((E)-4-Fluorobut-2-en-1-yl)-2β-carbomethoxy-3β-(4′-halophenyl)nortropanes: Candidate Radioligands for In Vivo Imaging of the Brain Dopamine Transporter with Positron Emission Tomography. (acs.org)
  • The present study sought to determine whether doses of methamphetamine in the range of those used recreationally by humans produce brain dopamine (DA) neurotoxicity in baboons and to ascertain whether positron emission tomography (PET) imaging with the DA transporter (DAT) ligand [ 11 C]WIN-35,428 ([ 11 C]2β-carbomethoxy-3β-(4-fluorophenyl)-tropane) could be used to detect methamphetamine-induced DAT loss in living primates. (jneurosci.org)
  • The effects of MDMA use on cortical 5-HT neurons was studied by means of single-photon emission computed tomography with iodine 123 labeled 2-carbomethoxy-3-(4-iodophenyl) tropane ([123I]-CIT) by quantification of brain 5-HT transporter densities. (erowid.org)
  • Phenyltropane Tropane alkaloid Tropine Merck Index, 11th Edition, 9689. (wikipedia.org)
  • Furthermore, all the differential metabolite were mapped to KEGG pathway, revealing significant differences in linoleic acid metabolism, tyrosine metabolism,glutathione metabolism, pentose phosphate pathway, tropane, piperidine and pyridine alkaloid biosynthesis, phenylpropanol metabolism and glycosylphosphatidylinositol(GPI)-anchor biosynthesis over time. (researchsquare.com)
  • Nguyen TK, Jamali A, Lanoue A, Gontier E, Dauwe R. Unravelling the architecture and dynamics of tropane alkaloid biosynthesis pathways using metabolite correlation networks. (medscape.com)
  • Tropane Alkaloids: Chemistry, Pharmacology, Biosynthesis and Production. (ac.rs)
  • Typical tropane alkaloids are atropine, hyoscyamine, scopolamine and cocaine. (abc.net.au)
  • Their active principles are mainly hyossyamine and scopolamine, which are tropane alkaloids. (erowid.org)
  • Atropine Hyoscine (scopolamine) Hyoscyamine Tropane alkaloids Note: This list may not include all poisonous ingredients. (nih.gov)
  • Rich in the tropane alkaloids scopolamine and hyoscyamine, belladonna (which means beautiful woman) was used by women to dilate their pupils, to make them appear more alluring. (medicinehunter.com)
  • Are tropane alkaloids present in organic foods? (ac.rs)
  • According to Samorini, tropane alkaloids present in L. serriola can be also found in plants of the nightshade family, such as the legendary mandrake, long reputed for its magic and aphrodisiac powers. (abc.net.au)
  • Nov. 21, 2022 Tropane alkaloids (TAs) are heterocyclic nitrogenous metabolites found across seven orders of angiosperms, including Malpighiales (Erythroxylaceae) and Solanales (Solanaceae). (sciencedaily.com)
  • Worldwide Occurrence and Investigations of Contamination of Herbal Medicines by Tropane Alkaloids. (ac.rs)
  • Further to last Friday's recall of the Chinese medicinal herb Rhizoma Atractylodis (batch number 06010108) from customers of a Yuen Long Chinese medicine practitioner (CMP), Kong Chi-wing, because of contamination by tropane alkaloids, the Department of Health (DH) today (May 16) also advised patrons of another CMP in Mong Kok, Chik King-sing, to check whether they have been prescribed Rhizoma Atractylodis as well. (gov.hk)
  • Complex investigations involving international food safety experts indicate that the probable cause of the sickness was contamination of Super Cereal by tropane alkaloids during harvesting or production. (wfp.org)
  • 11 Malison R, Price L, Berman R. Reduced brain serotonin transporter availability in major depression as measured by [I 123 ]2 β-carbomethoxy-3 β-(4-iodophenyl)-tropane and single photon emission computed tomography. (thieme-connect.com)
  • Analysis of alkaloids (indole alkaloids, isoquinoline alkaloids, tropane alkaloids). (ac.rs)
  • The chemical reactions and pathways involving tropane alkaloids, compounds containing the 8-methyl-8-azabicyclo(3.2.1)octane ring system. (mcw.edu)
  • Also known as deadly nightshade, belladonna contains tropane alkaloids that can induce hallucinations, delirium, and even death. (edgarallanpoets.com)
  • 8-Azabicyclo[3.2.1]octane (tropane without the N-methyl group) is known as nortropane or nor-tropane. (wikipedia.org)
  • Ipratropium bromide is partially metabolized to ester hydrolysis products, tropic acid, and tropane. (nih.gov)
  • Tropane is a nitrogenous bicyclic organic compound. (wikipedia.org)
  • While carbons 1 and 5 are asymmetric carbons, tropane itself is optically inactive due to mirror symmetry. (wikipedia.org)
  • This study investigates whether there is a change in 123iodine-2ß- carbomethoxy-3ß-(4-iodophenyl) tropane ([123I]ß-CIT) uptake after short-term treatment with levodopa compared to either dopamine agonist or placebo. (drugpatentwatch.com)
  • Meanwhile, chemical analysis by the Government Laboratory on another batch of Rhizoma Atractylodis kept by KLH found no tropane alkaloids. (gov.hk)
  • The obtained results show the seriousness of the tropane alkaloids problem in maize as well as the need for monitoring and further research. (ac.rs)
  • Mandragora (all from the same Solananeae family) contain a well-defined group of tropane alkaloids. (medprep.info)
  • Determination of tropane alkaloids in cereals, tea and herbal infusions: Exploiting proficiency testing data as a basis to derive interlaboratory performance characteristics of an improved LC-MS/MS method. (ac.rs)
  • Tropane alkaloids are considered to be serious health hazard for humans and that their maximum residue levels in food and feed are still not established. (ac.rs)
  • Occurrence and Determination of Tropane Alkaloids in Food and Feed. (ac.rs)
  • This review on " The role of the Tropane skeleton in new drug research " was presented as a lecture by Dr. Laszlo Gyermek in Hungarian, on the occasion of his election as Foreign Member of the Hungarian Academy of Medical Sciences (Division V - Medical Sciences), on September 21, 2005. (inhn.org)
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