• The presence of m1G improves the cellular growth rate and the polypeptide steptime and also prevents the tRNA from shifting the reading frame [ PMID: 2207153 ]. (ebi.ac.uk)
  • This domain can also be found in the SPOUT superfamily members, including tRNA:Gm18 MTase TrmH [ PMID: 9321663 , PMID: 15062082 , PMID: 16848900 ]. (ebi.ac.uk)
  • In enzymology, a methylenetetrahydrofolate-tRNA-(uracil-5-)-methyltransferase (EC 2.1.1.74) is an enzyme that catalyzes the chemical reaction 5,10-methylenetetrahydrofolate + tRNA containing uridine at position 54 + FADH2 ⇌ {\displaystyle \rightleftharpoons } tetrahydrofolate + tRNA containing ribothymidine at position 54 + FAD The 3 substrates of this enzyme are 5,10-methylenetetrahydrofolate, tRNA containing uridine at position 54, and FADH2, whereas its 3 products are tetrahydrofolate, tRNA containing ribothymidine at position 54, and FAD. (wikipedia.org)
  • T-loop and D-loop are splayed apart showing how A58, normally buried in tRNA, becomes accessible for modification. (nih.gov)
  • Role of tRNA modification in translational fidelity. (ebi.ac.uk)
  • Deep knot structure for construction of active site and cofactor binding site of tRNA modification enzyme. (ebi.ac.uk)
  • View all proteins of this organism that are known to be involved in the pathway N(7)-methylguanine-tRNA biosynthesis and in tRNA modification . (uniprot.org)
  • The catalytic site resembles a molecular basket, unlike most other SAM-dependent methyltransferases, which therefore suggests that GNMT may be capable of capturing unidentified chemicals as a part of a detoxification process. (wikipedia.org)
  • Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA. (rcsb.org)
  • S-adenosyl-L-methionine + uridine 32 in tRNA = S-adenosyl-L-homocysteine + 2'-O-methyluridine 32 in tRNA. (rcsb.org)
  • Catalyzes the folate-dependent formation of 5-methyl-uridine at position 54 (M-5-U54) in all tRNAs. (cusabio.com)
  • Glycine N-methyltransferase catalyzes the synthesis of N-methylglycine (sarcosine) from glycine using S-adenosylmethionine(SAM) (AdoMet) as the methyl donor. (wikipedia.org)
  • a) Ribbon drawing of tRNA 3 Lys -bound human m 1 A58 MTase heterotetramer viewed looking down the crystallographic 2-fold that coincides with the molecular 2-fold of the heterotetramer in the tetragonal crystal form. (nih.gov)
  • Required for the formation of N 7 -methylguanine at position 46 (m7G46) in tRNA. (uniprot.org)