In squamous cell carcinoma, researchers have found that anoikis resistance can be induced through hepatocyte growth factor (HGF) activating BOTH extracellular signalling-receptor kinase (ERK) and PI3K[citation needed]. (wikipedia.org)
Hepatocyte growth factor inhibits anoikis in head and neck squamous cell carcinoma cells by activation of ERK and Akt signaling independent of NFkappa B". The Journal of Biological Chemistry. (wikipedia.org)
A few reports have suggested that induction of resistance against anoikis is also derived from ac tivation of the PI3Kinase signaling and extracellular signaling receptor kinase via various proteins involving TrkB, its ligand brain derived neurotrophic factor, and hepatocyte growth factor. (microrna21.com)
BDNF2
Recent findings suggest that the protein TrkB, best known for its role in the nervous system, might be involved together with its ligand, brain-derived neurotrophic factor (BDNF)[citation needed]. (wikipedia.org)
However, metastatic tumor cells may escape from anoikis and invade other organs. (wikipedia.org)
The mechanism by which invading tumor cells survive the anoikis process remains largely unknown. (wikipedia.org)
It seems that TrkB could make tumor cells resistant to anoikis by activating phosphatidylinositol 3-kinase (PI3K) signaling cascade[citation needed]. (wikipedia.org)
showed that anisomycin can sensitize metastatic epithelial cells to anoikis and reduce circulating tumor cell implantation in vivo. (wikipedia.org)
Cancer3
Cancer cells develop anoikis resistance by several mechanisms, including changes in integrin and matrix signaling, metabolic deregulation, and stress responses of cancer cells. (wikipedia.org)
Activation of the PI3Kinase pathway in metastatic cancer cells due to the highly glycolytic state of the cells and aerobic glycolysis could also induce drug resistance http://www.selleckchem.com/products/Imatinib(STI571).html in cancer cells. (microrna21.com)
Re sistance against anoikis induced upon cell detach ment from the extracellular matrix, might also be involved in survival of migrating cancer cells. (microrna21.com)
Cell3
Anoikis is a form of programmed cell death that occurs in anchorage-dependent cells when they detach from the surrounding extracellular matrix (ECM). (wikipedia.org)
When cells are detached from the ECM, there is a loss of normal cell-matrix interactions, and they may undergo anoikis. (wikipedia.org)
The word "anoikis" was coined by Frisch and Francis in a paper published in the Journal of Cell Biology in 1994. (wikipedia.org)
3. Suppression of anoikis and induction of metastasis by the neurotrophic receptor TrkB. (nih.gov)
8. Critical role for TrkB kinase function in anoikis suppression, tumorigenesis, and metastasis. (nih.gov)
20. The neurotrophic receptor TrkB in anoikis resistance and metastasis: a perspective. (nih.gov)
Neurotrophic3
Recent findings suggest that the protein TrkB, best known for its role in the nervous system, might be involved together with its ligand, brain-derived neurotrophic factor (BDNF)[citation needed]. (wikipedia.org)
1. Suppression of anoikis by the neurotrophic receptor TrkB in human ovarian cancer. (nih.gov)
6. Brain-derived neurotrophic factor activation of TrkB protects neuroblastoma cells from chemotherapy-induced apoptosis via phosphatidylinositol 3'-kinase pathway. (nih.gov)
Hepatocyte3
In squamous cell carcinoma, researchers have found that anoikis resistance can be induced through hepatocyte growth factor (HGF) activating BOTH extracellular signalling-receptor kinase (ERK) and PI3K[citation needed]. (wikipedia.org)
Hepatocyte growth factor inhibits anoikis in head and neck squamous cell carcinoma cells by activation of ERK and Akt signaling independent of NFkappa B". The Journal of Biological Chemistry. (wikipedia.org)
12. Hepatocyte growth factor induces anoikis resistance by up-regulation of cyclooxygenase-2 expression in uterine endometrial cancer cells. (nih.gov)
Phosphatidylinositol1
It seems that TrkB could make tumor cells resistant to anoikis by activating phosphatidylinositol 3-kinase (PI3K) signaling cascade[citation needed]. (wikipedia.org)
Mechanisms2
Cancer cells develop anoikis resistance by several mechanisms, including changes in integrin and matrix signaling, metabolic deregulation, and stress responses of cancer cells. (wikipedia.org)
However, the "Achilles heel" of cancer treatment has been failure of current treatments because of the emergence of genetic mechanisms of drug resistance. (medscape.com)
Head1
10. Implications of tropomyosin-related kinase B (TrkB) in head and neck cancer. (nih.gov)
Develop1
BACKGROUND: Although immune checkpoint blockade (ICB) therapy has shown remarkable benefits in cancers, a subset of patients with cancer exhibits unresponsiveness or develop acquired resistance due to the existence of abundant immunosuppressive cells. (bvsalud.org)
Cells6
Anoikis is a form of programmed cell death that occurs in anchorage-dependent cells when they detach from the surrounding extracellular matrix (ECM). (wikipedia.org)
When cells are detached from the ECM, there is a loss of normal cell-matrix interactions, and they may undergo anoikis. (wikipedia.org)
In related work, Schimmer's team showed that FLIP levels are higher in metastatic cells than non-metastatic cells, and that reducing FLIP levels using RNAi (RNA Interference) or other small molecule inhibitors of FLIP can sensitize metastatic cells to anoikis. (wikipedia.org)
Given that FLIP is an inhibitor of anoikis, and that reducing FLIP can sensitize metastatic cells to anoikis, Mawji et al. (wikipedia.org)
2. [Anoikis-suppression and invasion induced by tyrosine kinase receptor B in OVCAR3 ovarian cancer cells]. (nih.gov)
19. Dieldrin promotes resistance to anoikis in breast cancer cells in vitro. (nih.gov)