• In Stable Radicals: Fundamentals and Applied Aspects of Odd-Electron Compounds a team of international experts provide a broad-based overview of stable radicals, from the fundamental aspects of specific classes of stable neutral radicals to their wide range of applications including synthesis, materials science and chemical biology. (wiley.com)
  • Alternately, an imine is named as a derivative of a carbonyl, adding the word "imine" to the name of a carbonyl compound whose oxo group is replaced by an imino group, for example sydnone imine and acetone imine (an intermediate in the synthesis of acetone azine ). (wikipedia.org)
  • Imine synthesis from a primary amine and a carbonyl compound. (wikipedia.org)
  • It is applied as a reactant involved in the synthesis of substituted dihydroazulene photo switches, carbene-based Lewis pairs for hydrogen activation, 1,3-Dipolar cycloaddition reactions for preparation of α-amino-β-hydroxy esters, oxidation of allenic compounds, Mukaiyama aldol addition reactions and ionic hydrogenation as a counteranion and ligand source. (alfa.com)
  • In the present work, representative compounds from the six different series of inhibitors were analyzed for their effects on membrane integrity and macromolecular synthesis. (asm.org)
  • 3-Acetyl-1,2-O-isopropylidene-6-O-trityl-β-L-arabino-hexofuranos-5-ulose (cas# 109680-98-0) is a compound useful in organic synthesis. (trc-canada.com)
  • In this study, conjugates consisting of N -trityl derivatives of p -fluoro, p -nitro and p -iodo-DL-phenylalanine were coupled to 8-(6-aminohexyl) amino-adenosine-3',5'-cyclic monophosphate and examined for their effect on DNA synthesis by M-MuLV RT. (scielo.org.za)
  • A tandem benzannulation-cyclization strategy was successfully applied to the synthesis of a tetracyclic heteroaromatic compound expected to have interesting electronic properties. (mit.edu)
  • We have already reported the synthesis of compound 7 in our asymmetric total synthesis of renieramycin M and jorumycin [ 9 ]. (hindawi.com)
  • The present invention relates to compounds and methods useful in the synthesis of amino-alkylenediols. (lens.org)
  • In another embodiment, the present invention provides a method for the synthesis of an aminoalkyl diol comprising the step of preparing a first intermediate compound comprising an aminoalkylene diol wherein the amino functionality comprises a protecting group. (lens.org)
  • The compound forms a number of unusual derivatives that are more stable than less bulky analogues. (wikipedia.org)
  • Sulphonylbenzyl-substituted imidazolylpropenoic acid derivatives can be prepared by reacting sulphonylbenzyl-substituted aldehydes with appropriate CH-acidic compounds and then dehydrating. (freepatentsonline.com)
  • These various acylated derivatives, as well as the free N -trityl substituted DL-phenylalanyl amino acids, were tested for their effect on the DNA polymerase activity of the Moloney murine leukaemia virus reverse transcriptase (M-MuLV RT). (scielo.org.za)
  • It was therefore of particular interest to see if replacement of the nucleotide adenosine-5'-phosphate component of N -trityl- p -substituted-DL-phenylalanine-8-(6-aminohexyl) amino-adenosine-5'-monophosphate by adenosine-3',5'-cyclic monophosphate would result in inhibitory derivatives against the reverse transcriptase. (scielo.org.za)
  • Seventeen silyl- and trityl-modified (5'-O- and 3',5'-di-O-) nucleosides were synthesized with the aim of investigating the in vitro antiproliferative activities of these nucleoside derivatives. (csir.co.za)
  • Optical brighteners are often derivatives of stilbene, biphenyl, naphthalene, anthracene and structurally related compounds . (scirp.org)
  • A highly regio- and enantioselective hydroxyamination of aldehydes with in situ generated nitrosocarbonyl compounds from hydroxamic acid derivatives was realized by combining TEMPO and BPO as oxidants in the presence of a binaphthyl-modified amine catalyst. (organic-chemistry.org)
  • Journal Article] Inhibition of hepatitis C virus NS5B polymerase by S-trityl-L-cysteine derivatives. (nii.ac.jp)
  • Heterocyclic compounds having a relatively flexible backbone are used to create combinatorial libraries that permit screening for lead compounds and selection of drug candidates for a variety of uses in human and veterinary medicine as well as in agriculture. (patentsencyclopedia.com)
  • These compounds have antiviral activity, and certain of these compounds have antiinflammatory activity and are PAF inhibitors. (patents.com)
  • These compounds are inhibitors of RNA-dependent 5 RNA viral replication and are useful as inhibitors of HCV NS5B polymerase, as inhibitors of HCV replication and for treatment of hepatitis C infection in mammals. (sumobrain.com)
  • The iodo-derivative, N -trityl- p -iodo-DL-phenylalanine-8-(6-aminohexyl) amino-adenosine-3',5'-cyclic monophosphate was found to be a very active inhibitor of the RT enzyme (IC 50 = 1 µM), while the p -nitro (IC 50 = 45 µM) and p -fluoro (IC 50 = 65 µM) were weak inhibitors. (scielo.org.za)
  • During random screening of a small in-house library of compounds, certain substituted imidazo[1,2-a]pyridines were found to be weak allosteric inhibitors of HIV-1 reverse transcriptase (RT). (csir.co.za)
  • Three chemical inhibitors, including Monastrol, ( S )-trityl- l -cysteine (STLC) and Dimethylenastron, are useful tools for studies about biological functions of Eg5. (biomedcentral.com)
  • Journal Article] Identification of novel N-(morpholine-4-carbonyloxy) amidine compounds as potent inhibitors against hepatitis C virus replication. (nii.ac.jp)
  • This compound may be prepared by the reaction of cycloheptatriene with phosphorus trichloride, followed by tetrafluoroboric acid. (wikipedia.org)
  • In general, Lewis acid catalysts are metal-based compounds that owe their reactivity to a low-lying empty orbital. (diva-portal.org)
  • 12. The compound according to claim 1, whereinQ is ##STR00033## R 5a , R 5b , R 7a and R 9a are each hydrogen, and R 7b is the residue of a natural or unnatural amino acid. (patentsencyclopedia.com)
  • As the structure of this product might be possible 4-phenyl-2 H -chromene-2-carboxylic acid 9a or 2-phenyl-2 H -chromene-4-carboxylic acid 10a , X-ray crystallographic analysis was used to elucidate the product as compound 8a . (hindawi.com)
  • Moreover, it has been reported so far that a pyrrolopyrimidine compound having a cyclic substituent at position 4 (Patent Document 1), a pyrrolopyrimidine compound having cyclohexene at position 4 (Patent Document 2), and a pyrrolopyrimidine compound having an aromatic group substituted with acrylamide at position 4 (Patent Document 3) exhibit JAK-inhibiting activity. (justia.com)
  • However, with regard to the compound described in Patent Document 1, a nitrogen atom directly binds to position 4 of a pyrrolo[2,3-d]pyrimidine compound, and Patent Document 1 does not describe a cycloalkenyl group substituted with acrylamide at position 4. (justia.com)
  • The common motif of the packing is the anti parallel arrangement of the trityl alcohol molecules into infinite chains. (rsc.org)
  • No short contacts between the included solvent molecules and triiodo trityl alcohol within the structures C and D , have been observed. (rsc.org)
  • Compound 6 was thought to be prepared from pentacyclic alcohol 7 by the selective acylation of the primary alcohol with 4 H -chromene-2-carboxylic acids ( 8 , Scheme 1 ). (hindawi.com)
  • Compounds and metal complexes comprising a polycyclic, fused ring ligand or inertly substituted derivative thereof having up to 60 atoms other than hydrogen, said ligand comprising at least: (1) a cyclopentadienyl ring, (2) a 6,7,or 8 membered ring other than a 6-carbon aromatic ring, and (3) an aromatic. (google.es)
  • This invention relates to pyrazole compounds that inhibit or modulate the activity of cyclin dependent kinases (CDK) and glycogen synthase kinase-3 (GSK-3), to the use of the compounds in the treatment or prophylaxis of disease states or conditions mediated by cyclin dependent kinases and glycogen synthase kinase-3, and to novel compounds having cyclin dependent kinase or glycogen synthase kinase-3 inhibitory or modulating activity. (allindianpatents.com)
  • A pharmaceutical composition for use as an antimicrobial agent which comprises the cephalosporin compound (I) or a salt thereof as an active ingredient together with an inert carrier therefor is also provided in the present invention. (google.com)
  • Provided are a novel compound or a salt thereof, and a pharmaceutical composition comprising the same, which selectively and strongly inhibit JAK3, exhibit an excellent activity for suppressing the growth of human peripheral blood monocytes and an excellent oral absorbability, and exhibits an activity of inhibiting IL-2-induced IFN-γ production in vivo. (justia.com)
  • The present invention relates to a novel pyrrolo[2,3-d]pyrimidine compound or a salt thereof having a selective JAK3-inhibiting action and a pharmaceutical composition comprising a pyrrolo[2,3-d]pyrimidine compound or a salt thereof as an active ingredient. (justia.com)
  • A pharmaceutical composition comprising a compound of claim 1 or a pharmaceutically acceptable salt thereof. (patsnap.com)
  • 19. A method of treating a cancer associated with aberrant or elevated function of glutaminase, the method comprising administering a compound of claim 1 or a pharmaceutically acceptable salt thereof to a subject in need thereof. (patsnap.com)
  • This may seem silly, but doesn't it seem weird for a compound that's stable (in this context, the tertiary carbocation) to be the most reactive? (stackexchange.com)
  • The invention relates to new nucleoside-lipid compounds with pH-sensitive dialkylorthoesterchains, to the process for their preparation and to their uses, in particular their use for transportation or vectorization of at least one therapeutic agent. (sumobrain.com)
  • The nitrogen atom can be attached to a hydrogen (H) or an organic group (R). If this group is not a hydrogen atom, then the compound can sometimes be referred to as a Schiff base . (wikipedia.org)
  • One intermediate compound of the invention comprises a laminodiol having a benzyl group linked at the nitrogen. (lens.org)
  • 6a) Infrared evidence suggests(7) that the compound of I 0 2 F and AsFS is (102)(AsF6)- and iodyl fluorosulphate has been prepared as a hygroscopic powder stable up to 1 0 0 ~ ~ ,b(ut~t)he structure of the 102 ion or group is not known. (binaryoptionstradinglist.com)
  • Hydrolysis of the ester and removal of the trityl group of 66 were to arise by the formation of the S Urechlorids to 68. (proteinkinaseinhibitor.com)
  • Traditionally, using trityl group to prepare 3', 5'-di-O-protected nucleosides gave poor yield due to the similar reactivity of 2'- and 3'-hydroxyl group and the preferential N7-tritylation of purine. (scibase.co)
  • Protection of 5'-hydroxyl group with dimethoxy-trityl (DMTr) instead of the trityl group (Tr) reported in the article also showed the equal performance with similar yield (70% for DMTr vs 71% for 5a). (scibase.co)
  • This is due to the much lability of DMTr protection group compared to the Trityl group. (scibase.co)
  • We now offer 5'-DMS(O)MT-Amino-Modifier C6 utilizing this new trityl based protecting group. (glenresearch.com)
  • The trityl alcohols bearing three bromine or three iodine atoms at the para -positions of the aromatic units, have been known for more than a hundred years. (rsc.org)
  • In the title compound, C11H8Br4, there is a norbornane skeleton with four Br atoms, having a benzene ring fused on one side. (cumhuriyet.edu.tr)