AnatomyOrganismsDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPhenomena and ProcessesTechnology, Industry, Agriculture
TriterpenesHypoglycemic AgentsPentacyclic TriterpenesPlant ExtractsDiabetes Mellitus, ExperimentalGanodermaStrychnosScopariaCornusOleanolic AcidBlood GlucoseCinnamomum zeylanicumMaytenusStreptozocinPhytotherapyBerberineDiabetes Mellitus, Type 2ThiazolidinedionesInsulinGlucose Tolerance TestAlstoniaMice, ObeseDrugs, Chinese HerbalResins, PlantCelastraceaeZiziphusRats, ZuckerCommiphoraRats, WistarGlucoseInsulin ResistanceMimusopsAlismaMetforminActaeaBarringtoniaBryoniaMomordica charantiaPoriaLecythidaceaeLiverBody WeightTriglyceridesCeanothusGardeniaIslets of LangerhansReishiLycopusHippocrateaceaeLoranthaceaeMolecular StructureLanosterolSulfonylurea CompoundsSesquiterpenes, EudesmaneSpectrophotometry, InfraredMice, Inbred C57BLSaxifragaceaeBoswelliaAster PlantRubiaceaePolyporaceaePlants, MedicinalObesityGlipizideOenotheraMagnetic Resonance SpectroscopyPlant LeavesTanninsCombretumPolyporalesDryopterisChromansDilleniaceaeRehmanniaThiazolesDiospyrosIntramolecular TransferasesGlycosidesDipeptidyl-Peptidase IV InhibitorsSaponinsPlant StemsGlyburideTerpenesSqualeneGliclazideFruitInhibitory Concentration 50Antineoplastic Agents, PhytogenicMolecular ConformationDiabetes MellitusPlant RootsHemoglobin A, GlycosylatedKrameriaceaePPAR gammaSpectrophotometry, UltravioletGlucagon-Like Peptide 1Hypolipidemic AgentsTrigonellaImmunomodulationAdministration, Oral
FlavonoidsSaponinsAntimicrobialUrsolic acidExertConstituentsBeta glucanVivoCompoundExtractsCompoundsHypoglycemicCardioprotectiveDiabetic ratsPolysaccharidesActivityRatsAssayDosesAntitumorAnticancer effectsInhibitoryApoptosisMedicinesAnti-inflammatory effectSynthesisMedicinalDiseasesSedativeVitroPhysiologicalStudiesCrudeMaslinic acidChemotherapy2020PlantShownStudyDiabetesAdverse effectsPotentialNaturalTherapeuticPharmacologicalSide effects
Flavonoids3
  • This is most likely due to the anti-inflammatory effects of its chemical constituents, namely Lupeol, Kaempherol, Zeatin, Rutin and other Flavonoids. (doctornishal.com)
  • The positive effects of savory on human health as well as its antibacterial activity are attributed to its active constituents such as EO, triterpenes, flavonoids and rosmarinic acid. (esencial.al)
  • According to these authors, the main chemical components of the aerial part of C. sicyoides were tannins, steroid-triterpenes, aminoacids, lipids and flavonoids. (biomedcentral.com)
Saponins1
Antimicrobial3
  • Antimicrobial, immunological and tooth remineralisation effect of Deer velvet antler of Cervus timorensis. (iium.edu.my)
  • Recent studies on coltsfoot flower buds showed the immunostimulant activities, antimicrobial, antioxidant, antidiabetic, a-glucosidase inhibitory effect, diacylglycerol acyltransferase inhibitory effect, and inhibitory effect on nitric oxide synthesis in lipopolysaccharide (LPS)-activated macrophages. (fountainofplants.com)
  • We now report our seminal findings on the major constituents including terpenes identified in native, historically significant herbal medicinal plant Elder (Sambucus nigra L.) flower and elder berry in particular and their concomitant strong antimicrobial effects exhibited on various nosocomial pathogens notably upon methicillin-resistant Staphylococcus aureus MRSA, recognised globally as a clinically significant pathogen, associated with skin and soft tissue infections. (researchgate.net)
Ursolic acid2
Exert5
  • With regard to cancer treatment, celastrol has been shown to exert considerable cell-killing effects and to shrink xenografted tumors in tissue and animal models of various malignancies including cancers of the prostate ( 16 - 18 ), breast ( 19 ), liver ( 20 , 21 ) and lung ( 22 , 23 ). (spandidos-publications.com)
  • Studies in our laboratories have demonstrated that some herbal extracts exert hypoglycaemic effects via unclear mechanism(s). (endocrine-abstracts.org)
  • This chapter deals with the anticancer effect exert by O. europaea leaf constituents and its possible anticancer mechanism. (springer.com)
  • Although maslinic acid did not exert any direct inhibitory effects on the formation of the first two species, the compound did reduce the generation of hydrogen peroxide (IC50 of 46.3 μM), in a way that was similar to that of catalase. (nuojiabio.com)
  • Accumulating evidence has shown that ginsenosides exert antidiabetic effects. (frontiersin.org)
Constituents1
  • To evaluate the therapeutic potential and toxicity effect of this leafy-vegetable, the antibacterial, antifungal, antioxidant activities and, toxicity and phytochemical constituents were investigated. (biomedcentral.com)
Beta glucan2
  • In a study of 42 healthy subjects, another intervention with beta glucan from reishi mushrooms of 225 mg per day for three months demonstrated its antioxidative effects -- enhanced total antioxidant capacity and enzyme activities as well as reduced mild fatty liver condition to normal by suppressing oxidative stress were observed. (greenmedinfo.com)
  • The focus of this report was to provide a concise and complete review of the novel medicinal properties of fresh or dry mushroom and extracts, fruiting body or mycelium and its extracts, fiber, polysaccharides, beta-glucan, triterpenes, fucoidan, ergothioneine from edible mushrooms that may help to prevent or treat metabolic syndrome and associated diseases. (tmu.edu.tw)
Vivo3
  • In vivo, antidiabetic test was conducted by animal diabetes modeling that has given streptozotocin 150 g/kg BW and 10% of sucrose solution intraperitoneally. (phcogj.com)
  • Reviewing in vivo and in vitro studies on mice and human cell lines using lion's mane (Hericium erinaceus) and tiger tail (Trametes versicolor) mushrooms, treatments showed immunomodulatory, anticancer, anti-inflammatory and neuroregenerative effects. (greenmedinfo.com)
  • Based on this finding, the hypoglycemic activity of the triterpene was evaluated in vivo, using a mouse model of diabetes induced by adrenalin, which is known to indirectly stimulate glycogenolysis and thus increase glucose blood concentration. (nuojiabio.com)
Compound2
  • It is a pleiotropic compound showing antitumor, anti-inflammatory, antihypertensive and antidiabetic activities ( 15 ). (spandidos-publications.com)
  • Some antidiabetic compound in jamun fruit converts the starch into energy and keep your blood sugar level in check. (planetayurveda.com)
Extracts3
  • Since the extracts did not have any significant effects on plasma insulin concentration, we speculated that they interfered with food intake and/or absorption to reduce blood glucose concentration. (endocrine-abstracts.org)
  • Antiallergic activity has been demonstrated by G. lucidum extracts, as well as some compounds isolated from this species, such as ganoderic acids, oleic acid, and cyclooctasulfur acid belonging to triterpenes [80]. (researchgate.net)
  • The leaf extracts and its derivative compounds have shown potent anticancer effects against different cell lines in different organs. (springer.com)
Compounds5
  • We have previously attributed the hypoglycaemic effects of Syzygium cordatum leaf extract to crude ethyl acetate extract solubles (EAS) containing triterpenoid compounds. (endocrine-abstracts.org)
  • Aurantiamide acetate, isoarborinol and triterpenes are the main active compounds found in it. (wildturmeric.net)
  • Chaga contains a variety of bioactive compounds, including beta-glucans, triterpenes, and ergosterol peroxide. (chagamushrooms.net)
  • These compounds have been shown to have antioxidant and anti-inflammatory effects, which may contribute to Chaga's potential health benefits. (chagamushrooms.net)
  • Antioxidants are compounds that help protect the body against the damaging effects of free radicals, which are unstable molecules that can damage cells and contribute to aging and disease. (chagamushrooms.net)
Hypoglycemic2
  • Al-Azzawie HF, Alhamdani M-SS (2006) Hypoglycemic and antioxidant effect of oleuropein in alloxan-diabetic rabbits. (springer.com)
  • In the present work, we studied the hypoglycemic and anti-lipemic effects of the aqueous extract prepared from fresh leaves of the plant (AECS), in the model of alloxan-induced diabetes in rats. (biomedcentral.com)
Cardioprotective2
  • In vitro experiments, ani-mal models, and even human studies have demonstrated not only fresh edible mushroom but also mushroom extract that has great therapeutic applications in human health as they possess many properties such as anti-obesity, cardioprotective and anti-diabetic effect. (tmu.edu.tw)
  • Recent several studies have proved that maslinic acid exerts a wide range of biological activities, i.e. antitumor, antidiabetic, antioxidant, cardioprotective, neuroprotective, antiparasitic and growth-stimulating. (nuojiabio.com)
Diabetic rats4
  • The present study was designed to isolate and characterize triterpene components EAS and investigate the antihyperglycaemic effects alone or in combination with insulin in non-diabetic and streptozotocin (STZ)-induced diabetic rats. (endocrine-abstracts.org)
  • The hypoglycaemic effect of Syzygium (i) cordatum (i) leaf extract was studied in non-diabetic and streptozotocin (STZ)-induced diabetic rats. (endocrine-abstracts.org)
  • This study aims to evaluate the effect of WTE on reducing fasting blood glucose levels in diabetic rats. (phcogj.com)
  • The administration of WTE for 14 days has potentially antidiabetic activity in diabetic rats induced streptozotocin-nicotinamide . (phcogj.com)
Polysaccharides2
  • The mushroom is rich in polysaccharides, polyphenols, and betulinic acid, which are believed to be responsible for its cancer-fighting effects. (chagamushrooms.net)
  • 13.Xianghong Chen, Xue Bai, Yihui Liu, Luanyuan Tian, Jianqiu Zhou, Qun Zhou, Jinbo Fang , Jiachun Chen, Anti-diabetic effects of water extract and crude polysaccharides from tuberous root of Liriope spicata var. (tjmu.edu.cn)
Activity9
  • To determine the phytochemical content and the activity of the ethanol extract of the galing stem as antioxidant and antidiabetic. (phcogj.com)
  • Isolation, computational studies, and antidiabetic activity evaluation. (natureloveyou.sg)
  • While there is ample scientific evidence on many isolated phytochemicals (mainly animal studies) and their physiological effects, we still do not understand the complete activity of most herbs, nor their effects when in combination. (vin.com)
  • These further leads to reduce blood sugar level and shows antidiabetic activity. (herbal-creations.com)
  • The antitumor activity of maslinic acid has become remarkable in recent years, as evidenced by the higher number of studies that address this issue, compared to those about other biological effects. (nuojiabio.com)
  • Maslinic acid not only retarded the initiation and decreased the rate of CuSO4-induced LDL oxidation, but also showed peroxyl radical scavenging activity and a slight metal (copper) chelating effect. (nuojiabio.com)
  • Cohosh and tamoxifen, used simultaneously, would provide a synergistic effect thus increasing the inhibitory activity of the product by the plant. (eoil.co.za)
  • Methods: Antidiabetic activity study of white tea extract performed on diabetic Sprague-Dawley male rats induced streptozotocin-nicotinamide for 14 days of oral administration. (phcogj.com)
  • The powder of jamun seeds also has an antidiabetic property which enhances the insulin activity in the body and ultimately lowers the sugar level in the blood. (planetayurveda.com)
Rats1
  • Pre-treatment of the rats once daily for 3 days with the triterpene at doses of 50 and 100 mg/kg reduced by approximately 18% plasma levels of endogenous lipid peroxides, at both doses, and by 6.5% and 19%, respectively, the susceptibility of plasma to lipid peroxidation. (nuojiabio.com)
Assay1
  • In DPPH radical scavenging assay, the effect on reducing free radicals increased in a dose dependent manner. (biomedcentral.com)
Doses1
  • Studies have shown the toxic effect of Gurmar extract when taken agains the recommended doses. (herbal-creations.com)
Antitumor1
  • Moreover, this antitumor effect has also been assessed in several animal models, with positive results that reinforce its potential as anticarcinogenic agent. (nuojiabio.com)
Anticancer effects1
  • However, more research is needed to fully understand the mechanisms behind Chaga's anticancer effects and to determine its safety and efficacy in humans. (chagamushrooms.net)
Inhibitory1
  • provided the first evidence of the inhibitory effect of the triterpene on glycogen phosphorylases (GP), which catalyze the first step of glycogen breakdown. (nuojiabio.com)
Apoptosis2
  • The effects of maslinic acid on cellular apoptosis, ROS generation, cell migration and invasion, caspase activation and targeting MAPK/ERK signaling pathway were investigated. (springeropen.com)
  • The underlying mechanism of cancer suppressive effects of maslinic acid was found to mediate via caspase-dependent apoptosis. (springeropen.com)
Medicines2
  • It's an ingredient in many traditional herbal medicines and is boasts anti-inflammatory, anti-oxidant, anti-apoptotic , and anti-carcinogenic effects. (queenbandcompany.com)
  • Up to now, many kinds of antidiabetic medicines have been developed for the patients and most of them are chemical or biochemical agents aiming at controlling or/and lowering blood glucose to a normal level. (gotomydoctor.com)
Anti-inflammatory effect1
  • In a recent work [ 5 ], the aqueous extract from C. sicyoides was shown to present an anti-inflammatory effect, as determined by the carrageenan-induced rat paw edema (a model for general inflammation), and in the mouse ear edema (a model of topical inflammation). (biomedcentral.com)
Synthesis1
  • In this study, the effect of the triterpene was tested on the synthesis of NO, superoxide and hydrogen peroxide. (nuojiabio.com)
Medicinal2
  • Pentacyclic triterpenes are present in human diet and in numerous medicinal plants. (springeropen.com)
  • It must be noted that many ethno-botanical surveys on medicinal plants used by the local population have been performed in different parts of the world and there is a considerable number of plants described as antidiabetic. (gotomydoctor.com)
Diseases2
  • have been used empirically to treat various diseases, one of them is antidiabetic. (phcogj.com)
  • But being a medical person, I have thought that it might have a slight effect on certain chronic diseases but on cancer, surely, must be greatly exaggerated. (weebly.com)
Sedative2
  • The plant is believed to have sedative effects that can promote relaxation and improve sleep quality. (eoil.co.za)
  • These data suggest that Satureja montana could be considered as a natural remedy for the treatment of premature ejaculation delaying ejaculation latency without exerting any negative effect on the other parameters of sexual behavior and without exerting a sedative effect. (esencial.al)
Vitro1
  • The vast majority of published references correspond to in vitro experiments that show the anti-proliferative and/or pro-apoptotic effect of maslinic acid, together with plausible mechanisms of action that involve different signaling pathways. (nuojiabio.com)
Physiological1
  • The crystal structure of the complex GPb (inactivated form of the enzyme)-maslinic acid was determined, which revealed that the triterpene binds at the allosteric activator site, where the physiological activator AMP binds. (nuojiabio.com)
Studies4
  • Previous studies from our laboratories indicate that the anti-diabetic effects of Syzygium cordatum (Hochst. (endocrine-abstracts.org)
  • One of the most significant areas of research has been in gastric cancer, but studies have also explored its effects on breast, colorectal, and lung cancers. (enrichd.com)
  • Reishi's tremendous effect warrants further studies. (weebly.com)
  • Colon cancer cell lines have been extensively used with this aim, but there is no shortage of studies that prove the above-mentioned effects in a wide range of cell lines from other origins. (nuojiabio.com)
Crude1
Maslinic acid3
  • The antioxidant effect of maslinic acid was first evaluated by Montilla et al. (nuojiabio.com)
  • Maslinic acid is an active member of pentacyclic triterpenes predominantly found in dietary plants including hawthorn berries and olive fruit skins. (springeropen.com)
  • To assess the anti-metastatic effects of maslinic acid on neuroblastoma cells, transwell chambers assays for migration as well as invasion were executed. (springeropen.com)
Chemotherapy1
  • For example, curcumin shows considerable prevention effects when used before chemotherapy in Phase I trials in colon cancer patients ( 12 ). (spandidos-publications.com)
20201
  • Asgharzade S, Sheikhshabani SH, Ghasempour E, Heidari R, Rahmati S, Mohammadi M, Jazaeri A, Amini-Farsani Z (2020) The effect of oleuropein on apoptotic pathway regulators in breast cancer cells. (springer.com)
Plant1
Shown3
  • Research conducted mainly in China has shown that PSP might have immune-modulating effects. (enrichd.com)
  • It is important to note that while chaga has been shown to have potential health benefits, more research is needed to fully understand its effects on the body and its potential use in cancer treatment. (chagamushrooms.net)
  • Furthermore, Chaga has been shown to have anti-inflammatory effects, which may help reduce inflammation in the body. (chagamushrooms.net)
Study1
  • A study sponsored by the National Institutes of Health (NIH) and conducted by the Bastyr University Research Institute in the US explored the effects of Turkey Tail on boosting the immune system of breast cancer patients who were undergoing radiation therapy. (enrichd.com)
Diabetes1
  • 1] Rafie Hamidpour, Soheila Hamidpour, Mohsen Hamidpour, Mina Shahlari, and Mahnaz Sohraby: Summer Savory: From the Selection of Traditional Applications to the Novel Effect in Relief, Prevention, and Treatment of a Number of Serious Illnesses such as Diabetes, Cardiovascular Disease, Alzheimer's Disease, and Cancer. (esencial.al)
Adverse effects2
  • Inadequate copper in your diet may have adverse effects on heart health. (queenbandcompany.com)
  • I strongly recommend using Amla under the proper medical guidance as it can have adverse effects if used improperly. (doctornishal.com)
Potential1
  • Its potential mood-boosting effects may be attributed to its influence on hormone levels and neurotransmitters. (eoil.co.za)
Natural1
  • Triterpenes, a most abundant and major class of natural products with around thirty thousand distinct structures recognized to date (Muffler et al. (springeropen.com)
Therapeutic1
  • This is because the cold-pressing procedure does not involve heat or chemical treatments, which may alter their composition and therapeutic effects. (queenbandcompany.com)
Pharmacological2
  • Their laxative effects have been supported by pharmacological research, and they also have anti-inflammatory action. (vin.com)
  • This paper highlights the underlying pharmacological mechanisms of the anti-diabetic effects of ginsenosides. (frontiersin.org)
Side effects2
  • PURPOSE: To mitigate side effects of conventional cancer care and improve quality of life, many patients with breast cancer in German-speaking countries opt for mistletoe therapy in addition to standard treatment. (bvsalud.org)
  • Traditional system of medicine practiced since time immemorial has emerged as an alternative for modern medicine as it is economical, nature-based and without side effects. (ac.ir)