• The hippocampus proper refers to the actual structure of the hippocampus which is made up of three regions or subfields. (wikipedia.org)
  • The subfields CA1, CA2, and CA3 use the initials of cornu Ammonis, an earlier name of the hippocampus. (wikipedia.org)
  • There are four hippocampal subfields, regions in the hippocampus proper which form a neural circuit called the trisynaptic circuit. (wikipedia.org)
  • This region is divided into the CA1, CA2, CA3/4, and dentate gyrus (DG) subfields. (biomedcentral.com)
  • The authors develop a new technique allowing simultaneous imaging of hippocampal subfields in behaving mice. (sciety.org)
  • Here, we developed an approach for two-photon imaging of the transverse hippocampal plane in awake mice via implanted glass microperiscopes, allowing optical access to the major hippocampal subfields and to the dendritic arbor of pyramidal neurons. (sciety.org)
  • CA1 is the first region in the hippocampal circuit, from which a major output pathway goes to layer V of the entorhinal cortex. (wikipedia.org)
  • PNAS (2014) etc.] the authors were able to visualize activity of a large neuronal circuit such as the hippocampal trisynaptic pathway - for the first time - in the same animal exploring an environment. (sciety.org)
  • The pyramidal cells in CA3 send some axons back to the dentate gyrus hilus, but they mostly project to regions CA2 and CA1 via the Schaffer collaterals. (wikipedia.org)
  • CA3 uniquely, has pyramidal cell axon collaterals that ramify extensively with local regions and make excitatory contacts with them. (wikipedia.org)
  • Redman and colleagues employed microprisms and two-photon optical imaging to track separately the structure of dorsal CA1 pyramidal neurons or the activity patterns of dorsal Dentate Gyrus, CA3, CA2 and CA1 pyramidal neurons, longitudinally in live mice. (sciety.org)
  • The classic hippocampal tri-synaptic circuit (EC-DG-CA3-CA1) is crucial in learning and memory [ 6 ]. (biomedcentral.com)
  • As a result of adult hippocampal neurogenesis (AHN), new DGCs are incorporated into the hippocampal circuit throughout life. (biomedcentral.com)
  • This paper will be of interest to the large number of neuroscientists who study the hippocampal circuit, and more broadly to those interested in methods to enable high-resolution in vivo imaging across depths in the brain. (sciety.org)
  • However, comprehensive measurements across the transverse hippocampal circuit in vivo are intractable with existing techniques. (sciety.org)
  • Alzheimer´s disease (AD), the most common form of dementia in industrialized countries, severely targets the hippocampal formation in humans and mouse models of this condition. (biomedcentral.com)
  • The main focus of the manuscript is technological and the authors show interesting data to support their technique, which I believe will be of relevance to neuroscientists interested in the hippocampal formation. (sciety.org)
  • CA3 has been implicated in a number of working theories on memory and hippocampal learning processes. (wikipedia.org)
  • Diagram of hippocampal regions in a rat brain. (wikipedia.org)
  • The accumulation of the latter protein is used to classify AD severity on the basis of the progressive spread of tangles across distinct regions of the brain [ 1 ]. (biomedcentral.com)
  • There are four hippocampal subfields, regions in the hippocampus proper which form a neural circuit called the trisynaptic circuit. (wikipedia.org)
  • Granule neurons from the dentate gyrus then shuttle the information to interneurons and pyramidal cells of the CA3 region of the hippocampus, which then sends the information to the CA1 region, the main source of hippocampal output. (nih.gov)
  • CA2 has 10 percent the number of neurons of CA1 or CA3, raising questions about its importance. (nih.gov)
  • To circumvent these problems, Siegelbaum, a neuroscience professor at Columbia University and a Howard Hughes Medical Institute Investigator, and Frederick L. Hitti, an M.D.-Ph.D. student, generated a special transgenic mouse in which the CA2 neurons could be selectively inhibited in adult animals. (nih.gov)
  • Individuals with schizophrenia and bipolar disorder have lowered numbers of CA2 inhibitory neurons. (nih.gov)
  • Knowledge of this region could lead to future treatments in brain disorders such as schizophrenia, bipolar disorder, and autism. (nih.gov)
  • That Hippocampal pathology is also strongly implicated in schizophrenia raises the possibility that thought disorder may be the result of disorganized Hippocampal cognitive maps. (nature.com)
  • The hippocampus proper refers to the actual structure of the hippocampus which is made up of three regions or subfields. (wikipedia.org)
  • The subfields CA1, CA2, and CA3 use the initials of cornu Ammonis, an earlier name of the hippocampus. (wikipedia.org)
  • A small region in the memory hub known as the hippocampus called CA2 (highlighted in green in this mouse brain section) is essential for social memory, the ability of an animal to recognize others of its kind. (nih.gov)
  • In the search for a neural basis of such cognitive mapping, research on the Hippocampus and associated regions in the medial temporal lobe has been particularly fruitful. (nature.com)
  • CA2 is a small region located between CA1 and CA3. (wikipedia.org)
  • Hippocampome.org v1.0 established a foundational classification system identifying 122 hippocampal neuron types based on their axonal and dendritic morphologies, main neurotransmitter, membrane biophysics, and molecular expression. (biorxiv.org)
  • Hippocampome.org is a mature open-access knowledge base of the rodent hippocampal formation focusing on neuron types and their properties. (biorxiv.org)