Triple negative breast neoplasms. Medical search. Frequent questions

Background & Objective: Invasive breast carcinoma of no special type (IBC-NST) is the most common type of breast cancer, which mainly causes axillary lymph-node metastasis (ALNM). (elabmarket.net)

It also covers the Metastatic Triple-Negative Breast Cancer therapeutics assessment by product type, stage, route of administration, and molecule type. (technewspoint.com)
The Metastatic Triple-Negative Breast Cancer companies which have their Metastatic Triple-Negative Breast Cancer (mTNBC) drug candidates in the most advanced stage, i.e. phase II include, G1 Therapeutics. (technewspoint.com)

BACKGROUND: Special histological types (SHT) of triple-negative breast cancer (TNBC) are a heterogeneous group of rare poorly understood diseases. (medscape.com)
Our objective is to conduct a systematic review to answer the question, "Is there a relationship between lower serum/plasma vitamin D levels and increased risk of triple negative breast cancer (TNBC) specifically? (nih.gov)
When grouped by relevancy to TNBC, the proportion of analyses across all study types showing a significant association between vitamin D status and breast cancer diagnosis was 37% for non-TNBC analyses, 48% for analyses that included some TNBC cases, and 88% for TNBC analyses. (nih.gov)
Triple negative breast cancers (TNBC), comprise 15-20% of breast cancers, and are associated with later stage at diagnosis, increased mortality, and occur more frequently in younger women where mammographic screening is less reliable. (nih.gov)
Determine the sensitivity, specificity, and positive predictive value of the top marker combinations found in aim 2 to distinguish TNBC from benign breast disease, and for the detection of ER+ and Her2+ breast cancer, using the EDRN Reference Set. (nih.gov)
The individual and composite sensitivities and specificities of these biomarkers for the detection of TNBC and non-TNBC breast cancers will be evaluated. (nih.gov)
Triple negative breast cancer (TNBC) is challenging to treat successfully because targeted therapies do not exist. (illinois.edu)
The management of patients with triple-negative breast cancer (TNBC) is challenging with several controversies and unmet needs. (bvsalud.org)
We used multilevel multinomial logistic regression models to estimate the association of nSES with breast cancer subtypes [triple-negative breast cancer (TNBC), HER2-positive vs. luminal A], adjusting for individual-level SES, body mass index, and reproductive factors. (princeton.edu)
Triple-negative breast cancer (TNBC) is an aggressive and difficult-to-treat cancer type that represents approximately 15% of all breast cancers. (dtu.dk)
PHILADELPHIA, PA-What makes triple negative breast cancer (TNBC) more lethal in African American women than white women or women of European descent? (oncologynurseadvisor.com)
To determine the objective response rate (ORR) of cediranib (cediranib maleate) plus olaparib in combination in patients with advanced or metastatic solid tumors of the following tumor types: non-small cell lung cancer (NSCLC), triple negative breast cancer (TNBC), pancreatic ductal adenocarcinoma (PDAC), and small cell lung cancer (SCLC). (ucsf.edu)
Due to the lack of effective therapies and poor prognosis in TNBC (triple-negative breast cancer) patients, there is a strong need to develop effective novel targeted therapies for this subtype of breast cancer. (biomedcentral.com)
Triple-negative breast cancer (TNBC), which accounts for about 10% of all breast cancer cases, is defined by the absence of ER (estrogen receptor) and PR (progesterone receptor) expression, together with lack of HER2 (human epidermal growth factor 2 receptor) gene amplification or protein overexpression at diagnosis. (biomedcentral.com)

The integrin alpha(v)beta(3-5) ligand MFG-E8 is a p63/p73 target gene in triple-negative breast cancers but exhibits suppressive functions in ER(+) and erbB2(+) breast cancers. (nih.gov)
Triple-negative breast cancer accounted for 12% of breast cancers diagnosed in the United States from 2012 to 2016, with a 5-year survival 8% to 16% lower than hormone receptor-positive disease. (lww.com)
Most notable is that triple-negative cancers disproportionately affect African American women and carriers of germline BRCA and PALB2 mutations. (lww.com)
Micronuclei and upper body cancers (head, neck, breast cancers) a systematic review and meta-analysis. (cdc.gov)
In this way, it is estimated that for the decade of 2020-2030, breast cancer will continue to be the most common cancer, along with lung and prostate cancer, but its mortality rate will drop to lower than that of pancreas and liver cancers [ 8 ]. (ecancer.org)
The leading neoplasia in women in this region is also breast cancer, affecting more than one in 10 women, and accounting for 28.8% of all female cancers [ 9 , 10 ]. (ecancer.org)
One in four of all newly diagnosed cases of cancer in women are breast cancer (24.2% of all female cancers) according to the GLOBOCAN 2018 report (2). (who.int)
This is exemplified by the discovery of genes underlying some breast and ovarian cancers, as described below. (ogmagazine.org.au)
therefore, they are known as triple-negative breast cancers (TNBCs) and constitute an aggressive histologic subtype. (technewspoint.com)
Papillary carcinomas of the breast (PCB), also termed malignant papillary carcinomas of the breast, are rare forms of the breast cancers. (wikipedia.org)
They are a clinically, histologically, and biologically heterogeneous group of breast cancers that are often difficult to distinguish from each other as well as from other papillary breast lesions. (wikipedia.org)
Morphologic and Genomic Characteristics of Breast Cancers Occurring in Individuals with Lynch Syndrome. (ucsf.edu)

The World Health Organization (2019) classified papillary neoplasms (i.e. benign or cancerous tumors) of the breast into 5 types: intraductal papilloma, papillary ductal carcinoma in situ (PDCIS), encapsulated papillary carcinoma (EPC), solid-papillary carcinoma (SPC), and invasive papillary carcinoma (IPC). (wikipedia.org)
Solid-basaloid adenoid cystic carcinoma of the breast: an aggressive subtype enriched for Notch pathway and chromatin-modifier mutations with MYB overexpression. (ucsf.edu)
HER-2 low status in early-stage invasive lobular carcinoma of the breast: associated factors and outcomes in an institutional series. (ucsf.edu)

Breast cancer (BC) is the most common malignant neoplasm in females. (technewspoint.com)

Despite methodological differences, findings evidence that although IBC presents particular features (lower survival rate and worse prognostics than most types of breast cancer), very few studies examine its epidemiology and specific risk factors in depth and use any other therapeutic approaches than those commonly used for other breast cancer subtypes. (bvsalud.org)
With an average survival rate of three years, IBC accounts for about 2.5% of all breast cancer types in the US. (bvsalud.org)
miR-21 expression was associated with survival in 53 triple negative breast cancer patients. (wikipedia.org)
In June 2019, the company announced preliminary overall survival (OS) data from a randomized Phase 2 trial, which demonstrated that women with Metastatic Triple-Negative Breast Cancer (mTNBC) lived significantly longer when receiving trilaciclib and chemotherapy compared with women receiving chemotherapy alone. (technewspoint.com)
Results of the CALGB 40502/NCCTG N063H (Alliance) trial, first reported at the American Society of Clinical Oncology annual meeting in 2012 and published online June 8 in the Journal of Clinical Oncology , show that patients with advanced breast cancer had better median progression-free survival (PFS) with once-weekly paclitaxel than with ixabepilone ( Ixempra, Bristol-Myers Squibb Company), a newer agent. (medscape.com)

inflammatory breast neoplasms, medical oncology. (bvsalud.org)

LEFTY1 binds BMPR2 to suppress BMP7-induced activation of SMAD5, and this LEFTY1-BMPR2 interaction is specific to tumor-initiating cells in triple-negative breast cancer xenografts that rely on LEFTY1 for growth. (iucc.ac.il)
Impact: Places people live may influence breast tumor biology. (princeton.edu)
Here, we map differentially enriched G-quadruplex (G4) DNA structure-forming regions (∆G4Rs) in 22 breast cancer patient-derived tumor xenograft (PDTX) models. (nih.gov)
Rapid blood and lymphatic spread and breast tumor emboli are the main features ofIBC 4 . (bvsalud.org)
15. Correlation between color power Doppler sonographic measurement of breast tumor vasculature and immunohistochemical analysis of microvessel density for the quantitation of angiogenesis. (nih.gov)

Hormone replacement therapy after prophylactic risk-reducing salpingo-oophorectomy and breast cancer risk in BRCA1 and BRCA2 mutation carriers: A meta-analysis. (cdc.gov)
Oral contraceptives and risk of breast cancer and ovarian cancer in women with a BRCA1 or BRCA2 mutation: a meta-analysis of observational studies. (cdc.gov)

In the care of patients with metastatic breast cancer, the next new thing is the same old thing: paclitaxel (multiple brands). (medscape.com)

Disease Behavior and Treatment Response of Special Histological Types of Triple-Negative Breast Cancer. (medscape.com)
4. Ultrasound characteristics of breast fibroadenomas are related to clinical and histological parameters. (nih.gov)

This is a systematic review of studies in the PubMed database to April 2013, which fit the eligibility criterion of "Inflammatory Breast Neoplasms" (MeSH Terms), filtered by Languages (English OR Portuguese OR Spanish). (bvsalud.org)

intraductal papilloma is a benign neoplasm. (wikipedia.org)

Additionally, it has been demonstrated as an independent prognostic factor in patients with pancreatic neuroendocrine neoplasms. (wikipedia.org)

These data reveal a novel chemotherapy resistance mechanism in this poor prognosis subtype of breast cancer. (illinois.edu)
G4Rs in most PDTXs (14 of 22) were found to associate with more than one breast cancer subtype, which we also call an integrative cluster (IC) 2 . (nih.gov)
Triple negative breast cancer is an aggressive subtype of breast cancer where limited treatment is available. (oncologynurseadvisor.com)

Quantifying hormone receptor status in lobular breast cancer in an institutional series: the relationship between estrogen and progesterone receptor status and outcomes. (ucsf.edu)

To level the playing field, we must integrate genomic predictors of disease and epidemiologic characteristics of molecular breast cancer subtypes to provide personalized risk assessment, screening, and treatment for each patient. (lww.com)
Background: The disproportionate burden of more aggressive breast cancer subtypes among African American/Black women may stem from multilevel determinants. (princeton.edu)
Methods: We evaluated the association between neighborhood-level socioeconomic status (nSES) and breast cancer subtypes in the Women's Circle of Health and Women's Circle of Health Follow-up Study, which included 1,220 Black women diagnosed from 2005 to 2017 with invasive breast cancer. (princeton.edu)
Inflammatory Breast Cancer (IBC) is a rare and very aggressive type of cancer that tends to develop at a younger age, compared with other subtypes of breast cancer. (bvsalud.org)

This phase II trial studies cediranib maleate in combination with olaparib in treating patients with solid tumors that have spread to other parts of the body (advanced/metastatic) or cannot be removed by surgery (unresectable), including breast cancer, non-small cell lung cancer, small cell lung cancer, and pancreatic cancer . (ucsf.edu)

Can breast MRI predict pathologic response following neoadjuvant chemotherapy for breast cancer? (johnshopkins.edu)

3. Invasive carcinomas and fibroadenomas of the breast: comparison of microvessel distributions--implications for imaging modalities. (nih.gov)
Triple-Negative Apocrine Carcinomas: Toward a Unified Group With Shared Molecular Features and Clinical Behavior. (ucsf.edu)

Ixabepilone has been shown to have superior efficacy in combination with capecitabine ( Xeloda , F. Hoffman-LaRoche, Ltd) than capecitabine alone in patients with taxane-resistant metastatic breast cancer and as a single agent against multidrug-resistant disease, Dr Rugo and colleagues note. (medscape.com)

Breast (Edinburgh, Scotland) 2021 Sep 60 155-162. (cdc.gov)

11. Contrast-enhanced color Doppler ultrasound characteristics in hypervascular breast tumors: comparison with MRI. (nih.gov)
16. D-galactose-based signal-enhanced color Doppler sonography of breast tumors and tumorlike lesions. (nih.gov)
19. Contrast enhanced harmonic ultrasound for differentiating breast tumors - first results. (nih.gov)
These tumors are the leading cause of breast cancer deaths in African-American women, which are usually diagnosed at an earlier age and in more advanced stages of the disease, when compared with white women," said Luciane R. Cavalli, PhD, assistant professor at Georgetown Lombardi Comprehensive Cancer Center in Washington, DC. (oncologynurseadvisor.com)
The identification of PBS tumors may require the input of breast pathologists familiar with papillary lesions of the breast. (wikipedia.org)

abstract = "Within the last decade, breast cancer is increasingly understood as a heterogeneous disease comprising distinct entities that vary significantly with regard to molecular biology and clinical features. (uni-luebeck.de)

Conclusion: Our findings indicate that TMEPAI promotes EMT and drug efflux transporters at least in part by shifting doxorubicin action from SMAD3 phosphorylation reduction to PI3K/AKT inhibition in triple-negative breast cancer cells. (ui.ac.id)

DelveInsight's, "Metastatic Triple-Negative Breast Cancer Pipeline Insight 2023" report provides comprehensive insights about 4+ companies and 4+ pipeline drugs in Metastatic Triple-Negative Breast Cancer (mTNBC) pipeline landscape. (technewspoint.com)

Triple negative means that the breast cancer does not express other hormone receptors called ER alpha, progesterone, and HER2. (fredhutch.org)
Whereas for patients with hormone receptor positive and/or HER2/neu-positive breast cancer overcoming resistance against endocrine and/or anti-HER2/neu-targeted therapy is of particular importance, patients with triple negative breast cancer suffer from a lack of sufficient targeted therapeutic options at all. (uni-luebeck.de)

If your breast cancer cells have more HER2 than normal, they can grow more quickly and spread to other parts of the body. (medlineplus.gov)

Inflammatory Breast Cancer (IBC) is a rare, although highly aggressive and lethal 3 type of cancer. (bvsalud.org)
What has been researched about inflammatory breast neoplasms? (bvsalud.org)
Inflammatory breast cancer , in which cancer cells block lymph vessels in the skin of the breast. (medlineplus.gov)

This phase II trial studies how well estradiol works in treating patients with estrogen receptor beta (ER beta) positive, triple negative breast cancer that has spread to nearby tissue or lymph nodes (locally advanced) or other places in the body (metastatic). (fredhutch.org)
CITED1 as a marker of favourable outcome in anti-endocrine treated, estrogen-receptor positive, lymph-node negative breast cancer. (lu.se)

Despite impressive advances in the treatment of patients with breast cancer, not all patients derive equal benefits from current therapeutic options and a significant number of patients still experience disease recurrence. (uni-luebeck.de)

Serum Vitamin D Status and Breast Cancer Risk by Receptor Status: A Systematic Review. (nih.gov)
Prevalence of pathogenic variants and variants of unknown significance in patients at high risk of breast cancer: A systematic review and meta-analysis of gene-panel data. (cdc.gov)

Breast cancer that is caused by inherited genetic changes is called hereditary breast cancer. (medlineplus.gov)

Role of mitogen-activated protein kinases and Mcl-1 in apoptosis induction by withaferin A in human breast cancer cells. (rush.edu)
Our previous study indicated that TMEPAI (transmembrane prostate androgen-induced protein) attenuated doxorubicin sensitivity in triple-negative breast cancer cells. (ui.ac.id)
Thus, the present study aimed to elucidate the mechanism of TMEPAI in doxorubicin resistance in triple-negative breast cancer cells. (ui.ac.id)
Methods: We used BT549, triple-negative cells wild type (WT), and BT549 TMEPAI knock-out. (ui.ac.id)
TMEPAI was also shown to modify the effect of doxorubicin by reducing PI3K expressions and Akt phosphorylation in triple-negative breast cancer cells. (ui.ac.id)
It happens when cells in the breast change and grow out of control. (medlineplus.gov)
The types are based on which breast cells turn into cancer. (medlineplus.gov)
If these tests show that you have breast cancer, you will have tests that study the cancer cells. (medlineplus.gov)
It is on the outside of all breast cells. (medlineplus.gov)

Breast and ovarian cancer penetrance of BRCA1/2 mutations among Hong Kong women. (cdc.gov)
Meta-Analysis of BRCA1 Polymorphisms and Breast Cancer Susceptibility. (cdc.gov)
Association between BRCA1 polymorphisms rs799917 and rs1799966 and breast cancer risk: a meta-analysis. (cdc.gov)
Correction to: Frequency of heterozygous germline pathogenic variants in genes for Fanconi anemia in patients with non-BRCA1/BRCA2 breast cancer: a meta-analysis. (cdc.gov)
Frequency of heterozygous germline pathogenic variants in genes for Fanconi anemia in patients with non-BRCA1/BRCA2 breast cancer: a meta-analysis. (cdc.gov)
Historically, the function of many of these genes was elucidated following a lengthy period of basic research, made possible by the identification of the gene underlying a striking inherited familial phenotype, for example that of the Retinoblastoma gene (Rb) 10 , or of familial breast and ovarian cancer (BRCA1) 11 or familial female and male breast cancer (BRCA2). (ogmagazine.org.au)
There are also certain genetic changes that can raise your risk of breast cancer, including changes in the BRCA1 and BRCA2 genes. (medlineplus.gov)

IBC may be diagnosed by an imaging test and by a breast biopsy of an invasive cancer 7 . (bvsalud.org)
If the cancer spreads outside the breast, the cancer is called "invasive. (medlineplus.gov)

Anatomy2

Organisms1

Diseases8

Chemicals and Drugs7

Analytical, Diagnostic and Therapeutic Techniques and Equipment7

Phenomena and Processes4

Disciplines and Occupations1

Information Science1

Health Care1

Geographicals1

Metastasis1

Therapeutics2

TNBC14

Cancers12

Carcinoma3

Malignant neoplasm1

Survival5

Medical Oncology1

Tumor5

Mutation2

Patients with metastatic breast cancer1

Histological2

Mesh1

Benign1

Prognostic1

Subtype3

Lobular1

Subtypes4

Pancreatic1

Neoadjuvant chemotherapy1

Carcinomas2

Metastatic breast1

20211

Tumors5

Abstract1

Inhibition1

20231

Hormone2

HER21

Inflammatory3

Estrogen-receptor2

Advances1

Systematic2

Hereditary breast cancer1

Cells9

BRCA17

Invasive2