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  • urine
  • Sulfamethoxazole/trimethoprim should be taken with 6 to 8 ounces of liquid to prevent crystals from forming in the urine. (medicinenet.com)
  • Urine concentrations of trimethoprim are considerably higher than are the concentrations in the blood. (nih.gov)
  • After a single oral dose of 100 mg, urine concentrations of trimethoprim ranged from 30 to 160 mcg/mL during the 0- to 4-hour period and declined to approximately 18 to 91 mcg/mL during the 8- to 24-hour period. (nih.gov)
  • A 200 mg single oral dose will result in trimethoprim urine levels approximately twice as high. (nih.gov)
  • After oral administration, 50% to 60% of trimethoprim is excreted in the urine within 24 hours, approximately 80% of this being unmetabolized trimethoprim. (nih.gov)
  • concentrations
  • Concentrations of trimethoprim in vaginal secretions are consistently greater than those found simultaneously in the serum, being typically 1.6 times the concentrations of simultaneously obtained serum samples. (nih.gov)