Triglyceride rich lipoproteins lipoproteins hdl. Medical search. Frequent questions

Fenofibric acid, the active metabolite of fenofibrate, produces reductions in total cholesterol, LDL cholesterol, apolipoprotein B, total triglycerides and triglyceride rich lipoprotein (VLDL) in treated patients. (nih.gov)
The niacin in peas helps reduce, the production of triglycerides and VLDL (very low-density lipoprotein, which results in in less bad cholesterol, increased HDL ("good") cholesterol, and lowered triglycerides . (vahrehvah.com)
Moreover, thyroid hormones stimulate the cholesteryl ester transfer protein (CETP), an enzyme which transports cholesteryl esters from HDL2 to the very low density lipoproteins (VLDL) and triglycerides in the opposite direction 9 (figure). (hormones.gr)
Elevated VLDL and LDL are reduced by treatment with Zaf, whilst HDL-levels are increased. (sdrugs.com)
In the course of the intensified degradation of triglyceride-rich lipoproteins (chylomicrons, VLDL) precursors for the formation of HDL are formed which explains an increase in HDL. (sdrugs.com)
Elevated triglyceride levels can arise from 2 abnormalities- overproduction of VLDL-C and impaired lipolysis of triglycerides. (ahdbonline.com)
Patients with type 2 diabetes have an overproduction of triglyceride-rich VLDL-C level, which is a result of high free fatty acid levels, hyperglycemia, obesity, and insulin resistance. (ahdbonline.com)
Lipolysis is a process of breaking down of triglycerides to glycerol and fatty acids, the process is done by hydrolysis by inducing some hormones like epinephrine, nor-epinephrine, cortisol, testosterone, etc. to release the compounds like High density lipoproteins (HDL), Low density lipoproteins (LDL) and Very low density lipoproteins (VLDL) [ 12 - 18 ]. (omicsonline.org)
These triglycerides transports through blood to reach the muscle or tissue, while transporting the LDL and VLDL accumulate on the walls of the blood vessels creating plaques which narrows the blood vessel and also generates fat deposits in the body [ 19 ]. (omicsonline.org)
By inhibiting the production of LDL and VLDL the risk factors for the hyperlipidemia can be controlled, Bile acid sequestrants like Cholestyramine, Colestipol and Colesevelam are used to regulate high serum levels by binding the bile acid which is secreting from liver to metabolize the triglycerides [ 20 - 24 ]. (omicsonline.org)
As apoE2 binds defectively to LDL receptors, apoE2 homozygosity can precipitate type III hyperlipoproteinemia, however, only occurs when another condition, including: diabetes, oestrogen deficiency, hypothyroidism, or obesity, leads to the overproduction of VLDL or fewer LDL receptors, overwhelming the limited ability of apoE2 to mediate the clearance of triglyceride-rich and cholesterol-rich β-VLDL. (randox.com)
The lipoprotein-binding preference of apoE4 to large (30-80nm), triglyceride-rick VLDL, is associated with elevated levels of LDL. (randox.com)
Allows the net movement of cholesteryl ester from high density lipoproteins/HDL to triglyceride-rich very low density lipoproteins/VLDL, and the equimolar transport of triglyceride from VLDL to HDL (PubMed:3600759, PubMed:24293641, PubMed:3281933). (icr.ac.uk)
One molecule of apo B is present on very large dense lipoproteins (VLDL), low density lipoproteins (LDL), chylomicron and lipoprotein(a) (Lp(a)) and as such, plasma apo B equates to the total number of apo B particles 8 . (biorexdiagnostics.com)
Infection of apoA-I-/- mice with 2x10(9) pfu (plaque-forming units) of an apoE4-expressing adenovirus increased both HDL and the triacylglycerol-rich VLDL (very-low-density lipoprotein)/IDL (intermediate-density lipoprotein)/LDL (low-density lipoprotein) fraction and generated discoidal HDL particles. (omicsdi.org)
Gene transfer of apoA-IV in apoA-I(-/-) × apoE(-/-) mice increased plasma cholesterol and triglyceride levels, and 80% of the protein was distributed in the VLDL/IDL/LDL region. (omicsdi.org)

In addition to regulating the size of HDL particles, this protein may be involved in cholesterol metabolism. (wikipedia.org)
There is also exploration of the relative atherogenicity of TG-rich lipoproteins and their remnants versus LDL, with the caveat that precise definition of the nature of remnant particles is currently uncertain. (eas-society.org)
Emerging approaches include measuring the cholesterol content of remnant particles, or TG-rich lipoprotein particle number or composition, although none of these is fully validated for their association with ASCVD risk. (eas-society.org)
Through this mechanism, fenofibrate increases lipolysis and elimination of triglyceride-rich particles from plasma by activating lipoprotein lipase and reducing production of apoprotein C-III (an inhibitor of lipoprotein lipase activity). (nih.gov)
The resulting fall in triglycerides produces an alteration in the size and composition of LDL from small, dense particles (which are thought to be atherogenic due to their susceptibility to oxidation), to large buoyant particles. (nih.gov)
Association of small low-density lipoprotein particles with the incidence of coronary artery disease in men and women. (jhsmr.org)
These receptors internalise apoE-containing lipoprotein particles and so apoE participates in the distribution or redistribution of lipids among various tissues and bodily cells. (randox.com)
Involved in the transfer of neutral lipids, including cholesteryl ester and triglyceride, among lipoprotein particles. (icr.ac.uk)
Apolipoprotein A-I (Apo A-I) is the major protein carried on high density lipoprotein cholesterol (HDL-C) particles. (biorexdiagnostics.com)
Apolipoprotein C-III (Apo C-III) is an inhibitor of lipoprotein lipase (LPL) activity, a key regulator of triglyceride-rich lipoproteins (TRLs) and contributes to the atherogenicity of low-density lipoprotein (LDL) and high-density lipoprotein (HDL) particles. (biorexdiagnostics.com)
We have investigated the ability of apoE (apolipoprotein E) to participate in the biogenesis of HDL (high-density lipoprotein) particles in vivo using adenovirus-mediated gene transfer in apoA-I-/- (apolipoprotein A-I) or ABCA1-/- (ATP-binding cassette A1) mice. (omicsdi.org)
ABCA1-/- mice treated similarly failed to form HDL particles, suggesting that ABCA1 is essential for the generation of apoE-containing HDL. (omicsdi.org)
Similarly, co-infection of apoE-/- mice with apoE4 and human LCAT corrected the hypercholesterolaemia and generated spherical particles, suggesting that LCAT is essential for the maturation of apoE-containing HDL. (omicsdi.org)
In addition to its documented functions in the clearance of triacylglycerol-rich lipoproteins, it participates in the biogenesis of HDL-sized apoE-containing particles. (omicsdi.org)
HDL particles generated by this pathway may account at least for some of the atheroprotective functions of apoE. (omicsdi.org)
Two-dimensional gel electrophoresis of plasma and electron microscopy showed that truncated apoE forms generated distinct HDL subpopulations and formed discoidal HDL particles which could be converted to spherical by co-administration of truncated apoE4-202 and LCAT. (omicsdi.org)
Overall, the in-vivo and in-vitro data are consistent and indicate that apoE4-185 is the shortest truncated form that supports formation of discoidal apoE4-containing HDL particles. (omicsdi.org)
ApoA-IV promotes the biogenesis of apoA-IV-containing HDL particles with the participation of ABCA1 and LCAT. (omicsdi.org)
migrating HDL particles were not detectable following gene transfer of apoA-IV in ABCA1(-/-) or LCAT(-/-) mice. (omicsdi.org)
Our findings are consistent with a novel function of apoA-IV in the biogenesis of discrete HDL-A-IV particles with the participation of ABCA1 and LCAT, and may explain previously reported anti-inflammatory and atheroprotective properties of apoA-IV. (omicsdi.org)

Indeed, beyond the lipoprotein lipase cofactor apolipoprotein (apo) CII, recent studies have identified the relevance of apoCIII in controlling the efficiency of TG clearance, and angiopoietin-like protein 3 (ANGPTL3) in modulating lipoprotein lipase activity, suggesting potential as therapeutic targets (14,15) . (eas-society.org)
ApoC-III (apolipoprotein C-III), an important regulator of lipoprotein metabolism, is strongly associated with hypertriglyceridaemia and the progression of CVD. (portlandpress.com)
A variety of clinical studies have demonstrated that elevated levels of total cholesterol (total-C), low density lipoprotein cholesterol (LDL-C), and apolipoprotein B (apo B), an LDL membrane complex, are associated with human atherosclerosis. (nih.gov)
Similarly, decreased levels of high density lipoprotein cholesterol (HDL-C) and its transport complex, apolipoprotein A (apo AI and apo AII) are associated with the development of atherosclerosis. (nih.gov)
A diet rich in safflower oil can increase the level of platelet linoleic acid and decrease the level of serum cholesterol, especially apolipoprotein B levels (6) and low-density lipoprotein (LDL) cholesterol without influencing high-density (HDL) lipoprotein cholesterol, serum triglyceride or the level of apolipoprotein A-1. (amazondiscovery.com)
Triglycerides (TGs) are proatherogenic lipoproteins involving the risk of coronary heart disease (CHD), while apolipoprotein A5 (APOA5) and apolipoprotein C3 (APOC3) are main lipoproteins composing TG-rich lipoproteins. (biomedcentral.com)
Apolipoprotein B (Apo B)-containing lipoproteins that are cholesterol-rich are widely accepted as one of the most causal agents of atherosclerotic cardiovascular disease (ASCVD) 7 . (biorexdiagnostics.com)
Pathway of biogenesis of apolipoprotein E-containing HDL in vivo with the participation of ABCA1 and LCAT. (omicsdi.org)
Formation of HDL in vivo was assessed by various methods following gene transfer in apolipoprotein A-I(-/-) × apoE(-/-) mice. (omicsdi.org)

Phospholipid transfer protein: its impact on lipoprotein homeostasis and atherosclerosis. (nih.gov)
Recent works highlight the effect of triglycerides-rich lipoproteins (TRL) in the pathogenesis of atherosclerosis. (urv.cat)
In dyslipidemia, serum low-density lipoprotein cholesterol (LDL-C) appears to have the greatest role in premature and early atherosclerosis and CAD development and must therefore be treated as aggressively as hyperglycemia to reduce CAD risk. (ahdbonline.com)
Therefore, we aim to investigate the mechanisms by which FGF21 improves cholesterol metabolism and unravel its effect on atherosclerosis development by using APOE*3-Leiden.CETP mice, a well-established human-like model for studies on (V)LDL and HDL metabolism, aiming at providing further preclinical evidence for developing FGF21 as a therapeutic strategy for the treatment of cardiovascular disease. (einthovenlaboratory.com)
HDL-C and apo A-I are protective against atherosclerosis through a few mechanisms, including the ability to mediate reverse cholesterol transport and their role in cellular cholesterol extraction 6 . (biorexdiagnostics.com)
There are several lipoproteins that instigate, develop and drive atherosclerosis, however some are not routinely tested. (biorexdiagnostics.com)

Diabetic dyslipidemia is characterized by elevated triglyceride levels, decreased high-density lipoprotein cholesterol levels, and elevated low-density lipoprotein cholesterol (LDL-C) levels. (ahdbonline.com)
Proof of benefit is strongest for lowering elevated low-density lipoprotein cholesterol (LDL-C) levels. (msdmanuals.com)

These changes are attributable to the decreased activity of LPL, which results in a decreased clearance of triglyceride-rich lipoproteins 16 . (hormones.gr)

More recently, studies in mice with targeted inactivation of ABCA1 ( 11 ) have demonstrated a critical role of ABCA1 in lipid metabolism and confirmed its role in the biogenesis of HDL. (jci.org)
Therefore, this latest EAS Statement reviewed what is known about the structure, function, metabolism, and atherogenicity of TG-rich lipoproteins and their remnants, with the ultimate aim of identifying targeted therapeutic approaches to address residual cardiovascular risk associated with elevated TG levels (9) . (eas-society.org)
These changes in the lipid profile are explained by the regulatory effect of thyroid hormones on the activity of some key enzymes of lipoprotein metabolism. (hormones.gr)
Lipoprotein and their metabolism. (jhsmr.org)
Fibroblast growth factor 21 (FGF21), a metabolic hormone with pleiotropic effects on lipid and lipoprotein metabolism, was shown to modulate BAT activity. (einthovenlaboratory.com)

Plasma levels of TG-rich lipoproteins depend on the rate of production, the efficiency of removal of TG content by lipolysis, and hepatic clearance. (eas-society.org)
ApoC-III impairs the lipolysis of TRLs [triacylglycerol (triglyceride)-rich lipoproteins] by inhibiting lipoprotein lipase and the hepatic uptake of TRLs by remnant receptors. (portlandpress.com)
The drugs which are used lower the low density lipoproteins (LDL) in the blood by preventing the conversion of them from high density lipoproteins by interrupting the various steps during lipolysis [ 6 - 11 ]. (omicsonline.org)

Zaf lowers elevated blood lipids (triglycerides and cholesterol). (sdrugs.com)
There are different types of lipids available in the body like fats, monoglycerides, diglycerides, triglycerides, phospholipids and others. (omicsonline.org)
The apoE protein binds with lipid forming lipoproteins which are responsible for the transportation of cholesterol and other lipids through the bloodstream 1 . (randox.com)
Lipids and lipoproteins significantly contribute to atherosclerotic cardiovascular disease (ASCVD), a specific type of arteriosclerosis, whereby the arteries harden and plaque formations, or atheroma occur. (biorexdiagnostics.com)
Triglycerides (TGs) and cholesterol contribute most to disease, although all lipids are physiologically important. (msdmanuals.com)

According to the Mayo Clinic , using red yeast rice can also reduce your total blood cholesterol and triglyceride levels. (healthline.com)
The study reports managing cholesterol and triglyceride levels could help to reduce Alzheimer's risk. (neurosciencenews.com)

The activity of triglyceride lipases (lipoprotein lipase and hepatic lipoproteinlipase) involved in the catabolism of triglyceride-rich lipoproteins is increased by Zaf. (sdrugs.com)
Furthermore, cholesterol biosynthesis is reduced by Zaf, which is accompanied by a stimulation of the LDL-receptor-mediated lipoprotein catabolism. (sdrugs.com)
In mice and humans, FGF21 treatment reduces plasma fatty acid and triglyceride (TG) levels by accelerating TG-rich lipoprotein catabolism in white and brown adipose tissue. (einthovenlaboratory.com)

Finally, thyroid hormones stimulate the lipoprotein lipase (LPL), which catabolizes the triglyceride-rich lipoproteins, and the hepatic lipase (HL), which hydrolyzes HDL2 to HDL310 (figure). (hormones.gr)

however, the contribution to the overall plasma HDL levels is minimal. (jci.org)
Since the discovery of the inverse relationship between HDL levels and coronary artery disease, the structure, function, and metabolic origin of HDL has been a subject of intense investigation. (jci.org)
This focus waned, however, as genetic studies and randomized clinical trials failed to show that raising HDL-C levels reduced cardiovascular events (5-7) . (eas-society.org)
Fibrates have been shown to decrease plasma levels of triglyceride-rich lipoproteins and LDL and to increase HDL. (embl.de)
Data on the effect of fibrates on lipoprotein(a) levels in man are not consistent. (embl.de)
Unusually low levels of triglycerides can be present in disease states, producing syndromes of malabsorption in addition to patients who carry genes for familial hypobetalipoproteinemia . (medscape.com)
Very high levels of triglycerides are defined by serum levels of 500 mg/dL or greater and can be concerning for development of pancreatitis . (medscape.com)
[ 4 ] If pancreatitis is likely or potentially threatening and levels of triglycerides are found to be 1000 mg/dL or greater, immediate institution of lipid lowering therapy should begin. (medscape.com)
The association between thyroid autoimmunity and lipoprotein (a) levels is controversial. (hormones.gr)
In general, overt and subclinical hypothyroidism is associated with hypercholesterolemia mainly due to elevation of low density lipoprotein (LDL) cholesterol levels, whereas high density lipoprotein (HDL) cholesterol concentration is usually normal or even elevated 3-5 . (hormones.gr)
On the other hand, hyperthyroidism (both overt and subclinical) is accompanied by a decrease in serum levels of total, LDL and HDL cholesterol 6 . (hormones.gr)
In hypothyroid patients, despite the reduced activity of HMG-CoA reductase, there is often an increase in the serum total cholesterol concentration, mainly due to raised levels of serum LDL cholesterol and intermediate density lipoprotein (IDL) cholesterol 4,12 . (hormones.gr)
Systemic uric acid concentrations are influenced by dietary levels of purine rich foods, body mass index (BMI), and cardiometabolic risk factors, such as high blood pressure, high density lipoprotein (HDL), triglyceride levels and fasting blood glucose. (salimetrics.com)
During therapy, the changes in disease activity and inflammatory status were inversely correlated with changes in plasma total and HDL cholesterol levels and positively correlated with the variation of atherogenic index. (bmj.com)
Honey helps lower blood pressure, decrease triglyceride levels, and prevent heart attack and stroke . (lecanadian.com)
The cholesterol content of these are reported for clinical reasons, as HDL cholesterol (HDL-C), LDL cholesterol (LDL-C), and remnant cholesterol in TG rich lipoproteins, with serum TG levels being marker of remnant cholesterol. (surgicalneurologyint.com)
they differ markedly from one another in their ratio of cholesterol and triglycerides to protein, and thus, in their effect on blood levels of cholesterol. (deblonchiropractic.com)
It's clear that high triglyceride levels aren't good for the body and can be particularly problematic when combined with excess levels of LDL cholesterol. (deblonchiropractic.com)
In patients with diabetes, the particle size of LDL-C is much smaller and denser because of elevated triglyceride levels, which in turn contributes to a 3-fold increase in the risk for developing CAD. (ahdbonline.com)
Solid data has shown that eating one to three daily portions of almonds (28 to 84 grams) can help lower LDL cholesterol levels," said study co-author Rick Mattes, Ph.D., R.D. from Purdue University in West Lafayette, USA. (digitalnaturopath.com)
Whole almonds or almond oil (replacing half of the habitual fat intake) reduced plasma triglyceride, total and LDL-cholesterol concentrations, and increased HDL-cholesterol levels in a trial of 22 men and women with normal lipid levels. (digitalnaturopath.com)
These can help lower your triglyceride levels and provide protection against heart disease. (healthline.com)
On the exercise front, physical activity helps you lose weight and boosts your high-density lipoprotein (HDL) cholesterol levels. (healthline.com)
Drinking 12 ounces of sugary drinks more than once per day is linked to lower levels of high-density lipoprotein cholesterol (HDL-C), ("good" cholesterol), and higher levels of triglycerides, in middle-aged and older adults, both of which have been shown to increase risk of cardiovascular disease. (news-medical.net)
High levels of low-density lipoproteins (LDL-the "bad cholesterol") and triglycerides, a type of blood fat, are associated with an increased risk of heart and blood vessel diseases. (medicalxpress.com)
None of the diets increased HDL levels significantly, but the Mediterranean diets did improve HDL function. (medicalxpress.com)
The key to maintaining healthy cholesterol levels is to increase your intake of high-density lipoprotein (HDL), also known as the "good cholesterol, and minimize your intake of low-density lipoprotein, which is the "bad cholesterol. (baycare.org)
Monitoring your levels of HDL, LDL, and triglycerides is an important part of heart disease prevention . (baycare.org)
Low levels of LDL cholesterol and triglycerides have been linked to an increased risk of hemorrhagic stroke in women. (neurosciencenews.com)
Children born with high levels of triglycerides and low-density lipoprotein in their cord blood samples were more likely to receive lower ratings from their teachers on both social and emotional development scales. (neurosciencenews.com)
Low HDL and high triglyceride levels in the blood at 35 were associated with an increased risk of developing Alzheimer's disease later in life. (neurosciencenews.com)
Drinking 29.5 mL to 188 mL of noni juice per day significantly reduced cholesterol levels, triglycerides, and hs-CRP. (hindawi.com)
Oxidative stress, as measured by serum malondialdehyde concentration, is positively correlated to elevated triglyceride and cholesterol levels in smokers [ 18 ]. (hindawi.com)
High cholesterol refers to elevated levels of cholesterol in the blood, primarily low-density lipoprotein (LDL) cholesterol, often referred to as "bad" cholesterol. (dalatonnantasket.com)
Diagnosis is by measuring plasma levels of total cholesterol, TGs, and individual lipoproteins. (msdmanuals.com)
In the general population, evidence is less strong for a benefit from lowering elevated TG and increasing low high-density lipoprotein cholesterol (HDL-C) levels. (msdmanuals.com)
HDL-C levels do not always predict cardiovascular risk. (msdmanuals.com)
For example, high HDL-C levels caused by some genetic disorders may not be associated with a lower risk of cardiovascular disorders, and low HDL-C levels caused by some genetic disorders may not be associated with an increased risk of cardiovascular disorders. (msdmanuals.com)
Although HDL-C levels predict cardiovascular risk in the general population, the increased risk may be caused by other factors, such as accompanying lipid and metabolic abnormalities, such as hypertriglyceridemia, rather than the HDL-C level itself. (msdmanuals.com)
This system does not take into account specific lipoprotein abnormalities (eg, low HDL-C or high LDL-C) that may contribute to disease despite normal cholesterol and TG levels. (msdmanuals.com)

A meta-analysis of 54 studies revealed that smokers have about 3% higher serum cholesterol and 9% greater serum triglyceride concentrations than nonsmokers. (hindawi.com)

Concomitantly, there was strong interest in high-density lipoprotein cholesterol (HDL-C) as a protective risk factor, supported by extensive epidemiological evidence (4) . (eas-society.org)
It is globally characterized by hypertriglyceridaemia, near normal LDL (low-density lipoprotein)-cholesterol and low plasma HDL (high-density lipoprotein)-cholesterol. (portlandpress.com)
Honey decreases LDL (low-density lipoprotein) cholesterol in the body. (lecanadian.com)
Total cholesterol, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol and lipoprotein (a) neither showed a significant difference between SAH and controls and nor any significant association with DCI. (surgicalneurologyint.com)
Diabetic dyslipidemia is characterized by elevated triglycerides, decreased high-density lipoprotein cholesterol (HDL-C), and elevated LDL-C in comparison with patients without diabetes. (ahdbonline.com)
One hundred thirty-two adult heavy smokers completed a randomized, double blind, placebo-controlled clinical trial designed to investigate the effect of noni juice on serum cholesterol, triglyceride, low density lipoprotein cholesterol (LDL), high density lipoprotein cholesterol (HDL), high-sensitivity C-reactive protein (hs-CRP), and homocysteine. (hindawi.com)
These include increased release of reactive oxygen species from phagocytes, such as superoxide from peripheral blood neutrophils, oxidized low density lipoprotein cholesterol (LDL), increased lipid hydroperoxides and malondialdehyde, and decreased plasma antioxidant capacity [ 4 - 11 ]. (hindawi.com)
The fact that cigarette smoke increases total cholesterol and triglycerides, as well as decreases high density lipoprotein cholesterol (HDL), has long been established. (hindawi.com)
TC), triglycerides (TG) and low-density lipoprotein cholesterol. (who.int)

Disease activity (DAS28) and plasma lipoproteins concentrations (total, HDL and LDL-cholesterol, triglycerides, ApoA, ApoB) were assessed in 55 RA patients and 55 controls. (bmj.com)
1 Among the traditional cardiovascular risk factors, the lipid profile in RA has often been described as "pro-atherogenic", 2 based on decreased HDL-cholesterol (HDL-C) and increased LDL:HDL-C ratio and lipoprotein (a) plasma concentrations in both active and treated RA. (bmj.com)

Apo E is involved in the removal of atherogenic remnant lipoproteins from plasma and exerts an influence on several cells, including those of the bone marrow, immune system and vessel wall 11 . (biorexdiagnostics.com)

Hypertriglyceridemia is indicative of insulin resistance when present with low high-density lipoprotein (HDL) and elevated low-density lipoprotein (LDL), while elevated triglyceride is a clinical risk factor for coronary artery disease (CAD), especially when low HDL is present. (medscape.com)

It decreases low density lipoproteins and increases high density lipoproteins. (sdrugs.com)
Decreases in LDL and homocysteine, as well increases in HDL, were also observed among noni juice drinkers. (hindawi.com)
The increases in total cholesterol and triglycerides, with the corresponding decreases in HDL, were found to be dose-dependent when the data were analyzed by smoking frequency. (hindawi.com)
In humans, FGF21 also decreases plasma total and LDL-cholesterol, and increases HDL-cholesterol. (einthovenlaboratory.com)

The increase in apoAI was accompanied by a small but significant increase in HDL cholesterol 6 weeks after transplantation. (jci.org)

as an adjunct to diet to reduce elevated LDL-C, Total-C, TG, and Apo B, and to increase HDL-C in patients with primary hyperlipidemia or mixed dyslipidemia when response to diet and non-pharmacological interventions alone has been inadequate. (nih.gov)
Fenoglide is indicated as adjunctive therapy to diet to reduce elevated LDL-C, Total-C, Triglycerides, and Apo B, and to increase HDL-C in adult patients with primary hyperlipidemia or mixed dyslipidemia. (nih.gov)
To describe the effective approach to the management of dyslipidemia in patients with diabetes to allow providers and payers to become familiar with the treatment goals for all the components of lipoproteins, to correctly initiate appropriate lipid-lowering medications based on treatment goals and lipid-lowering capability, and to apply the data presented in lipid clinical trials to the treatment of patients with diabetes. (ahdbonline.com)

The encoded protein transfers phospholipids from triglyceride-rich lipoproteins to high density lipoprotein (HDL). (wikipedia.org)
Recent studies have demonstrated that ATP-binding cassette protein A1 (ABCA1) is highly regulated in macrophages and mediates the efflux of cholesterol and phospholipids to apolipoproteins, a process necessary for HDL formation. (jci.org)
HDL originates as discoidal complexes of apolipoproteins and phospholipids. (jci.org)
Lipid-poor HDL precursors mature by obtaining cholesterol and phospholipids from cell membranes or triglyceride-rich lipoproteins. (jci.org)
ABCA1 is expressed in many organs and is thought to mediate HDL maturation by facilitating the efflux of cellular phospholipids and cholesterol onto apolipoproteins. (jci.org)

At all times, the level of HDL in ABC1 -/- recipient mice remained low relative to WT recipient mice irrespective of the genotype of the donor macrophage ABCA1 or high-fat feeding. (jci.org)
In addition, treatment with fenofibrate results in increases in high density lipoprotein (HDL) and apoproteins apoAI and apoAII. (nih.gov)
She continued, "It is full of medium chain triglycerides, better known as the good fat, and even appears to raise high-density lipoprotein (HDL), also known as the good cholesterol. (inspiredeconomist.com)
High-quality honey is rich in antioxidants. (lecanadian.com)
At the same time, honey increases HDL (high-density lipoprotein) or "good" cholesterol, which helps remove other forms of cholesterol from the blood. (lecanadian.com)
18 21 ] The lipid profile includes total cholesterol (TC) and triglycerides (TGs), which are carried as lipoproteins, the smallest being high-density lipoprotein (HDL), medium sized low-density lipoprotein (LDL), and larger sized TG rich lipoproteins (chylomicron remnants, very LDLs, etc. (surgicalneurologyint.com)
On other hand, it does not appear to enhance high-density lipoprotein (HDL) cholesterol or decrease triglycerides. (amazondiscovery.com)
People with high triglycerides often have high total cholesterol, high LDL cholesterol, and low HDL cholesterol. (deblonchiropractic.com)
A Mediterranean diet rich in virgin olive oil may enhance the cardioprotective benefits of high-density lipoproteins (HDL-the "good" cholesterol) compared to other diets, according to new research in the American Heart Association's journal Circulation . (medicalxpress.com)
HDL - High-density lipoproteins are thought to carry cholesterol directly to the liver, where it is processed and removed from the body. (baycare.org)
T. lutea rich diet showed an apparent digestibility similar to that of the non enriched AIN-76 diet and did not affect growth or animal behavior, but was associated to higher water intake, urinary excretion and urinary sodium probably due to the high salt content of the algal biomass. (unifi.it)
We have studied the functions of truncated apoE4 forms in vitro and in vivo in order to identify the domains of apoE4 required for the biogenesis of apoE-containing high-density lipoprotein (HDL). (omicsdi.org)

In the circulation, apoC-III is associated with TRLs and HDL, and freely exchanges among these lipoprotein particle systems. (portlandpress.com)
Correlations of plasma lipoproteins with LDL subfractions by particle size in men and women. (jhsmr.org)
besides, excess of TG in the HDL particle contribute to HDL dysfunction [ 8 ]. (biomedcentral.com)

Reverse cholesterol transport, the process by which HDL removes cholesterol from plaque in the arteries and transports it to the liver where it is used to produce hormonal compounds or eliminated from the body. (medicalxpress.com)
Antioxidant protection, the ability of HDL to counteract the oxidation of LDL, which has been found to trigger the development of plaque in the arteries. (medicalxpress.com)
Arteries are blood vessels that carry oxygen-rich blood to your heart and other parts of your body. (cdc.gov)
These arteries supply oxygen-rich blood to your heart muscle. (cdc.gov)

WW domain-mediated interactions reveal a spliceosome-associated protein that binds a third class of proline-rich motif: the proline glycine and methionine-rich motif. (embl.de)
In yeast, this bridging involves interactions between the WW domains in the splicing factor PRP40 and a proline-rich domain in the branchpoint binding protein, BBP. (embl.de)
Fast protein liquid chromatography of plasma showed that the truncated apoE forms, except apoE4-185, generated an apoE-containing HDL peak. (omicsdi.org)

Levy Y, Maor I, Presser D, Aviram M. Cinsumption of eggs with meals increases the susceptibility of human plasma and low-density lipoprotein to lipid peroxidation. (jhsmr.org)
Additional consumption of one egg per day increases serum lutein plus zeaxanthin concentration and lowers oxidized low-density lipoprotein in moderately hypercholesterolemic males. (jhsmr.org)

Safflower powder is possibly effective for: Hypercholesterolemia - Oral consumption of safflower oil as a dietary supplement may decrease total and low-density lipoprotein (LDL) cholesterol. (amazondiscovery.com)
They also noted a decrease in total carbohydrate intake, suggesting almonds may have replaced carbohydrate-rich foods. (digitalnaturopath.com)

Epidemiologic investigations have established that cardiovascular morbidity and mortality vary directly with the level of total-C, LDL-C, and triglycerides, and inversely with the level of HDL-C. The independent effect of raising HDL-C or lowering triglycerides (TG) on the risk of cardiovascular morbidity and mortality has not been determined. (nih.gov)

Given the strong metabolic interaction with HDL and covariation the stage was set for a resurgence of interest in TG. (eas-society.org)
One of the studies, conducted in Malaysia, showed that the rodent subjects had better parameters for a number of metabolic syndrome indicators, such as fasting blood glucose and triglycerides. (vitanetonline.com)
Most people with heart disease and diabetes are insulin-resistant, which is a root cause of the metabolic syndrome that leads to the same destination-raised blood sugar, increased triglycerides, reduced HDL, heightened inflammation, and an increased risk of heart attack, stroke, and diabetes. (fitnessology.net)
The first step in guarding against metabolic syndrome is to gauge the risk of insulin resistance through simple blood tests such as triglycerides, insulin, HDL, CRP, and DHEA. (fitnessology.net)

It was unclear when I got into the field which of the two-HDL, the so-called "good cholesterol," or triglycerides-was more important. (medscape.com)
HDL: the 'good' cholesterol. (deblonchiropractic.com)
Still, Fitó said, "following a Mediterranean diet rich in virgin olive oil could protect our cardiovascular health in several ways, including making our 'good cholesterol' work in a more complete way. (medicalxpress.com)
Another type, HDL , is sometimes called the "good" cholesterol. (medlineplus.gov)
it can raise your LDL and lower you HDL (good cholesterol). (medlineplus.gov)

In the quail group, plasma triglyceride (TG) and LDL-TG were significantly decreased, whereas the plasma cholesterol and HDL-C were unchanged. (jhsmr.org)
Cholesterol, both good (HDL) and bad (LDL), decreased significantly after the four-week period. (digitalnaturopath.com)

Circulating triglyceride-rich lipoproteins from hypertriglyceridemic subjects mediated endothelial inflammation and drive monocyte infiltration into the wall of arterial [ 9 ]. (biomedcentral.com)

these accumulate if there is overproduction of TG-rich lipoproteins or compromised (albeit not absent) lipase action. (eas-society.org)

Using a proline-rich domain derived from formin (a product of the murine limb deformity locus), we have identified a family of murine formin binding proteins (FBP's), each of which contains one or more of a special class of tyrosine-rich WW domains. (embl.de)
Because cholesterol isn't water-soluble, cholesterol and triglycerides (a blood lipid) combine with proteins to form lipoproteins, which then transport cholesterol through the watery blood system. (deblonchiropractic.com)
Cholesterol travels through the blood on proteins called lipoproteins. (medlineplus.gov)

Fernandez ML. Dietary cholesterol provided by eggs and plasma lipoproteins in healthy populations. (jhsmr.org)
LDL, HDL AND TRIGLYCERIDES First, a little technical background: Dietary fat is absorbed by the intestine and transported to the liver. (deblonchiropractic.com)
Oats and whole grains like brown rice, quinoa, and whole wheat bread are rich in dietary fiber. (dalatonnantasket.com)

However, too much low-density lipoprotein (LDL) cholesterol - also called "bad cholesterol" - in your blood will cause blockages in your blood vessels. (healthline.com)
Angina is chest pain or discomfort that occurs if an area of your heart muscle doesn't get enough oxygen-rich blood. (cdc.gov)
Too much alcohol can also increase your risk of heart diseases because it can raise your blood pressure and triglyceride level. (medlineplus.gov)
It is defined by the presence of visceral obesity, elevated triglycerides, decreased HDL, elevated blood pressure and blood glucose. (bvsalud.org)

This EAS Statement provides a state-of-the art review of current thinking on how TG-rich lipoproteins and their remnants are retained in the arterial wall and promote maladaptive responses central to plaque initiation and progression. (eas-society.org)
Trapped apo B-containing lipoproteins in the arterial wall instigates, develops and drives the atherosclerotic process from start to finish. (biorexdiagnostics.com)
Apo C-III has been identified as influencing atherogenesis through increasing the affinity of LDL for the arterial wall proteoglycans and so, increasing the accumulation of atherogenic lipoproteins in the arterial walls 10 . (biorexdiagnostics.com)

Plasma TG is, however, merely a surrogate for estimating the critical lipoproteins - TG-rich lipoproteins and their remnants. (eas-society.org)
First, there is clarification of what is meant by TG, TG-rich lipoproteins, and remnants. (eas-society.org)
Second, this EAS Statement provides a framework for understanding how remnants of TG-rich lipoproteins are generated and cleared from the circulation. (eas-society.org)
Two key gaps in knowledge about TG-rich lipoproteins and remnants are highlighted. (eas-society.org)
The Panel concludes that clinicians should continue to use plasma TG (either fasting or nonfasting) as a surrogate for quantitating TG-rich lipoproteins and remnants, as recommended by the 2019 European Society of Cardiology/EAS dyslipidaemia guidelines (12,16) . (eas-society.org)

Low-density lipoprotein subclass patterns and risk of myocardial infarction. (jhsmr.org)

Triglycerides are lipid compounds composed of a glycerol esterified to 3 fatty acid chains of varying length and composition. (medscape.com)
These preliminary data indicate that the T. lutea-rich diet was well tolerated in the short term and suggest that this marine microalga may represent a promising source of functional foods and bioactive compounds for the control of dyslipidemias. (unifi.it)
A diet rich in fruits and vegetables can increase important cholesterol-lowering compounds in your diet. (medlineplus.gov)

Antilipemic agent that lowers cholesterol and triglycerides. (sdrugs.com)

Combined infection of apoA-I-/- mice with a mixture of adenoviruses expressing both apoE4 (2x10(9) pfu) and human LCAT (lecithin:cholesterol acyltransferase) (5x10(8) pfu) cleared the triacylglycerol-rich lipoproteins, increased HDL and converted the discoidal HDL into spherical HDL. (omicsdi.org)
Domains of apoE4 required for the biogenesis of apoE-containing HDL. (omicsdi.org)

How are elevated TG-rich lipoproteins linked to cardiovascular risk? (eas-society.org)

Triglycerides have long been considered a possible risk factor for atherosclerotic cardiovascular disease. (eas-society.org)
A study by Aberra et al indicated that the average value of triglyceride measurements over time is more accurate than a single triglyceride value in predicting the risk of cardiovascular disease (CVD). (medscape.com)
Basically, HDL cholesterol is a very good marker of risk but it's unlikely to be a causal factor. (medscape.com)
Quail egg and hen egg consumptions for 30 days did not change the lipoprotein profiles, sd-LDL as well as the LDL-oxidation, which not modified the cardiovascular disease risk factor. (jhsmr.org)
HDL cholesterol is associated with a lower risk because these lipoproteins help eliminate the excess cholesterol from the bloodstream. (medicalxpress.com)

Eggs distinctly modulate plasma carotenoid and lipoprotein subclasses in adult men following a carbohydraterestricted diet. (jhsmr.org)

Anatomy17

Organisms8

Diseases32

Chemicals and Drugs135

Analytical, Diagnostic and Therapeutic Techniques and Equipment29

Psychiatry and Psychology1

Phenomena and Processes40

Technology, Industry, Agriculture8

Information Science3

Health Care9

VLDL16

Particles20

Apolipoprotein9

Atherosclerosis6

Elevated low-density lipoprotein cho2

Clearance of triglyceride-rich1

Metabolism5

Lipolysis3

Lipids5

Cholesterol and triglyceride levels2

Catabolism3

Hepatic1

Levels40

Serum triglyceride1

Density lipoprotein cholesterol9

Concentrations2

Remnant1

Coronary1

Decreases4

Increase in HDL cholesterol1

Dyslipidemia3

Phospholipids5

High12

Particle3

Arteries4

Protein3

Increases2

Decrease2

Inversely1

Metabolic4

Good cholesterol5

Significantly2

Inflammation1

Overproduction1

Proteins3

Dietary3

Blood4

Arterial wall3

Remnants5

Myocardial infarction1

Compounds3

Lowers1

ApoE42

Cardiovascular risk1

Risk5

Modulate1