• In the primary prevention component of the Helsinki Heart Study, in which 4081 male patients between the ages of 40 and 55 were studied in a randomized, double-blind, placebo-controlled fashion, gemfibrozil therapy was associated with significant reductions in total plasma triglycerides and a significant increase in high density lipoprotein cholesterol. (nih.gov)
  • Reduce elevated total cholesterol (total-C), low-density lipoprotein cholesterol (LDL-C), apolipoprotein B (Apo B), and triglycerides (TG), and to increase high-density lipoprotein cholesterol (HDL-C) in patients with primary hyperlipidemia (Fredrickson type IIa, heterozygous familial and nonfamilial) or mixed dyslipidemia (Fredrickson type IIb). (druglib.com)
  • Apolipoprotein B48 on chylomicra and Apolipoprotein B100 on LDL, IDL, and VLDL are important for MTP binding. (wikipedia.org)
  • The liver secretes the triglyceride-rich VLDL that contains apoproteins B-100, C-II, and E into the circulation. (medscape.com)
  • In the peripheral tissues, particularly adipose and muscle tissue, VLDL is cleaved by lipoprotein lipase (LPL), extracting most of the triglycerides and forming an IDL that contains apoproteins B-100 and E. IDL can be taken up by the liver through the LDL receptor, or it can be converted to the cholesterol-rich LDL that contains apoprotein B-100. (medscape.com)
  • In the metabolic syndrome, increased apoC-III concentration, resulting from hepatic overproduction of VLDL (very-LDL) apoC-III, is strongly associated with delayed catabolism of triacylglycerols and TRLs. (portlandpress.com)
  • Moreover, thyroid hormones stimulate the cholesteryl ester transfer protein (CETP), an enzyme which transports cholesteryl esters from HDL2 to the very low density lipoproteins (VLDL) and triglycerides in the opposite direction 9 (figure). (hormones.gr)
  • Circulating levels of ApoH are postively correlated with triglyceride-rich lipoprotein (VLDL) components in type II diabetes (9). (rndsystems.com)
  • Gemfibrozil is a lipid regulating agent which decreases serum triglycerides and very low density lipoprotein (VLDL) cholesterol, and increases high density lipoprotein (HDL) cholesterol. (nih.gov)
  • Most of the circulating cholesterol is found in three major lipoprotein fractions: very low-density lipoproteins (VLDL), low-density lipoproteins (LDL), and high-density lipoproteins (HDL). (cdc.gov)
  • where [triglycerides/5] is an estimate of VLDL-cholesterol and all values are expressed in mg/dL. (cdc.gov)
  • PPAR-alpha activation increases the expression of lipoprotein lipase and apolipoprotein A-V (apoA-V) while simultaneously decreasing expression of apoC-III in the liver, which decreases VLDL particles and lowering plasma triglycerides in chylomicrons (Staels and Fruchart 2005). (bodybuilding.com)
  • As apoE2 binds defectively to LDL receptors, apoE2 homozygosity can precipitate type III hyperlipoproteinemia, however, only occurs when another condition, including: diabetes, oestrogen deficiency, hypothyroidism, or obesity, leads to the overproduction of VLDL or fewer LDL receptors, overwhelming the limited ability of apoE2 to mediate the clearance of triglyceride-rich and cholesterol-rich β-VLDL. (randox.com)
  • The lipoprotein-binding preference of apoE4 to large (30-80nm), triglyceride-rick VLDL, is associated with elevated levels of LDL. (randox.com)
  • The enrichment of VLDL with apoE4 accelerates their clearance from the plasma by receptor-mediated endocytosis in the liver and consequently, LDL receptors are downregulated, and LDL levels rise 3 . (randox.com)
  • The transfer of the major egg yolk proteins such as Very Low Density Lipoproteins (VLDL) containing essentially apovitellenin and apolipoprotein-B, but also vitellogenins and some other plasma proteins from the blood such as serum albumin to the interstitial fluid of the thecae is possible due to the presence of broad discontinuities in the capillary endothelium. (biomedcentral.com)
  • Reduce elevated TG and VLDL-C in patients with primary dysbetalipoproteinemia (Fredrickson type III hyperlipidemia). (druglib.com)
  • Lipolysis is a process of breaking down of triglycerides to glycerol and fatty acids, the process is done by hydrolysis by inducing some hormones like epinephrine, nor-epinephrine, cortisol, testosterone, etc. to release the compounds like High density lipoproteins (HDL), Low density lipoproteins (LDL) and Very low density lipoproteins (VLDL) [ 12 - 18 ]. (omicsonline.org)
  • These triglycerides transports through blood to reach the muscle or tissue, while transporting the LDL and VLDL accumulate on the walls of the blood vessels creating plaques which narrows the blood vessel and also generates fat deposits in the body [ 19 ]. (omicsonline.org)
  • By inhibiting the production of LDL and VLDL the risk factors for the hyperlipidemia can be controlled, Bile acid sequestrants like Cholestyramine, Colestipol and Colesevelam are used to regulate high serum levels by binding the bile acid which is secreting from liver to metabolize the triglycerides [ 20 - 24 ]. (omicsonline.org)
  • In all conditions most apo(a) (57-88%) dissociated from the triglyceride-rich lipoproteins upon recentrifugation and was recovered as lipoprotein(a). (jci.org)
  • The exogenous lipoprotein pathway refers to the metabolism of intestinal lipoproteins, the triglyceride-rich chylomicrons, primarily formed in response to dietary fat. (medscape.com)
  • Alterations in lipoproteins result either from genetic mutations that yield defective apolipoproteins (primary hyperlipoproteinemia) or from some other underlying systemic disorder, such as diabetes mellitus , hypothyroidism , or nephrotic syndrome (secondary hyperlipoproteinemia). (medscape.com)
  • ApoC-III impairs the lipolysis of TRLs [triacylglycerol (triglyceride)-rich lipoproteins] by inhibiting lipoprotein lipase and the hepatic uptake of TRLs by remnant receptors. (portlandpress.com)
  • It is well known that alterations in thyroid function result in changes in the composition and transport of lipoproteins 1-3 . (hormones.gr)
  • Finally, thyroid hormones stimulate the lipoprotein lipase (LPL), which catabolizes the triglyceride-rich lipoproteins, and the hepatic lipase (HL), which hydrolyzes HDL2 to HDL310 (figure). (hormones.gr)
  • These changes are attributable to the decreased activity of LPL, which results in a decreased clearance of triglyceride-rich lipoproteins 16 . (hormones.gr)
  • However, even in the absence of the hyperglycaemic state which characterizes type 2 diabetic patients, non diabetic individuals with a specific form of obesity, named abdominal obesity, often show clustering metabolic abnormalities which include high triglyceride levels, increased apolipoprotein B, small dense low density lipoproteins and decreased high density lipoproteins-cholesterol levels, a hyperinsulinemic-insulin resistant state, alterations in coagulation factors as well as an inflammatory profile. (researchgate.net)
  • This protein helps produce beta-lipoproteins, which are molecules that are made up of proteins (including one called apolipoprotein B), cholesterol, and particular types of fats called phospholipids and triglycerides. (medlineplus.gov)
  • Most MTTP gene mutations lead to the production of microsomal triglyceride transfer protein with reduced or absent function, preventing the formation of beta-lipoproteins. (medlineplus.gov)
  • Our results show that Aβ can be metabolised in association with triglyceride rich lipoproteins (TRLs). (iospress.com)
  • Apolipoprotein E (APOE) is a lipid-transport protein abundantly expressed in most neurons in the central nervous system. (dovepress.com)
  • This review will summarize the updated research progress on APOE functions and its role in Alzheimer's disease, Parkinson's disease, cardiovascular diseases, multiple sclerosis, type 2 diabetes mellitus, Type III hyperlipoproteinemia, vascular dementia, and ischemic stroke. (dovepress.com)
  • The apolipoprotein E (APOE) gene is located on chromosome 19 and encodes a glycoprotein that is 299 amino acids long. (dovepress.com)
  • 3 In this review, we discuss the biological functions of human APOE and its role in Alzheimer's disease (AD), Parkinson's disease (PD), cardiovascular diseases (CVD), multiple sclerosis (MS), type 2 diabetes mellitus (T2DM), vascular dementia (VD), and ischemic (occlusive) stroke (IS). (dovepress.com)
  • The APOE gene encodes 3 isoforms Ɛ4, Ɛ3 and Ɛ2 with APOE Ɛ4 associated with higher plasma cholesterol levels and increased pathogenesis in several infectious diseases (HIV, HSV). (edu.au)
  • These transporters promote unidirectional cholesterol efflux to lipid-poor apolipoprotein A-I (apoA-I), apoE, or HDL particles, respectively, and are under the transcriptional control of liver X receptors (LXRs), master intracellular sensors that are activated in response to cholesterol biosynthetic intermediates and oxysterols ( 11 , 12 ). (diabetesjournals.org)
  • The apolipoproteinE (APOE) gene provides instructions for the production of the apolipoprotein E (apoE) protein. (randox.com)
  • Apolipoprotein E (apoE) is a multifunctional glycoprotein with central roles in lipid metabolism, neurobiology, and neurodegenerative diseases. (randox.com)
  • ApoE has three major isoforms (apoE2, apoE3, and apoE4) all of which have different effects on lipid and neuronal homeostasis (fig 1). (randox.com)
  • Other dominant and recessive mutations in apoE that affect residues in or around the receptor binding region also causes type III hyperlipoproteinemia 3 . (randox.com)
  • Apolipoprotein E knockout (apoE-/-) mice, fed a Western diet, were exposed to GMA-SS at 40mg/m3 for 3h/day for ten days (approximately 8.26 mu g daily alveolar deposition). (cdc.gov)
  • In two independent experiments, plasma TG, apolipoprotein E (apoE), and A42/40 ratio were transiently increased following CS-6253 intravenous injection. (cdc.gov)
  • Small HDL concentrations in CSF were positively associated with performance in three domains of cognitive function independent of apolipoprotein E (APOE) 4 status, age, sex, and years of education. (cdc.gov)
  • This CETP inhibition, which exchanges a triglyceride molecule for a cholesteryl ester molecule between HDL-C-containing and apolipoprotein B (ApoB)-containing particles, also this particular therapeutic has been shown in prior studies to decrease ApoB significantly and, actually, to even decrease Lp(a), which is interesting. (medscape.com)
  • The apolipoprotein B/apolipoprotein A-I (ApoB/ApoA-I) index was also positively correlated with mercury, supporting a possible causal relationship. (bvsalud.org)
  • There are different types of lipids available in the body like fats, monoglycerides, diglycerides, triglycerides, phospholipids and others. (omicsonline.org)
  • Together, our findings provide new insights into molecular changes associated with metabolic risk conditions, suggest new condition-specific associations between apolipoproteins and lipids, and may inform new biomarker discovery in lipid metabolism-associated disorders. (cdc.gov)
  • In contrast to plasma, CS-6253 had no effect on the assessed CSF apolipoproteins or lipids. (cdc.gov)
  • Microsomal triglyceride transfer protein large subunit is a protein that in humans is encoded by the MTTP gene. (wikipedia.org)
  • MTP encodes the large subunit of the heterodimeric microsomal triglyceride transfer protein. (wikipedia.org)
  • The MTTP gene provides instructions for making a protein called microsomal triglyceride transfer protein. (medlineplus.gov)
  • this mutation replaces the protein building block (amino acid) glycine with a premature stop signal at position 865 (written as Gly865Ter or G865X) in the instructions used to make the microsomal triglyceride transfer protein. (medlineplus.gov)
  • Gunduz M, Ozaydin E, Atar MB, Koc N, Kirsaclioglu C, Kose G, Cefalu AB, Averna M, Tarugi P. Microsomal triglyceride transfer protein gene mutations in Turkish children: A novel mutation and clinical follow up. (medlineplus.gov)
  • Microsomal triglyceride transfer protein expression in adipocytes: a new component in fat metabolism. (medlineplus.gov)
  • Walsh MT, Di Leo E, Okur I, Tarugi P, Hussain MM. Structure-function analyses of microsomal triglyceride transfer protein missense mutations in abetalipoproteinemia and hypobetalipoproteinemia subjects. (medlineplus.gov)
  • ApoC-III (apolipoprotein C-III), an important regulator of lipoprotein metabolism, is strongly associated with hypertriglyceridaemia and the progression of CVD. (portlandpress.com)
  • Regulating apoC-III metabolism may be an important new therapeutic approach to managing dyslipidaemia and CVD risk in the metabolic syndrome. (portlandpress.com)
  • Hooper AJ, van Bockxmeer FM, Burnett JR. Monogenic hypocholesterolaemic lipid disorders and apolipoprotein B metabolism. (medlineplus.gov)
  • Members of the apolipoprotein gene cluster (APOA1/C3/A4/A5) on human chromosome 11q23 play an important role in lipid metabolism. (doe.gov)
  • Triglycerides play an important role in metabolism as energy sources. (bodybuilding.com)
  • Apolipoprotein C-III (ApoC3) is a key molecule in triglycerides metabolism that has been linked to cardiovascular (CV) disease. (unican.es)
  • This agglomeration of abnormalities has been referred to as the metabolic syndrome which can be identified by the presence of three of the five following variables: abdominal obesity, elevated triglyceride concentrations, low HDL-cholesterol levels, increased blood pressure and elevated fasting glucose. (researchgate.net)
  • Polymorphisms in both APOA5 and APOC3 are strongly associated with plasma triglyceride concentrations. (doe.gov)
  • The close genomic locations of these two genes as well as their functional similarity have hindered efforts to define whether each gene independently influences human triglyceride concentrations. (doe.gov)
  • High triglycerides are associated with increased risk for CAD in patients with other risk factors, such as low HDL-cholesterol, some patient groups with elevated apolipoprotein B concentrations, and patients with forms of LDL that may be particularly atherogenic. (cdc.gov)
  • Triglycerides are also measured because the value is used to calculate LDL-cholesterol concentrations. (cdc.gov)
  • Distribution of apolipoprotein(a) in the plasma from patients with lipoprotein lipase deficiency and with type III hyperlipoproteinemia. (jci.org)
  • We have determined the phenotype, concentration, and distribution of apo(a) in plasma from patients with lipoprotein lipase (LPL) deficiency (type I hyperlipoproteinemia, n = 14), in apo E 2/2 homozygotes with type III hyperlipoproteinemia (n = 12) and in controls (n = 16). (jci.org)
  • While modest decreases in total and low density lipoprotein (LDL) cholesterol may be observed with gemfibrozil therapy, treatment of patients with elevated triglycerides due to Type IV hyperlipoproteinemia often results in a rise in LDL-cholesterol. (nih.gov)
  • Triglycerides are measured enzymatically in serum using a series of coupled reactions. (cdc.gov)
  • High levels of serum triglycerides help mark conditions that are associated with increased risk for CHD and peripheral atherosclerosis. (cdc.gov)
  • In an immunochemical reaction, Apolipoprotein B in the human serum sample form immune complexes with specific antibodies. (cdc.gov)
  • There were no significant changes in serum total cholesterol, triglycerides or alanine aminotransferase. (cdc.gov)
  • Inflammatory serum proteins interleukin 1 beta (IL-1 beta) and monocyte chemoattractant protein 3 (MCP-3)were increased two weeks after GMA-SS exposure. (cdc.gov)
  • RESULTS: Abdominal circumference, obesity, type 2 diabetes, and circulating triglycerides were significantly associated with higher ApoC3 serum levels. (unican.es)
  • Epistatic Interactions between apolipoprotein E and hemoglobin S Genes in regulation of malaria para. (edu.au)
  • This list of 582 genes contains 12 proteases and 3 antiproteases. (biomedcentral.com)
  • The A-I and A-IV genes are transcribed from the same strand, while the A-1 and C-III genes are convergently transcribed. (nsjbio.com)
  • Polymorphisms rs662799, rs693, rs429358 and rs7412 (of genes of apolipoproteins A-V, B, and E at positions 112 and 158, respectively) were genotyped by real-time PCR. (bvsalud.org)
  • A unique feature of APOA4 is that it is an intestinal apolipoprotein secreted on HDL and chylomicrons. (jci.org)
  • The chylomicrons with APOA4 then enter circulation (step 2), where APOA4 is exchanged for APOC2 on liver-derived large HDL (step 3), generating APOA4-containing large HDL (step 4). (jci.org)
  • Once on chylomicrons, APOC2 activates triglyceride lipolysis and uptake via lipoprotein lipase (LPL) on peripheral tissues (step 5). (jci.org)
  • APOA4 on prebeta and prebeta-b particles efflux cholesterol from peripheral tissues via ATP-binding cassette transporter A1 (ABCA1) (step 3). (jci.org)
  • It was observed that there was no difference in the plasma clearance of [125 I]Aβ and that of the 3 H-cholesteryl ester, a marker of the emulsion particles, demonstrating that Aβ remains associated with these particles throughout both their lipolysis and tissue uptake. (iospress.com)
  • it is thought to delay catabolism of triglyceride-rich particles. (nsjbio.com)
  • At least 1/3 of proteases and antiproteases identified in egg yolk and vitelline membrane proteomes are expressed similarly in the liver regardless of the maturity of hens, and have been initially identified as regulators of haemostasis and inflammatory events. (biomedcentral.com)
  • Protein synthesis and lipogenesis are highly stimulated in the liver at sexual maturity in hens (15 to 20 fold) to support the incorporation of 0.75 kg proteins and 1.5 kg of triglycerides into the yolk over a year of commercial production. (biomedcentral.com)
  • Those associated with INH treatment and susceptibility to INH-induced steatosis in the liver included apolipoprotein A-IV, lysosomal-associated membrane protein 1, and choline phosphotransferase 1. (nih.gov)
  • Western blot testing of 1) rat liver, 2) rat RH35, 3) mouse liver and 4) mouse HEPA1-6 cell lysate with APOC3 antibody at 0.5ug/ml. (nsjbio.com)
  • Indeed, beyond the lipoprotein lipase cofactor apolipoprotein (apo) CII, recent studies have identified the relevance of apoCIII in controlling the efficiency of TG clearance, and angiopoietin-like protein 3 (ANGPTL3) in modulating lipoprotein lipase activity, suggesting potential as therapeutic targets (14,15) . (eas-society.org)
  • Apolipoprotein B is the main protein component of LDL and accounts for approximately 95% of the total protein content of LDL. (cdc.gov)
  • Apolipoprotein C-III, also known as apo-CIII, is a protein that in humans is encoded by the APOC3 gene. (nsjbio.com)
  • ApoE4 is the major genetic risk factor, or causative gene, for Alzheimer's disease (AD) and other neurological disorders, including poor clinical outcomes following traumatic brain injury, stroke, frontotemporal dementia, Down syndrome, certain patients with Parkinson's disease, and Lewy body disease 3 . (randox.com)
  • We tried to identify the interaction between dietary quality indices and apolipoprotein B Ins/Del and EcoR1 polymorphisms on cardio-metabolic risk factors in patients with type 2 diabetes mellitus (T2DM). (researchsquare.com)
  • Finally, genome-wide association mapping revealed that polymorphisms in perilipin 2 were linked to increased triglyceride levels following INH treatment, implicating a role for inter-individual differences in lipid packaging in the susceptibility to INH-induced steatosis. (nih.gov)
  • In the last decade, it has been shown that metformin, thiazolidinediones, vitamin E, ezetimibe, n-3 polyunsaturated fatty acids, renin-angiotensin system (RAS) blockers, and antiobesity drugs may improve hepatic pathophysiological disorders as well as clinical parameters. (hindawi.com)
  • C. ApoA-V, triglycerides, insulin, free fatty acids, and lipoprotein profiles were analyzed. (elsevierpure.com)
  • Among the polyunsaturated fatty acids, both n-3 and n-6 fatty acids exhibit differential effects, and their dietary ratio plays a significant role in the overall impact in an individual. (intechopen.com)
  • They consist of glycerin (a sweet, syrupy liquid) plus 3 individual fatty acids all mixed together. (bodybuilding.com)
  • Cardiovascular exercise and low-moderate carbohydrate diets containing essential fatty acids are recommended for reducing triglyceride levels. (bodybuilding.com)
  • A fat tolerance test evidenced delayed plasma triglyceride clearance and greater transient availability of non-esterified fatty acids (NEFA) during the post-prandial state in the apoCIII mice plasma. (biomedcentral.com)
  • Over the past two decades, the prevalence of metabolic abnormalities such as type 2 diabetes and metabolic syndrome (MetS) has been increasing worldwide together with the escalating obesity pandemic [ 1 - 3 ]. (hindawi.com)
  • We found a higher odds of obesity (BMI ≥95th percentile) with increasing quartiles of BPA for quartiles 2 vs 1 (odds ratio [OR] 1.74, 95% confidence interval [CI] 1.17-2.60, P = .008), 3 vs 1 (OR 1.64, 95% CI 1.09-2.47, P = .02), and 4 vs 1 (OR 2.01, 95% CI 1.36-2.98, P = .001). (aap.org)
  • Our study aimed to assess the cholesterol efflux capacity (CEC) of HDL as a negative risk factor for CVD in individuals with obesity and identify the factors associated with improvement in CEC 3 months following bariatric surgery. (biomedcentral.com)
  • The study included 56 individuals with obesity, of whom 30 individuals underwent Roux-en-Y gastric bypass surgery (RYGB) and twenty-six underwent sleeve gastrectomy (SG). (biomedcentral.com)
  • Among men, Canadian Community Health Survey, the prevalence of factors were age, apolipoprotein A1 level, apolipoprotein B obesity among people who self-identified as Aboriginal level, and insulin resistance. (cdc.gov)
  • This is because NAFLD may be more tightly associated with insulin resistance and with markers of oxidative stress and endothelial dysfunction than with the Adult Treatment Panel III criteria for MetS in nonobese, nondiabetic subjects [ 8 ]. (hindawi.com)
  • Triglycerides are hydrolyzed by lipase to produce glycerol. (cdc.gov)
  • Considering apo(a) type, the plasma concentration of apo(a) was normal in type III patients but significantly reduced in LPL deficiency. (jci.org)
  • This effect results in a severe elevation of plasma triglyceride levels. (medscape.com)
  • Among Fredrickson types, during the 5-year double-blind portion of the primary prevention component of the Helsinki Heart Study, the greatest reduction in the incidence of serious coronary events occurred in Type IIb patients who had elevations of both LDL-cholesterol and total plasma triglycerides. (nih.gov)
  • This subgroup of Type IIb gemfibrozil group patients had a lower mean HDL-cholesterol level at baseline than the Type IIa subgroup that had elevations of LDL-cholesterol and normal plasma triglycerides. (nih.gov)
  • Evidences have suggested that proteins primarily related to plasma lipoprotein transport, such as apolipoprotein (apo) CIII and E, may significantly affect the process of body fat accumulation. (biomedcentral.com)
  • Subjects with hyperhomocysteinaemia had significantly elevated total cholesterol, LDL cholesterol, apolipoprotein A and apolipoprotein B and lower vitamin B levels compared with subjects with 12 normohomocysteinaemia. (who.int)
  • Hcy levels correlated with total cholesterol ( r = 0.09), apolipoprotein A ( r = 0.012), and B ( r = 0.013) levels and total/HDL cholesterol ratio ( r = -0.085). (who.int)
  • C genotypes and triglyceride levels remains controversial. (elsevierpure.com)
  • In general, overt and subclinical hypothyroidism is associated with hypercholesterolemia mainly due to elevation of low density lipoprotein (LDL) cholesterol levels, whereas high density lipoprotein (HDL) cholesterol concentration is usually normal or even elevated 3-5 . (hormones.gr)
  • 9.5% of the participants of the Colorado prevalence study had elevated levels of thyroid stimulating hormone 3 . (hormones.gr)
  • Levels of total and LDL cholesterol tend to increase as the thyroid function declines 3 . (hormones.gr)
  • Gemfibrozil increases levels of high density lipoprotein (HDL) subfractions HDL 2 and HDL 3 , as well as apolipoproteins AI and AII. (nih.gov)
  • When these fail, statin drugs are often used to reduce triglyceride levels. (bodybuilding.com)
  • An increase in apoC-III levels induces the development of hypertriglyceridemia. (nsjbio.com)
  • Doctors measure levels of triglycerides and the various types of cholesterol in the blood. (msdmanuals.com)
  • Simvastatin in aneurysmal subarachnoid haemorrhage (STASH): a multicentre randomised phase 3 trial. (druglib.com)
  • In addition, experimental evidence shows that apoC-III may also have a direct role in atherosclerosis. (portlandpress.com)
  • He has unique expertise across all three disciplines of basic, translational and clinical research, and leads bench-to-bedside projects spanning topics of developmental, macrophage biology, vascular stem cells, inflammatory regulation of atherosclerosis, pharmacological modification of atherosclerosis and coronary plaque imaging. (edu.au)
  • Triglycerides are the main components of vegetable oil and animal fats, and form much of the fat stored by the human body. (bodybuilding.com)
  • We observed a negative correlation between apoA-V and triglyceride in controls and a positive correlation in hypertriglyceridemic patients, regardless of genotype. (elsevierpure.com)
  • has completed phase III clinical development at AstraZeneca for the treatment of patients with dyslipidemia. (aspetjournals.org)
  • Differentiating patients with GSD type III from those with GSD type I solely on the basis of physical findings is not easy. (medscape.com)
  • [ 3 ] proposed that a transport defect of glucose-6-phosphate (G6P) into the microsomal compartment may be present in some patients with GSD type I. Thus, GSD type I is divided into GSD type Ia caused by G6Pase deficiency and GSD type Ib resulting from deficiency of a specific translocase T1. (medscape.com)
  • This is most evident with the fact that the decrease in the n-3 intake in recent times has significantly contributed to the severity of chronic inflammation. (intechopen.com)
  • Triglycerides have long been considered a possible risk factor for atherosclerotic cardiovascular disease. (eas-society.org)
  • Dietary alpha-lipoic acid supplementation inhibits atherosclerotic lesion development in apolipoprotein E-deficient and apolipoprotein E/low-density lipoprotein receptor-deficient mice. (oregonstate.edu)
  • Inhalation exposure of gas-metal arc stainless steel welding fume increased atherosclerotic lesions in apolipoprotein E knockout mice. (cdc.gov)
  • PVDF membrane was probed with 0.25 µg/mL of Sheep Anti-Mouse/Rat Apolipoprotein H/ApoH Antigen Affinity-purified Polyclonal Antibody (Catalog # AF6575) followed by HRP-conjugated Anti-Sheep IgG Secondary Antibody (Catalog # HAF016 ). (rndsystems.com)
  • Apolipoprotein H (ApoH), also known as beta 2‑Glycoprotein I/ beta 2-GPI, is a variably glycosylated member of the complement control superfamily of proteins with a molecular weight of aproximately 50 kDa (1, 2). (rndsystems.com)
  • Three hundred and sixteen distinct proteins have been identified in egg yolk. (biomedcentral.com)
  • The intensity of the scattered light is proportional to the concentration of Apolipoprotein B in the sample. (cdc.gov)
  • Another small molecule that's in development now is obicetrapib in two phase 3 studies. (medscape.com)
  • The production of estrogen and at a lower magnitude testosterone by the theca of the growing follicle increases 2 to 3 weeks before the production of the first egg and contributes to the development of reproductive organs and the synthesis of egg constituents [ 1 - 6 ]. (biomedcentral.com)
  • This cross-sectional study evaluated the association between human exposure to mercury and cardiovascular risk using lipid profile (including apolipoproteins) and genetic analysis of Amazonian riverine population. (bvsalud.org)
  • It was originally supposed to be just a 2-year stint in genetic epidemiology, but I ended up liking it so much that I spent 5 years as a postdoctoral fellow-2 years at the Framingham Heart Study and 3 years at the Broad Institute, learning human genetics. (medscape.com)
  • Autophagy prevents NAFLD and AFLD progression through enhanced lipid catabolism and decreasing hepatic steatosis, which is characterized by the accumulation of triglycerides and increased inflammation. (hindawi.com)
  • Adipo IR = − 16%, p = 0.009) and inflammation [log resistin = − 6%, p = 0.07] were observed 3 months post-surgery. (biomedcentral.com)
  • Consistent with the view that adipose tissue behaves as a cholesterol sink, and its accumulation is proportional to triglycerides in response to nutritional changes to maintain cellular integrity and to regulate cellular hypertrophy, it is not surprising that adipocytes have developed a unique ability to deal with cholesterol ( 1 ). (diabetesjournals.org)
  • In the early 1980s, it was established that adipose tissue not only plays an important role in triglyceride storage but also accounts for approximately 25% of total body cholesterol in humans ( 1 ). (diabetesjournals.org)
  • Principal component analysis (PCA) of the fatty-acid data yielded three significant PCs, which together account for 80.0% of the total variance in the data set. (preprints.org)
  • Specifically, the thyroid hormone stimulates the hepatic de novo cholesterol synthesis by inducing the 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase that catalyzes the conversion of HMG-CoA to mevalonate, the first step in the biosynthesis of cholesterol 7 . (hormones.gr)
  • Rosuvastatin is a new 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor. (aspetjournals.org)
  • Rosuvastatin (Crestor), calcium bis[(+)-(3 R ,5 S ,6 E )-7-[4-( p -fluorophenyl)-6-isopropyl-2-( N -methylmethanesulfonamido)-5-pyrimidinyl]-3,5-dihydroxy-6-heptenoate], is a new and highly effective inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA 1 ) reductase (the rate-limiting enzyme in cholesterol biosynthesis). (aspetjournals.org)
  • This is an inhibitor of 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase. (druglib.com)