Trigger cell death. Medical search. Frequent questions

Understanding the basic mechanisms that lead to cell death (apoptosis) is essential for the development of therapies for cancer and other diseases. (uni-koeln.de)
Scientists led by Professor Ana J. Garcia-Saez at the CECAD Cluster of Excellence for Aging Research at the University of Cologne have shown that apoptosis, the programmed cell death, involves a direct physical interplay between the two proteins BAX and DRP1. (uni-koeln.de)
Their in vitro effects on hypoxic cells concerning cell viability, apoptosis, migration, and angiogenesis were detected through gain- and loss-of-function assays. (hindawi.com)
LCN2 was increased by SOX9 and SIRT1 deacetylated SOX9 to promote its nuclear translocation, which further inhibited the viability of human retinal pigment epithelial cells and promoted cell apoptosis and angiogenesis as well as CNV-induced AMD formation. (hindawi.com)
Although the conventional activities of p53 such as cell cycle arrest, senescence, and apoptosis are well accepted as the major checkpoints in stress responses, accumulating evidence implicates the importance of other tumor suppression mechanisms. (nature.com)
Is p53-dependent ferroptosis sufficient for tumor suppression in the absence of cell cycle arrest, senescence, and apoptosis? (nature.com)
To date, various mechanisms have been suggested to explain the powerful tumor-suppressive effect of p53, including the induction of cell cycle arrest, senescence, and apoptosis. (nature.com)
Intriguingly, the characteristics of typical apoptosis such as phosphatidylserine externalization and DNA fragmentation were not detected in the cell death process caused by this PDT regime. (tmu.edu.tw)
Apoptosis - or programmed cell death - is necessary for clearing our bodies of unnecessary or harmful cells, such as those that are infected by viruses. (livescience.com)
But it had been unclear how apoptosis, after being triggered, actually spread through the cell . (livescience.com)
They filled test tubes with fluid from the eggs and triggered apoptosis, which they watched unfold by tagging involved proteins with fluorescent light. (livescience.com)
It doesn't get any lower in amplitude because every step of the way it's generating its own impetus by converting more inactive molecules to active molecules, until apoptosis has spread to every nook and cranny of the cell. (livescience.com)
Apoptosis is the most common form of cell death and is referred to as programmed cell suicide. (medicalnewstoday.com)
During apoptosis, a cell is broken up and packaged into small, self-contained pieces, which are easily recycled by phagocytes. (medicalnewstoday.com)
Apoptosis can also be initiated by outside triggers. (medicalnewstoday.com)
There is some evidence that necroptosis may be a backup system that kicks in when certain pathogens, which can inhibit apoptosis, infect a cell. (medicalnewstoday.com)
This is specific to necroptosis and pyroptosis and does not usually occur during apoptosis, in which cell components are neatly packaged. (medicalnewstoday.com)
This led us to investigate a cell-suicide process called Apoptosis-which has important roles in normal physiology as well as in disease. (gene.com)
We have discovered that the key UPR enzyme IRE1 is hijacked by certain cancer cells to avert apoptosis and resist proteotoxic stress. (gene.com)
As the scientists increased the CQA concentration, cancer cells died as a result of apoptosis. (sciencedaily.com)
The ability to induce apoptosis, or cell death, is a promising tactic for therapeutic interventions in all types of cancer, she said. (sciencedaily.com)
We identified a novel mode of communication by which apoptotic cells induce additional apoptosis in the same tissue. (elifesciences.org)
Strong induction of apoptosis in one compartment of the Drosophila wing disc causes apoptosis of cells in the other compartment, indicating that dying cells can release long-range death factors. (elifesciences.org)
The tissues of developing organisms can be shaped by apoptosis, a form of regulated cell killing. (elifesciences.org)
Apoptosis has been thought to resemble a form of silent suicide by cells, but more recent work suggests that apoptotic cells can also transmit signals. (elifesciences.org)
created 'undead' cells in which one of these proteins was turned on, but other downstream proteins (that are responsible for the cellular execution phase of apoptosis) had been turned off: these cells were undergoing apoptosis, but could not complete the process and die. (elifesciences.org)
Strikingly, undead cells in the posterior (back) region of the wing imaginal disc-the tissue in the larva that gives rise to the wing in the adult fruit fly-could trigger apoptosis in cells in the anterior (front) half. (elifesciences.org)
found that the JNK pathway activated apoptosis in anterior cells. (elifesciences.org)
when Eiger was absent from posterior cells in the wing imaginal disc, apoptosis in anterior cells ceased, indicating that Eiger might signal at long range. (elifesciences.org)
Apoptosis is a distinct form of programmed cell death in which cells activate an intrinsic suicide program to self-destruct. (elifesciences.org)
Apoptosis and necrosis are characterized by different mechanisms leading to cell death. (news-medical.net)
Apoptosis is associated with nuclear disintegration, followed by removal of the cell by macrophages. (news-medical.net)
Studies show that necrotic death is induced by a ligand binding to a receptor, such as when apoptosis is initiated. (news-medical.net)
The "death receptors", which typically cause cell death by apoptosis, can be activated by ligands, such as TNF. (news-medical.net)
However, apoptosis can be blocked by caspase inhibitors resulting in a "ballooning cell membrane", typical of necrosis. (news-medical.net)
Necroptosis can therefore start in an apoptosis-like manner, but result in necrotic-like cell death. (news-medical.net)
Cancer, characterized by uncontrolled cell proliferation, is treated by chemotherapy and radiotherapy to induce apoptosis and kill cancerous cells. (news-medical.net)
This programmed death, called apoptosis, is a kind of cell suicide. (msdmanuals.com)
Elimination of BCR/ABL-dependent intracellular signals triggers apoptosis, but it is unclear whether this activates additional cell survival and/or death pathways. (lu.se)
CoCl2 increased expression of superoxide radical in hair cells and SGNs and SGN loss was characterized by nuclear condensation and fragmentation, morphological features of apoptosis. (cdc.gov)

Ironomycin promotes the recruitment and activation of BAX/BAK, but the resulting mitochondrial outer membrane permeabilization (MOMP) does not lead to potent activation of the apoptotic caspases, nor is the ensuing cell death prevented by inhibiting the previously established pathways of programmed cell death. (institut-curie.org)
This was found to be caused by a triggering of the inflammatory cell death pathways. (freerepublic.com)
We also identified the specific cytokines that activate inflammatory cell death pathways and have considerable potential for treatment of COVID-19. (freerepublic.com)
Once activated, p53 coordinates multiple downstream pathways, thereby maintaining the homeostasis of the host cell or organism (if the stress is mild, transient, and repairable) or eliminating damaged cells (if the stress is acute, prolonged, and difficult to resist). (nature.com)
Recent developments include a new treatment option for relapsed/refractory mantle cell lymphoma, a better understanding of protein variants that trigger tumor cell death and activate antitumor immunity, insights into the relationship between sickle cell trait and renal medullary carcinoma, the clinical relevance of CD8 T cell state in acute myeloid leukemia, and an understanding of the distinct neuronal pathways triggered by chemotherapy and nerve injury. (mdanderson.org)
Further study revealed that the mechanism through which damaged mtDNA causes pathology in healthy neurons involves dual activation of Toll-like receptor (TLR) 9 and 4 pathways, leading to increased oxidative stress and neuronal cell death, respectively. (medscape.com)

CD95 receptors - also referred to as Fas - have gained the nickname "death receptors" because they send a signal that causes cancer cells to "self-destruct," according to a press release from UC Davis. (newsrollup.com)

Some cytokines have been found to trigger inflammation, which explains the high cytokine levels in COVID-19 patients. (freerepublic.com)
The study found that the cytokine PANoptosis was the main source fueling the inflammation through cell death and inflammatory molecules. (freerepublic.com)
The research concludes that the cytokine-mediated inflammatory cell death process caused by PANoptosis is at the center of the inflammation damage. (freerepublic.com)
Phosphorylated IκB is degraded via the ubiquitination pathway, freeing NF-κB, and allowing its entry into the nucleus of the cell where it activates various genes involved in inflammation and other immune responses. (wikipedia.org)
We have, for the first time, identified that plastic leaked into the environment undergoes an accelerated weathering process, transforming into secondary microplastics that can serve as neurotoxic substances, leading to increased inflammation and cell death in the brain," explains Choi. (sciencealert.com)
They are also the gatekeepers of inflammation , and cell death can either be pro- or anti-inflammatory, leading to different outcomes. (medicalnewstoday.com)
Phagocytes and other immune cells react strongly to DAMPs by springing into action and causing inflammation. (medicalnewstoday.com)
However, if phagocytes fail to clear apoptotic cells quickly, these cells can turn necrotic, resulting in inflammation. (medicalnewstoday.com)
The caffeine derivatives in mate tea not only induced death in human colon cancer cells, they also reduced important markers of inflammation," said Elvira de Mejia, a U of I associate professor of food chemistry and food toxicology. (sciencedaily.com)
That's important because inflammation can trigger the steps of cancer progression, she said. (sciencedaily.com)
If we can reduce the activity of NF-kappa-B, the important marker that links inflammation and cancer, we'll be better able to control the transformation of normal cells to cancer cells," she added. (sciencedaily.com)
TNF-α and IFN-Î³ caused a lethal cytokine shock in mice that mirrors the tissue damage and inflammation of COVID-19, and inhibiting PANoptosis protected mice from this pathology and death . (bvsalud.org)
Collectively, our findings suggest that blocking the cytokine -mediated inflammatory cell death signaling pathway identified here may benefit patients with COVID-19 or other infectious and autoinflammatory diseases by limiting tissue damage/ inflammation . (bvsalud.org)
These can trigger inflammation and an immune response. (news-medical.net)
The induced necrotic cell death by virial agents is important for virus-induced inflammation, and blockage of necroptosis is a primary concern for controlling certain viral diseases. (news-medical.net)
Institute scientists have revealed a potent inflammatory molecule released by dying cells triggers inflammation during necroptosis, a recently described form of cell death linked to inflammatory disease. (edu.au)
Dr Lisa Lindqvist, Dr Kate Lawlor, Dr James Vince and PhD student Ms Stephanie Conos led research that showed interleukin-1 beta (IL-1b) triggers inflammation during necroptotic cell death. (edu.au)
However, necroptosis can become inappropriately or excessively activated, triggering damaging inflammation that leads to inflammatory disease. (edu.au)
Dr Lindqvist said the discovery challenged a long-standing dogma that inflammation triggered by necroptosis was a byproduct of dead cell debris. (edu.au)

IKK-β is an enzyme that serves as a protein subunit of IκB kinase, which is a component of the cytokine-activated intracellular signaling pathway involved in triggering immune responses. (wikipedia.org)
Cell death by necroptosis involves membrane breakage, which leaks intracellular molecules such as heat shock proteins. (news-medical.net)

In this study, we found that RING finger protein 4 (RNF4), a RING finger E3 ubiquitin ligase, is required for the RIPK1 autophosphorylation and subsequent cell death. (mdpi.com)
It is known that the so-called 'apoptotic enforcer protein' BAX encounters DRP1 in the cell at the mitochondrial membrane. (uni-koeln.de)
BAX is a key protein in the pathway to cell death. (uni-koeln.de)
When we artificially force the interaction of the two proteins, they move from the cytoplasm to the mitochondria, where the protein complex triggers a reorganization of the mitochondria. (uni-koeln.de)
Scientists at the UC Davis Comprehensive Cancer Center in Sacramento, California, have identified a protein on the CD95 receptor that can "program" cancer cells to die, as detailed in a study published in the journal Cell Death & Differentiation last month. (newsrollup.com)
A receptor is a protein within a cell that receives and transmits signals. (newsrollup.com)
IKK-β also known as inhibitor of nuclear factor kappa-B kinase subunit beta is a protein that in humans is encoded by the IKBKB (inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta) gene. (wikipedia.org)
CuO NPs undergo dissolution in lysosomes leading to copper-dependent macrophage cell death characterized by protein misfolding and proteasomal insufficiency. (biomedcentral.com)
Usually, it's used to permeabilize cells and make cell extracts in order to isolate protein, DNA, RNA, or other cell constituents. (scienceblogs.com)
Professor Xu Dong Zhang and his team investigated the role a particular protein plays in melanoma cell survival. (cancercouncil.com.au)
The gasdermin B (GSDMB) protein can trigger cancer-associated pyroptosis - a form of programmed cell death that activates antitumor immune responses - but its exact role is controversial. (mdanderson.org)
Mutations in the GJA1 gene lead to the production of an abnormal connexin 43 protein that is unable to reach the cell surface to become part of gap junctions. (medlineplus.gov)
Cells do not simply burst at the end of their lives but rather, a specific protein serves as a breaking point for cell membrane rupture. (phys.org)
In the journal Nature , they describe how a protein called ninjurin-1 assembles into filaments that work like a zipper and open the cell membrane , thus leading to the disintegration of the cell. (phys.org)
Instead of bursting like a balloon, the protein ninjurin-1 provides a breaking point in the cell membrane, causing rupture at specific sites. (phys.org)
Ninjurin-1 is a small protein embedded in the cell membrane. (phys.org)
Alzheimer Disease Alzheimer disease is a progressive loss of mental function, characterized by degeneration of brain tissue, including loss of nerve cells, the accumulation of an abnormal protein called beta-amyloid. (msdmanuals.com)

In contrast, calcium entry through extrasynaptic NMDA receptors, triggered by bath glutamate exposure or hypoxic/ischemic conditions, activated a general and dominant CREB shut-off pathway that blocked induction of BDNF expression. (nih.gov)
Synaptic NMDA receptors have anti-apoptotic activity, whereas stimulation of extrasynaptic NMDA receptors caused loss of mitochondrial membrane potential (an early marker for glutamate-induced neuronal damage) and cell death. (nih.gov)
These activate so-called death receptors on the cell. (medicalnewstoday.com)
My postdoc studies on neurotransmitter receptors led to papers in Science, Nature and Cell, and earned the 1988 Boeringer Ingelheim Award. (gene.com)
In the 1990's, the Human Genome Project inspired my team to discover several novel members of the TNF cytokine superfamily, most notably, Apo2L/TRAIL and its "death" and "decoy" receptors. (gene.com)

The main hallmark of necrotic cell death is swelling leading to rupture of the cell membrane. (medicalnewstoday.com)
Now, necrosis is known to have programmed aspects, with "necroptosis" describing regulated necrotic cell death. (news-medical.net)
They found that TNF induced both apoptotic and necrotic cell death. (news-medical.net)
This result sparked further interest in how necrotic cell death occurs. (news-medical.net)

This is rank speculation, but I've wondered if these over-reactions in the immune systems of elderly people might be partly triggered by the fact that they are the people who've probably had the most flu shots in their lives, and their systems might therefore overreact because they've been loaded with too many antibodies. (freerepublic.com)
Terracciano, Mario (2014) Cell death mechanisms triggered by monoclonal antibodies against CD99 in Ewing sarcoma: Cross-talk between MDM2, IGF-1R and Ras/MAPK , [Dissertation thesis], Alma Mater Studiorum Università di Bologna. (unibo.it)
In addition to its diagnostic value, CD99 has therapeutic potential since it leads to rapid and massive ES cell death when engaged with specific antibodies. (unibo.it)
Second, these antibodies impair the induction of synaptic plasticity, rebound potentiation, and LTD, on Purkinje cells, resulting in loss of restoration and compensation of the distorted "internal models. (springer.com)
The presence of antigens in the body triggers an immune response, usually the production of antibodies . (cdc.gov)

This means that in every nematode, the same 131 cells follow exactly the same pathway and die at exactly the same time of life. (technologyreview.com)
Even more remarkable, Horvitz realized that the programmed cell-death pathway is fundamentally the same in more complex organisms. (technologyreview.com)
Eiger is produced in apoptotic cells and, through activation of the c-Jun N-terminal kinase (JNK) pathway, is able to propagate the initial apoptotic stimulus. (elifesciences.org)
Yet, ferroptosis also occurs in non-transformed tissues as demonstrated by this study, thus implicating this cell death pathway in the development of a wide range of pathological conditions. (sciencedaily.com)
My results show that treatment of colon cancer cells with Foxy-5, a WNT5A mimicking peptide, leads to up-regulation of 15-PGDH through JNK/AP-1 pathway. (lu.se)

In conclusion, our results show that when plasma membranes are the main targets, Photofrin-PDT can lead to instant ROS formation and subsequent activation of downstream signaling events similar to those elicited by many apoptotic stimuli, but the damage of plasma membranes renders the death phenotype more necrosis like. (tmu.edu.tw)
There is a second way cells can die, called necrosis, which is a different process that occurs as an unplanned response to a stressful event ). (livescience.com)
Scientists call this the passive form of necrosis, as it does not require any specific activity by the cell. (medicalnewstoday.com)
However, there are two forms of necrosis - necroptosis and pyroptosis - which are actively regulated by the cell and are now recognized as specialized forms of programmed cell death. (medicalnewstoday.com)
As with passive necrosis, swelling causes the cell to burst. (medicalnewstoday.com)
In 1988, Laster and colleagues exposed two cell lines to TNF to investigate whether TNF (tumor necrosis factor) targets underwent DNA fragmentation. (news-medical.net)
and all cases showed typical morphology of Kikuchi disease, with necrosis, karyorrhectic debris, and the presence of the typical cell types, namely crescentic histiocytes and plasmacytoid monocytes. (medscape.com)

The discovery provides insight into how plants sense and respond to mechanical signals, such as cell swelling, rather than chemicals signals, such as nutrients or growth factors. (futurity.org)
Trigger waves also help cells reproduce, neurons propagate signals through the brain and viruses spread from cell to cell. (livescience.com)
Phagocytes patrol our tissues on the lookout for "find-me" signals released by dying cells, and then engulf them when they encounter "eat-me" signals. (medicalnewstoday.com)
To make it easy for patrolling phagocytes to home in and engulf apoptotic cells, they release strong "find-me" and "eat-me" signals. (medicalnewstoday.com)
Apoptotic cells can produce signals to instruct cells in their local environment, including ones that stimulate engulfment and proliferation. (elifesciences.org)
Although this process can occur in individual cells, apoptotic signals may also dictate the 'communal death' of many cells simultaneously. (elifesciences.org)
Only more recently has it become clear that apoptotic cells are the source of signals that can have profound effects on their neighbors. (elifesciences.org)
Various signals, such as bacterial components, trigger the cell death machinery. (phys.org)

Our results propose the possibility that MSL10 senses the cell swelling and activates a different channel that then transports the calcium. (futurity.org)
Basu found that MSL10 activates programmed cell death-a regulatory mechanism that originates from inside of the cell. (futurity.org)

Relative to other variants, isoforms 3/4 were cytotoxic for tumor cells, triggering pyroptosis and resulting in better antitumor outcomes in bladder and cervical cancer models. (mdanderson.org)

Brenner had been credited with realizing that because of its simplicity, C. elegans provides an ideal model for studying cell differentiation and organ development. (technologyreview.com)

The chelation of copper ions using tetrathiomolybdate (TTM) prevented cell death whereas inhibition of the cellular SOD1 chaperone aggravated toxicity. (biomedcentral.com)

As the cell responds to the swelling, specific genes get turned on or off. (futurity.org)
Building on preliminary work by Sydney Brenner and John E. Sulston, the scientists with whom he shared last year's Nobel Prize, Horvitz identified specific genes that trigger cell death in the cells of a millimeter-long soil-dwelling nematode named Caenorhabditis elegans . (technologyreview.com)
Without the presence of these genes, Horvitz determined, certain cells could live indefinitely. (technologyreview.com)
Bacteria sense these microenvironments and adapt by up or down regulating the expression of certain genes to influence different cell processes. (the-scientist.com)
The genes of cells program a process that, when triggered, results in death of the cell. (msdmanuals.com)
We further demonstrated that suppression of autophagy using either pharmacological inhibitors or RNA interference of essential autophagy genes enhanced cell death induced by IM in cell lines and primary CML cells. (lu.se)

Using super-resolution confocal fluorescence microscopy and biochemical as well as biophysical methods in model membrane systems, the research team was able to demonstrate the direct interaction of the two proteins in dying cells. (uni-koeln.de)
Cytokines are small proteins that are secreted by immune cells and help ensure a rapid response to restrict a virus. (freerepublic.com)
We also observed a dose-dependent accumulation of polyubiquitinated proteins and loss of proteasomal function in CuO NP-exposed cells, and we could demonstrate misfolding and mitochondrial translocation of superoxide dismutase 1 (SOD1), a Cu/Zn-dependent enzyme that plays a pivotal role in the defense against oxidative stress. (biomedcentral.com)
Kim and colleagues found the weathered microplastics affected proteins involved in breaking down sugars into energy, increasing their expression in the microglial cells 10 to 15 times more than in cells belonging to control groups. (sciencealert.com)
They also increased the concentrations of proteins involved in brain cell death by a factor of 5. (sciencealert.com)
CheKine™ microquantitative test kits and recombinant proteins help you explore cells with ease! (abbkine.com)
The UPR normally helps secretory cells to resolve issues with 3D shaping of newly synthesized proteins. (gene.com)
These proteins are part of the connexin family, a group of proteins that form channels called gap junctions on the surface of cells. (medlineplus.gov)
Ninjurin-1 proteins assemble (green/yellow) into filaments and rupture the cell membrane (gray) until the cell disintegrates completely. (phys.org)

Or perhaps these damaged cells are more susceptible to infection, and the plant commits cell suicide as a way to save the plant at the sacrifice of a few cells. (futurity.org)
We already know that when a pathogen infects a plant, the plant will kill off a bunch of the cells that are infected to prevent the spread of the infection," Haswell says. (futurity.org)
and IFN-Î³ Triggers Inflammatory Cell Death, Tissue Damage, and Mortality in SARS-CoV-2 Infection and Cytokine Shock Syndromes. (bvsalud.org)
While multiple inflammatory cytokines are produced by innate immune cells during SARS-CoV-2 infection, we found that only the combination of TNF-α and IFN-Î³ induced inflammatory cell death characterized by inflammatory cell death , PANoptosis. (bvsalud.org)
Case reports describe Kikuchi disease occurring together with, or following, conditions that could have served as triggers, including COVID-19 infection and vaccination. (medscape.com)

More specifically, the deletion of the ferroptosis-regulating enzyme Gpx4 in a pre-clinical model results in high ferroptosis rates in kidney tubular epithelial cells causing acute renal failure. (sciencedaily.com)
In the present study, the team was able to show that Liproxstatin-1 suppresses ferroptosis both in human kidney cells, Gpx4 deletion-induced acute renal failure and in a pre-clinical model of hepatic ischemia reperfusion injury. (sciencedaily.com)
Three deaths have been reported that occurred during the acute phase of generalized Kikuchi disease. (medscape.com)

The caspases that are first activated, activate other molecules of caspases, which activate yet others, until the entire cell is destroyed. (livescience.com)

Moreover, we find that administration of celecoxib, a specific COX-2 inhibitor, greatly diminishes the neurotoxicity triggered by TDP-43-depleted microglia. (nature.com)
Moreover, CuO NP-triggered cell death was insensitive to the pan-caspase inhibitor, zVAD-fmk, and to wortmannin, an inhibitor of autophagy, implying that this was a non-apoptotic cell death. (biomedcentral.com)

The study, published in the online journal Cell, discovered that the hyperinflammatory immune response connected with COVID-19, lead to multi-organ failure and tissue damage in mice. (freerepublic.com)
The initiation and development of tumor cell is accompanied by elevated stresses, such as oncogene activation, DNA damage, genome instability, and reprogrammed tumor metabolism. (nature.com)
Scientists have used a synthetic form of a recreational heroine-like drug developed back in the 1980s to demonstrate that dopamine-producing nerve cell death caused by Parkinson disease may be due to mitochondrial damage. (genengnews.com)
The mechanisms by which epidermal damage and cell death contribute to hyperkeratosis and erythematous areas are poorly understood. (medlineplus.gov)
In the presence of water (sweat, saliva, tears), the liquid or gas slowly hydrolyzes to hydrochloric acid, which can irritate and damage cells. (cdc.gov)
Other triggers include an excess number of cells and possibly damage to a cell. (msdmanuals.com)
Sometimes damage to a cell directly causes its death. (msdmanuals.com)
Accordingly, we treated postnatal day 3 rat cochlear organotypic cultures with various doses and durations of CoCl2 and quantified the damage to the hair cells, peripheral auditory nerve fibers, and spiral ganglion neurons (SGN). (cdc.gov)
Five-day treatment with 250 µM CoCl2 caused extensive damage to hair cells and neurons which increased with dose and treatment duration. (cdc.gov)

The key is that cells weren't dying a normal kind of death, they were undergoing programmed cell death. (futurity.org)

Cells may be damaged by harmful substances, such as radiation, sunlight, and chemotherapy drugs. (msdmanuals.com)

Herein is described the unprecedented biological properties of platinum( II ) complexes relevant to induction of cancer cell death via manifesting such intermolecular interactions. (rsc.org)
CArOGlu)](CF 3 SO 3 ) ( 1a , tpy = 2,2′:6′,2′′-terpyridine, Glu = glucose) is able to self-assemble into about 100 nm nanoparticles in physiological medium, be taken up by lung cancer cells via energy-dependent endocytosis, and eventually transform into other superstructures distributed in endosomal/lysosomal and mitochondrial compartments apparently following cleavage of the glycosidic linkage. (rsc.org)
This finding could lead to the development of new cell death regulators for cancer therapies, for example. (uni-koeln.de)
We also studied the effect of our compounds at the subcellular level using confocal microscopy from which we have obtained strong evidence that our compounds show greater selectivity for cancer cells than the healthy ones. (atlasofscience.org)
Our study also showed that these compounds have strong preferential toxic effects on cancer cells rather than normal ones. (atlasofscience.org)
Novel cis-selective and non-epimerisable C3 hydroxy azapodophyllotoxins targeting microtubules in cancer cells. (atlasofscience.org)
Researchers say they've located a "kill switch" that can trigger the death of cancer cells. (newsrollup.com)
Immune-based therapies, such as CAR (chimeric antigen receptor) T-cell therapy, have shown promise for a subset of patients, but have had limited effectiveness against many cancer types. (newsrollup.com)
Despite many breakthroughs in the cancer immunotherapeutic field, targeting Fas remains neglected, primarily due to fear of retaliation against immune-system T-cells," Tushir-Singh told Fox News Digital. (newsrollup.com)
Cancer cell metabolism is increasingly recognized as providing an exciting therapeutic opportunity. (institut-curie.org)
However, a drug that directly couples targeting of a metabolic dependency with the induction of cell death in cancer cells has largely remained elusive. (institut-curie.org)
And sometimes our cells don't die when we really do want them to - say, in cancer," senior author Dr. James Ferrell, a professor of chemical and systems biology and biochemistry at Stanford University, said in a statement . (livescience.com)
Cancer , autoimmune conditions, and neurodegeneration are all linked to failures of normal cell death and cell clearance. (medicalnewstoday.com)
At the time [Horvitz began his research], most scientists thought that cells died because they had no choice," says Craig B. Thompson, chair of the Department of Cancer Biology at the University of Pennsylvania. (technologyreview.com)
Our research further revealed that inhibiting IRE1 activity in cancer-surveilling dendritic cells augments anti-tumor immunity. (gene.com)
We are currently developing strategies that aim to kill cancer cells by directly disrupting their inherent stress-adaptation mechanisms or by augmenting the anti-tumor immune response. (gene.com)
In a recent study, scientists showed that human colon cancer cells die when they are exposed to the approximate number of bioactive compounds present in one cup of mate tea, which has long been consumed in South America for its medicinal properties. (sciencedaily.com)
In the in vitro study, de Mejia and former graduate student Sirima Puangpraphant isolated, purified, and then treated human colon cancer cells with caffeoylquinic acid (CQA) derivatives from mate tea. (sciencedaily.com)
Put simply, the cancer cell self-destructs because its DNA has been damaged," she said. (sciencedaily.com)
Ultimately cancer cells died with the induction of two specific enzymes, caspase-3 and caspase-8, de Mejia said. (sciencedaily.com)
Therapeutic interventions to treat cancer are conceivable, since some tumor cells evade programmed cell death. (phys.org)
Colon cancer is the third most common cancer in the world and the fourth most common cause of cancer related deaths. (lu.se)
Interestingly immune cells as mast cells and inflammatory mediators as LTC4 play an important role in colon cancer. (lu.se)
I investigated the underlying mechanisms/signaling triggered by these tumor suppressors in colon cancer cells and whether the re-expression of these tumor suppressors could be an attractive therapeutic strategy for treatment of colon cancer patients. (lu.se)
I found that presence of mast cells in colon cancer tissue was associated with better prognosis of colon cancer patients, and the presence of mast cells in polyps/tumors in a colitis-associated colon cancer mouse model was also beneficial. (lu.se)
I found that the tumor suppressor gene 15-PGDH is down-regulated in colon cancer patients as well as in colon cancer cell lines. (lu.se)
In fact, studies have shown that alcohol was responsible for about 20,000 cancer deaths in the United States in 2009. (cdc.gov)

This technique is an evolutionarily invaluable contribution to innate immunity, combining the killing of pathogen-infected cells with alerting the immune system through the release of DAMPs," noted the authors of a recent review about programmed cell death. (medicalnewstoday.com)
However, serologic and molecular studies have failed to link Kikuchi disease to a specific pathogen, and more than one pathogen may be capable of triggering the characteristic hyperimmune reaction leading to Kikuchi disease. (medscape.com)

Sandwiched between the outer cell wall and the internal contents of the cell is the plasma membrane. (futurity.org)
The deposition of Cu in lysosomes isolated from macrophages was also determined by ICP-MS. Cell viability (metabolic activity) was assessed using the Alamar Blue assay, and oxidative stress was monitored by a variety of methods including a luminescence-based assay for cellular glutathione (GSH), and flow cytometry-based detection of mitochondrial superoxide and mitochondrial membrane potential. (biomedcentral.com)
The effects of PDT on cells with plasma membrane-localized Photofrin were further studied in details. (tmu.edu.tw)
7 μg/ml, and at higher dose (28 μg/ml) plasma membrane disruption and cell swelling were observed immediately after PDT. (tmu.edu.tw)
Dramatic alterations of several important signaling events were detected in A431 cells post Photofrin®-PDT, including (i) immediate formation of reactive oxygen species (ROS), (ii) rapid activation of c-Jun N-terminal kinase, (iii) delayed activation of caspase-3 and cleavage of polyADP-ribose polymerase and p21-activated kinase 2, and (iv) loss of mitochondrial membrane potential. (tmu.edu.tw)
At the final stage of this process, the cell's protective membrane is compromised by tiny pores which allow ions to stream into the cell. (phys.org)
In this way, the cell membrane is cleaved open piece by piece until the cell disintegrates completely. (phys.org)
Morris Degen et al, Structural basis of NINJ1-mediated plasma membrane rupture in cell death, Nature (2023). (phys.org)

This all amounts to an increased inflammatory response by brain cells - far more severe than what was produced by unweathered microplastics tested at equivalent doses. (sciencealert.com)
Our research has pinpointed that, during necroptosis, dying cells release IL-1b, a potent inflammatory signal," Dr Lindqvist said. (edu.au)

Lymphadenitis results from apoptotic cell death induced by cytotoxic T lymphocytes. (medscape.com)

Ironomycin couples targeting of cellular metabolism with cell death by reducing mitochondrial iron, resulting in the alteration of mitochondrial metabolism and the activation of BAX/BAK. (institut-curie.org)
CuO NP-elicited cell death was characterized by mitochondrial swelling with signs of oxidative stress including the production of mitochondrial superoxide and cellular depletion of GSH. (biomedcentral.com)

MSL10 triggered a program of cell suicide. (futurity.org)
Why the plant triggers cell suicide in response to cell swelling is still a mystery. (futurity.org)
Damaged cells or cells infected with viruses or bacteria eliminate themselves by starting a built-in "suicide" program, which prevents the development of tumors and the spread of pathogens in the body. (phys.org)

First author and Humboldt fellow at the HMGU, Dr. Jose Pedro Friedmann Angeli sums it up as follows: "Our data show that we can use pharmacological approaches to stop this form of regulated cell death. (sciencedaily.com)

It is unclear how a shortage of connexin 43 at the cell surface affects the structure of gap junctions in the epidermis, or how these changes result in the skin abnormalities characteristic of EKVP. (medlineplus.gov)

Researchers have documented that cell swelling leads to a release of calcium into the cell cytoplasm and a buildup of reactive oxygen species, unstable molecules containing oxygen that can lead to cell death. (futurity.org)
The researchers discovered that MSL10 is not only an ion transporter but also a primary responder to cell swelling. (futurity.org)
Since it didn't, the researchers concluded that the process they observed must be "trigger waves," which they likened to "the spread of a fire through a field. (livescience.com)
However, very little was known about the mechanism until Robert Horvitz '68 and other researchers identified and described the process of programmed cell death. (technologyreview.com)
Researchers will explore the role and function of a different group of immune cells called innate lymphoid cells in treating melanoma. (cancercouncil.com.au)
Using cultured cells, the Washington University School of Medicine researchers found that the toxin MPP+ stopped the circulation of mitochondria in dopamine-producing cell axons, leading to the axonal withering and subsequently cell death. (genengnews.com)
Looking more closely at the mitochondria in treated cells, the researchers found that in some cases mitochondria seemed to be moving back toward the cell body, against the flow of other molecules and organelles, which suggested they were being trafficked back for repair. (genengnews.com)
Researchers suspect that ER stress damages cells in the epidermis and leads to their premature death. (medlineplus.gov)
Now, researchers at the Biozentrum of the University of Basel, the University of Lausanne and the Department of Biosystems Science and Engineering (D-BSSE) at ETH Zurich have provided new insights into the final step of cell death. (phys.org)
It also caused neurodegeneration in brain regions distant from the injection site, suggesting that damaged mtDNA triggers spread of PDD characteristics in an "infectious-like" manner, the researchers report. (medscape.com)

Among these unconventional activities, an iron-dependent form of non-apoptotic cell death, termed ferroptosis, attracts great interest. (nature.com)

Proliferation-linked shifts in eligibility of T-cell progenitors, population dynamics, DN1 cells to undergo specification thus control kinetics of T-cell generation. (lu.se)

Necroptosis falls somewhere in the middle, with several molecules and processes that can trigger, modulate, and effect necroptosis in cells. (news-medical.net)
The signaling cascade following ligand binding is also important in deciding cell fate and potentially initiating necroptosis. (news-medical.net)
For example, HIV-1 induce necroptosis in T cells . (news-medical.net)
In such cases, alternate mechanisms of cell death, such as necroptosis can be successfully induced. (news-medical.net)

Severe cases of Covid-19 have been known to lead to a mysterious condition whereby the body's immune system goes haywire and starts attacking healthy cells, rather than just those that are infected. (freerepublic.com)
Very rarely, the mutation is found in some of the body's cells but not others. (medlineplus.gov)
The cell debris is then removed by the body's own cleaning service. (phys.org)
Eventually, old cells must die, which is a normal part of the body's functioning. (msdmanuals.com)

In the absence of MbcA, MbcT triggers rapid M. tuberculosis cell death, which reduces mycobacterial survival in macrophages and prolongs the survival of infected mice. (figshare.com)
This project will investigate how to hijack the stress-response techniques melanoma cells have developed to promote their survival. (cancercouncil.com.au)

Scientists found that death travels in unremitting waves through a cell, moving at a rate of 30 micrometers (one-thousandth of an inch) every minute, they report in a new study published Aug. 10 in the journal Science . (livescience.com)
Scientists believed that cells died when they were deprived of oxygen or damaged by something in their environment. (technologyreview.com)
Scientists find that respiratory organelles in toxin-treated cells stop circulating along neuronal axon. (genengnews.com)

We also show that during coordinated cell death of hair follicle cells in mice, TNF-α is expressed in apoptotic cells and is required for normal cell death. (elifesciences.org)
find that these cells can stimulate other cells to die in both fruit flies and mice. (elifesciences.org)

To explore whether apoptotic cells could communicate with other cells, Pérez-Garijo et al. (elifesciences.org)
found that TNF is produced by apoptotic cells in hair follicles, and that blocking TNF inhibits the death of other cells in the same cohort: this suggests that a common mechanism could regulate the communal death of cells in flies and mammals. (elifesciences.org)

To figure this out, Ferrell and his team observed the process in one of the larger cells present in nature: egg cells of Xenopus laevis , or African clawed frogs . (livescience.com)
By proving the genetic component, Horvitz was able to demonstrate that programmed cell death is a normal, fundamental, and controlled biological process in cells. (technologyreview.com)
ER), triggering a harmful process known as ER stress. (medlineplus.gov)
Also, in the case of premature cell death observed in neurodegenerative diseases such as Parkinson's disease or in life-threatening conditions such as septic shock, drugs that interfere in this process could be a potential treatment option. (phys.org)
[ 26 ] The most favored theory proposes that Kikuchi disease results when one or more unidentified agents trigger a self-limited autoimmune process. (medscape.com)

The contents of the mitochondria enter the cell plasma, which ultimately leads to cell death," said Andreas Jenner, first author of the study. (uni-koeln.de)
This causes leaks in the membranes of mitochondria, which are the powerhouses that convert oxygen into energy in the cell. (medicalnewstoday.com)
Once mitochondria are damaged, a cell is well and truly on its way to becoming a corpse. (medicalnewstoday.com)
Interestingly, the toxin had no effect on transportation of mitochondria in other types of nerve cells. (genengnews.com)
While the specificity for dopamine-producing neurons has still to be worked out, a clue may lie in the team's observation that in comparison with other types of nerve cells, mitochondria in this type of neuron are smaller in size and travel three times more slowly. (genengnews.com)

Distinct types of cell death may be elicited by different PDT regimes. (tmu.edu.tw)
Cells with differentially localized Photofrin displayed distinct death phenotypes in response to PDT. (tmu.edu.tw)

Neuroinflammation, a striking and common hallmark involved in many neurodegenerative diseases, including ALS, is characterized by extensive activation of glial cells including microglia, astrocytes and oligodendrocytes. (nature.com)
Sometimes our cells die when we really don't want them to - say, in neurodegenerative diseases. (livescience.com)

However, the sensor that detects cell swelling in the first place was not known," says Liz Haswell, a professor of biology at Washington University in St. Louis. (futurity.org)
Ferrell and his team hope to find out where else in biology trigger waves occur. (livescience.com)

The mouse macrophage cell line RAW264.7 was used as an in vitro model. (biomedcentral.com)
These results identify hair cells and spiral ganglion neurons as the main targets of Co ototoxicity in vitro and implicate the superoxide radical as a trigger of caspase-mediated ototoxicity. (cdc.gov)

however, its ototoxic effects on the sensory hair cells, neurons, and support cells in the cochlea are poorly understood. (cdc.gov)

AiA provides a mechanism to explain cohort behavior of dying cells that is seen both in normal development and under pathological conditions. (elifesciences.org)
Food-seeking behavior is triggered by skin ultraviolet exposure in males: Here we show that solar exposure induces food-seeking behavior, food intake, and food-seeking behavior and food intake in men, but not in women. (reddit.com)

For example, cancerous cells, happily living on, having slipped the grasp of the Grim Reaper, begin to spread instead of dying off. (livescience.com)

Gap junctions open and close to regulate the flow of nutrients, charged atoms (ions), and other signaling molecules from one cell to another. (medlineplus.gov)
Other GJB3 or GJB4 gene mutations alter the flow of molecules through gap junctions, which may also lead to premature cell death in the epidermis. (medlineplus.gov)

Cell death stops excessive and damaged cells from accumulating. (medicalnewstoday.com)
When Ced-9 is turned on, it stops Ced-4 from triggering Ced-3. (technologyreview.com)
When a cell stops dividing, it is called senescence. (msdmanuals.com)

Dopamine production in the brain is diminished by nerve cell death. (helenastudy.com)

High-expressing CD99 mesenchymal stem cells show mild Ras induction but no p53 activation and escape cell death, but in presence of EWS/FLI1 mesenchymal stem cells expressing CD99 show a stronger Ras induction and a p53 reactivation, leading to a significant cell death rate. (unibo.it)
Photodynamic therapy (PDT) is a kind of photochemo-therapeutic treatment that exerts its effect mainly through the induction of cell death. (tmu.edu.tw)

It has been reported that RNF4 negatively regulates TNF-α-induced activation of the nuclear factor-κB (NF-κB) through downregulation of transforming growth factor β-activated kinase 1 (TAK1) activity, indicating the possibility that RNF4-mediated TAK1 suppression results in enhanced sensitivity to cell death. (mdpi.com)
Much of the research into Parkinson disease treatments is focused on saving the bodies of these cells, but our results suggest that keeping axons healthy also is essential," Dr. O'Malley notes. (genengnews.com)

The body changes with aging because changes occur in individual cells and in whole organs. (msdmanuals.com)

Plant cells, carrying a mutation that made MSL10 overly active, responded to cell swelling similarly to wildtype plants-they released calcium, making reactive oxygen species, and chaning gene expression. (futurity.org)

Anatomy23

Organisms7

Diseases9

Chemicals and Drugs84

Analytical, Diagnostic and Therapeutic Techniques and Equipment19

Psychiatry and Psychology1

Phenomena and Processes45

Disciplines and Occupations1

Anthropology, Education, Sociology and Social Phenomena1

Information Science5

Health Care5

Apoptosis40

Pathways6

Self-destruct1

Inflammation19

Intracellular2

Protein17

Receptors5

Necrotic cell death4

Antibodies5

Pathway5

Necrosis7

Signals8

Activates2

Pyroptosis1

Differentiation1

Inhibition1

Genes6

Proteins9

Infection5

Acute3

Activate1

Inhibitor2

Damage9

Undergoing programmed cell1

Chemotherapy1

Cancer27

Pathogen2

Membrane8

Inflammatory2

Cytotoxic1

Mitochondrial2

Suicide3

Form of regulated cell1

Unclear1

Researchers10

Ferroptosis1

Proliferation1

Necroptosis4

Body's4

Survival2

Scientists3

Mice2

Apoptotic cells2

Process5

Mitochondria5

Distinct2

Neurodegenerative diseases2

Biology2

Vitro2

Neurons1

Behavior2

Cancerous cells1

Molecules2

Stops3

Nerve cell death1

Induction2

Results2

Occur in individual cells1

Calcium1