EC50 = 0.53 μM), similarly to some tricyclic antidepressants (TCAs). (wikipedia.org)
An increase in the odds ratio of suicide attempts was also observed in comparing SSRIs with therapeutic interventions other than tricyclic antidepressants (1.94, 1.06 to 3.57, 239). (bmj.com)
In the pooled analysis of SSRIs versus tricyclic antidepressants, we did not detect a difference in the odds ratio of suicide attempts (0.88, 0.54 to 1.42). (bmj.com)
Tricyclic antidepressants are less preferred options and should generally be avoided. (sps.nhs.uk)
The tricyclic antidepressants amitriptyline, clomipramine, imipramine and desipramine increased phospho-ERK1/2 levels in HEK-LPA1 and -LPA3 cells but were relatively poor agonists in LPA2-expressing cells. (bvsalud.org)
The tetracyclic antidepressants mianserin and mirtazapine were active at all three LPA receptors. (bvsalud.org)
These results indicate that tricyclic and tetracyclic antidepressants can act on LPA1, LPA2 and LPA3 receptor subtypes and exert differential effects on LPA signalling through these receptors. (bvsalud.org)
Concomitant administration of tricyclic antidepressants escalates the threat of seizures. (bioinbrief.com)
Compared to tricyclic antidepressants, these tend to be stronger antihistamines and have less anticholinergic side effects. (drugbank.com)
The tricyclic antidepressants and amphetamines are among the therapeutically important drugs that may act via inhibition of adrenergic transport. (mcw.edu)
Mirtazapine4
Mianserin is closely related to mirtazapine, both chemically and in terms of its actions and effects, although there are significant differences between the two drugs. (wikipedia.org)
Along with mirtazapine, although to a lesser extent in comparison, mianserin has sometimes been described as a noradrenergic and specific serotonergic antidepressant (NaSSA). (wikipedia.org)
Nevertheless, mianserin and mirtazapine usually do not impact serotonin levels , nor inhibit CYP2D6, however they are substrates of the enzyme [14]. (bioinbrief.com)
Mianserin, sold under the brand name Tolvon among others, is an atypical antidepressant that is used primarily in the treatment of depression in Europe and elsewhere in the world. (wikipedia.org)
The use of mianserin is restricted to those who do not respond to other antidepressant drugs. (medscape.co.uk)
A tricyclic antidepressant used in the treatment of neurotic or reactive depressive disorders and endogenous or psychotic depression. (drugbank.com)
Life‐threatening or severe DILI has been reported for the monoamine‐oxidase inhibitor phenelzine, the tricyclic antidepressant imipramine, the selective serotonin reuptake inhibitor (SSRI) sertraline, the serotonin noradrenaline reuptake inhibitors venlafaxine and duloxetine, and serotonin‐2 antagonist/reuptake inhibitor trazodone, while the SSRIs citalopram and fluvoxamine are characterized by lower risk. (abdominalkey.com)
Perhaps the tricyclic-like antidepressant effect of ziprasidone interesting randomized trial of amisulpride, paroxetine, and ser- traline for burning mouth syndrome (BMS). (pdftreatment.com)
if you are taking a serotonin reuptake inhibitor (such as a selective serotonin reuptake inhibitor (SSRI), serotonin-norepinephrine reuptake inhibitor (SNRI), tricyclic antidepressant (TCA)), and certain other medicines and herbal products to treat depression or have taken these medicines within the last 14 days (see Taking other medicines for examples of serotonin reuptake inhibitors and other medicines used to treat depression). (mydr.com.au)
T ianeptine is a tricyclic antidepressant which enhances serotonin uptake in certain brain areas. (tianeptine.com)
Serotonin2
Mianserin appears to exert its effects via antagonism of histamine and serotonin receptors, and inhibition of norepinephrine reuptake. (wikipedia.org)
By antagonizing the somatodendritic and presynaptic α2-adrenergic receptors, which function predominantly as inhibitory autoreceptors and heteroreceptors, mianserin disinhibits the release of norepinephrine, dopamine, serotonin, and acetylcholine in various areas of the brain and body. (wikipedia.org)
Doxepin1
Of the TCAs: doxepin, lofepramine and mianserin may be considered lower risk, but should still be used with caution. (sps.nhs.uk)
Amitriptyline2
When combined with LPA, both amitriptyline and mianserin potentiated Gi/o-mediated phosphorylation of ERK1/2 induced by LPA in HEK-LPA1, -LPA2 and -LPA3 cells, CHO-K1 fibroblasts and HT22 hippocampal neuroblasts. (bvsalud.org)
The manufacturer states that anticholinergic side effects are not anticipated with mianserin therapy. (medscape.co.uk)
Depressive Disorder1
Mianserin at higher doses (30-90mg/day) is used for the treatment of major depressive disorder. (wikipedia.org)
Antihistamines1
Mianserin can make antihistamines and antimuscarinics have stronger effects. (wikipedia.org)
Therapy1
If based on clinical decision, normal precautions should be exercised and the dosages of mianserin and any concurrent therapy kept under review and adjusted as needed. (wikipedia.org)
Drugs1
Mianserin may enhance the sedative effects of drugs such as alcohol, anxiolytics, hypnotics, or antipsychotics when co-administered. (wikipedia.org)
Combination1
Mianserin should not be taken with apraclonidine, brimonidine, sibutramine, or the combination drug of artemether with lumefantrine. (wikipedia.org)
As an H1 receptor inverse agonist with high affinity, mianserin has strong antihistamine effects (e.g., sedation). (wikipedia.org)
Clomipramine2
Tianeptine appears to be as effective as fluoxetine, sertraline, amitriptyline, clomipramine and mianserin and more effective than maprotiline in improving associated anxiety in patients with depressive disorders. (tianeptine.com)
Robust evidence supports the use of the selective serotonin reuptake inhibitors and the older tricyclic drug clomipramine. (bvsalud.org)
Mianserin may enhance the sedative effects of drugs such as alcohol, anxiolytics, hypnotics, or antipsychotics when co-administered. (wikipedia.org)
Common1
Common tricyclic medications and their approximate half-life are listed below. (news-medical.net)
Drug1
Mianserin should not be taken with apraclonidine, brimonidine, sibutramine, or the combination drug of artemether with lumefantrine. (wikipedia.org)
Review1
If based on clinical decision, normal precautions should be exercised and the dosages of mianserin and any concurrent therapy kept under review and adjusted as needed. (wikipedia.org)
High1
As an H1 receptor inverse agonist with high affinity, mianserin has strong antihistamine effects (e.g., sedation). (wikipedia.org)
Major1
Mianserin at higher doses (30-90mg/day) is used for the treatment of major depressive disorder. (wikipedia.org)