• Severe hypertension may occur with monoamine oxidase inhibitors and possibly tricyclic antidepressants. (wikipedia.org)
  • Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron. (medscape.com)
  • Tricyclic antidepressants, monoamine oxidase inhibitors, levothyroxine sodium, and certain antihistamines potentiate effects of epinephrine. (nih.gov)
  • Tricyclic antidepressants and guanethidine may potentiate the pressor response to Dopamine-Rotex 200 mg/5 ml. (medeasy.health)
  • Carbamazepine is an anticonvulsant that is structurally related to tricyclic antidepressants such as amitriptyline and imipramine. (minddisorders.com)
  • Tricyclic antidepressants, desipramine, protriptyline, imipramine and amitriptyline, inhibit NA and 5-HT uptake but do not affect DA uptake. (erowid.org)
  • Tricyclic antidepressants: Examples of tricyclic antidepressants include amitriptyline, doxepin, and imipramine. (beerdelux.com)
  • or tricyclic antidepressants such as desipramine (Norpramin), clomipramine (Anafranil), imipramine (Tofranil), and trimipramine (Surmontil) Many other medications may also interact with scopolamine patch, so be sure to tell your doctor about all the medications you are taking, even those that do not appear on this list. (medlineplus.gov)
  • Colchicine is a tricyclic alkaloid derived from colchicum plants. (bmj.com)
  • Digoxin: A drug for treating heart failure and unusual heart rhythms, Ergot alkaloids: Usually used for the treatment of migraine, An example of an ergot alkaloid is ergotamine. (beerdelux.com)
  • According to Wikipedia , colchicine is a very toxic tricyclic alkaloid, originally extracted from colchicum (plants of the genus Colchicum), mainly fall colchicum. (covexit.com)
  • The third chapter covers the author's total synthesis of stemoamide, a 1-azabicyclo[5.3.0]decane motif containing alkaloid. (jyu.fi)
  • 2014 ) Synthesis of the tricyclic core in stemonamine alkaloids via one-pot gold(I)-catalyzed cyclization and schmidt rearrangement: formal synthesis of (±)-stemonamine. (academictree.org)
  • An attempted extension of this work into the synthesis of ergot alkaloids provided insight into the factors affecting Friedel-Crafts acylation of 4-substituted indoles. (uwaterloo.ca)
  • 2) total synthesis of calyciphylline B-type alkaloids and evolution of a novel methodology to access oxazaborinine heterocycles (Chapters 5-6). (escholarship.org)
  • Chapter 5 focuses on our early approach toward the synthesis of calyciphylline B-type natural products, a subfamily of the polycyclic Daphniphyllum alkaloids. (escholarship.org)
  • Monocyclic, bicyclic and tricyclic aromatic hydrocarbons, and monocyclic compounds with one hetero atom: synthesis, reactivity and properties. (mahasarkar.co.in)
  • However, the active compound, a tricyclic alkaloid, was first reported in 1955 and its name was derived from Colchis, an ancient region close to the Black Sea, where plants of Colchicum were widespread (figure 1). (bmj.com)
  • tell your doctor and pharmacist if you are allergic to scopolamine, other belladonna alkaloids, any other medications, or any of the ingredients in scopolamine patches. (medlineplus.gov)
  • Crucial steps In the artificial string toward these kinds of lycopodium alkaloids incorporate development of the tricyclic key with a conformationally more rapid, intramolecular Mannich cyclization with an organocatalyzed, intramolecular Eileen accessory from the C-7-C-12 linkage. (erk-signal.com)
  • a toxic alkaloid used as a veterinary anthelmintic. (absp.org.uk)
  • A one-pot Diels-Alder/Friedel-Crafts process was used as an entry into the 6-5-6-tricyclic skeleton of a family of natural products that have been of interest in our group. (uwaterloo.ca)
  • Subsequent conjugate addition of the requisite antipode of lithium N -benzyl- N -(α-methylbenzyl)amide to the resultant α,β-unsaturated esters gave a range of diamines for elaboration to T1-T8 via a sequence involving reduction of the ester moiety to give the corresponding aldehyde, olefination, tandem hydrogenation/hydrogenolysis, and cyclization upon reaction with 4-bromobutanal to give the tricyclic skeleton. (researcher-app.com)
  • May interact with cardiac, hypotensive drugs & tricyclic anti-depressants. (florapal.org)
  • With neuroleptic drugs, the most significant changes in 5-HT metabolism in the brain are produced by Rauwolfia serpentine alkaloids and benzoquinoline derivatives. (erowid.org)
  • Lupinus species are broadly divided into bitter lupins, which contain high levels of alkaloids in their seeds, and sweet lupins, which contain lower levels of alkaloids and are cultivated for human consumption. (medscape.com)
  • Caffeine is a white, bitter crystalline alkaloid derived from coffee or tea. (minddisorders.com)
  • Cytisine, a tricyclic quinolizidine alkaloid found in Baptisia, Cytisus, Laburnum , and Sophora species, has nicotinelike effects on the gastrointestinal (GI) tract and the central nervous system (CNS). (medscape.com)
  • Lupinus species contain sparteine, a tetracyclic quinolizidine alkaloid, and lupinine, a bicyclical quinolizidine alkaloid. (medscape.com)
  • Conjugate addition of either lithium ( R )- N -allyl- N -(α-methylbenzyl)amide or lithium ( R )- N -(but-3-en-1-yl)- N -(α-methylbenzyl)amide to tert -butyl sorbate was followed by ring-closing metathesis of the resultant N -alkenyl β-amino esters, reduction to the corresponding aldehydes, and reaction with tert -butyl (triphenylphosphoranylidene)acetate. (researcher-app.com)
  • Tentative studies towards a divergent route to other stemona alkaloids from a key precursor were also carried out. (jyu.fi)
  • Chapter 6 highlights our successful route to access calyciphylline B-type alkaloids. (escholarship.org)
  • Nalivela, Kumara Swamy, Towards the total synthesis of the Stemona alkaloids Oxyprotostemonine and 1-Hydroxyprotostemonine, Doctor of Philosophy thesis, School of Chemistry, University of Wollongong, 2010. (edu.au)
  • The main aim of this project was to develop a new synthetic methodology towards the total synthesis of the Stemona alkaloids oxyprotostemonine 10 and 1-hydroxyprotostemonine 11 as shown in Figure 1. (edu.au)
  • In addition, work is presently in progress on total synthesis of the biogenetically related anticancer marine alkaloid madangamine A. (psu.edu)
  • This chemistry is now being applied in an approach to total synthesis of the marine sponge anticancer alkaloid fasicularin. (psu.edu)
  • Weinreb, S.M. Total Synthesis of the Monoterpenoid Indole Alkaloids (±)-Alstoscholarisine B and C. (psu.edu)
  • Weinreb, S. M. Construction of the Myrioneuron Alkaloids: A Total Synthesis of (±)-Myrioneurinol. (psu.edu)
  • Weinreb, S. M. Total Synthesis of the Tetracyclic Antimalarial Alkaloid (±)-Myrioneurinol. (psu.edu)
  • Weinreb, S. M. Total Synthesis of the Unusual Monoterpenoid Indole Alkaloid (±)-Alstilobanine A. Angew. (psu.edu)
  • The developed strategy enables easily available lactams to be used as stable surrogates of multisubstituted amines and would be applicable to a unified total synthesis of complex Aspidosperma alkaloids. (elsevierpure.com)
  • In Chapter 3 we describe synthesis of the tricyclic compound 244 and the tetracyclic compound 47. (edu.au)
  • This finding was highlighted through the synthesis of the complete carbon skeleton of the archetypal normal corynanthe alkaloid dihydrocorynantheol. (utexas.edu)
  • An efficient synthesis of the tricyclic spiroindolinone ABC-fragment of the marine alkaloid citrinadin A has been achieved. (utexas.edu)
  • opioid receptor agonist, the only non-alkaloid psychoactive substance, and the most potent naturally occurring hallucinogen.2 As a result of its therapeutic potential, renewed isolation efforts have discovered a number of related salvinorin congeners,3 and a number of analogues of 1 have been prepared by semisynthesis to probe the pharmacophore and mode of binding.4 This communication describes the first synthesis of this natural product. (erowid.org)
  • Weinreb, S. M. Synthesis of Alstoscholarisines A-E, Monoterpene Indole Alkaloids with Modulating Effects on Neural Stem Cells. (psu.edu)
  • Weinreb, S. M. Synthesis of the Tetracyclic Skeleton of the Lycopodium Alkaloid Lycopladine H via a Pivotal Double Hydroformylation/Intramolecular Reductive Amination Sequence. (psu.edu)
  • Our synthesis features an iridium-catalyzed reductive Michael addition/[3+2] cycloaddition cascade to give a tricyclic ketone intermediate from a simple lactam via an azomethine ylide. (elsevierpure.com)
  • Among the numerous indole alkaloids, 3,n-fused ( n = 4-7) tricyclic indoles have attracted much attention for their typical biological activities and synthetic challenges in recent years [ 7 ] [ 8 ] . (encyclopedia.pub)
  • Weinreb, S. M. Convergent Approach to the Tetracyclic Core of the Apparicine Class of Indole Alkaloids via a Key Intermolecular Nitrosoalkene Conjugate Addition. (psu.edu)
  • Weinreb, S. M. Total Syntheses of the Monoterpene Indole Alkaloids (±)-Alstilobanine A and E, and (±)-Angustilodine. (psu.edu)
  • Tropane alkaloids in auxin-independent root cultures of Physochlaina physaloides. (ncats.io)
  • Enhanced secretion of tropane alkaloids in Nicotiana tabacum hairy roots expressing heterologous hyoscyamine-6beta-hydroxylase. (ncats.io)
  • tell your doctor and pharmacist if you are allergic to scopolamine, other belladonna alkaloids, any other medications, or any of the ingredients in scopolamine patches. (medlineplus.gov)
  • From the two sponges, seven new guanidine alkaloids, designated netamines A-G (1-7), have been isolated and their structures elucidated. (tau.ac.il)
  • Cylindrospermopsin is a tricyclic alkaloid consisting of a tricyclic guanidine moiety combined with hydroxymethyluracil. (nih.gov)
  • In addition, these alkaloids are able to bind to serotonin receptors, an important immune regulatory molecule in both vertebrates and invertebrates. (biomedcentral.com)
  • Observations and measurements performed 24 h later revealed decreased responses, suggesting decomposition and/or exertion of alkaloids and/or serotonin. (biomedcentral.com)
  • Since the first reports that β-carboline alkaloids are able to bind to serotonin (5-HT) receptors of isolated tissue [ 4 ], this relationship has been the subject of many investigations. (biomedcentral.com)
  • Hyoscyamine as a natural plant alkaloid derivative and anticholinergic. (ncats.io)
  • A tricyclic antidepressant that has actions and uses similar to those of AMITRIPTYLINE , but has only weak antimuscarinic and sedative effects. (bvsalud.org)
  • Selective protection of the amines, followed by bromocyclisation generated the 6,5,5-fused tricyclic product in excellent yield, generating the key precursor for their chemistry after converting the ester to a methyl amide. (chemistryworld.com)
  • The Hudlicky research team's paper entitled, "Rapid Access to the Tricyclic Core of Calyciphylline A-Type Alkaloids via Allyl Cyanate-to-Isocyanate Rearrangement" has been rated as "Very Important" by the European Journal of Organic Chemistry , an honour afforded to less than 10% of the manuscripts that it receives. (brocku.ca)
  • The chemistry is currently being utilized in enantioselective total syntheses of the poison frog neurotoxin (-)-gephyrotoxin and the indole alkaloid (-)-ibogamine. (psu.edu)
  • 2 Bisindole alkaloids , G A Cordell, J E Saxton in The alkaloids: chemistry and physiology , Vol. 20 (Eds. (chemistryworld.com)
  • We first aimed to synthesize the tricyclic compound 244 and then the tetracyclic ether bridged compound 47. (edu.au)
  • In medicine, phenanthrene can synthesize alkaloids. (chemenu.com)
  • For example, the unusual polycyclic marine natural product sarain A will be synthesized from the tricyclic intermediate in Figure 1 . (psu.edu)
  • During the last two decades, the major bioactive constituents of the drugs have been isolated from various terrestrial plants, these being numerous simple and complicated β-carboline alkaloids with saturated or unsaturated tricyclic ring systems. (biomedcentral.com)
  • Among them, palladium has been widely used as a versatile catalyst for their typical atom orbital to get a series of tricyclic indole skeletons. (encyclopedia.pub)
  • Dehydration of 241 followed by reduction of the resulting a,B-unsaturated lactone 242 gave the desired tricyclic compound 244. (edu.au)
  • 3,n-fused ( n = 4-7) tricyclic indoles are pervasive motifs, embedded in a variety of biologically active molecules and natural products. (encyclopedia.pub)
  • To showcase this technology, Stephenson quickly leapt upon a group of natural products known as the hexahydropyrroloindoline alkaloids. (chemistryworld.com)
  • The β-carboline alkaloids were originally isolated from Peganum harmala (Zygophillaceae, Syrian Rue), a traditional herbal drug commonly used as an emmenagogue and abortifacient in the Middle East and North Africa [ 1 ]. (biomedcentral.com)
  • As a result, we have developed a unified approach to both the "normal" and "pseudo" corynanthe alkaloids. (utexas.edu)