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  • introduction
  • Interestingly, the introduction of OVA into the airway of triclosan-exposed mice was associated with increased swelling of the ear tissue along with an influx of CD11b+ cells and dramatic increase in TSLP and TNF-alpha expression. (cdc.gov)
  • effects of triclosan
  • The applications of triclosan which contribute to those high environmental concentrations cannot be properly identified nor quantified at present and the presence of other chemicals (e.g. antibiotics, surfactants, other biocides, etc.) in the environment, which may also affect microbial populations, would preclude assessing the effects of triclosan independently. (wired.com)
  • June 8, 2018 -- The effects of triclosan on human health should be urgently re-examined, according to the authors of a new preclinical study that found the chemical might increase the risk of colon cancer and other harmful consequences. (drbicuspid.com)
  • (drbicuspid.com)
  • levels of triclosan
  • Biomonitoring studies on levels of triclosan provide physicians and public health officials with reference values so that they can determine whether people have been exposed to higher levels of triclosan than are found in the general population, as well as helping health scientists plan and conduct research on exposure and health effects. (isotope.com)
  • 1 However, notwithstanding significant differences in excreted levels of triclosan, the results of this study are not consistent with the hypotheses that use of triclosan at physiologic levels achieved through the use of consumer products has a major impact on human gut or oral microbiome composition, or the metabolic and inflammatory markers measured in this study. (ada.org)
  • gingivitis
  • This paper provides an overview and summary of the data that demonstrate the effectiveness of a dentifrice containing triclosan/copolymer/fluoride in significantly reducing plaque, calculus, gingivitis, and the onset and progression of periodontitis. (biomedsearch.com)
  • A study by Colgate-Palmolive found a significant reduction in gingivitis, bleeding, and plaque with the use of triclosan-containing toothpaste, but an independent review of the Cochrane group suggests that while the reduction in gingivitis, bleeding, and plaque may be statistically significant, it may not be beneficial enough to yield clinical significance. (wikipedia.org)
  • Triclosan or zinc chloride prevent gingivitis and, according to the American Dental Association, helps reduce tartar and bad breath. (wikipedia.org)
  • A 2006 review of clinical research concluded there was evidence for the effectiveness of 0.30% triclosan in reducing plaque and gingivitis. (wikipedia.org)
  • 2002
  • Adolfsson-Erici M, Pettersson M, Parkkonen J, Sturve J (2002) Triclosan, a commonly used bactericide found in human milk and in the aquatic environment in Sweden. (springer.com)
  • Environmental Protec
  • In December of 2013 the Food and Drug Administration announced it would look further into the safety and efficacy of the biocide triclosan and requested further safety data as part of a new review with the Environmental Protection Agency. (biomedsearch.com)
  • The Environmental Protection Agency, which shares triclosan regulation with the FDA, is conducting a review of the antimicrobial agent and recently released its early findings. (medpagetoday.com)
  • While the US Food and Drug Administration, the Environmental Protection Agency, and the European Union all regulate triclosan, the chemical is not monitored and often gets absorbed into sewage sludge after wastewater treatment. (enn.com)
  • exposure
  • The exposure is greatest during the first few brushes after switching to a triclosan-free toothpaste and continuing to use the same brush, Han said. (healthline.com)
  • Allmyr M, Adolfsson-Erici M, McLachlan MS, Sandborgh-Englund G (2006) Triclosan in plasma and milk from Swedish nursing mothers and their exposure via personal care products. (springer.com)
  • Clostridium difficile , Serratia marcescens and Pseudomonas putida have come to light as bacteria that are not killed by exposure to triclosan. (everything2.com)
  • The human health effects from low-level triclosan exposure are unknown, although skin products containing triclosan can infrequently cause irritation. (isotope.com)
  • In the Fourth National Report on Human Exposure to Environmental Chemicals (Fourth Report), CDC scientists measured triclosan in the urine of 2,517 participants aged six years and older who took part in the National Health and Nutrition Examination Survey (NHANES) during 2003-2004. (isotope.com)
  • Because of its ubiquity, exposure to triclosan is practically unavoidable in the U.S., but little is known about how ingestion affects human health. (drbicuspid.com)
  • efficacy
  • Some debate surrounds triclosan use regarding its efficacy and toxicity. (reference.com)
  • In September 2016, the FDA announced that effective September 2017, it would prohibit the sale of "consumer antiseptic washes" containing triclosan or 18 other ingredients marketed as antimicrobials due to FDA findings of the lack of efficacy in these products. (wikipedia.org)
  • antimicrobial resistance
  • Based on the available scientific information including recent data from in vitro investigations (proteomic and genomic analyses), it is not possible to quantify the risk associated with triclosan (including its use in cosmetics) in terms of development of antimicrobial resistance. (wired.com)
  • But when the researchers examined four community-based studies to look for antimicrobial resistance associated with triclosan, it found none. (medpagetoday.com)
  • concentrations
  • In small concentrations allowed in over-the-counter toothpastes, triclosan is considered safe. (healthline.com)
  • However, at the lower concentrations seen in commercial products, triclosan appears bacteriostatic, and it targets bacteria primarily by inhibiting fatty acid synthesis. (wikipedia.org)
  • antibacterial soap
  • If you are doing something that could spread germs to a number of other people, then it's not a bad idea to use triclosan or some other antibacterial soap, but for everyday purposes, 'normal' soap plus some common sense and basic hygiene is plenty good enough, and safer for us all. (everything2.com)
  • Claims that antibacterial soap is effective stem from the long-standing knowledge that triclosan can inhibit the growth of various bacteria, as well as some viruses and fungi. (wikipedia.org)
  • Chemicals
  • A Toxicological Sciences study found that triclosan affected estrogen-mediated responses, and many chemicals that imitate estrogen are known to increase breast cancer risk. (mercola.com)
  • Researchers studied the metabolism of triclosan and other chemicals after their uptake into carrot cell cultures and found that plant uptake of environmental contaminants may severely underestimate the extent of uptake into plants. (enn.com)
  • chlorine
  • Triclosan combines with chlorine to form, among other things, chloroform gas, which is a suspected human carcinogen . (everything2.com)
  • Dioxins can be found in triclosan as impurities formed during the manufacturing process, and triclosan can break down into various types of dioxins when added to water and then exposed to UV radiation (the chlorine molecules in tap water can make it even worse). (everything2.com)
  • Triclosan reacts with chlorine in tap water to produce chloroform, a suspected carcinogen. (brighthub.com)
  • plaque
  • Studies indicate that Salvadora persica extract exhibits low antimicrobial activity compared to other oral disinfectants and anti-plaque agents like triclosan and chlorhexidine gluconate. (wikipedia.org)
  • toothpastes
  • A toxic pesticide linked to serious health problems should not be in our soap or toothpastes," contends EWG scientist Rebecca Sutton, Ph.D. "It's time to ban triclosan from all personal care and household products. (medpagetoday.com)
  • regulation
  • Although it said that it "is not known to be hazardous to humans", it noted that animal studies have shown that triclosan alters hormone regulation. (truthinaging.com)
  • resistance
  • Triclosan has been shown to interfere with hormones, kill some aquatic life, and contribute to antibiotic resistance. (healthline.com)
  • Due to the limited number of in situ studies of resistance induced by triclosan to date, SCCS can only recommend the prudent use of triclosan, for example in applications where a health benefit can be demonstrated. (wired.com)
  • However, conclusions from in vitro studies cannot be ignored, notably the role of triclosan (and other biocides) in triggering resistance. (wired.com)
  • Eleven of the studies Dr. Aiello reviewed found triclosan-tolerant species and cross-resistant to clinical antibiotics, suggesting that -- at least at the laboratory level -- cleaning with triclosan products can lead to antibacterial resistance. (medpagetoday.com)
  • The Michigan researchers concluded that "further research is clearly needed to assess whether the emergence of antibiotic resistance in the community setting is associated with the growing use of soaps containing triclosan. (medpagetoday.com)
  • This has been observed already with resistance genes for triclosan, tetracycline, and trimethoprim. (wikipedia.org)
  • researchers
  • Researchers from Germany and Slovakia are claiming that triclosan is harmful to the ecology of rivers and are calling for further monitoring of the chemical. (enn.com)
  • The researchers wanted to examine the effects and mechanisms of triclosan on colonic inflammation and colitis-associated colon cancer by starting with an animal model. (drbicuspid.com)
  • The researchers noted that mice in the study were exposed to triclosan via diet or drinking water, which is different from how people ingest the chemical. (drbicuspid.com)
  • Swedish researchers detected triclosan in 3 out of 5 breast milk samples. (brighthub.com)
  • found
  • I haven't found any statistics on how much triclosan is used daily by the average person vs. how much is needed to be a serious cancer risk from chloroform gas. (everything2.com)
  • Triclosan has been in the news lately as it has recently been found to function as an endocrine-disrupting compound, and since this compound is so ubiquitous in everyday items, the FDA and the EPA are taking a closer look at its effects on the body and the environment. (isotope.com)
  • Triclosan is found in virtually everyone's home and is pervasive in the environment. (mercola.com)
  • Triclosan was found to affect hormone levels in animals. (wikipedia.org)
  • The United States FDA has found that triclosan provides no health benefits over soap and water. (wikipedia.org)
  • enzyme
  • Bacteria become resistant when random mutations generate alternate forms of the enzyme that are unaffected by triclosan, and these resistant bacteria can then multiply and spread. (brighthub.com)
  • products
  • Triclosan has been banned in many products, but not in toothpaste. (healthline.com)
  • In the European Union, triclosan has been restricted in products where it would come in contact with food , such as storage containers. (wired.com)
  • Products that use triclosan are required to say so somewhere on their label. (everything2.com)
  • 2,4,4'-Trichloro-2'-hydroxydiphenyl ether - more commonly known as triclosan - is an antimicrobial agent present in a variety of products where it works to slow or arrest the growth of bacteria, fungi, and mildew. (isotope.com)
  • when using these products, small amounts of triclosan can be absorbed through the skin or the mouth. (isotope.com)
  • Evidence of such effects has emerged since the FDA last addressed the use of triclosan in consumer products in 1994. (empowher.com)
  • Now a sizable posse of public health and environmental groups are lobbying for triclosan to be banned from non-medical products. (truthinaging.com)
  • However, there is little evidence that triclosan-containing soaps clean better than any other soap products. (reference.com)
  • As of 2015, not enough evidence exists to remove triclosan from any consumer products. (reference.com)
  • Explain to interested patients that triclosan is a broad-spectrum antimicrobial agent that is used in hundreds of household and industry products, most prominently hand soaps. (medpagetoday.com)
  • Explain that an environmental activist organization believes that hints of hazards from triclosan are merely the tip of the iceberg and that the agent should be banned from household products. (medpagetoday.com)
  • WASHINGTON -- An environmental activist group believes that triclosan, an antimicrobial agent added to hundreds of everyday products, offers no demonstrable benefits while threatening human health. (medpagetoday.com)
  • In recent years, the use of antibacterial agents in personal care and household products has skyrocketed, and triclosan is the most widely-used antimicrobial agent. (brighthub.com)
  • Crossover Control Study of the Effect of Personal Care Products Containing Triclosan on the Microbiome. (ada.org)
  • Triclosan and other antibacterial agents have long been used in commercial cleaning products for hospitals and other healthcare settings, however they began to be used in home cleaning products during the 1990s. (wikipedia.org)
  • health
  • The statement said there is no evidence of health benefits from the use of triclosan in soaps, although the scientists don't refute the gum disease-treatment benefits. (healthline.com)
  • Although triclosan has been approved for use by both the U.S. Food and Drug Administration and by the European Union, there are some health and environmental concerns. (everything2.com)
  • The FDA said that there is no proof that triclosan adds any health benefit at all to the antibacterial soaps in which it is used. (empowher.com)
  • Triclosan persists in the environment, breaks down into substances highly toxic to wildlife, pollutes the human body, and poses health risks that are barely studied and poorly understood," the EWG asserted. (medpagetoday.com)
  • Triclosan is harmful in many different ways, both to human health and to the environment. (brighthub.com)
  • Vivimed was mainly into health care until its foray into the Home and Personal Care industry came with the advent of Triclosan. (wikipedia.org)
  • antibiotics
  • Five out of 12 triclosan-selected mutants were less susceptible to antibiotics than the wild-type strain and overproduced SmeDEF. (biomedsearch.com)
  • But if that doesn't do it for you, you should consider that triclosan is said to bioaccumulate in humans, rendering some antibiotics ineffective. (truthinaging.com)
  • hormone
  • 3 Triclosan also suppressed thyroid hormone in rats, and this is only one study in an accumulating body of research showing this chemical to be a potent endocrine disrupter. (mercola.com)
  • study
  • The purpose of this study was to determine and compare the antimicrobial action of a urea-based handwash lotion with triclosan with a lipid-depleting detergent-based handwash product with 4% chlorhexidine gluconate. (biomedsearch.com)
  • Also, according to a recent study, triclosan may even enter agricultural fields through municipal irrigation water that may contain sewage sludge, or through manure. (enn.com)
  • Zhang and colleagues conducted a randomized trial of eight different study protocols involving brief, low-level exposures to triclosan via the animals' diet. (drbicuspid.com)
  • This study does not address questions related to environmental impact of triclosan, but is strongly suggestive of its safety for use by humans. (ada.org)
  • resistant
  • showering with 2% triclosan has become a recommended regimen in surgical units for the decolonization of patients whose skin carries methicillin-resistant Staphylococcus aureus (MRSA). (wikipedia.org)
  • humans
  • But there has been little agreement with the claim that triclosan might foster cancer in humans. (medpagetoday.com)
  • They dispute the EWG's claims that triclosan may cause cancer in humans. (medpagetoday.com)
  • Yet the U.S. Food and Drug Administration (FDA) states that "Triclosan is not currently known to be hazardous to humans. (mercola.com)
  • 6 Although they still maintain that triclosan is not known to be hazardous to humans, they are conducting a review of the chemical, the results of which they expect to release to the public in the winter of 2012. (mercola.com)
  • pesticide
  • Now the Environmental Working Group has called triclosan a toxic pesticide, with ominous hints of carcinogenicity, and has demanded that federal agencies ban it from consumer goods. (medpagetoday.com)
  • sodium
  • Triclosan is soluble in ethanol, methanol, diethyl ether, and strongly basic solutions such as a 1M sodium hydroxide solution, but only slightly soluble in water. (wikipedia.org)
  • chemical
  • The chemical triclosan is not one of these new candidates on the list of priority substances that are monitored by the European Union. (enn.com)