• Reddy, Synthesis and biological evaluation of pyrazolo-triazole hybrids as cytotoxic and apoptosis inducing agents, Org. (dntb.gov.ua)
  • Li, Synthesis and evaluation of novel 1, 2, 3-triazole-based acetylcholinesterase inhibitors with neuroprotective activity, Bioorganic Med. (dntb.gov.ua)
  • Akin, Synthesis of 1, 2, 4-triazole-5-on derivatives and determination of carbonic anhydrase II isoenzyme inhibition effects, Bioorg. (dntb.gov.ua)
  • Sağlık, Synthesis, molecular docking analysis and carbonic anhydrase I-II inhibitory evaluation of new sulfonamide derivatives, Bioorg. (dntb.gov.ua)
  • Singh, Synthesis and carbonic anhydrase inhibition studies of sulfonamide based indole-1, 2, 3-triazole chalcone hybrids, Bioorg. (dntb.gov.ua)
  • In this study, we explored the catalyst‐free one‐pot multi‐component synthesis of 1,4‐dihydropyridine derivatives by following green chemistry protocol. (researchgate.net)
  • These transformations tolerated a broad range of the nucleophilic reagents thus allowing the synthesis of a wide variety of hetero- and carbocyclic compounds including the derivatives of pyridine, pyrimidine, pyrazole, pyran, dioxane, and isoxazole as well as their heterofused derivatives. (researchgate.net)
  • Triazoles: a new class of precursors for the synthesis of negatively charged carbon nitride derivatives. (mpg.de)
  • Derivatives of ribavirin are also prepared by enzymatic synthesis and Vorbrüggen coupling methods. (news-medical.net)
  • Barus, Synthesis and evaluation of antimicrobial activities of new functional derivatives of 3-[5-(4-nitrophenyl)-2-furyl]-4-pyrazole-carbaldehydes, Biointerface Res. (dntb.gov.ua)
  • Sun, Synthesis and antifungal activity of the derivatives of novel pyrazole carboxamide and isoxazolol pyrazole carboxylate, Molecules, № 20, с. (dntb.gov.ua)
  • Ouyang, Synthesis and antiviral activities of pyrazole derivatives containing an oxime moiety, J. Agric. (dntb.gov.ua)
  • Burlov, Synthesis, structure, photo- and electroluminescent properties of zinc (II) complexes with aminomethylene derivatives of 1-phenyl-3-methyl-4-formylpyrazol-5-one and 3- and 6-aminoquinolines, Synth. (dntb.gov.ua)
  • it is a synthetic triazole antifungal agent that inhibits fungal cell growth by inhibiting the cytochrome P-450-dependent synthesis of ergosterol, a vital component of fungal cell membranes. (medscape.com)
  • Isavuconazole is a novel triazole antifungal agent with many advantages, including excellent oral bioavailability, linear and predictable pharmacokinetics, and minimal CYP450 interactions. (medscape.com)
  • The present study was designed to synthesize a series of novel triazole analogs of the bioactive apigenin‑7‑methyl ether to evaluate its anticancer activity against three human ovarian cancer cell lines. (spandidos-publications.com)
  • Both molybdenum oxide-triazole compounds displayed superior catalytic performance in comparison with the known hybrid materials [MoO₃(trz) 0.5 ], which have different structures based on organic-inorganic perovskite-like layers. (nih.gov)
  • The resulting functional 1,4-disubstituted 1,2,3-triazole compounds were fully characterized and subsequently tested for their antiproliferative activity against four different cancer cell lines. (uv.es)
  • The phosphonate 1,2,3-triazole derivative was found to exhibit the best antiproliferative activity among the studied compounds against the HT-1080 cell lines. (uv.es)
  • Zhou, Recent researches in triazole compounds as medicinal drugs, Curr. (dntb.gov.ua)
  • A convenient and simple way to synthesize polymerizable ribavirin derivatives is via transesterification between ribavirin and divinyl dicarboxylates in acetone at 50 ºC, catalyzed by lipase immobilized on acrylic resin from Candida antarctica (CAL-B). These ribavirin esters can be consequently homo-polymerized or copolymerized with other bioactivity compounds such as sugar vinyl esters to form prodrugs which are useful in pharmacy. (news-medical.net)
  • The cell cycle study showed that the phosphonate derivative, compound 8, is the most active inhibitor of the cell cycle at the G0/G1 phase, inducing apoptosis independently of Caspase-3 and causing an increase in the mitochondrial membrane potential (ΔΨm) in the HT-1080 cell lines. (uv.es)
  • Scientists used a set of 1,2,3-triazole derivatives and modeled the structure of the putative inhibitor. (sflorg.com)
  • For this purpose, we used a set of derivatives of 1,2,3-triazole, a pharmacophore whose fragments are contained in many drugs, and modeled the structure of the putative TP-10 inhibitor. (sflorg.com)
  • A triazole and benzonitrile derivative that is a selective non-steroidal aromatase inhibitor, similar to ANASTROZOLE. (bvsalud.org)
  • Ribavirin (1-β-D-ribofuranosyl-1,2,4-triazole-3-carboxamide) is a purine analogue and a commonly used antiviral agent against both RNA and DNA viruses. (news-medical.net)
  • Structure modification of ribavirin and the production of derivatives represent promising approaches in the search for new antiviral agents. (news-medical.net)
  • Sever, Thiazolyl-pyrazoline derivatives: In vitro and in silico evaluation as potential acetylcholinesterase and carbonic anhydrase inhibitors, Int. J. Biol. (dntb.gov.ua)
  • 1-β-D-ribofuranosyl-1,2,4-triazole-3-carboxamidine (TCNR) and 5-amino-TCNR act as competitive reversible inhibitors of human lymphoblast purine nucleoside phosphorylase (PNP). (news-medical.net)
  • Cherrak, Performance evaluation of newly synthetized bi-pyrazole derivatives as corrosion inhibitors for mild steel in acid environment, J. Mol. (dntb.gov.ua)
  • Oxiconazole belongs to a group of drugs called imidazole derivative antifungals. (rxwiki.com)
  • Triazole and tetrazole derivatives were also prepared for comparison with the lead imidazole derivative. (cardiff.ac.uk)
  • However, newer potent and less toxic triazoles and echinocandins are now often recommended as first-line drugs for many invasive fungal infections. (msdmanuals.com)
  • In this report, new 1,4-disubstituted 1,2,3-triazoles with the bioisoster triazole moiety were straightforwardly prepared under copper-catalyzed azide-alkyne [3+2] cycloaddition reactions (CuAAC) regime using a variety of both functional organic azides and terminal alkynes. (uv.es)
  • to t riazole pyrimidine derivatives - florasulam, and flumetsulam were established. (weedscience.org)
  • Kharb, Pharmacological significance of triazole scaffold, J. Enzyme Inhib. (dntb.gov.ua)
  • Structurally, loreclezole is a triazole derivative. (wikipedia.org)
  • The drug is a triazole derivative that maker Esai Corporation says is structurally unrelated to currently available antiepileptic drugs. (medscape.com)
  • The 2 main classes of antifungal medications used to treat mucormycosis are the polyenes (amphotericin formulations) and triazoles (isavuconazole and posaconazole). (medscape.com)
  • Antileishmanial activity of 4-phenyl-1-[2-(phthalimido-2-yl)ethyl]-1H-1,2,3-triazole (PT4) derivative on Leishmania amazonensis and Leishmania braziliensis: In silico ADMET, in vitro activity, docking and molecular dynamic simulations. (bvsalud.org)
  • In this study we investigated the in vitro effects of a phthalimide-1,2,3- triazole derivative, the 4-Phenyl-1-[2-(phthalimido-2-yl)ethyl]-1H-1,2,3- triazole (PT4) obtained by click chemistry , on mammalian cells and on L. amazonensis and L. braziliensis, the causative agents of CL in Brazil . (bvsalud.org)
  • The pyrazole-3-carboxamide derivatives (which are formally considered as 4-deaza-analogues of ribavirin) have shown activity against T-cell lymphocytes and influenza viruses in vitro . (news-medical.net)
  • A pronounced ligand influence on catalytic performance was found and the best result (quantitative epoxide yield within 1 h at 70 °C) was obtained with the 1,2,3-triazole oxomolybdenum(VI) hybrid. (nih.gov)
  • Ribavirin was initially synthesized using the acid-catalyzed fusion procedure by heating a mixture of the 1-2-4 triazole with catalytic bis(p-nitrophenyl)phosphate and peracetylated sugar at 165 ºC. (news-medical.net)
  • Sever, An extensive research on aldose reductase inhibitory effects of new 4H-1, 2, 4-triazole derivatives, J. Mol. (dntb.gov.ua)
  • Due to the interaction of the protonated carboxamidine with the glutamine 201 and asparagine 243 residues in PNP active site, the abovementioned derivatives are better substrates for human PNP when compared to ribavirin. (news-medical.net)
  • The cytotoxicity tests carried out with these 1,2,3-triazole derivatives show average IC50 values ranging from 15 to 50 μM by comparison with the standard reference drug, namely doxorubicin. (uv.es)
  • Among the derivatives, 3,5-dimethyl substituted compound 24 exhibited the best neuroprotective effect with weak cytotoxicity. (sophion.com)
  • Cytotoxicity of phosphorylated derivatives of ribavirin against lung cancer cell lines (NCI-69) is high. (news-medical.net)
  • The ligand substitution reactions of hydrophobic vitamin B12 derivatives. (scielo.org.za)
  • The molybdenum(0)-carbonyl-triazole complexes [Mo(CO)₃(L)₃] [L = 1,2,3-triazole (1,2,3-trz) or 1,2,4-triazole (1,2,4-trz)] have been prepared and examined as precursors to molybdenum(VI) oxide catalysts for the epoxidation of cis -cyclooctene. (nih.gov)
  • Reaction of the carbonyl complexes with the oxidant tert -butyl hydroperoxide (TBHP) (either separately or in situ) gives oxomolybdenum(VI) hybrid materials that are proposed to possess one-dimensional polymeric structures in which adjacent oxo-bridged dioxomolybdenum(VI) moieties are further linked by bidentate bridging triazole (trz) ligands. (nih.gov)
  • it is a synthetic allylamine derivative that inhibits squalene epoxidase, a key enzyme in sterol biosynthesis of fungi, resulting in a deficiency in ergosterol that causes fungal cell death. (medscape.com)
  • Molecular docking studies of this phosphonate derivative into the MMP-2 and MMP-9 metalloproteinases receptors demonstrated the relevance of triazole scaffolds and the pendant phosphonate group in establishing -anion, -alkyl and hydrogen bonding type interactions with residual components in the active MMP pocket. (uv.es)
  • The focus of the present work was to develop the 3D-QSAR-based k-nearestneighbour molecular field analysis (kNN-MF) studies on benzylamine derivatives. (ijpsonline.com)
  • Of all the derivatives, a derivative named 3d exhibited significant and dose‑dependent anticancer activity against the SKOV3 ovarian cancer cell line. (spandidos-publications.com)
  • A chromatographic method for determination of 3-amino-5-mercapto-1,2,4-triazole in biological fluids. (cdc.gov)
  • The active substance in Voriconazole Accord, voriconazole, is an antifungal medicine that belongs to the 'triazole' group. (europa.eu)
  • Combinations of imidazole and triazole derivatives, gentamicin and corticosteroids are classified in D07C - Corticosteroids, combinations with antibiotics. (whocc.no)
  • In this work, we designed and synthesized a series of 1,3,5-triaryl substituent triazole derivatives by introducing a phenolic group and phenyl ring to 3,5-diaryl substituents oxadiazole. (sophion.com)
  • The single-crystal X-ray investigation of this complex reveals an oxo-bridged dinuclear structure with oxodiperoxo groups being further linked by a single triazole bridge. (nih.gov)
  • IMPORTANT: El repositori està en manteniment des del dia 28 de Novembre fins al 4 de Desembre, només es pot consultar, però no afegir contingut. (uv.es)
  • In patients with hematologic malignancy, posaconazole is superior to other triazoles as prophylaxis for invasive mold infection. (medscape.com)
  • 1,2,3-triazole skeleton is a privileged building block for the discovery of new promising anticancer agents. (uv.es)
  • In the current study, twenty-five indole-carbohydrazide derivatives linked to different aryl substitutions were rationally designed and synthesized. (researchgate.net)
  • In this article, different s-substituted benzimidazole-thioquinoline derivatives were designed, synthesized, and evaluated for their possible α-glucosidase inhibitory activities. (researchgate.net)
  • Benzylamine derivatives have recently been demonstrated interesting potential as the treatment for chronic obstructive pulmonary disease via interaction with the PDE4 enzymes. (ijpsonline.com)
  • We have synthesized a new quinoline (4,7-dichloroquinoline) derivative which showed significant larvicidal and pupicidal properties against a malarial and a dengue vector and a lethal toxicity ranging from 4.408 µM/mL (first instar larvae) to 7.958 µM/mL (pupal populations) for Anopheles stephensi and 5.016 µM/mL (larva 1) to 10.669 µM/mL (pupae) for Aedes aegypti . (nature.com)