Trials of passive immunization. Medical search. Frequent questions

This review offers summarized information about IgY production and the use of these antibodies for passive immunization, particularly in poultry. (ac.be)
and monoclonal recombinant antibodies are also currently being pursued for prevention of HIV-1 infection in large Phase IIb clinical trials (NTC02716675 and NCT02568215). (frontiersin.org)
3×Tg-AD mice were subjected to Morris water maze and one-trial novel object recognition tasks after immunization with six doses of mouse IgG (control), 43D, 77E9, and combination (50% each) of 43D and 77E9 antibodies. (biomedcentral.com)
The use of passive immunization for protection against viruses is a hot topic in HIV research due to the discovery of broad and extremely potent neutralizing antibodies against HIV. (microbe.tv)
At least three groups started Phase I trials with such antibodies, and others are closely behind. (microbe.tv)
The VRC01 Antibody Mediated Prevention (AMP) efficacy trials conducted between 2016 and 2020 showed for the first time that passively administered broadly neutralizing antibodies (bnAbs) could prevent HIV-1 acquisition against bnAb-sensitive viruses. (bvsalud.org)
HIV-1 viruses isolated from AMP participants who acquired infection during the study in the sub-Saharan African (HVTN 703/HPTN 081) and the Americas/European (HVTN 704/HPTN 085) trials represent a panel of currently circulating strains of HIV-1 and offer a unique opportunity to investigate the sensitivity of the virus to broadly neutralizing antibodies (bnAbs) being considered for clinical development. (bvsalud.org)
Recent studies have suggested that passive or active immunization with anti-amyloid β peptide (Aβ) antibodies may enhance microglial clearance of Aβ deposits from the brain. (biomedcentral.com)
The nirsevimab injection is a form of passive immunization , which means that rather than training the immune system to recognize the virus and produce antibodies, as occurs with a vaccine, it provides the body with ready-made antibodies. (washingtoninformer.com)
He is specifically interested in evaluating passive and active immunization approaches using broadly neutralizing antibodies and novel vaccine candidates. (harvard.edu)
Passive immunotherapy involves regular infusions of in vitro-produced monoclonal antibodies. (parkinsonsdaily.com)
A one-page document describing passive immunization, the transfer of pre-made antibodies, and its potential for HIV prevention. (avac.org)

Since licensure of hepatitis A vaccine during 1995--1996, the hepatitis A childhood immunization strategy has been implemented incrementally, starting with the recommendation of the Advisory Committee on Immunization Practices (ACIP) in 1996 to vaccinate children living in communities with the highest disease rates and continuing in 1999 with ACIP's recommendations for vaccination of children living in states, counties, and communities with consistently elevated hepatitis A rates. (cdc.gov)
These updated recommendations represent the final step in the childhood hepatitis A immunization strategy, routine hepatitis A vaccination of children nationwide. (cdc.gov)
New approved clinical trials are under investigation to test the effectiveness of those different vaccination approaches, although previous data showed modest clinical success with some adverse inflammatory events in immunized elderly patients. (benthamscience.com)
The UK should introduce routine vaccination for respiratory syncytial virus (RSV) to protect babies and older adults, the Joint Committee on Vaccination and Immunisation (JCVI) has recommended. (pulsetoday.co.uk)
There was no preference whether a maternal vaccination or a passive immunisation programme should be chosen to protect babies and both should be considered. (pulsetoday.co.uk)
But a year-round vaccination programme would ensure high uptake and would be less complex and resource intensive to deliver than seasonal immunisation, the JCVI advised. (pulsetoday.co.uk)
Although a high proportion of healthy vaccine recipients in clinical trials respond to hepatitis B (HepB) vaccination, the proportion of responders can be lower among the general population, particularly among persons with chronic medical conditions ( 6 , 7 ). (cdc.gov)
the Advisory Committee on Immunization Practices then recommended qHPV for routine vaccination of girls aged 11 to 12 years. (nih.gov)
At its February 2008 meeting, the Advisory Committee on Immunization Practices (ACIP) decided not to recommend routine vaccination of children aged 2--10 years against meningococcal disease unless the child is at increased risk for the disease. (cdc.gov)
While pregnant people were not allowed to take part in the clinical trials for the COVID-19 vaccines, many healthcare workers who are pregnant or lactating have received the vaccine and have registered for a COVID-19 vaccine registry so that scientists can better understand the impacts of COVID-19 vaccination on pregnancy. (societyofobgynhospitalists.org)
Once a vaccination series is initiated, it usually is completed with the same vaccine product, although no trials have been done to study the effects (beneficial or adverse) of beginning with one and ending with another. (medscape.com)

One potential vaccine developed by Sanofi and AstraZeneca - long acting monoclonal medicine Beyfortus (nirsevimab) for passive immunisation against RSV infection and disease in infants - was licensed by UK regulators in November. (pulsetoday.co.uk)
In summary, JCVI advises that a RSV immunisation programme, that is cost effective, should be developed for both infants and older adults,' it said. (pulsetoday.co.uk)
A total of 60.0% of infants were reported to be exposed to passive smoking at home and 36.4% had detectable levels of urine cotinine (mean 7.1 ng/mL, range 0.27-41 ng/mL). (who.int)

In 1996, the Advisory Committee on Immunization Practices (ACIP) first made recommendations to prevent hepatitis A through immunization, focusing primarily on vaccinating persons in groups shown to be at high risk for infection and children living in communities with high rates of disease ( 2 ). (cdc.gov)
Nevertheless, the so far accumulated clinical evidence from published CCP trials [ 4 - 7 ] does not verify anticipated special hazards such as an Antibody-Dependent Enhancement (ADE) in SARS-CoV2 infection, the safety profile of CCP appears to be comparable to standard plasma transfusion. (hilarispublisher.com)
New immunizations for RSV are making this respiratory infection preventable in ways it never was before. (contemporarypediatrics.com)
After an explicit, evidence-based review of all available data, the Advisory Committee on Immunization Practices (ACIP) has issued recommendations for use of these vaccines, as both have been demonstrated safe and effective in preventing COVID-19 infection, and thereby increasing community immunity against the virus," said Cyndy Krening, MS, RN, President of the Association of Women's Health, Obstetric and Neonatal Nurses. (societyofobgynhospitalists.org)
HIV-1 vaccine efficacy trials in humans, complemented by active and passive immunization studies in non-human primates, have identified several key vaccine-induced immunological responses that may correlate with protection against HIV-1 infection. (researcher-app.com)
Passive immunization with CMV-specific hyperimmune globulin has shown promise in lowering the risk of congenital CMV infection when given to pregnant women with primary disease. (doctorlib.info)

No RSV vaccines are presently available, although some have entered clinical trials. (rtmagazine.com)
New vaccines for other diseases continue to be introduced into the infant immunisation schedule, resulting in an increasingly crowded schedule. (biomedcentral.com)
The OptImms trial will assess whether antibody titres against pertussis and other antigens in childhood can be maintained whilst adjusting the current Expanded Programme on Immunisation (EPI) schedule to provide space for the introduction of new vaccines. (biomedcentral.com)
Following the success of the smallpox eradication programme, the World Health Organisation Expanded Programme on Immunisation (WHO EPI) began in 1974, with the aim that all children in all countries could benefit from life-saving vaccines. (biomedcentral.com)
Vaccines to prevent HBV became available in the United States in 1981 and were recommended by the Advisory Committee on Immunization Practices (ACIP) for HCP in 1982 ( 5 ). (cdc.gov)
Active immunization by vaccines against SARS-CoV-2 spike protein provides good protection from a severe course of COVID-19. (hilarispublisher.com)
Beginning in the 1960s, RSV vaccines have been studied and trialed, with the structure of the virus driving many of these endeavors. (contemporarypediatrics.com)
PassItOn is one of two clinical trials of convalescent plasma funded through Operation Warp Speed, a collaborative initiative across federal agencies to advance development, manufacturing and distribution of COVID-19 vaccines, therapeutics and diagnostics. (vumc.org)
Where the cure is still not known and vaccines are taking long enough to be developed, the news flash that "PASSIVE IMMUNIZATION CAN BE USED FOR TREATMENT" has built hope for the community with a thought that they will be as right as rain soon. (edu.pk)
Most mRNA vaccines currently undergoing preclinical trials and clinical use are injected into the skin, muscle or subcutaneously in a single dose, where they are absorbed by immune or non-immune cells and converted into antigens, which are displayed to T cells And B cells. (medicaltrend.org)
As of the end of 2019, 15 candidate mRNA vaccines for infectious diseases have entered clinical trials. (medicaltrend.org)
In clinical trials, 19 are mRNA vaccines. (medicaltrend.org)
The two candidate vaccines are well tolerated and effective, but only the BNT162b2 vaccine entered the phase II/III trial due to its milder systemic and local adverse reactions. (medicaltrend.org)
with pre-existing medical conditions are going to get this vaccine, and that's why it's important to continue to monitor the safety of vaccines once they're out there being used in the population outside of the controlled clinical trial environment. (cdc.gov)

This report contains CDC guidance that augments the 2011 recommendations of the Advisory Committee on Immunization Practices (ACIP) for evaluating hepatitis B protection among health-care personnel (HCP) and administering post-exposure prophylaxis. (cdc.gov)

Among them, bapineuzumab, a humanized monoclonal antibody targeting Aβ, completed its phase II trial in 234 mild to moderate AD patients. (en-journal.org)
The drug also showed an "overall favorable safety profile," according to an FDA briefing document, and deaths of children who received nirsevimab in clinical trials were not likely to be related to the monoclonal antibody. (washingtoninformer.com)

It has been explored in numerous clinical trials, whether also passive immunization by transfusion of convalescent plasma could positively influence the course of COVID-19. (hilarispublisher.com)
Arguments are presented that convalescent plasma should be further evaluated in clinical trials as proactive, quasi "prophylactic" treatment by giving a sufficient amount of CCP early enough (before massive virus replication). (hilarispublisher.com)
Convalescent plasma constitutes a more than 100 years old strategy of passive immunization [ 1 ]. (hilarispublisher.com)
An excellent review published in July 2020 [ 3 ] under the heading "Now Is the Time for Better Science" explored the rationale for and potential harm from COVID-19 Convalescent Plasma (CCP), and expressed the urgent need for Randomized Controlled Trials (RCT). (hilarispublisher.com)
Passive immunotherapy with convalescent plasma may be the only available agent during the early phases of a pandemic. (regionh.dk)
Convalescent plasma could offer promise, but we must answer this question rigorously in a randomized trial, especially for the sickest patients at increased risk of mortality. (vumc.org)
Convalescent plasma, one form of a treatment called passive immunization, has been used for more than a century to treat a wide variety of infections, including pneumonia, meningitis, measles, influenza and Ebola but without clear evidence of safety and effectiveness. (vumc.org)
Our goal is to rapidly complete a scientifically rigorous, randomized, placebo-controlled trial of anti-SARS-2 convalescent plasma to inform clinical practice," said Self, associate professor and vice chair for Research in the Department of Emergency Medicine. (vumc.org)
This plan is under consideration with medical bodies and researchers are rushing to set up clinical trials to test how effective convalescent plasma is against COVID-19. (edu.pk)
em [4] Open up in another windowpane Convalescent plasma: among the neglected immunologically centered strategies Passive immunization continues to be successfully used to take care of infectious illnesses. (sdfca.org)

Due to the urgent need for this vaccine, large-scale manufacture is being conducted in parallel with the clinical trial and regulatory program, with a view to making regulatory submissions to the US Food and Drug Administration ("FDA") in 2003. (globenewswire.com)
While both of these primate model studies demonstrated protective effects of mucosal IgAs, the RV144 clinical trial identified plasma IgA responses to HIV Env as risk factors for increased HIV acquisition. (biomedcentral.com)
Clinical trial on the efficacy of a new symbiotic formulation, Flortec, in patients with irritable bowel syndrome: a multicenter, randomized study. (keywen.com)
However, in a human clinical trial, several patients developed secondary inflammatory responses in brain that were sufficient to halt the study. (biomedcentral.com)
These approaches include improvements on the ALVAC-HIV/AIDSVAX B/E vaccine regimen used in the RV144 clinical trial in Thailand, adenovirus serotype 26 vectors with gp140 boosting, intravenous infusions of bNAbs, and replicating viral vectors. (researcher-app.com)
Following a toxicology study, MHRA and Ethical approvals, a Phase 1 clinical trial (EN41CT1.1.2. (europa.eu)

Universal immunisation is the cornerstone of preventive medicine for children, The World Health Organisation (WHO) recommends diphtheria-tetanus-pertussis (DTP) vaccine administered at 6, 10 and 14 weeks of age as part of routine immunisation. (biomedcentral.com)
In neighbouring Arab for routine check-ups, immunizations or countries such as the Syrian Arab Republic, other medical care. (who.int)

Most of these studies have shown that both active and passive immunization can drastically reduce amyloid deposition and prevent the decline in cognitive performance. (benthamscience.com)
The purpose of this Notice of Funding Opportunity (NOFO) is to advance synthetic nucleic acid platforms for the rapid development and iterative testing of active and passive immunization strategies for HIV prevention, treatment, and cure. (nih.gov)

Early passive immunization studies in primates were performed with single high-dose, intravenous virus challenges rather than low-dose mucosal virus exposures that more closely resemble sexual HIV-1 transmission among humans. (biomedcentral.com)

In clinical trials of babies entering their first RSV season, nirsevimab reduced the risk of RSV-associated illness requiring medical attention by 70% to 75% during the first five months after the injection. (washingtoninformer.com)
In clinical trials, 12 out of 3,710 children who received nirsevimab and four out of 1,797 in the control groups died of various causes. (washingtoninformer.com)

The Committee has today issued a rapid short statement, advising that a RSV immunisation programme, that is cost effective, should be developed for both infant and older adults. (pulsetoday.co.uk)

This report updates ACIP's 1999 recommendations concerning the prevention of hepatitis A through immunization (CDC. (cdc.gov)
In the third phase of the trial, BNT162B2 showed 95% overall prevention and 90-100% efficacy. (medicaltrend.org)
In a phase III trial involving 30,420 volunteers, the prevention rate of two 100μg doses of vaccine was 94.1%, and local pain at the injection site was the most common side effect. (medicaltrend.org)

Pfizer has also developed a bivalent RSV maternal vaccine which has undergone clinical trials and has a potential licensing timeline in 2023, the committee said. (pulsetoday.co.uk)
Maternal-Pediatric Work Group in the Coronavirus and Other Respiratory Viruses Division in the National Center for Immunization and Respiratory Diseases at CDC. (cdc.gov)

Center for Immunization and Respiratory Diseases at CDC. (cdc.gov)

Domperidone in the management of symptoms of diabetic gastroparesis: efficacy, tolerability, and quality-of-life outcomes in a multicenter controlled trial. (keywen.com)
Double-blinded randomized multicenter placebo-controlled trial of adult patients hospitalized with COVID-19 pneumonia. (regionh.dk)

These results are consistent with well known, differential NSAID actions on immune cell functions, and suggest that concurrent NSAID administration might serve as a useful adjunct to Aβ immunization, permitting unfettered clearance of Aβ while dampening secondary, inflammation-related adverse events. (biomedcentral.com)
Our findings will impact the risk-benefit assessment of BCMA-targeted CAR-T cell therapy for multiple myeloma and have already led to improved monitoring and proactive management of neurologic adverse events across clinical trials of BCMA-targeted therapy, said Oliver Van Oekelen, MD, PhD student at the Icahn School of Medicine at Mount Sinai and the first author of the manuscript. (parkinsonsdaily.com)

Unlike many of the ongoing clinical trials in COVID-19, PassItOn has few exclusion criteria and will include pregnant women and the elderly, patients with chronic heart, liver or kidney disease as well as those who are immunocompromised. (vumc.org)

Nevertheless, as a result of concerns about the validity of initial trials and the high cost associated with treatment, a 1996 revision of the AAP recommendations 19 was released. (rtmagazine.com)

The objective was to develop a vaccine that could be manufactured using modern cell-culture techniques, to conduct clinical trials sufficient to obtain regulatory approval and to create and maintain a stockpile of 40 million doses of the vaccine over 20 years. (globenewswire.com)

and Immunization Schedule, Adults. (medscape.com)
Compared to adults, passive smokers [ 17 ]. (who.int)

With the ban on sub-therapeutic antibiotic usage in Europe and the increasingly strictness of the European legislation on food hygiene, passive immunization by oral administration of pathogen-specific hen egg yolk antibody (IgY) may be a useful and attractive alternative. (ac.be)

Other specific initiatives were conducted such as evaluation of the sublingual route for immunization, investigation of the Principal Immunodominant Domain (PID) of gp41, and direct HIV inhibition with an Ag family which demonstrated in vitro antiviral activities comparable to the antiretroviral drug T20 (Fuzeon). (europa.eu)

The trial was registered at ClinicalTrials.Gov, NCT04345289, 14/04/2020. (regionh.dk)

The OptImms studies are two randomised, five-arm, non-inferiority clinical trials in Nepal and Uganda. (biomedcentral.com)
In 2009 the European Centre for Disease Control reviewed evidence for the optimal timing of DTP immunisation and due to the lack of available data, called for new studies to assess the differing schedules [ 9 ]. (biomedcentral.com)
The averages displayed are based on pooled data from 2 placebo-controlled, outpatient trials providing evidence of efficacy (Studies 1 and 2). (keywen.com)

Our data also suggests that combining bnAbs in passive immunization trials would improve coverage of global viruses. (bvsalud.org)

The randomized, controlled trial will test whether infusions of plasma, the liquid part of blood collected from COVID-19 survivors, can help other hospitalized patients with COVID-19. (vumc.org)

Key limitation is inconsistent quality and completeness of information, and a limitation of spontaneous reporting and passive surveillance, in general, is that we generally cannot determine cause and effect from VAERS data alone. (cdc.gov)

More recently, a passive mucosal immunization study provided the first direct proof that dimeric IgAs (dIgAs) can prevent SHIV acquisition in RMs challenged mucosally. (biomedcentral.com)
The study, called Passive Immunity Trial for Our Nation (PassItOn), was launched thanks to support from the Dolly Parton COVID-19 Research Fund. (vumc.org)

Doody et al (2013) conducted a double-blind, placebocontrolled trial in which 1,537 patients with probable AD underwent randomization to receive 100 mg of semagacestat, 140 mg of semagacestat, or placebo daily. (kipdf.com)
The first randomization led to four subcutaneous priming immunizations with either 15 g or 75 g and 52 weeks of follow-up. (parkinsonsdaily.com)

Mabs capable of targeting the malignancies noted above were produced following immunization of BALBc mice with the Tumor Specific Antigens. (jcancer.org)

In parallel, a questionnaire was submitted to a population of women in Haiti to assess their willingness to participate in a future HIV vaccine trial. (europa.eu)

Passive immunization, which is quick-acting, producing an immune response within hours or days, faster than a vaccine. (edu.pk)

These three trials provided good evidence for the efficacy and safety of gabapentin monotherapy for the treatment of partial-onset seizures. (keywen.com)
The efficacy of VIOXX in the acute treatment of migraine headaches was demonstrated in two double-blind, placebo-controlled, outpatient trials. (keywen.com)
The present paper reviews the potential therapeutic value of such mAbs in the treatment of recurrent malignancies, especially those having failed chemotherapy in established clinical trials. (jcancer.org)

This is called passive immunization and would protect them for several weeks to months. (utexas.edu)
The protection offered by passive immunization is short-lived but it helps protect right away. (edu.pk)

And modelling has also been done by the London School of Hygiene and Tropical Medicine on the impact and cost effectiveness of potential immunisation strategies, the committee said. (pulsetoday.co.uk)

to find out any published outcomes of rigorous medical trials. (sdfca.org)

In phase 1 clinical trials, mRNA-1273 was very effective and well tolerated. (medicaltrend.org)
In close collaboration with other investigators at the Ragon Institute, Dr. Juelg is conducting phase I/II clinical trials that are testing such concepts and translating findings from the lab into the clinic. (harvard.edu)

Passive immunization with human rabies immunoglobulin (HRIG, HyperRab S/D, KedRab, Imogam Rabies-HT) provides immediate protection. (medscape.com)

For COVID-19, FDA will issue VAERS reporting requirements under emergency use authorization, and in addition, CDC encourages reporting of any clinically important adverse event following immunization. (cdc.gov)

Additional analyses were performed for some AEFIs in prelicensure trials, those of unusual severity, or those that had received public attention. (nih.gov)

They're now working to develop a more stable version that could be tested in human clinical trials. (utexas.edu)

This statement represents a synthesis of evidence and experts' consensus on critical care, despite the lack of clinical trials. (springeropen.com)

The National Center for Advancing Translational Sciences is supporting the clinical trials through its Clinical and Translational Science Awards (CTSA) Program and under award number UL1TR002243. (vumc.org)

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