Trials of pain treatment. Medical search. Frequent questions

Riad Sherif MD, CEO of Oculis, said: "Oculis has taken a material step forward in advancing OCS-01's Phase 3 clinical trial and I wish to congratulate everyone involved. (swissbiotech.org)
OCS-01 is also being evaluated in another ongoing Phase 3 clinical trial, the DIAMOND study, as potentially the first topical treatment for diabetic macular edema (DME), if approved. (swissbiotech.org)
The main objective of the intervention(s) being evaluated by the clinical trial. (uclahealth.org)
The purpose of this study was to compare two alternative treatments (nutraceutical and acupuncture) in FMS patients through a randomized clinical trial. (nih.gov)
Phase 2 clinical trial participants should generally not be allowed to treat conditions other than migraine. (clinicalpainadvisor.com)
The results of a clinical trial of a novel drug revealed that it can eliminate head pain and reduce other symptoms of migraine. (medicalnewstoday.com)
As someone who has studied CGRP blockers for more than a decade, I'm gratified to see their benefits confirmed in a large-scale clinical trial. (medicalnewstoday.com)
The UK's first clinical trial of pure cannabis has been approved by regulators in a move that could open the door for the drug being rolled out on the NHS. (telegraph.co.uk)
Methods and analysis Status migrainosus inpatient treatment with eptinezumab is a randomised, controlled, single-centre clinical trial conducted in a parallel design with an active comparator conducted in Melbourne, Australia. (bmj.com)
Here, we present the protocol of a randomized clinical trial for comparing clinical and biomechanical outcomes of dynamic versus static medial patellofemoral ligament reconstruction. (springer.com)
Now, a double-blind, placebo-controlled clinical trial of a gene therapy gel developed at Stanford Medicine shows improved wound healing in 31 people with the disease, including 19 who were 18 years old or younger. (stanford.edu)
Marinkovich, an associate professor of dermatology, is the senior author of a study detailing the clinical trial results that was published Dec. 15 in The New England Journal of Medicine . (stanford.edu)
The clinical trial represents the first human study of a stem cell therapy to be funded by the National Eye Institute (NEI), a part of the National Institutes of Health (NIH). (worldhealth.net)
Having developed and implemented this process, it was very gratifying to see encouraging clinical outcomes in the first cohort of patients enrolled on this clinical trial. (worldhealth.net)
Methods Randomised double-blind, placebo-controlled clinical trial comparing a 12-week programme of using a GTN or placebo patch in combination with eccentric squats on a decline board. (bmj.com)
This equivalence, randomized, clinical trial aimed to compare the postoperative pain of root canal therapy (RCT) with pulpotomy with mineral trioxide aggregate (PMTA) or calcium -enriched mixture (PCEM) in permanent mature teeth . (bvsalud.org)
Methods: Fifty percent of the 681 patients participating in a clinical trial of LBP treatment strategies were randomized to chiropractic care with physical modalities (n = 172) or without physical modalities (n = 169). (cdc.gov)
If your healthcare provider thinks you have mpox, they may ask you to consider taking part in a clinical trial called the Study of Tecovirimat for Human Monkeypox Virus (STOMP) . (cdc.gov)
ABSTRACT To examine whether dietary supplementation with omega-3 fatty acids from Clupeonella grimmi can relieve symptoms of dysmenorrhoea, we carried out a cross-over clinical trial on 36 girls aged 18-22 years. (who.int)
Trial registration: The original RCT was registered with the German Clinical Trial Register (DRKS study ID: DRKS00008745). (lu.se)
A randomized clinical trial. (bvsalud.org)
The protocol of this randomized clinical trial was registered at www. (bvsalud.org)
One way to do this is by joining a clinical trial. (medlineplus.gov)

The late-stage trial results mirror those seen in an earlier, smaller trial in nine patients conducted at the Stanford School of Medicine and published in Nature Medicine in March of 2022. (stanford.edu)
The 2022 American Urological Association guidelines recommend tailoring treatments to the patient's specific symptoms, with the aim of optimizing quality of life. (medscape.com)

Several studies have reported that complementary and alternative therapies can have positive effects against pain in these patients. (ugr.es)
Following successful clinical trials of a gene therapy for Leber hereditary optic neuropathy, Pitceathly and colleagues discuss progress towards genetic therapies for other primary mitochondrial diseases. (nature.com)
Treatments not for migraine: If a trial allows participants to treat conditions other than migraine, the permitted use of concomitant therapies should be pre-specified. (clinicalpainadvisor.com)
These findings point to targeting Piezo2 as a new therapeutic treatment for osteoarthritis-related pain, which could serve as an effective alternative to therapies that include opioids. (rush.edu)
Dr. Walco is interested in collaborating with potential industry partners on designing and conducting pediatric clinical trials, especially for non-opioid pain therapies. (seattlechildrens.org)
This symposium presents a remarkable opportunity to convene with other researchers, clinicians, and industry leaders to discuss the extraordinary progress and immense potential of new drug therapies and technologies in paving the way for a brighter future in cancer treatment. (nyas.org)
His research showed that approximately 60% of IBS patients refractory to medical therapies can relieve abdominal pain and bowel problems (diarrhea and/or constipation) on their own by learning thinking skills with little indication of erosion. (wikipedia.org)
With this in mind, MindMed's has two classes of treatment options: Experiential Therapies and Psychedelic Inspired. (investmentu.com)
These therapies and more cost-effective treatments do not eliminate HPV infection. (cdc.gov)
Continue active treatment and try alternative therapies until erythema, ulceration, and symptoms are controlled. (medscape.com)

o Chronic migraine: participants who meet the diagnostic criteria for chronic migraine or who have a history of chronic migraine within the past 12 months should be excluded from efficacy trials for the acute treatment of migraine. (clinicalpainadvisor.com)
Acute migraine treatment: Researchers should administer investigational treatments only after 48 hours have passed since the participants have last used another acute treatment for migraine. (clinicalpainadvisor.com)
o Stratification: Acute treatment trials generally don't need stratification. (clinicalpainadvisor.com)
o Intention to treat: Randomized controlled trials of acute treatments for migraine should follow the principle of intention to treat (ITT). (clinicalpainadvisor.com)
People who experience acute migraine may soon find relief in a new treatment. (medicalnewstoday.com)
The phase III trial tested the safety and efficacy of rimegepant in adults with acute migraine. (medicalnewstoday.com)
These results confirm that rimegepant's mechanism of action - blocking the CGRP pathway - effectively relieves pain and associated symptoms that occur during acute migraine attacks," Dr. Lipton concludes. (medicalnewstoday.com)
They are waiting for the Food and Drug Administration (FDA) to approve the drug for the treatment of acute migraine. (medicalnewstoday.com)
While extrapolation may be reasonable for many medications used for acute pain, the problem is much more challenging for chronic and recurrent pain. (seattlechildrens.org)
The open-label experience has launched a randomized trial, featuring a sham control group, that could ultimately challenge dogma about volume overload in patients with chronic and acute HF and the perceived essential role of diuretics. (medscape.com)
Pain: Acute & Chronic Pain. (investmentu.com)
Pain has sensory and emotional components and is often classified as acute or chronic. (msdmanuals.com)
Acute pain is frequently associated with anxiety. (msdmanuals.com)

The objective was to investigate the effectiveness of an Ai-Chi aquatic exercise program against pain and other symptoms in MS patients. (ugr.es)
however, at present, it is also studied and used for the treatment of broader symptoms, such as urinary incontinence. (spandidos-publications.com)
Acupuncture was initially described as a successful treatment for certain overactive bladder symptoms in the 1980s ( 4 , 5 ), and, since then, a number of clinical trials on incontinence have been carried out ( 6 - 8 ). (spandidos-publications.com)
o Other primary headache types: participants with other concomitant primary headache types are eligible if attacks are infrequent and can be differentiated from migraine based on pain and symptoms. (clinicalpainadvisor.com)
They also asked them to complete electronic questionnaires about their pain and symptoms before they took the tablet and for the following 48 hours. (medicalnewstoday.com)
The second aim was to evaluate the effect of whole body vibration therapy and classic physiotherapy on postural stability and the influence of depressive symptoms and pain. (galileo-training.com)
The following standard questionnaires were used to investigate pain and depressive symptoms: HADS, ODI, NASS, SF-36. (galileo-training.com)
Depressive symptoms had a significant correlation with pain intensity in back pain participants. (galileo-training.com)
His collaborative research with Emeran Mayer and his team at UCLA has focused on identifying biological mechanisms that drive symptom relief of behaviorally-treated IBS patients with treatment-refractory symptoms. (wikipedia.org)
In rare cases, pain and other symptoms occur in a matching location on the opposite limb. (nih.gov)
The level of initial treatment may also be influenced by clinical judgment, taking into account the severity of presenting symptoms and patient-specific factors. (medscape.com)
DISCUSSION: The results of this meta-analysis suggest that acupuncture is a reasonable adjunctive treatment for producing a short-term analgesic effect in patients with painful TMD symptoms. (ocom.edu)
Treatment The goal of treatment is removal of exophytic warts and the amelioration of signs and symptoms -- not the eradication of HPV. (cdc.gov)
During the trial, you'll fill out a diary to keep track of your symptoms and do daily skin checks at home. (cdc.gov)
Re-examine patients with oral lichen planus (OLP) during active treatment, and monitor lesions for reduction in mucosal erythema and ulceration and alleviation of symptoms. (medscape.com)

Recruits treated with a simple elastic knee sleeve had a statistically significant better comfort score and more had their pain resolved by the end of training than those treated with elastic knee sleeves with a silicone patellar ring. (nih.gov)
Migratens ® treatment shows a statistically significant reduction of pain 1 month after the start of therapy (T1, p = 0.025), strengthened after 3 months with maintenance of treatment (p = 0.012). (nih.gov)
The study demonstrated that patients who received two doses of tanezumab separated by eight weeks experienced a statistically significant improvement in pain, physical function and the patients' overall assessment of their OA, compared to those receiving placebo. (pfizer.com)
Regarding the post revascularization/obturation pain , there was no statistically significant difference between severity of pain in the two groups at all time intervals except after 12 h, revascularization group showed statistically significantly higher prevalence of no pain than endodontic treatment group. (bvsalud.org)

A total of 60 FMS female patients were randomized for treatment with a nutritional combination containing coenzyme Q10, vitamin D, alpha-lipoic acid, magnesium, and tryptophan (Migratens ® Group) or acupuncture treatment (Acupuncture Group) performed according the principles of traditional Chinese medicine (TCM), both for 3 months. (nih.gov)
After exclusions, a total of 63 patients were randomized into one of two treatment groups. (medpagetoday.com)
At the second visit, the patients were randomized either to control group where standard endodontic treatment was completed by lateral condensation technique or assigned to intervention group where PRP revascularization technique . (bvsalud.org)

Other effectiveness and safety endpoints, including leg pain, disability using Oswestry Disability Index (ODI), quality of life using EQ-5D, and SIJ function using active straight leg raise test (ASLR), were assessed up to 12 months. (eurekamag.com)
Objective To determine the effectiveness of commercially available magnetic bracelets for pain control in osteoarthritis of the hip and knee. (bmj.com)
therefore, further RCTs are required to confirm the effectiveness of acupuncture or acupressure in the treatment of urinary incontinence. (spandidos-publications.com)
In addition to the unique ethical and pragmatic challenges facing pediatric clinical trials in chronic pain, lack of appropriate models and methodologies for assessing analgesic effectiveness in children contributes to the paucity of research in this area. (seattlechildrens.org)
It is anticipated that such a database could be useful in designing clinical trials by providing data on incidence, prevalence, population demographics, drugs currently in use, effectiveness in specific populations for specific indications, etc. (seattlechildrens.org)
Second Prize: the effectiveness of physical modalities among patients with low back pain randomized to chiropractic care: findings from the UCLA low back pain study. (cdc.gov)
Perceived treatment effectiveness was greater in the modalities group. (cdc.gov)
State the evidence related to effectiveness and potential risk associated with non-opioid treatment for chronic pain. (cdc.gov)

Standard or conventional medical treatment included modalities such as physical therapy, pharmacologic management, behaviour therapy, spinal injections, and more. (medpagetoday.com)
Lackner and his collaborator Jim Jaccard, from the NYU, identified symptom relief in CBT-treated patients as driven by a well-defined combination of specific and nonspecific factors common to all treatment modalities. (wikipedia.org)
In patients who have shown no response to multiple treatment modalities, reassessment for any underlying patient condition should be undertaken. (medscape.com)
Objective: The purpose of the study was to estimate the net effect of physical modalities on low back pain (LBP) outcomes among chiropractic patients in a managed-care setting. (cdc.gov)
Clinically relevant improvements in average pain and disability were more likely in the modalities group at 2 and 6 weeks, but this apparent advantage disappeared at 6 months. (cdc.gov)
Conclusions: Physical modalities used by chiropractors in this managed-care organization did not appear to be effective in the treatment of patients with LBP, although a small short-term benefit for some patients cannot be ruled out. (cdc.gov)
A multitude of randomized clinical trials and other treatment studies have demonstrated that currently available therapeutic methods are 22%-94% effective in clearing external exophytic genital warts, and that recurrence rates are high (usually at least 25% within 3 months) with all modalities. (cdc.gov)

For some Americans, managing severe osteoarthritis-related pain means taking opioid medications. (rush.edu)
Persons who use drugs are at heightened risk for HIV and often present clinical complexities requiring engagement with multiple services such as preventive HIV care, antiretroviral treatment, medication for opioid use disorder (MOUD), and treatment for other comorbidities, including other infectious diseases and mental illnesses. (nih.gov)
Opioid analgesics administered for pain on the inpatient pediatric setting. (seattlechildrens.org)
CDC's Recommendations for Non-Opioid Treatment in the Management of Chronic Pain. (cdc.gov)
Outline non-pharmacologic and opioid pharmacologic treatment options for various chronic pain conditions. (cdc.gov)
And describe the role of patient beliefs and expectations and value of exercise, education, and non-opioid drug treatments and the management of muscular skeletal pain complaints. (cdc.gov)

Participants were given a full strength bracelet at the end of the trial. (bmj.com)
During Stage 1, participants in each cohort will be randomly assigned to treatment arms. (uclahealth.org)
Participants in the control or experimental arms who experience unacceptable toxicity, disease progression as determined by the investigator according to RECIST v1.1, or loss of clinical benefit as determined by the investigator during Stage 1 will be given the option of receiving a different treatment combination during Stage 2, provided they meet eligibility criteria and a treatment arm is open for enrollment. (uclahealth.org)
Preventative migraine treatment: If exclusionary, participants should withdraw from migraine preventative treatment at least 1 month before treatment. (clinicalpainadvisor.com)
If the protocol allows preventative treatment, participants should be on a stable dose of no more than 1 preventative agent for at least 2 months before the study. (clinicalpainadvisor.com)
Antipsychotics and antidepressants: Participants using antipsychotics regularly during the 3 months before enrollment should be excluded from phase 2 trials, but patients co-medicating with antidepressants can be considered. (clinicalpainadvisor.com)
o Randomization: Participants in parallel-group and crossover trials should be randomized at entry to trial unless the researchers are considering adaptive randomization. (clinicalpainadvisor.com)
The full analysis set may be modified to exclude participants from analysis if no treatment was received or if no data points after treatment were recorded. (clinicalpainadvisor.com)
The trial was a double-blind one, meaning that neither the participants nor the administrators who gave them the drugs knew who took the placebo and who took rimegepant. (medicalnewstoday.com)
The investigators instructed the participants to take a tablet when they experienced a migraine attack, and the pain had become moderate or severe. (medicalnewstoday.com)
Ethics and dissemination This study has been reviewed and approved by the Human Research Ethics Committee of Alfred Health, local reference number 443/21, and all participants will provide informed consent for participation in the trial and dissemination of results. (bmj.com)
STUDY DESIGN: This 2-step prospective randomized parallel trial evaluated postural stability in 65 back pain participants (61.6+/-7.9 y) and 50 nonback pain participants (61.2+/-8.6 y) in a first step using the MFT-S3-Check. (galileo-training.com)
In a second step, postural stability and questionnaires were evaluated in back pain participants before and after therapy with either whole body vibration therapy or classic physiotherapy. (galileo-training.com)
OBJECTIVE: The first aim was to investigate whether the MFT-S3-Check is suitable to evaluate differences in postural stability in back pain and nonback pain participants. (galileo-training.com)
RESULTS: No significant difference in postural stability was found between back pain participants and the nonback pain group. (galileo-training.com)
None of the two training concepts in back pain participants was superior, concerning postural stability and pain. (galileo-training.com)
This treatment made a huge difference in quality of life for Vincenzo and other trial participants. (stanford.edu)
We performed a register-based 3-year follow-up study of participants in the randomized controlled trial REGASSA (n = 940) using healthcare utilization and dispensed medicines as outcomes. (lu.se)
We found no difference between the three groups regarding proportion of participants consulting healthcare due to mental illness or pain during follow-up. (lu.se)

Oculis Holding AG (Nasdaq: OCS) ("Oculis") a global biopharmaceutical company purposefully driven to save sight and improve eye care, today announces the completion of enrollment for its Phase 3 OPTIMIZE trial evaluating the efficacy and safety of once-daily OCS-01, a novel, high concentration, preservative-free, topical OPTIREACH formulation of dexamethasone for the treatment of inflammation and pain following cataract surgery. (swissbiotech.org)

Outcome variables were pain, disability, spasm, depression, fatigue, and autonomy, which were assessed before the intervention and immediately and at 4 and 10weeks after the last treatment session. (ugr.es)
Main outcome measures Change in the Western Ontario and McMaster Universities osteoarthritis lower limb pain scale (WOMAC A) after 12 weeks, with the primary comparison between the standard and dummy groups. (bmj.com)
It will assess the effect of eptinezumab compared with intravenous lignocaine in aborting status migrainosus, with the primary outcome of time from infusion until resolution of pain. (bmj.com)
Patient-reported knee function and anterior knee pain as assessed with the Kujala score will serve as primary outcome. (springer.com)
The work clarified their "true" efficacy profile and operationalized the methodological features for high-quality behavioral IBS trials when the field suffered from a lack of standardization about what defined an outcome study with strong rigor and reproducibility. (wikipedia.org)
Objectives To assess if continuous topical glyceryl trinitrate (GTN) treatment improves outcome in patients with chronic patellar tendinopathy when compared with eccentric training alone. (bmj.com)
Secondary outcome measures were patient satisfaction and pain scores during sports. (bmj.com)
Conclusion It seems that continuous topical GTN treatment in addition to an eccentric exercise programme does not improve clinical outcome compared to placebo patches and an eccentric exercise programme in patients with chronic patellar tendinopathy. (bmj.com)
Background papers were written and tables of evidence constructed summarizing the type of study (e.g., randomized controlled trial, case series), the study population and setting, the treatments or other interventions, outcome measures assessed, reported findings, and weaknesses and biases in study design and analysis. (cdc.gov)
For this outcome both treatment arms had significantly fewer consultations compared to usual care, during year 2-3, the risk ratio (RR) for physical exercise and internet-CBT was 0.64 (95% CI = 0.43-0.95) and 0.61 (95% CI = 0.41-0.90), respectively. (lu.se)

The OPTIMIZE ( O nce-daily P ost ocular surgery T reatment for I nfla M mation and pa I n to minimi ZE drops) trial is a randomized, double-blind, placebo-controlled Phase 3 trial in 25 participating sites across the US, with 240 patients. (swissbiotech.org)
However their study found that pain in the elbow was significantly increased in the injection group as compared with both placebo and naproxen groups at the six months stage. (bmj.com)
Overall, the area under the pain curve (i.e. total pain experienced) was 221 in the injection group, compared with 201 in the naproxen group and 188 in the placebo group. (bmj.com)
Design Randomised, placebo controlled trial with three parallel groups. (bmj.com)
If 2 active treatments are being compared, a placebo control should be included for assay sensitivity. (clinicalpainadvisor.com)
At 49 trial centers across the United States, investigators randomly assigned more than 1,000 women and men with migraine to receive either rimegepant tablets or placebo tablets that looked the same. (medicalnewstoday.com)
The results showed that 19.6% of those who took rimegepant tablets had no pain after 2 hours compared with only 12.0% of those who took placebo tablets. (medicalnewstoday.com)
For the meta-analysis, an adequate description of the results' statistical data was required along with a comparison of the treatment with a control group using a placebo or sham. (ocom.edu)
In placebo-controlled studies, genital warts have cleared spontaneously without treatment in 20%-30% of patients within 3 months. (cdc.gov)
Two randomized trials established systemic interferon alpha to be no more effective than placebo. (cdc.gov)
If you are part of the STOMP trial , you may be part of a group that receives either the medication or a placebo, and you won't know which one. (cdc.gov)
The treatment groups reported a significant difference after 3 months of supplementation with fish oil (visual analogue scale score 20.9 compared with 61.8 for the placebo ( P = 0.001). (who.int)
Patients were given a placebo to be administrated in case of pain . (bvsalud.org)

Our findings will help to inform decisions regarding its use as a treatment option in this patient population.Key words: Sacroiliac joint dysfunction, pelvic girdle pain, randomized controlled trial, quality of life, spine implants. (eurekamag.com)
However, one such complementary therapy, pelvic floor massage, has been shown to have some modest efficacy in a select group of patients in a well-done controlled trial. (medscape.com)
[ 60 , 61 ] The urinary frequency and urgency components seem to respond better to these interventions than the pelvic pain component. (medscape.com)
Pelvic pain from endometriosis can look different in teens and adults. (medlineplus.gov)
A research team asked more than 1,200 adolescents and young adults with and without endometriosis about their pelvic pain. (medlineplus.gov)
People with endometriosis had more frequent and more intense pelvic pain. (medlineplus.gov)
In comparison, those without endometriosis had fewer changes in their pelvic pain. (medlineplus.gov)

It's a database of treatments for brain tumors. (bvsalud.org)

however, there are no validated cross-disease allocation algorithms available for the treatment of chronic pain in validated personalized pain interventions. (iasp-pain.org)
[ 3 ] Although practice guidelines recommend considering spinal manipulation for chronic or persistent low back pain, [ 4 , 5 ] a Cochrane Collaboration review concluded that spinal manipulation is not more effective than sham interventions for short-term relief of chronic low back pain. (medscape.com)

The therapy of chronic musculoskeletal pain (CMSP) is complex and the treatment results are often insufficient despite numerous therapeutic options. (iasp-pain.org)
Eric Donnenfeld, co-chair of Oculis' Scientific Advisory Board, commented: "OCS-01 could bring significant therapeutic benefit as a once-daily treatment for inflammation and pain following ocular surgery. (swissbiotech.org)
This finding suggests that there is a new therapeutic target for managing pain. (rush.edu)

The aim of this study is to assess the efficacy and safety of eptinezumab in the treatment of status migrainosus in comparison to intravenous lidocaine. (bmj.com)

For patients with chronic LBP originating from the SIJ, minimally invasive SIJF with triangular titanium implants was safe and more effective than CM in relieving pain, reducing disability, and improving patient function and quality of life. (eurekamag.com)
Background Rotator cuff disease (RCD) causes prolonged shoulder pain and disability in adults. (bmj.com)
It is estimated that 5 to 10 percent of children experience disability related to chronic pain. (seattlechildrens.org)
The adjusted mean differences between groups in improvements in average and most severe pain and disability were clinically insignificant at all follow-up assessments. (cdc.gov)
Back-specific functioning, general health, work disability specific to low back pain, safety outcomes, and treatment adherence did not differ between patients receiving OMT and sham OMT. (medscape.com)

Treatment of overuse patellofemoral pain. (nih.gov)
The efficacy of treatment of overuse patellofemoral pain with an elastic knee sleeve with a silicone patellar ring was compared with a simple elastic sleeve and with no treatment in a prospective study of 395 army recruits. (nih.gov)
During 14 weeks of basic training, 84 knees were diagnosed as having overuse patellofemoral pain. (nih.gov)

Pfizer Inc.(NYSE:PFE) and Eli Lilly and Company (NYSE:LLY) today announced that a 16-week Phase 3 study in patients with osteoarthritis (OA) pain evaluating subcutaneous administration of tanezumab, an investigational humanized monoclonal antibody, met all three co-primary endpoints. (pfizer.com)
Tanezumab is part of an investigational class of pain medications known as nerve growth factor (NGF) inhibitors and in addition to OA pain, is being evaluated for chronic low back pain (CLBP) and cancer pain (due to bone metastases). (pfizer.com)
If you are prescribed tecovirimat, you will be asked to sign a consent form stating you understand tecovirimat is an investigational drug that has not yet been approved by the FDA for treatment of mpox. (cdc.gov)

So patients tend to seek other forms of pain management and alternative treatments that could be anything from acupuncture to physiotherapy. (telegraph.co.uk)
Reflecting a time-honoured device for ensuring fairness ( Silverman and Chalmers 2002 ), van Helmont ( 1648 ) proposed casting lots to decide which patients should be assigned to orthodox physicians (to be bled and purged), and which to his own, alternative treatments. (jameslindlibrary.org)

Seven databases were searched for any randomized controlled trials (RCTs) that investigated the use of acupuncture or acupressure as a treatment for urinary incontinence, and the Cochrane risk of bias tool was utilized to evaluate the risk of bias in each study. (spandidos-publications.com)
The bottom line: "We found the benefits of massage are about as strong as those reported for other effective treatments: medications, acupuncture, exercise and yoga," Cherkin said. (massagemag.com)
OBJECTIVES: The aim of this study is to perform a qualitative and quantitative analysis of the scientific literature regarding the use of acupuncture in the treatment of pain associated with temporomandibular disorders (TMDs). (ocom.edu)
METHODS: By using electronic databases, the goal was to search and evaluate all the randomized controlled trials (RCTs) in which acupuncture was used in the management of pain attributed to these clinical entities. (ocom.edu)

The treatment is delivered by a lead connected to a matchbox-sized battery-powered generator, with both implanted under the skin near the lower back during a minor surgical procedure. (guysandstthomas.nhs.uk)
By testing the treatment against a sham surgical procedure this study will, for the first time, provide a robust, definitive judgement on whether or not the procedure really works. (guysandstthomas.nhs.uk)
Recent studies have shown that subacromial decompression and non-surgical treatments provide equivalent results in RCD without a full-thickness tendon lesion. (bmj.com)
Of these, 190 shoulders remained symptomatic and were randomised to non-surgical or surgical treatments. (bmj.com)
Results At the 2-year follow-up, both non-surgical and surgical treatments for RCD reduced pain and improved shoulder function. (bmj.com)
Conclusions Non-surgical and surgical treatments for RCD provided equivalent improvements in pain and function. (bmj.com)
Therefore, we recommend non-surgical treatment as the primary choice for patients with RCD. (bmj.com)
Therefore, rotator cuff repair may be suggested after failed non-surgical treatment. (bmj.com)
Sometimes in studies of surgical or catheter-based SAVM, Fudim said, "we have observationally seen that people discontinued diuretics or decreased doses in the treatment arm. (medscape.com)
Surgical versus nonsurgical treatment for back pain. (ox.ac.uk)
Comparison of non-surgical treatment met. (pcori.org)
A randomized trial of surgical excision demonstrated efficacy of 93%, with recurrences among 29% of patients. (cdc.gov)

SEATTLE-Massage therapy helps ease chronic low-back pain and improve function, according to a randomized controlled trial that the Annals of Internal Medicine is scheduled to publish in its July 5 issue. (massagemag.com)

The primary outcomes were the mean changes in the Visual Analogue Scale for pain and the Constant Murley Score for shoulder function at the 2-year follow-up. (bmj.com)
Secondary outcomes included changes in WOMAC B and C scales and a visual analogue scale for pain. (bmj.com)
Our main aim was to evaluate the effect of a 6-week intervention on health-related outcomes (body composition, hemodynamic and functionality changes) in 24 individuals aged 65 and older with multimorbidity in a randomized controlled trial. (nature.com)
This Funding Opportunity Announcement (FOA) encourages Small Business Innovation Research (SBIR) grant applications from small business concerns (SBCs) proposing commercially-directed research for the development of cancer prevention, diagnosis, or treatment technologies to improve cancer outcomes in low- and middle-income countries (LMICs), and low-resource settings in the US. (nih.gov)
Five secondary outcomes, safety, and treatment adherence were also assessed. (medscape.com)
[ 14 ] The OSTEOPAThic Health outcomes In Chronic low back pain (OSTEOPATHIC) Trial aims to fill these voids by studying OMT and UST for shortterm relief of nonspecific chronic low back pain. (medscape.com)

If approved, OCS-01 has the potential to become the first once-daily, topical, preservative-free corticosteroid for treating inflammation and pain following ocular surgery. (swissbiotech.org)
Efficacy measures include the absence of inflammation at Day 15 and absence of pain at Day 4. (swissbiotech.org)
In the completed Phase 2 SKYGGN study, OCS-01 met its primary and secondary endpoints of absence of anterior chamber cells and absence of pain, achieving statistical significance for patients who received once-daily dosing of OCS-01 vs vehicle in the treatment of inflammation and pain following cataract surgery. (swissbiotech.org)
The study, "OCS-01 in Treating Inflammation and Pain in Post-cataract Patients (SKYGGN)" on the National Institutes of Health (NIH) website. (swissbiotech.org)
The results from the SKYGGN Phase 2 trial showed OCS-01, administered once daily or twice daily, was more effective than vehicle with respect to the primary and secondary endpoints and well-tolerated in the treatment of inflammation and pain following cataract surgery. (swissbiotech.org)
According to the study - a collaboration between RUSH and Northwestern - a subset of sensory neurons that promote osteoarthritis-related joint pain and inflammation was discovered. (rush.edu)
Using Piezo2 knock-out mice , investigators found that osteoarthritis-related pain and inflammation were significantly reduced. (rush.edu)
We found that reducing the amount of Piezo2 expressed by nociceptors could reduce pain in mouse models of osteoarthritis and joint inflammation," Malfait and Miller say. (rush.edu)
We saw no inflammation, significant side effects or immune neutralization of the drug, even with repeated administration of the gel over the six months of the trial period," Marinkovich said. (stanford.edu)
Complex regional pain syndrome (CRPS) is a broad term describing excess and prolonged pain and inflammation that follows an injury to an arm or leg. (nih.gov)
Pathophysiology is unclear, but peripheral nociceptor and central sensitization and release of neuropeptides (substance P, calcitonin gene-related peptide) help maintain pain and inflammation. (msdmanuals.com)

Therefore, we hypothesized that targeting Piezo2 may be useful for alleviating osteoarthritis pain. (rush.edu)

The PerPAIN trial: a pilot randomized controlled trial of personalized treatment allocation for chronic musculoskeletal pain-a protocol. (iasp-pain.org)
This trial aims to test the feasibility and safety of a personalized pain psychotherapy allocation with three different treatment modules and estimate initial signals of efficacy and utility of such an approach compared to non-personalized allocation. (iasp-pain.org)
The advent of fair treatment allocation schedules in clinical trials during the 19th and early 20th centuries. (jameslindlibrary.org)
Although the report of the streptomycin trial is rightly iconic, the attention it has attracted has led many historians to overlook earlier evidence relevant to the evolution of unbiased prospective allocation of patients to treatment comparison groups. (jameslindlibrary.org)
In fact, for half a century before the MRC trial and Fisher's writings, some medical practitioners wishing to evaluate the effects of treatments had used alternate allocation to assemble similar groups of patients, and so ensure that like would be compared with like. (jameslindlibrary.org)

Gepants stop head pain by blocking the receptor for calcitonin gene-related peptide (CGRP), a small protein that the body releases during migraine episodes. (medicalnewstoday.com)

The ground-breaking Modulate-LBP study will investigate whether a pioneering treatment known as spinal cord stimulation can treat chronic back pain. (guysandstthomas.nhs.uk)
The study, which is funded by the National Institute for Health Research (NIHR), marks the first time in the world that a non-commercial body has funded a spinal cord stimulation trial which will test the treatment against a 'sham' procedure. (guysandstthomas.nhs.uk)
Dr Adnan Al-Kaisy, consultant in pain medicine and neuromodulation at Guy's and St Thomas' and chief investigator for the study, said: "This unique study has the potential to completely revolutionise how we treat chronic back pain on the NHS. (guysandstthomas.nhs.uk)
Further study of late complications of the injection procedure is needed to find out why it resulted in increased pain in later follow-up. (bmj.com)
The study is designed with the flexibility to open new treatment arms as new treatments become available, close existing treatment arms that demonstrate minimal clinical activity or unacceptable toxicity, or modify the patient population. (uclahealth.org)
Limitations of this study include that it is a single-site study, the allowance of concomitant medications during the trial period and the paucity of high-quality data to guide statistical power analyses. (bmj.com)
The first study to compare structural and relaxation (Swedish) massage, the trial found that both types of massage worked well, with few side effects. (massagemag.com)
Trial registration The study protocol was registered at clinicaltrials.gov (NCT04849130). (springer.com)
The TAPUR Study aims to describe the safety and efficacy of Food and Drug Administration (FDA)-approved, targeted anticancer drugs prescribed for treatment of patients with advanced cancer that has a potentially actionable genomic alteration. (facingourrisk.org)
CONCLUSIONS: The MFT-S3-Check could not find a significant difference in postural stability between the back pain and nonback pain group in the study setting. (galileo-training.com)
This study is testing the use of a statin in young people to see whether early treatment of high blood cholesterol can affect the risk of developing plaque in blood vessels. (nih.gov)
This study tests a treatment called arginine therapy for pain episodes in children with sickle cell disease. (nih.gov)
To participate in this study, you or your child must have sickle cell disease and pain that requires medical attention. (nih.gov)
According to the study published August 18 in Science Advances, the patients who were followed for 12 months experienced restored cornea surfaces -- two were able to undergo a corneal transplant and two reported significant improvements in vision without additional treatment. (worldhealth.net)
While the phase I study was designed to determine preliminary safety and feasibility before advancing to a second phase of the trial, the researchers consider the early findings promising. (worldhealth.net)
Our early results suggest that CALEC might offer hope to patients who had been left with untreatable vision loss and pain associated with major cornea injuries," said principal investigator and lead study author Ula Jurkunas, MD, associate director of the Cornea Service at Mass Eye and Ear and an associate professor of ophthalmology at Harvard Medical School. (worldhealth.net)
We are hopeful with further study, CALEC can one day fill this crucially needed treatment gap. (worldhealth.net)
Mean Visual Analogue Scores pain scores during sports for both groups increased over the study period to 6.6±3 and 7.8±3.1. (bmj.com)
The mean preoperative PIs were similar (P=0.998), the mean sum PIs recorded during 10 postoperative intervals were comparable (P=0.939), and the trend/changes in pain relief were parallel (P=0.821) in all study arms . (bvsalud.org)
Oral tecovirimat for treatment of mpox is primarily available through Study of Tecovirimat for Human Mpox Virus (STOMP) . (cdc.gov)
Within the limitation of this study, PRP revascularization could be an alternative treatment to root canal treatment but further randomized clinical trials with standardized techniques and long follow up periods are recommended for more reliable results. (bvsalud.org)
Methods A randomized, double-blind, sham-controlled, 2 × 2 factorial design was used to study OMT and UST for short-term relief of nonspecific chronic low back pain. (medscape.com)

0.028) and clinically relevant decrease in pain intensity versus baseline, with an immediate posttreatment reduction in median visual analogue scale scores of 50% that was maintained for up to 10weeks. (ugr.es)
Among patients with full-thickness ruptures, the reduction in pain (13, 95% CI 5 to 22, p=0.002) and improvement in function (7.0, 95% CI 1.8 to 12.2, p=0.008) favoured surgery. (bmj.com)
Some studies of permanent static magnets have found significant pain reduction 2 4 - 9 whereas others reported no effect. (bmj.com)
Their progress will be monitored and compared to a control group of 5,000 adults of similar health, age, and sex receiving standard pain care to test whether cannabis causes a significant reduction in pain. (telegraph.co.uk)
The treatment led to a mean 2.4-point decrease in patient-reported pain scores over 6 months using a standard visual analogue scale (VAS) in a randomized, multicenter, cross-over trial -- a clinically meaningful result equating to about a 30% reduction in pain, said the lead investigator, Michael Gofeld, MD , of the University of Toronto. (medpagetoday.com)
At 6 months, only 7% of patients assigned to conventional treatment group had a VAS score reduction of 50% or more, compared to 42% of the group who underwent biacuplasty at the start, as well as 27% of control patients who later underwent the procedure. (medpagetoday.com)

Among the treatment options tried, the simple elastic knee sleeve was no more effective than no treatment at all, but it was more effective than the more elaborate patellar brace. (nih.gov)
Patellar tendinopathy (PT) (jumper's knee) is a clinical condition characterised by activity-related patellar tendon pain, most commonly at the insertion at the inferior pole of the patella. (bmj.com)

New guidelines from the International Headache Society aim to affect the design, conduct, and reporting for clinical trials in migraine. (clinicalpainadvisor.com)
The International Headache Society (IHS) Clinical Trials Standing Committee has released the updated fourth edition of their guidelines for controlled trials of drugs in migraine , which has been published in Cephalagia . (clinicalpainadvisor.com)
These guidelines for the treatment of patients with sexually transmitted diseases (STDs) were developed by staff members of CDC after consultation with a group of invited experts who met in Atlanta on January 19-21, 1993. (cdc.gov)
Beginning in the spring of 1992, CDC personnel systematically reviewed literature on each of the major STDs, focusing on data and reports that have become available since the 1989 STD Treatment Guidelines were published. (cdc.gov)
CRPS type I was previously known as reflex sympathetic dystrophy (see also Complex Regional Pain Syndrome: Treatment Guidelines ), and type II was known as causalgia. (msdmanuals.com)

A new trial which could revolutionise the way chronic back pain is treated on the NHS has been launched by Guy's and St Thomas' NHS Foundation Trust. (guysandstthomas.nhs.uk)
Dr Al-Kaisy added: "Due to our increasingly sedentary lifestyles we are seeing more and more patients with chronic back pain. (guysandstthomas.nhs.uk)
Dean Walker, 42, from Chelmsford in Essex, had spinal cord stimulation therapy six years ago at Guy's and St Thomas' after suffering from chronic back pain for more than six years following a fall at work. (guysandstthomas.nhs.uk)
This is important because chronic back pain is among the most common reasons people see doctors and alternative practitioners, including massage therapists," Dr. Cherkin added. (massagemag.com)

People with migraine experience recurring attacks of head pain. (medicalnewstoday.com)

Two SIJF patients had recurrent pain attributed to possible device loosening and one had postoperative hematoma. (eurekamag.com)
Preoperative " Pain Intensity " (PI) on Numerical Rating Scale and postoperative PIs until day 7 were recorded. (bvsalud.org)
Pulpotomy with MTA /CEM and RCT demonstrate comparable and effective postoperative pain relief. (bvsalud.org)
Evaluation of postoperative pain and healing following regenerative endodontics using platelet-rich plasma versus conventional endodontic treatment in necrotic mature mandibular molars with chronic periapical periodontitis. (bvsalud.org)

Trial pragmatic but not accurate? (bmj.com)
With reference to the above paper, the trial may have been pragmatic but it DID NOT include all modes of treatment for so called "lateral epicondylitis", for instance there was not an inclusion of conservative measures such as physiotherapy and forarm constriction bands. (bmj.com)
Methods In a pragmatic, randomised, controlled trial, 417 patients with subacromial pain underwent 3-month initial rehabilitation and MRI arthrography (MRA) for the diagnosis of RCD. (bmj.com)

Researchers hope to learn whether giving the longer-acting local anesthetic liposomal bupivacaine prior to closing the sternum is more effective in managing pain following sternotomy, than in patients who received standard bupivacaine before sternal closure. (centerwatch.com)
Researchers will measure this based on how much IV pain medication is used, rates on confusion, and time to remove the breathing tube. (centerwatch.com)
Researchers have been looking for pain treatments that are not only more effective but can serve as an alternative to opioids. (rush.edu)
Knowing this, RUSH researchers set off to find if Piezo2 could hold the key to reducing joint pain. (rush.edu)
Researchers are investigating how safe and effective this treatment is, as well as how arginine is metabolized in the body and its effects on cells. (nih.gov)
A team led by researchers from Mass Eye and Ear, a member of Mass General Brigham, reports the results of a phase I trial of a revolutionary stem cell treatment called cultivated autologous limbal epithelial cell transplantation (CALEC), which was found to be safe and well-tolerated over the short term in four patients with significant chemical burns in one eye. (worldhealth.net)

Mean improvements in leg pain and EQ-5D scores were large after SIJF and superior to those after CM. CM patients were allowed to crossover to SIJF after 6 months. (eurekamag.com)
Both treatments showed positive effects, with significant improvements in postural stability in the classic physiotherapy group. (galileo-training.com)
Intention-to-treat analysis was performed to measure moderate and substantial improvements in low back pain at week 12 (30% or greater and 50% or greater pain reductions from baseline, respectively). (medscape.com)
P = .002) improvements in low back pain at week 12. (medscape.com)

The results from the Modulate-LP trial are expected in late 2020. (guysandstthomas.nhs.uk)
Significant progress made with OCS-01 (Oculis' lead clinical candidate) - additional results expected later this year from stage one of the Phase 3 DIAMOND trial in Diabetic Macular Edema (DME). (swissbiotech.org)
Results Mean pain scores were reduced more in the standard magnet group than in the dummy group (mean difference 1.3 points, 95% confidence interval 0.05 to 2.55). (bmj.com)
Considering the complexity of the management of FMS patients, our results suggest a cyclical and sequential, or even concurrent treatment with different approaches, to improve the efficacy and the compliance of patients to long-term treatment. (nih.gov)
It may be considered when an imbalance between the treatment groups or factors may influence the trial's results. (clinicalpainadvisor.com)
Gofeld reported the results here at the annual meeting of the American Academy of Pain Medicine . (medpagetoday.com)
In particular, Gofeld described the use of internally-cooled radiofrequency ablation that utilizes two probes applied to a lumbar disc where abnormal ingrowth of nerves results in chronic low back pain. (medpagetoday.com)
These 4 studies showed positive results such as reducing pain, improving masticatory function, and increasing maximum interincisal opening. (ocom.edu)

They highlight novel approaches to enhance causal inference and discuss ways in which observational data can provide a bridge between preclinical findings and clinical trials. (nature.com)

Trial nurses arranged radiological confirmation of diagnosis if needed, and they collected data in surgery based clinics at 0, 4, and 12 weeks. (bmj.com)
Specifically, the FOA encourages grant applications from SBCs to develop or adapt, apply, and validate existing or emerging technologies into user-friendly products for cancer prevention, diagnosis, or treatment in low-resource settings. (nih.gov)
The technologies may include, but are not limited to tools for vaccine dissemination/delivery, imaging, in vitro diagnosis, or treatment of pre-cancerous (pre-neoplastic) or cancerous lesions that are preventable or treatable within low-resource settings. (nih.gov)
Reducing and eliminating structural barriers to immediate linkage to care is critical to minimizing time between diagnosis and prevention and treatment of both substance use disorder(s) (SUD) and HIV and promoting long-term adherence to achieve viral suppression. (nih.gov)

[ 6 ] High-quality trials of ultrasound therapy (UST) are also needed to assess its efficacy compared with sham procedures. (medscape.com)

Conclusions The OMT regimen met or exceeded the Cochrane Back Review Group criterion for a medium effect size in relieving chronic low back pain. (medscape.com)

Pain Res Manag;2020: 5853412, 2020. (bvsalud.org)

Regimens - Treatment of genital warts should be guided by the preference of the patient. (cdc.gov)
After 3 months, the treatment regimens were swapped. (who.int)

It would be the first topical gene therapy treatment approved for use in the United States. (stanford.edu)
That trial was the first to show that gene therapy vectors for skin diseases can be effective when applied topically and was the first trial of gene therapy in children with epidermolysis bullosa. (stanford.edu)

In the CM group, one crossover surgery patient had recurrent pain requiring a revision surgery. (eurekamag.com)

Around 10 million people in the UK suffer from back pain. (guysandstthomas.nhs.uk)
Spinal cord stimulation is an alternative to major back surgery and works by delivering small electrical currents to the spinal cord, which disrupt pain signals to the brain. (guysandstthomas.nhs.uk)
Dean, a father of three, said: "After I injured my back the pain gradually got worse and the painkillers weren't helping. (guysandstthomas.nhs.uk)
In addition, given its ability to reach the back of the eye, it could also offer further benefit in treating retinal edema, as shown in Oculis' DME Phase 2 trial and previous exploratory trial in CME, a significant complication following ocular surgery. (swissbiotech.org)
Low back pain (LBP) emanating from the sacroiliac joint (SIJ) is a common finding. (eurekamag.com)
We found that massage helps people with back pain to function even after six months," said trial leader Daniel C. Cherkin, Ph.D., a senior investigator at Group Health Research Institute. (massagemag.com)
The trial enrolled 400 Group Health Cooperative patients who had had low-back pain for at least three months. (massagemag.com)
At 10 weeks, more than one in three patients who received either type of massage-but only one in 25 patients who got usual care-said their back pain was much better or gone. (massagemag.com)
So people who have persistent back pain may want to consider massage as an option. (massagemag.com)
Prior studies of massage for back pain had tested only structural forms of massage, not relaxation massage. (massagemag.com)
They were surprised when patients in the relaxation group got so much relief from their back pain. (massagemag.com)
or becoming more aware of your own body, so you're better able to avoid triggers for your back pain. (massagemag.com)
PALM SPRINGS, Calif. -- Biacuplasty combined with conventional treatment reduces pain and leads to improved quality of life and function in patients with discogenic back pain better than conventional treatments alone, a researcher said here. (medpagetoday.com)
Effects of Whole Body Vibration Therapy and Classic Physiotherapy on Postural Stability in People With Back Pain: A Randomized Trial. (galileo-training.com)
After four months, I saw an improvement on a large wound on my back that I had for 20 years," said trial participant Vincenzo Mascoli, 22. (stanford.edu)
Now he can bathe and sleep on his back without pain. (stanford.edu)
Existing treatment strategies have limitations and associated risks the CALEC procedure aims to address through its unique approach of using a small amount of a patient's own stem cells that can then be grown and expanded to create a sheet of cells that serves as a surface for normal tissue to grow back. (worldhealth.net)
Purpose We studied the efficacy of osteopathic manual treatment (OMT) and ultrasound therapy (UST) for chronic low back pain. (medscape.com)
Low back pain is primarily responsible for more than 20 million ambulatory medical care visits [ 1 ] and $100 billion in costs [ 2 ] annually in the United States. (medscape.com)
When low back pain persists for 3 months, it is considered chronic and may cause progressive physical and psychological effects. (medscape.com)
No trial of OMT has conclusively found efficacy in relieving low back pain [ 8-13 ] or achieved a status of low risk of bias. (medscape.com)

In the first group, 29 patients underwent conventional treatment plus IDB. (medpagetoday.com)
In the second group, 34 patients underwent conventional treatment alone, followed in 6 months by IDB if they wished. (medpagetoday.com)

Dr. Walco is currently a special government employee, consulting to the United States Food and Drug Administration's Anesthetic and Analgesic Products Advisory Committee, and is the founder and chair of the Pediatric Research Network for Pain (PRN-Pain), an international collaborative organized to conduct analgesic trials in children. (seattlechildrens.org)
He has also served as a consultant to a number of pharmaceutical firms on analgesic trials for children. (seattlechildrens.org)
An analgesic ( ibuprofen 400mg) was prescribed in case of persistent pain . (bvsalud.org)

Prospective, multicenter randomized controlled trial. (eurekamag.com)
Postendodontic Pain after Pulpotomy or Root Canal Treatment in Mature Teeth with Carious Pulp Exposure: A Multicenter Randomized Controlled Trial. (bvsalud.org)

Treatment of external genital warts is not likely to influence the development of cervical cancer. (cdc.gov)
Several well-designed studies have indicated that treatment is more successful for genital warts that are small and that have been present less than 1 year. (cdc.gov)
Efficacy of interferon injected directly into genital warts (intralesional therapy) during two randomized trials was 44%-61%, with recurrences among none to 67% of patients. (cdc.gov)
Therapy with 5-fluorouracil cream has not been evaluated in controlled studies, frequently causes local irritation, and is not recommended for the treatment of genital warts. (cdc.gov)
or Podofilox 0.5% solution for self-treatment (genital warts only). (cdc.gov)

Patients with greater preoperative pain , symptomatic apical periodontitis , or presence of PDL widening suffered more pain (P=0.002, 0.035, and 0.023, resp. (bvsalud.org)
To evaluate the post-operative pain and the healing of necrotic mature permanent mandibular molar teeth with peri- apical periodontitis after conventional endodontic treatment versus after platelet-rich plasma (PRP) revascularization. (bvsalud.org)

Despite substantial research advances, treatment of neuropathic pain remains inadequate and responses to treatment are highly variable. (nature.com)
The purpose of the Funding Opportunity Announcement (FOA) is to support research that addresses limitations in understanding how to ensure all people who use drugs (PWUD) and are at risk for, or living with HIV have rapid access to high quality substance use disorder (SUD) treatment and HIV care services, including Pre-exposure prophylaxis (PrEP). (nih.gov)
The detailed and exceptionally clear 1948 report of the British Medical Research Council's randomised trial of streptomycin for pulmonary tuberculosis is rightly regarded as a landmark in the history of clinical trials ( MRC 1948 ). (jameslindlibrary.org)
Although the Best Pharmaceuticals for Children Act (BPCA) and the Pediatric Research Equity Act (PREA) were enacted over 15 years ago to encourage the pharmaceutical industry to perform pediatric studies for patented drugs, many companies continue to find it too risky, difficult, and expensive to successfully complete studies targeting chronic pain in children and adolescents. (seattlechildrens.org)
Our Featured Research Page lists cancer prevention, treatment and quality of life studies enrolling people with or at high risk for hereditary cancers. (facingourrisk.org)
Lifespan clinical trials provide valuable research information and cutting-edge treatment for patients in the region. (lifespan.org)
The mission of the American Pain Society is to advance pain-related research. (bvsalud.org)
If you have mpox, your healthcare provider might ask you to consider taking part in this research, known as the STOMP trial . (cdc.gov)
There is no cure for endometriosis, but NIH supports research to find new treatments. (medlineplus.gov)
NIH supported research and development for the first FDA-approved medicine for endometriosis pain. (medlineplus.gov)
Including people from all backgrounds in clinical research helps scientists develop better treatments. (medlineplus.gov)

He is known for his work on low-intensity behavioral self-management approaches for high-impact pain disorders, and has worked to improve the methodological rigor of behavioral trials and developing clinical innovations that have impacted the lives of many underserved people. (wikipedia.org)
Lackner's program focuses on developing and testing novel, low-intensity, and effective treatments for chronic pain disorders, understanding the "active ingredients" that explain why, how, and when they work, identifying patients for whom they are most effective, and their "real-world" value (e.g., economic cost). (wikipedia.org)

In this randomized controlled trial, 73MS patients were randomly assigned to an experimental or control group for a 20-week treatment program. (ugr.es)
They were randomly assigned to one of three treatments: structural massage, relaxation massage or usual care. (massagemag.com)

CM consisted of optimization of medical therapy, individualized physiotherapy, and adequate information and reassurance as part of a multifactorial treatment. (eurekamag.com)

COCA is excited to partner with CDC's National Center for Injury Prevention and Control to offer this call series on CDC's Guideline for Prescribing Opioids for Chronic Pain. (cdc.gov)
Memorial Sloan-Kettering Cancer Center, composed of Memorial Hospital for Cancer and Allied Diseases and the Sloan-Kettering Institute, is dedicated to excellence in the prevention, treatment, and cur. (bvsalud.org)

But about a year ago in a trial suddenly suffered from severe cramp in the right hand/wrist when exiting a section, instant full throttle action! (trialscentral.com)
Mirror pain is less severe and resolves as the injured nerves recover. (nih.gov)
You also might notice severe or prolonged pain after a mildly painful stimulus such as a pin prick, known as hyperalgesia. (nih.gov)
The incidences of preoperative moderate-severe pain in RCT, PMTA, and PCEM arms were 56.5%, 55.7%, and 56.7%, which after 24 hours considerably decreased to 13.1%, 10.6%, and 12.9%, respectively (P=0.578). (bvsalud.org)
Complex regional pain syndrome (CRPS) is chronic neuropathic pain that follows soft-tissue or bone injury (type I) or nerve injury (type II) and lasts longer and is more severe than expected for the original tissue damage. (msdmanuals.com)

Completed enrollment in Phase 3 OPTIMIZE trial brings OCS-01 one step further on the regulatory path to approval. (swissbiotech.org)
o Blinding: Phase 2 and 3 efficacy trials should use a double-blind design. (clinicalpainadvisor.com)
Limited to phase 2 trials, group-sequential, adaptive treatment, and dose-defining designs may be appropriate. (clinicalpainadvisor.com)
After gaining FDA approval for MM-120 to proceed to Phase 2b trials, the company is leading psychedelic medicine to new heights. (investmentu.com)

In this Perspective, the authors argue that rational stratification of patients with neuropathic pain will aid identification of subgroups of patients who will benefit most from a given treatment. (nature.com)
The sympathetic nervous system is more involved in CRPS than in other neuropathic pain syndromes. (msdmanuals.com)

Anatomy5

Organisms1

Diseases49

Chemicals and Drugs17

Analytical, Diagnostic and Therapeutic Techniques and Equipment78

Psychiatry and Psychology14

Phenomena and Processes13

Disciplines and Occupations4

Anthropology, Education, Sociology and Social Phenomena4

Technology, Industry, Agriculture1

Humanities1

Information Science5

Named Groups1

Health Care60

Geographicals2

Clinical Trial23

20222

Therapies10

Acute13

Symptoms15

Statistically significant4

Patients were randomized3

Effectiveness8

Modalities7

Opioid6

Participants19

Evaluating the efficacy1

Outcome10

Placebo13

Pelvic7

Brain tumors1

Interventions2

Therapeutic3

Efficacy and safety1

Disability5

Patellofemoral3

Investigational3

Alternative treatments2

Acupuncture4

Surgical12

Annals of Inter1

Outcomes6

Inflammation11

Osteoarthritis pain1

Allocation5

Calcitonin gene-re1

Study22

Reduction6

Patellar2

Guidelines5

Chronic back pain4

Migraine1

Postoperative4

Pragmatic3

Researchers6

Improvements4

Results8

Findings1

Diagnosis4

Sham1

Conclusions1

20201

Regimens2

Gene therapy2

Recurrent pain1

Back21

Underwent2

Analgesic3

Multicenter2

Genital warts5

Apical periodontitis2

Research11

Intensity2

Randomly assigned2

Physiotherapy1

Prevention2

Severe5

Phase4

Neuropathic2