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  • Albendazole is a benzimidazole anthelmintic used to treat parenchymal neurocysticercosis and other helminth infections. (drugbank.com)
  • DRUGSBUGS has two Phase 2a trials with emodepside, an anthelmintic drug, against Trichuris trichiura and hookworm in adults including pharmacokinetic studies. (swisstph.ch)
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  • Trials in loiasis-endemic countries showed that short courses of albendazole had little effect on L. loa infection ( 6 , 7 ), but longer treatments (200 mg 2×/d for 21 d) resulted in decreased microfilaremia, blood eosinophil levels, and antifilarial antibodies ( 8 ). (cdc.gov)
  • He is particularly interested in the link between HIV infection and other STIs and worked with Richard Hayes on the Mwanza intervention trial, which showed that it was possible to reduce the transmission of HIV by improved case management of other STIs at the primary health care level. (lshtm.ac.uk)
  • The effectiveness of Albendazole can differ based on the seriousness and type of infection. (buy-pharma.md)
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  • After at least 2 years of treatment, weight at ages 3·0-6·0 years (standardised to age 4·0 years, 50% male) was 12·72 kg albendazole versus 12·68 kg control (difference 0·04 kg, 95% CI -0·14 to 0·21, p=0·66). (ox.ac.uk)
  • In a randomized, double-blind, placebo-controlled trial in rural southern Malawi , asymptomatic children , 1 to 3 years old and at high risk for EE, received either a single dose of albendazole , a 14-day course of 20 mg zinc sulfate , or a placebo. (bvsalud.org)
  • Albendazole was administered at a dose of 15 mg/kg/day in 3 cycles of 28 days each. (biomedcentral.com)
  • In a recent prospective evaluation, besides a comprehensive review of literature, we demonstrated that the standard dose (15 mg/kg/body weight) of albendazole given for 4 weeks was safe in patients with disseminated cysticercosis, and those who received albendazole did better in terms of clinical and radiological outcome as compared to patients who received symptomatic treatment alone. (biomedcentral.com)
  • Urinary excretion of albendazole sulfoxide is a minor elimination pathway with less than 1% of the dose recovered in the urine. (drugbank.com)
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  • Subsequent Phase 2b studies will assess whether emodepside is superior to albendazole, another treatment against parasitic worm infections. (swisstph.ch)
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  • The participants were randomly assigned to emodepside, albendazole or placebo treatment groups. (unibas.ch)
  • To further strengthen the regulatory provisions and the monitoring mechanism of clinical trials in the country, the Drugs and Cosmetics Rules, 1945 have been amended, he said. (medindia.net)
  • Treatment with zinc or albendazole protects against a significant increase in the LM ratio, a biomarker for EE, in asymptomatic rural Malawian children . (bvsalud.org)
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  • The drug of choice for the treatment of loiasis is diethylcarbamazine (DEC). Most patients will achieve cure, defined as resolution of symptoms, resolution of eosinophilia, and decreasing antifilarial antibody titers, with one or two courses of DEC. Some will require additional courses of DEC or a trial of albendazole. (cdc.gov)
  • Dr. Walson conducts clinical trials evaluating the treatment and prevention of intestinal worms, malaria and diarrheal disease in delaying HIV progression. (uw.edu)
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  • Listing steps to contain the irregularities, Health Minister Ghulam Nabi Azad told the Rajya Sabha that 12 new drug advisory committees consisting of leading experts from government medical colleges and institutes from across the country have been constituted to advise the Central Drugs Standard Control Organisation (CDSCO) in matters related to approval of clinical trials and new drugs. (medindia.net)
  • Clinical trials are ongoing for cancer therapy with benzimidazole drugs. (cures.news)
  • initial clinical trials indicated that the combination of three drugs was significantly more effective at reducing LF parasite counts than the two-drug regimen, suggesting that IDA could cut years off MDA timelines. (taskforce.org)
  • ABSTRACT We examined the therapeutic effects of albendazole compared to metronidazole in 120 patients with giardiasis in Hamdan. (who.int)
  • Patients were randomized to receive albendazole (400 mg, once daily for 5 days) or metronidazole (250 mg, 3 times a day for 5 days). (who.int)
  • Groups of four neighbouring blocks were cluster-randomly allocated in Oxford between 6-monthly vitamin A (retinol capsule of 200,000 IU retinyl acetate in oil, to be cut and dripped into the child's mouth every 6 months), albendazole (400 mg tablet every 6 months), both, or neither (open control). (ox.ac.uk)
  • Each tablet contains 400 mg albendazole. (who.int)
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  • Zinc or albendazole attenuates the progression of environmental enteropathy: a randomized controlled trial. (bvsalud.org)
  • We tested the hypothesis that zinc and albendazole treatments would reduce the severity of EE in rural African children . (bvsalud.org)
  • Pinworms (Enterobiasis) are a problem in children and adults, but Albendazole is a powerful drug that can eradicate them. (buy-pharma.md)
  • FDA approval is sought for artificial womb clinical trials (mimicking lamb trials) in humans, that can potentially reduce mortality in premature babies. (medindia.net)
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  • Rapidly converted in the liver to the primary metabolite, albendazole sulfoxide, which is further metabolized to albendazole sulfone and other primary oxidative metabolites that have been identified in human urine. (drugbank.com)
  • Caution should be used if [NT005 trade name] is given to patients with liver disease, since albendazole is metabolised by the liver and has been associated with idiosyncratic hepatotoxicity. (who.int)
  • Almost all the data underlying GiveWell's cost-effectiveness estimate comes from a single 1998 randomized trial of deworming in 75 Kenyan schools. (effectivealtruism.org)
  • He hopes that these tests can provide evidence to run a clinical trial for any successful medicine combinations. (littleprincesses.org.uk)
  • Registration of clinical trial in ICMR's registry at www.ctri.in has been made mandatory, he said adding that guidelines for conducting inspection of clinical trial sites and sponsor or clinical research organizations have also been prepared. (medindia.net)
  • Eli Lilly's Mounjaro may prove an alternative to bariatric surgery, stated clinical trial results. (medindia.net)
  • Biliary elimination presumably accounts for a portion of the elimination as evidenced by biliary concentrations of albendazole sulfoxide similar to those achieved in plasma. (drugbank.com)
  • Albendazole is commonly used to address both cases and larger-scale outbreaks of worm infestations. (buy-pharma.md)
  • The recent results of the clinical trials are important and good news in the field of neglected tropical diseases. (unibas.ch)
  • Due to its lipophilic characteristics, this structure enables Albendazole to penetrate the cuticles of parasitic worms effectively. (buy-pharma.md)
  • It is well tolerated and most adverse side effects in the trial were mild," says Mrimi. (unibas.ch)
  • Analyses of albendazole effects are by block (36 vs 36 clusters). (ox.ac.uk)
  • Population deworming every 6 months with albendazole in 1 million pre-school children in North India: DEVTA, a cluster-randomised trial. (ox.ac.uk)
  • Annually, one centre per block was randomly selected and visited by a study team 1-5 months after any trial deworming to sample faeces (for presence of worm eggs, reliably assessed only after mid-study), weigh children, and interview caregivers. (ox.ac.uk)
  • Costa Rica is considered the most endemic angiostrongiliasis en un country, and it has been shown in different reviews that most cases occur in children and males. (bvsalud.org)
  • Three Phase 1 clinical trials are also ongoing for mebendazole and brain tumors (NCT02644291, NCT01729260, NCT0183787862). (cures.news)