• This study is investigating the safety and efficacy of platelet transfusion as a treatment for infants with thrombocytopenia. (nih.gov)
  • In one randomized controlled trial, baloxavir had greater efficacy than oseltamivir in adolescents and adults with influenza B virus infection ( Ison, 2020 ). (cdc.gov)
  • The article titled " Efficacy of Reduced-Intensity Chemotherapy With Oxaliplatin and Capecitabine on Quality of Life and Cancer Control Among Older and Frail Patients With Advanced Gastroesophageal Cancer - The GO2 Phase 3 Randomized Clinical Trial " presents evidence that reduced-intensity chemotherapy provides a better patient experience without significantly compromising cancer control and should be considered for older and/or frail patients. (ed.ac.uk)
  • There is no standard therapy for patients whose cancers progress after initial treatment, with most second-line therapies typically showing little if any efficacy. (cancer.gov)
  • Conclusions Further studies and interventions should explore the efficacy of tobacco treatment interventions in a larger segment of the population, notably in the subpopulations of people with nicotine dependence who smoke fewer than 10 cigarettes per day or who have comorbid depression. (bmj.com)
  • In the fall, a large phase III randomized clinical trial sponsored by the Research Institute of the McGill University Health Centre (RI-MUHC) could start testing the efficacy of a reformulated generic drug in COVID-19 positive outpatients to mitigate severe pulmonary inflammation caused by the SARS-CoV-2 virus and consequently, to reduce hospital admissions. (biospace.com)
  • Repurposing an existing drug for a new indication has the added benefit of allowing researchers to jump straight to phase III of a clinical trial and evaluate the efficacy and safety of the reformulation with minimal investment of time and money. (biospace.com)
  • The Dapsone Coronavirus SARS-CoV-2 Trial (DAP-CORONA) COVID-19 study is a randomized, triple blind, placebo-controlled, parallel, multicentre trial which will evaluate the efficacy and safety of a new version of dapsone developed and patented by Pulmonem , a Canadian biotech start-up. (biospace.com)
  • 2 This rule is still applicable today despite the availability and efficacy of treatments that could substantially improve these ratios. (bmj.com)
  • An international team of researchers investigated the efficacy of group Tai Chi compared with group neck exercises and no treatment to improve neck pain, disability and quality of life in groups of people with nonspecific chronic neck pain. (news-medical.net)
  • Research on social robot interventions in clinical and health settings needs to transition from exploratory investigations to include large-scale controlled trials with sophisticated methodology, to increase confidence in their efficacy. (jmir.org)
  • Since CA125 is not a good marker for those on Doxil initially (if anything, it spikes for 50% of the women even when the treatment is working), I can't use that as a way to get a "peek" at treatment efficacy or lack thereof. (cancer.org)
  • Efficacy was not shown in the clinical trial participants aged 18 years or older. (medscape.com)
  • The efficacy of Haegarda was demonstrated in a multicenter controlled clinical trial. (fda.gov)
  • PhaRmacogEnomiC medIcines optimiSatIon for peOple with caNcer - a multicentre teletrial enabled Interrupted Time Series trial (PRECISION-ITS): A nested cohort substudy evaluating the safety & efficacy of 5-Fluorouracil Therapeutic Drug Monitoring in patients with metastatic/unresectable colorectal cancer. (who.int)
  • Participants in this study must be at least 7 years old, be healthy or have cardiovascular disease, and not be pregnant. (nih.gov)
  • This treatment made a huge difference in quality of life for Vincenzo and other trial participants. (stanford.edu)
  • With older people, for example, it's often difficult to recruit the required number of participants who fit strict eligibility requirements. (nih.gov)
  • In pragmatic trials, though, researchers often relax eligibility requirements and accept participants with these conditions and control for it in their analysis. (nih.gov)
  • Another feature of pragmatic trials is how participants are randomized to treatment and control groups. (nih.gov)
  • In an explanatory trial, participants may be randomized in the order that they are recruited. (nih.gov)
  • In pragmatic trials, participants are often randomized at the group level. (nih.gov)
  • We applied a standard set of eligibility criteria representative of smoking cessation clinical trials to all the 4962 adults with nicotine dependence in the past 12 months, and then to a subgroup of participants motivated to quit (n=4121). (bmj.com)
  • No trials on adolescents, young adults, or other problem areas were identified, and no studies had interventions where robots spontaneously modified verbal responses based on speech by participants. (jmir.org)
  • BPV was lower for participants with low alcohol consumption and treatment with calcium channel blockers. (lu.se)
  • Implementing participants' strategies for overcoming these barriers can enhance delivery of PEARLS to a greater number of older adults and help them improve their depression symptoms. (cdc.gov)
  • To participate in this study, you must be at least 18 years old and have a sleep phase disorder, such as advanced sleep-wake phase syndrome or delayed sleep-wake phase syndrome. (nih.gov)
  • To participate in this study, you must be at least 18 years old and either healthy or diagnosed with coronary heart disease. (nih.gov)
  • Methods Eligibility criteria were drawn from typical criteria of clinical trials for nicotine dependence. (bmj.com)
  • Eligibility requirements were age18 years or older and having chronic neck pain for three consecutives months. (news-medical.net)
  • Among the criteria for selection are that the trial is addressing an important question and is not expected to close in the immediate future (less than 1 year), and that initial staging or laboratory tests required for patient eligibility are widely practiced and available. (cancernetwork.com)
  • 3. Patients receiving a pharmacogenomics drug of interest (Appendix 1) as an investigational medicinal product in another interventional clinical drug trial that prohibits concurrent enrolment (as part of eligibility or PI's discretion), or that represents an unreasonable burden of patient participation at the discretion of the patient or investigator. (who.int)
  • The Established Status Epilepticus Treatment Trial (ESETT) is a multicenter, randomized, double-blind, comparative effectiveness study of fos-phenytoin, levetiracetam, and valproic acid in subjects with benzodiazepine-refractory status epilepticus. (cureepilepsy.org)
  • NESARC interviewed more than 43 000 adults aged 18 years and older. (bmj.com)
  • Our main aim was to evaluate the effect of a 6-week intervention on health-related outcomes (body composition, hemodynamic and functionality changes) in 24 individuals aged 65 and older with multimorbidity in a randomized controlled trial. (nature.com)
  • and level C: 60% of level A doses) using Overall Treatment Utility (OTU) assessment tool to help determine the outcomes. (ed.ac.uk)
  • The primary outcomes included quality o f l ife (36-item Short Form Survey [SF-36]), satisfaction (Charleston Psychiatric Outpatient Satisfaction Scale), treatment credibility, and service delivery perception scores obtained at 4 weeks, 8 weeks, 3 months, and 12 months. (psychiatrist.com)
  • In an early-phase clinical trial, a drug combination that targets tumors with a specific genetic mutation improved outcomes for patients with rare gastrointestinal (GI) cancers that have the mutation. (cancer.gov)
  • Here, we present the protocol of a randomized clinical trial for comparing clinical and biomechanical outcomes of dynamic versus static medial patellofemoral ligament reconstruction. (springer.com)
  • Often, the positive results from explanatory trials have been found to be less effective in practice than they were in the lab, because several factors not present in the controlled setting can affect the eventual outcomes. (nih.gov)
  • However, evidence from randomized controlled trials (RCTs) on health or well-being outcomes has not yet been clearly synthesized across all health domains where social robots have been tested. (jmir.org)
  • All papers reported some positive outcomes from robotic interventions, although most trials had some measures that showed no difference or favored alternate treatments. (jmir.org)
  • Surgical and rehabilitative robotics offer distinct advances in their exceptional ability to augment treatment practices to enhance patient outcomes but are restricted to a highly specific field of medical assistance. (jmir.org)
  • If, as has been argued, the therapeutic relationship is key to positive treatment outcomes [ 10 ], how could a robot perform such a task? (jmir.org)
  • Outcomes of the treatment strategies adopted are described. (bvsalud.org)
  • 1 2 3 4 5 Similarly, the benefit in reducing stroke in trials of treatment is that predicted from observational studies. (bmj.com)
  • To participate in this study, you must be between 18 and 65 years old, regularly sleep for 6.5 or fewer hours, and be able to adjust your sleep schedule for the study. (nih.gov)
  • To participate in this study, you must be at least 21 years old and not have high blood pressure. (nih.gov)
  • To participate in this study, your child must be younger than 6 months old and have a low platelet count (less than 100 × 109/L). This study takes place in Boston, Massachusetts. (nih.gov)
  • To participate in this study, you must be between 18 and 80 years old and have orthostatic intolerance. (nih.gov)
  • The specific objectives of this study were to compare the energy intakes of solid RUTF and F100, as well as water intakes, in children during the recovery phase of treatment of severe malnutrition. (ennonline.net)
  • All non-breastfed children, aged between 12 and 59 months and approaching the end of transition phase of standard treatment (see box 2), were eligible for the study. (ennonline.net)
  • Therefore, the aim of the study was to evaluate the short- and long-term effects of spa therapy on quality of life and pain in patients aged 60 years and older with osteoarthritis. (hindawi.com)
  • To confirm the results of this study, there is a need for a randomized controlled trial comparing spa treatment with usual care in the older population with osteoarthritis. (hindawi.com)
  • Marinkovich, an associate professor of dermatology, is the senior author of a study detailing the clinical trial results that was published Dec. 15 in The New England Journal of Medicine . (stanford.edu)
  • None o f t he SF-36 scores showed a significant difference between the 2 treatment groups by the end o f t he study period, with little significance shown throughout the intermediate time points. (psychiatrist.com)
  • The study treatments, ATH-1017 or a placebo, will be assigned randomly. (rush.edu)
  • Trial registration The study protocol was registered at clinicaltrials.gov (NCT04849130). (springer.com)
  • The study cohort included adults with dementia (excluding patients with chronic psychotic illnesses) living in long-term care and aged 66 years and older. (cmaj.ca)
  • The study results showed that 12 weeks of Tai Chi was more effective than no treatment to improve pain, disability, quality of life and postural control in persons with chronic neck pain,' said Peter M. Wayne, Ph.D., a co-author, founder of the Tree of Life Tai Chi Center and assistant professor of medicine at Harvard Medical School. (news-medical.net)
  • This study may help doctors find out which treatment combination is better at prolonging life in older patients with metastatic pancreatic cancer. (rochester.edu)
  • This article reports on a 2-year follow-up study of girls with serious and chronic delinquency who were enrolled in a randomized clinical trial conducted from 1997 to 2002 that compared multidimensional treatment foster care (MTFC) and group care (N - 81). (ojp.gov)
  • Learn more about clinical research and participating in a study at About Clinical Trials . (clinicalconnection.com)
  • The study included 90 subjects ranging in age from 12 to 72 years old with symptomatic HAE. (fda.gov)
  • The objective of this study was to determine the clinical characteristics, comorbidities, polysomnographic findings, and response to treatment of veterans with OSA. (cdc.gov)
  • Trial registration: The study was registered with ClinicalTrials.gov [NCT03554382]. (lu.se)
  • In this trial researchers want to see how well this works for older people or those who are frail. (cancerresearchuk.org)
  • This trial brought together researchers and clinicians from multiple centres in the UK to assess whether older and/or frail patients with advanced gastroesophageal cancer benefit from less intensive palliative chemotherapy and whether a formal Geriatric Assessment can assist treatment decision-making. (ed.ac.uk)
  • The trial involved researchers from universities, medical institutions, and pharmaceutical companies in eight countries in Europe as well as the United States. (cancer.gov)
  • Well, back in the 1950s, some mouse researchers discovered that if you take blood from a young mouse and give it to an older mouse, it reverses aging and the molecular process. (newsweek.com)
  • Many researchers are familiar with explanatory clinical trials, which look at the effectiveness of a particular intervention to improve health in a controlled setting. (nih.gov)
  • Although researchers develop evidence-based programs for public health practice, rates of adoption and implementation are often low (1), and incorporating knowledge from randomized controlled trials into routine practice takes an average of 17 years (2-4). (cdc.gov)
  • This trial is looking at chemotherapy before surgery for bowel cancer to improve treatment. (cancerresearchuk.org)
  • The main treatment for bowel cancer is surgery. (cancerresearchuk.org)
  • New Trials in Prostate Cancer: Could Your Patient Benefit? (nih.gov)
  • August 24, 2023 - Several new clinical trials in prostate cancer have opened in recent months. (nih.gov)
  • June 1, 2023 - ComboMATCH will comprise numerous phase 2 precision medicine cancer treatment trials that aim to identify promising drug combinations that can advance to larger clinical trials. (nih.gov)
  • January 19, 2023 - When breast cancer metastasizes to the brain, new tumors usually develop even after treatment. (nih.gov)
  • January 11, 2023 - The initial treatment used for some younger women with an aggressive form of breast cancer may be about to change, based on results of a new clinical trial. (nih.gov)
  • There is no standard of care for the treatment of advanced gastroesophageal cancer in the United Kingdom, and practices vary widely as to which regimen is used. (ed.ac.uk)
  • In order to find the best way to treat people with cancer of the stomach or oesophagus who are not well enough for standard chemotherapy a clinical trial, known as GO2 phase III trial, has been designed. (ed.ac.uk)
  • This is the largest randomized controlled trial to date specifically investigating frail and/or elderly patients with advanced gastroesophageal cancer, and the results should guide future treatment. (ed.ac.uk)
  • Cancer patients in Scotland will be among the first to trial a new treatment aimed at those with rare forms of the disease. (yahoo.com)
  • Cancer Research UK is urging those who may be eligible to discuss the treatment with their clinicians. (yahoo.com)
  • Principal investigator Dr Patricia Roxburgh, of the Cancer Research UK Scotland Centre and University of Glasgow, said: "We are very excited in Scotland to be amongst the first in the UK to offer these targeted drugs to patients with rare cancer as part of the Determine clinical trial. (yahoo.com)
  • We are hopeful that, if successful, patients across the UK will be able to access treatments that have been approved for other types of cancer. (yahoo.com)
  • The trial is being run by the University of Manchester and managed by Cancer Research UK's Centre for Drug Development. (yahoo.com)
  • Sarah Mellor, Cancer Research UK's lead on the Determine project, said: "Precision medicine is an exciting focus for cancer research, and we hope this trial - the UK's first national precision medicine trial for rare cancers - will offer hundreds of patients across the UK the opportunity to access new treatments. (yahoo.com)
  • There are few effective treatments for either type of cancer, and long-term survival is poor, particularly for patients with biliary tract cancer. (cancer.gov)
  • The trial findings were presented November 16 at a symposium on molecular targets and cancer therapeutics sponsored by the European Organisation for Research and Treatment of Cancer, NCI, and the American Association for Cancer Research. (cancer.gov)
  • This international phase 2 trial, called ROAR , is not focused on a specific cancer type. (cancer.gov)
  • Patients with advanced or metastatic biliary tract cancer like those enrolled in the trial would normally be expected to survive a few more months. (cancer.gov)
  • He noted that other genetic features found in some cases of biliary tract cancer-mutations in the IDH1 and IDH2 genes and FGFR fusion gene -are also under investigation as potential molecular targets for treatment, with ongoing clinical trials at various stages. (cancer.gov)
  • Dr. Wainberg said the trial attempted to recruit at least 10 patients for each type of rare cancer studied, but the investigators were only able to enroll three with small intestine cancer. (cancer.gov)
  • This phase II trial compares two treatment combinations: gemcitabine hydrochloride and nab-paclitaxel, or fluorouracil, leucovorin calcium, and liposomal irinotecan in older patients with pancreatic cancer that has spread to other places in the body (metastatic). (rochester.edu)
  • In fact, the clinical trial I am on is for the ovarian cancer patients who are deemed platinum resistant. (cancer.org)
  • Earlier in the year, I was on a preventive cancer vaccine trial. (cancer.org)
  • This month's installment of Clinical Trials Referral Resource is devoted to current clinical trials of the Cancer Trials Support Unit, a National Cancer Institute pilot program. (cancernetwork.com)
  • Part 1 of this two-part series will discuss prevention, screening, adjuvant treatment, neoadjuvant chemotherapy, and adjuvant chemotherapy trials for ovarian cancer. (cancernetwork.com)
  • 4. Diagnosis of neuroendocrine cancer (due to differences in treatment pathways and routine follow-up schedules). (who.int)
  • March 15, 2023 - Results are similar to findings seen in previous artificial pancreas trials in older children and adults. (nih.gov)
  • This article describes the main findings of a clinical trial by ACF in Sierra Leone, which compares the use of solid RUTF (BP100) with the standard F100 treatment, during the rehabilitation phase of a TFC. (ennonline.net)
  • Evidence is from endpoints of well-designed RCT (or trials that depart only minimally from randomization) that provide a consistent pattern of findings in the population for which the recommendation is made. (lww.com)
  • Objective To examine the generalisability of findings from clinical trials of individuals with nicotine dependence to a large general population sample. (bmj.com)
  • We assessed potential correlations of clinical data with polysomnography findings and response to treatment. (cdc.gov)
  • Nonpharmacologic interventions are frequently recommended for treatment of hypertension in the elderly, but there is a paucity of evidence from randomized controlled trials in support of this recommendation. (johnshopkins.edu)
  • To determine whether weight loss or reduced sodium intake is effective in the treatment of older parsons with hypertension. (johnshopkins.edu)
  • Reduced sodium intake and weight loss constitute a feasible, effective, and safe nonpharmacologic therapy of hypertension in older persons. (johnshopkins.edu)
  • Hypertension was defined as systolic blood pressure !160 mm Hg or diastolic blood pressure !95 mm Hg, or both, on at least two occasions within any three month period or any history of treatment with antihypertensive drugs. (bmj.com)
  • Hypertension was more prevalent in women, in Arabs than non-Arabs and in older age groups. (who.int)
  • This is a phase 3 trial . (cancerresearchuk.org)
  • But recurrence was low among women who received low-dose temozolomide with T-DM1 in a phase I clinical trial. (nih.gov)
  • The standard treatment started with a stabilisation phase, comprising of dietary treatment with F75 milk (80 kcal/kg/day in 8 feeds), plus systematic antibiotics, and treatment of acute conditions (i.e. hypoglycaemia, hypothermia, dehydration) until recovery of appetite. (ennonline.net)
  • By using data from a 2015 clinical trial on Ebola convalescent-phase plasma in Guinea, we assessed the prevalence of electrolyte and metabolic abnormalities at admission and their predictive value to stratify patients into risk groups. (cdc.gov)
  • The manufacturer has now supplied data from the larger and more recent Phase III EXIST-1 trial that included 117 pediatric and adult patients randomly assigned to take everolimus or a placebo daily. (medscape.com)
  • August 14, 2023 - Early NIH-funded trial is first step towards development of a potential stroke treatment. (nih.gov)
  • July 27, 2023 - Trial results show that engineered T cells can effectively target mesothelin, a protein found on many solid tumors. (nih.gov)
  • May 25, 2023 - NIH-funded research effort identifies most common symptoms, potential subgroups, and initial symptom-based scoring system - with aim of improving future diagnostics and treatment. (nih.gov)
  • May 15, 2023 - NIH-funded clinical trial will determine safety, tolerability of experimental drug. (nih.gov)
  • April 11, 2023 - For older adults whose depression persisted while taking an antidepressant, adding aripiprazole had greater benefits than switching to another antidepressant. (nih.gov)
  • February 15, 2023 - Trial protocol may be adapted to evaluate additional therapeutics. (nih.gov)
  • Kaitlin Armstrong enters the courtroom during the first day of her trial at the Blackwell-Thurman Criminal Justice Center, Wednesday, Nov. 1, 2023, in Austin, Texas. (pahomepage.com)
  • December 28, 2022 - A clinical trial led by NCI has resulted in FDA approval of the immunotherapy drug atezolizumab (Tecentriq) to treat advanced alveolar soft part sarcoma. (nih.gov)
  • AUSTIN, Texas (AP) - The murder trial of a Texas woman charged in the May 2022 shooting death of rising professional cyclist Anna "Mo" Wilson has ended with a guilty verdict. (pahomepage.com)
  • The late-stage trial results mirror those seen in an earlier, smaller trial in nine patients conducted at the Stanford School of Medicine and published in Nature Medicine in March of 2022. (stanford.edu)
  • Part 2, to be published in next month's issue of ONCOLOGY , will detail diagnosis and treatment trials for recurrent disease. (cancernetwork.com)
  • Our objective was to describe the comparative risk of falls and fractures among older adults with dementia dispensed trazodone or atypical antipsychotics. (cmaj.ca)
  • TRAIN-AD - a cluster randomized controlled trial to evaluate a multicomponent intervention to improve infection management for suspected urinary and lower respiratory tract infections among advanced dementia residents in 24 Boston area nursing homes. (nih.gov)
  • The three major mental health problems affecting older people are dementia, delirium, and depression. (bmj.com)
  • 3 The national service framework for older people targets stroke, falls, dementia, and depression, but only the first three seem to attract new funding or services commissioned by primary care trusts. (bmj.com)
  • 7 Older people may be distrustful of tablets, not take them, and in recent research have expressed a preference for psychological interventions. (bmj.com)
  • The parents' hope that their terminally-ill child can be saved through experimental treatment has led to a series of court cases, along with interventions from Donald Trump and the Pope. (independent.co.uk)
  • Clinicians may also wish to consult the IDSA antiviral treatment and antiviral chemoprophylaxis recommendations , and the ATS-IDSA Adult CAP Guidelines . (cdc.gov)
  • She's not the only celebrity to undergo treatments. (yahoo.com)
  • These cancers are more frequent in older people who are often too frail to undergo full course of chemotherapy. (ed.ac.uk)
  • This case will be precedent-setting because Ortis will be the first Canadian to undergo a trial for charges under the Security of Information Act. (ctvnews.ca)
  • Treatment protocols for acute myeloid leukemia (AML) are provided below, including a general treatment approach and treatment recommendations for relapsed or refractory disease. (medscape.com)
  • More than a millennium ago, some clinicians appreciated that comparisons are needed to arrive at causal inferences about the effects of medical treatments. (jameslindlibrary.org)
  • In recent years, we have seen exciting developments in the application of robotics to medical treatments. (jmir.org)
  • With the need to prevent complications leading to hospital admissions and the absence of proven effective treatments for COVID-19 outpatients, showing that dapsone has a net clinical benefit should be a public health priority. (biospace.com)
  • The frequency of cardiovascular events during follow-up was similar in each of the 6 treatment groups. (johnshopkins.edu)
  • Prospective, randomised, unblinded trial of either 2 mg naloxone injected intramuscularly or 2 mg naloxone delivered intranasally with a mucosal atomiser. (mja.com.au)
  • Although the report of the streptomycin trial is rightly iconic, the attention it has attracted has led many historians to overlook earlier evidence relevant to the evolution of unbiased prospective allocation of patients to treatment comparison groups. (jameslindlibrary.org)
  • Shed MEDS - a randomized controlled trial to evaluate the effects of an intervention to reduce medication use among hospitalized older adults discharged to skilled nursing facilities. (nih.gov)
  • In fact, for half a century before the MRC trial and Fisher's writings, some medical practitioners wishing to evaluate the effects of treatments had used alternate allocation to assemble similar groups of patients, and so ensure that like would be compared with like. (jameslindlibrary.org)
  • Jesse Karmazin, a 32-year-old physician and graduate of Stanford University's medical school, says yes. (newsweek.com)
  • In addition to testing a particular intervention, pragmatic trials can also illustrate the differences in how the intervention works in different health care settings, such as hospitals, clinics, or physician practices. (nih.gov)
  • Less-fit patients (70-75 years and older, or younger patients with significant comorbidities) receive low-intensity therapy. (medscape.com)
  • 4] In addition, older patients appear to receive less aggressive treatment than younger patients. (cancernetwork.com)
  • Trials for adults are set to be held in Edinburgh and children will be treated in Glasgow as part of the UK's first national precision medicine trial for rare cancers. (yahoo.com)
  • Precision medicine matches treatment to a specific patient and is a growing area. (yahoo.com)
  • Clinicians can consider early empiric antiviral treatment of non-higher-risk outpatients with suspected influenza based upon clinical judgment if treatment can be initiated within 48 hours of illness onset. (cdc.gov)
  • However, clinicians should not wait for the results of influenza testing ( Table 3 ), SARS-CoV-2 testing, or multiplex molecular assays that detect influenza A and B viruses and SARS-CoV-2 ( Table 4 ) to initiate empiric antiviral treatment for influenza in the above priority groups. (cdc.gov)
  • Pragmatic trials may test the same intervention as an explanatory trial, but they are conducted in real-world clinical practice settings, with typical patients and by qualified clinicians, who may not, however, have a research background. (nih.gov)
  • We hope it will also enhance accrual to clinical trials by informing practicing oncologists of ongoing protocols. (cancernetwork.com)
  • Out of 408 extracted records, 27 trials met the inclusion criteria: 6 in child health or well-being, 9 in children with autism spectrum disorder, and 12 with older adults. (jmir.org)
  • A total of 875 men and women aged 60 to 80 years with systolic blood pressure lower than 145 mm Hg and diastolic blood pressure lower than 85 mm Hg while receiving treatment with a single antihypertensive medication. (johnshopkins.edu)
  • Now, a double-blind, placebo-controlled clinical trial of a gene therapy gel developed at Stanford Medicine shows improved wound healing in 31 people with the disease, including 19 who were 18 years old or younger. (stanford.edu)
  • Decisions about starting antiviral treatment for patients with suspected influenza should not wait for laboratory confirmation of influenza virus infection. (cdc.gov)
  • Empiric antiviral treatment should be started as soon as possible in the above priority groups. (cdc.gov)
  • For hospitalized patients with suspected or confirmed influenza, initiation of antiviral treatment with oral or enterically administered oseltamivir is recommended as soon as possible. (cdc.gov)
  • For outpatients with complications or progressive disease and suspected or confirmed influenza (e.g., pneumonia, or exacerbation of underlying chronic medical conditions), initiation of antiviral treatment with oral oseltamivir is recommended as soon as possible. (cdc.gov)
  • For hospitalized patients with suspected influenza who are started on empiric antiviral treatment with oseltamivir, use of influenza molecular assays ( Table 3 ) or multiplex assays that detect both influenza viruses and SARS-CoV-2 ( Table 4 ) can inform clinical management. (cdc.gov)
  • Patients at higher risk for influenza complications should be advised to call their provider as soon as possible if they have acute respiratory illness symptoms (with or without fever) for consideration of infection with influenza A or B viruses (and early antiviral treatment), SARS-CoV-2, and other respiratory pathogens. (cdc.gov)
  • For outpatients with suspected or confirmed uncomplicated influenza, oral oseltamivir, inhaled zanamivir, intravenous peramivir, or oral baloxavir may be used for treatment, depending upon approved age groups and contraindications. (cdc.gov)
  • The approval of Haegarda provides a new treatment option for adolescents and adults with Hereditary Angioedema," said Peter Marks, M.D., Ph.D., director of FDA's Center for Biologics Evaluation and Research. (fda.gov)
  • If you aren't sure, please ask your treating clinician whether you may be eligible to take part in this trial. (yahoo.com)
  • The advent of fair treatment allocation schedules in clinical trials during the 19th and early 20th centuries. (jameslindlibrary.org)
  • Recommendations of rPA in adults aged 65 years and older state a minimum of 150 min of moderate-intensity aerobic physical activity throughout the week, at least 75 min of vigorous-intensity aerobic physical activity throughout the week, or an equivalent combination of moderate- and vigorous-intensity activity 10 . (nature.com)
  • To analyze the impact o f t elepsychology and same-room care on functioning, satisfaction, and perception of care based on a noninferiority trial of psychotherapy delivered via telemedicine or same-room care to elderly patients with depression. (psychiatrist.com)
  • 241 elderly patients with depression (meeting DSM-IV diagnostic criteria) were randomly assigned to either telemedicine (n = 120) or same-room treatment (n = 121) between April 1, 2007, and July 31, 2011. (psychiatrist.com)
  • In treatment-resistant depression, repetitive transcranial magnetic stimulation had higher. (psychiatrist.com)
  • To determine the effectiveness of intranasal (IN) naloxone compared with intramuscular (IM) naloxone for treatment of respiratory depression due to suspected opiate overdose in the prehospital setting. (mja.com.au)
  • Two thirds of older people with serious depression do not have symptoms that fit current classifications of mood disorders, 1 which have been generated to reflect symptoms in younger people. (bmj.com)
  • The Program to Encourage Active, Rewarding Lives for Seniors (PEARLS) is a home-based, care management program to detect and manage depression among community-based older adults (www.pearlsprogram.org). (cdc.gov)
  • Two randomized controlled trials (8-10) demonstrated that PEARLS resulted in significantly lower severity and greater remission of late-life depression. (cdc.gov)
  • The central modality of spa treatment is balneotherapy, which is defined as the use of baths containing thermal mineral waters from natural springs at a temperature of at least 20°C and with a mineral content of at least 1 g/l. (hindawi.com)
  • Results provide evidence that quality o f l ife and satisfaction with care are not adversely influenced by the decision to use a telehealth modality instead of in-person treatment, and, as a result, resources can be devoted to offering services in patients' homes through telemedicine. (psychiatrist.com)
  • Be 55-85 years old. (rush.edu)
  • The victim, who is now 65 years old and living in Connecticut, has claimed the emotional effects from the abuse have had a long-term impact on her. (metro.co.uk)
  • Dapsone is a decades-old safe and affordable oral antibacterial that has well-recognized anti-inflammatory and immuno-modulatory properties used against malaria, lupus, HIV and many other inflammatory infections. (biospace.com)
  • When they have the results, they'll let you know if you are suitable for this trial or not. (cancerresearchuk.org)
  • Some of the results from the trial have been recently published in the journal JAMA Oncology. (ed.ac.uk)
  • Using multiple health systems as the trial setting increases the likelihood that the results of the research can be widely applied. (nih.gov)
  • Tai Chi, a low-impact mind-body exercise, can be as effective as neck exercises in relieving persistent neck pain, according to results of randomized controlled trial reported in The Journal of Pain, the peer-reviewed publication of the American Pain Society, www.americanpainsociety.org . (news-medical.net)
  • Treatment results of five Cooperative Weichteilsarkom Studiengruppe (CWS) trials and one registry. (bvsalud.org)
  • At trial commencement this will be based on peripheral blood sample results, with the aim for within trial validation and conversion to finger prick blood sampling. (who.int)
  • Clinical Trials Referral Resource is designed to serve as a ready reference for oncologists to help identify clinical trials that might be suitable for their patients. (cancernetwork.com)
  • Clinical trials are medical research studies designed to test the safety and/or effectiveness of new investigational drugs, devices, or treatments in humans. (clinicalconnection.com)
  • Content will not include any discussion of the unlabeled use of a product or a product under investigational use, with the exception of Dr. Louise Francois Watkins's discussion of treatment options for shigellosis, some of which are considered off-label use for infectious diarrhea. (cdc.gov)
  • Each network has successfully undertaken a Status Epilepticus treatment trial under exception from informed consent (EFIC) rules. (cureepilepsy.org)
  • Each network has successfully undertaken a SE treatment trial under EFIC rules. (cureepilepsy.org)
  • 3. Diagnostic work-up and treatment planned to be undertaken at participating trial site. (who.int)
  • Accordingly, patient-oriented treatments reduce pain and improve functions and functional capacity of patients. (hindawi.com)
  • Similarly, over all time points, there was no statistically significant difference in patient satisfaction or treatment credibility. (psychiatrist.com)
  • Memorial Sloan Kettering had the last remaining full treatment dosage left for a clinical trial patient, and I signed on it the moment it was offered to me: if not anything else, just to get Doxil, but I think the other experimental drug that comes with it is actually working - more later on this). (cancer.org)
  • If the patient has systemic symptoms, the treatment of choice is self-injectable epinephrine administered by intramuscular injection in the lateral thigh. (medscape.com)
  • For patient entry information, see the individual trials. (cancernetwork.com)
  • The aim of this article was to report the case of an 8-year old patient with Cri-du-Chat syndrome (CdCS) referred to the pediatric dental clinic for urgent dental treatment. (bvsalud.org)
  • The patient was extremely cooperative during clinical evaluation, demonstrating ability to withstand conservative treatment options. (bvsalud.org)
  • When faced with a CdCS patient, dentists should try to provide the best treatment possible and prioritize the use of conservative techniques. (bvsalud.org)
  • 5. Patient is receiving HIPEC (due to differences in treatment pathways and routine follow-up schedules). (who.int)
  • It is the decision of the clinician to implement/not implement dose changes after considering both exposure levels and other clinical factors such as observed toxicities and treatment intent/patient goals of care. (who.int)
  • The treatment regimen for patients with ALL is determined primarily by the Philadelphia chromosome status of the leukemia and the age of the patient. (medscape.com)
  • healthy older adults and those with disabilities and chronic diseases often have less access to safe, accessible, affordable, and appropriate spaces and places in which they can be physically active 9 . (nature.com)
  • They hypothesized that 12 weeks of Tai Chi would prove superior to no treatment for chronic neck pain. (news-medical.net)
  • up-dosing and maintenance may be continued in patients aged 4 years or older. (medscape.com)
  • The new formulation is recommended for patients aged 1 year or older with tuberous sclerosis complex who are diagnosed with inoperable SEGA. (medscape.com)
  • However, there is little evidence on adequate doses of exercise in older people, especially in those with multimorbidity. (nature.com)
  • The limitation of the aforementioned WHO recommendation lies in its underlying scientific evidence, which is mainly based on studies with healthy older adults and may not be applicable in older people who are habitually characterized by low physical fitness and/or NCDs 11 , 12 . (nature.com)
  • The writing group used the rating system of the National Heart Lung and Blood Institute ( Table 1 ) and a consensus approach to synthesize the available evidence from clinical trials and case reports, narrative and systematic reviews, and meta-analyses ( 3 ). (lww.com)
  • Stanford neuroscientist Tony Wyss-Coray told Science Magazine that the trial is "abusing people's trust" and said there's "no clinical evidence" to support the benefits. (newsweek.com)
  • Important new evidence shows that this approach is very effective in older depressed patients. (bmj.com)
  • Pragmatic trials are becoming increasingly popular because they're well suited for studies of how to get health services out into wider practice. (nih.gov)
  • Objectives: The primary objective is to determine the most effective and/or the least effective treatment of benzodiazepine-refractory SE among patients older than 2 years. (cureepilepsy.org)
  • Clinical and radiographic evaluations were necessary to diagnose and determine treatment strategies for the traumatic injuries, carious lesions, and gingivitis, which were implemented over a total of five dental visits. (bvsalud.org)
  • You are older and or frail or have other health conditions. (cancerresearchuk.org)
  • The GO2 trial is the largest randomised controlled trial to date investigating frail and/or elderly. (ed.ac.uk)
  • Few studies evaluated the effects of spa therapy on pain perception and quality of life in older people with osteoarthritis. (hindawi.com)
  • Spa treatment reduced the level of pain in majority of the patients in short- and long-term follow-up and contributed to improving the quality of life in the domain of social relations and environment. (hindawi.com)
  • Medications are approved for use in the NHS to treat specific cancers in specific circumstances, but the success of the trial could lead to them being approved for rarer cancers. (yahoo.com)