Treponema pallidum include yaws. Medical search. Frequent questions

Several monkey species in sub-Saharan Africa are infected with Treponema pallidum subspecies pertenue (TPE) and typically manifest yaws-like lesions on the face and distal extremities or syphilis-like lesions in the anogenital region ( 1 ). (cdc.gov)
Yaws is a tropical infection of the skin, bones, and joints caused by the spirochete bacterium Treponema pallidum pertenue. (wikipedia.org)
These include yaws (caused by subspecies pertenue), bejel (subspecies endemicum) and pinta (caused by subspecies carateum) which all affect the skin or bones. (ada.com)
In humans, the pathogenic treponemes include T pallidum pallidum (syphilis), Treponema pallidum pertenue ( yaws ), Treponema pallidum endemicum (bejel or endemic syphilis), and Treponema carateum (pinta). (medscape.com)
Yaws ( T pallidum pertenue ) occurs mainly in equatorial regions and can be found in South America, Central America, the Caribbean, Africa, and Southeast Asia. (medscape.com)
Yaws caused by Treponema pertenue. (mlivehosted.com)
Yaws is an infectious tropical disease caused by the spirochete (spiral shaped) bacterium known as Treponema pertenue. (rarediseases.org)
[2] [4] Other human diseases caused by related Treponema pallidum subspecies include yaws (subspecies pertenue ), pinta (subspecies carateum ), and bejel (subspecies endemicum ). (ipfs.io)
Some of these diseases, including Buruli ulcer, caused by Mycobacterium ulcerans , and yaws, caused by Treponema pallidum subspecies pertenue , occur only in tropical and subtropical climates. (cdc.gov)
Other clinically relevant species include T. pallidum pertenue, T. pallidum endemicum, and T. carateum. (lecturio.com)
Yaws is an infectious disease caused by Treponema pallidum subspecies pertenue, a gram-negative bacterium closely related to T pallidum subsp pallidum, which causes syphilis. (umn.edu)
In addition to Treponema pallidum , which causes syphilis, other treponemal subspecies (e.g., pertenue, which causes yaws, and carateum, which causes pinta) also can produce reactive results to treponemal tests, but these subspecies are rare in the United States. (cdc.gov)

Other related treponemal diseases are bejel (T. pallidum endemicum), pinta (T. carateum), and syphilis (T. p. pallidum). (wikipedia.org)
Pinta is a rare infectious tropical disease affecting the skin that is caused by the bacterium Treponema carateum, which is transmitted by direct, nonsexual contact. (rarediseases.org)
Pinta is classified as a treponematosis, which is an infectious disease caused by a treponema. (rarediseases.org)
Treponemas caused several infectious diseases including pinta, yaws, and syphilis. (rarediseases.org)
Pinta is an infectious tropical disease caused by the spiral-shaped bacterium (spirochete) known as Treponema carateum. (rarediseases.org)
Although individuals of any age can acquire treponematosis, endemic syphilis and yaws are more common in children younger than 10 years, whereas pinta is more common in young adults. (medscape.com)
Other illnesses, such as yaws and pinta (two other kinds of skin diseases), may also result in positive FTA-ABS results. (medlineplus.gov)
The Serodia TP-PA test is a treponemal test for the serologic detection of antibodies to the various species and subspecies of pathogenic Treponema , the causative agents of syphilis, yaws, pinta, bejel, and endemic syphilis. (cdc.gov)
There's also another theory--so called an Italian hypotheses--that syphilis is a single organism that is Treponema , caused different clinical manifestations depending upon climatic, social, and demographic factors, producing the clinical manifestation named pinta, yaws, bejel, and syphilis. (cdc.gov)

Transmission of yaws and bejel typically occurs in children. (medscape.com)
Endemic syphilis (bejel) ( T pallidum endemicum ) is typically spread among children, most commonly in the Middle East and the southern regions of the Sahara Desert. (medscape.com)

. endemicum, and T. carateum are endemic include Liberia and Somalia ( 3 ). (cdc.gov)

Venereal syphilis, commonly known as simply "syphilis", is an infection caused by the bacteria Treponema pallidum (subspecies pallidum). (ada.com)
Yaws is an infection caused by a form of the Treponema pallidum bacteria. (medlineplus.gov)
About 2 to 4 weeks after infection, the person develops a sore called a "mother yaw" where bacteria entered the skin. (medlineplus.gov)
Scratching the sore can spread the bacteria from the mother yaw to uninfected skin. (medlineplus.gov)
However, the blood test for syphilis is often positive in people with yaws because the bacteria that cause these two conditions are closely related. (medlineplus.gov)
The FTA-ABS test is used to detect antibodies to the bacteria Treponema pallidum, which causes syphilis . (medlineplus.gov)
Yaws - from the same bacteria species responsible for syphilis ( Treponema pallidum ) - is a childhood disease causing highly infectious skin lesions. (sciencereuters.com)
Antonio Fornaciari] Syphilis is an infectious disease, sexually transmitted, caused by the bacteria Treponema pallidum . (cdc.gov)

Syphilis is a sexually transmitted infection caused by the bacterium Treponema pallidum subspecies pallidum . (ipfs.io)

Other spirochetes include pathogens that cause syphilis and yaws. (lymedisease.org)

We describe yaws-like lesions in a wild chimpanzee in Guinea for which we demonstrate infection with Treponema pallidum subsp. (cdc.gov)
Infection with Treponema pallidum subsp. (cdc.gov)
Geographically structured genomic diversity of non-human primate-infecting Treponema pallidum subsp. (researchgate.net)
pallidum , Treponema pallidum subsp. (ncdc.gov.in)

Lewis' team is also studying whether Hygromycin A will be able to treat other spirochete-caused diseases, such as syphilis, which is caused by Treponema pallidum . (lymedisease.org)
Syphilis is a bacterial infection caused by the spirochete Treponema pallidum subspecies pallidum (T. pallidum), which is usually spread through sexual contact. (lecturio.com)
Treponema is a gram-negative, microaerophilic spirochete. (lecturio.com)
Syphilis Syphilis is caused by the spirochete Treponema pallidum and is characterized by 3 sequential symptomatic stages separated by periods of asymptomatic latent infection. (msdmanuals.com)

If the screening test is positive (irrespective of titer), a treponemal confirmatory test (e.g., the fluorescent treponemal antibody absorbed test [FTA-ABS] or the T. pallidum particle agglutination assay [TP-PA]) should be performed. (cdc.gov)
Serum samples were tested by using T. pallidum particle agglutination (Mast Diagnostics, Merseyside, UK) at the London School of Hygiene & Tropical Medicine. (cdc.gov)
For samples with a positive T. pallidum particle agglutination, a rapid plasma regain test was performed (Deben Diagnostics, Ipswich, UK). (cdc.gov)
Treponemal tests include fluorescent treponemal antibody absorption test (FTA-ABS), T pallidum particle agglutination test (TP-PA), chemiluminescence immunoassay (CIA), and enzyme immunoassay (EIA). (medscape.com)

A dilution of the patient's serum is added to the well to allow any T. pallidum -specific antibodies present to bind to the treponemal antigens. (cdc.gov)
If the patient has antibodies to T. pallidum , a color reaction takes place. (cdc.gov)
These tests are used to detect immunoglobulin G (IgG) and immunoglobulin M (IgM) antibodies against a cardiolipin-lecithin-cholesterol antigen, which are formed indirectly during infection with T pallidum. (medscape.com)
Because these antibodies are not specific for T pallidum, false-positive results on nontreponemal tests are frequently encountered in numerous physiologic and pathologic conditions (see Interpretation). (medscape.com)
Serological tests to detect treponemal antibodies can be useful in diagnosis of yaws only if sexual transmitted syphilis is excluded. (ncdc.gov.in)
Treponemal tests detect antibodies specific to Treponema pallidum . (cdc.gov)
2019. Endemicity of Yaws and seroprevalence of Treponema pallidum antibodies in nonhuman primates, Kenya . (ucdavis.edu)

Treponematosis, also known as treponemiasis, traditionally refers to the group of nonvenereal diseases (including endemic syphilis [nonvenereal syphilis]) caused by Treponema species that are morphologically and serologically identical to each other and to Treponema pallidum subspecies pallidum, the cause of venereal syphilis . (medscape.com)
Treponema species typically associated with nonvenereal disease are transmitted among children living in tropical, subtropical, or warm arid climates, chiefly by direct contact. (medscape.com)
The most common species involved in human disease is Treponema pallidum subspecies pallidum, which is the causative agent of syphilis. (lecturio.com)
Sub-species of Treponema pallidum , i.e. (ncdc.gov.in)

Treatment is typically with antibiotics, including azithromycin by mouth or benzathine penicillin by injection. (wikipedia.org)
For upper respiratory infections due to group A beta-hemolytic streptococci, penicillin is the usual drug of choice, including prophylaxis of rheumatic fever. (rxlist.com)
Single dose of injection benzathine benzyl Penicillin was the treatment of choice for both cases and contacts of yaws. (ncdc.gov.in)
Syphilis remains a common cause of morbidity and mortality during pregnancy, despite the continued sensitivity of T. pallidum to penicillin, the widespread availability of inexpensive, accurate tests, and substantial efforts to encourage routine screening through early prenatal care. (glowm.com)

Within 9-90 days (but usually about 21 days) of infection, a painless but distinctive "mother yaw" nodule appears. (wikipedia.org)
better source needed] Mother yaws are most commonly found on the legs and ankles, and are rarely found on the genitals (unlike syphilis) The mother yaw enlarges and becomes warty in appearance. (wikipedia.org)
Papilloma mother yaw Mother yaw nodule with central ulceration and a yellow crust Ulcerated mother yaw Ulcerated mother yaw Healed primary yaw lesion, showing pigmented scar The secondary stage occurs months to two years later (but usually 1-2 months later), and may thus begin when the mother yaw has not yet healed. (wikipedia.org)
More sores may appear shortly before or after the mother yaw heals. (medlineplus.gov)

Other treponemal diseases caused by Treponema pallidum are related to syphilis but are not spread by sexual contact. (ada.com)
Local penile factors and systemic diseases, including diabetes, cardiac disease, and neurologic disorders, can cause ED. Diagnosis is via physical exam and history. (lecturio.com)
Yaws belongs to a group of chronic bacterial infections (endemic treponematoses, nonvenereal spirochetal diseases) caused by treponemes. (ncdc.gov.in)
It is possible this movement of people brought diseases, including yaws, at the same time. (sciencereuters.com)
ANUG may also be associated with diseases in which the immune system is compromised, including HIV/AIDS. (mdwiki.org)

Yaws is spread by direct contact with the fluid from a lesion of an infected person. (wikipedia.org)
The lesion heals but is followed after months to a year by successive generalized eruptions that resemble the primary lesion (secondary yaws). (msdmanuals.com)
Yaws most commonly occurs in young children is characterized by a primary skin lesion (Early Yaws). (ncdc.gov.in)

Yaws-like lesions are widely reported in wild African great apes, yet the causative agent has not been confirmed in affected animals. (cdc.gov)

A real-time duplex PCR targeting the DNA polymerase I gene ( polA , tp0105 ) of pathogenic treponemes (which detects all 3 T. pallidum subspecies) and the human RNase P gene (to monitor for PCR inhibition) was performed by using a Rotor-Gene-Q real-time PCR instrument (QIAGEN Inc., Valencia, CA, USA) ( 9 ). (cdc.gov)

Emergence of H. ducreyi as a cause of nongenital ulcers may affect the World Health Organization's yaws eradication program. (cdc.gov)
Mass treatment with azithromycin-a central component of the World Health Organization's (WHO's) strategy to eradicate yaws-was followed by a drop in disease prevalence to one-eighth the previous level on an island where the disease is endemic, according to a study in the New England Journal of Medicine today. (umn.edu)

In 2012, the World Health Organization (WHO) launched a worldwide yaws eradication program based on treatment by mass distribution of azithromycin and monitoring for skin ulcers ( 3 ). (cdc.gov)
If this organism is a common cause of skin ulcers in the region, this factor has crucial implications for the yaws eradication strategy. (cdc.gov)
One such disease, yaws has been the target since decades and particularly after the inception of yaws eradication programme (YEP) since 1996-97. (ncdc.gov.in)
An accompanying commentary in the same issue said that, although challenges to yaws eradication lie ahead, today's study shows that the WHO strategy of mass treatment with azithromycin "should result in the eradication of yaws, if it is implemented and sustained long enough. (umn.edu)

Yaws-like lesions in wild chimpanzees, Guinea. (cdc.gov)
A) Yaws-like lesions observed during a necropsy of an adult female chimpanzee found in the Sangaredi area, Guinea. (cdc.gov)
Yaws is often diagnosed by the appearance of the lesions. (wikipedia.org)
Secondary yaws typically shows widespread skin lesions that vary in appearance, including "crab yaws" (areas of skin of abnormal colour) on the palms of the hands and soles of the feet (named for the crab-like gait they cause people with painful soles to assume). (wikipedia.org)
The long-term effects of these infections include multiple cutaneous lesions and destruction of bones or cartilage. (medscape.com)
We recorded location, classification, and duration of skin lesions and yaws treatment history using the LINKS system ( 7 , http://www.linkssystem.org/ ). (cdc.gov)
Lesions were classified by using the WHO pictorial grading scheme for yaws ( 8 ). (cdc.gov)
Yaws causes periostitis and dermal lesions. (msdmanuals.com)
These painless lesions may resolve spontaneously but are usually followed by papulosquamous and erosive papular lesions of the trunk and extremities that are similar to yaws. (msdmanuals.com)
Keratotic lesions may develop on the palms and soles, causing painful ulcerations (crab yaws). (msdmanuals.com)
Yaws is transmitted by direct (person-to-person) contact with the exudates and serum from infectious lesions. (ncdc.gov.in)
Usually after 5 years of onset of illness, destructive lesions of the skin, bone and cartilage (Late yaws) may appear which are non-infectious but may result in disabilities like gangosa and pathological fractures. (ncdc.gov.in)
The yaws may also coexist with any of these lesions. (ncdc.gov.in)

Classical primary ulcer of yaws. (ajtmh.org)
We used real-time PCR to detect H. ducreyi in skin ulcer samples collected during a survey for yaws in the Solomon Islands. (cdc.gov)

Pathogenic spirochetes include Treponema , Leptospira , and Borrelia . (msdmanuals.com)

Unlike T. pallidum subspecies pallidum , other human treponemal subspecies are not transmitted via blood or transplacentally. (msdmanuals.com)

In a minority of cases there may be a tertiary stage characterized by deep tissue destruction including more severe bone and cartilage destruction. (medscape.com)

Yaws, after an incubation period of several weeks, begins at the site of inoculation as a red papule that enlarges, erodes, and ulcerates (primary yaws). (msdmanuals.com)

Nontreponemal tests include the Venereal Disease Research Laboratory (VDRL) test and the rapid plasma reagin (RPR) test. (medscape.com)

Yaws is a long-term (chronic) bacterial infection that mainly affects the skin, bones, and joints. (medlineplus.gov)
Necrotizing periodontal disease is caused by a mixed bacterial infection that includes anaerobes such as P. intermedia [5] and Fusobacterium as well as spirochetes , such as Treponema . (mdwiki.org)

Syphilis is a sexually transmitted disease caused by Treponema pallidum, with human beings as the only host. (medscape.com)

[16] There may be a symmetrical, reddish-pink, non-itchy rash on the trunk and extremities, including the palms and soles. (ipfs.io)

The complications can include severe neurological and cardiovascular effects. (ada.com)
[1] Complications can include necrotizing ulcerative periodontitis (NUP) or cancrum oris . (mdwiki.org)
Untreated or inadequately treated syphilis can lead to severe long term health complications including blindness, deafness, severe birth defects and even death. (daserotikportal.de)

Meta-regression analyses investigated associations and sources of heterogeneity.ResultsThe 844 included publications yielded 1,573 prevalence measures. (bvsalud.org)
During a survey of yaws prevalence in the Solomon Islands, we collected samples from skin ulcers of 41 children. (cdc.gov)
The prevalence of yaws dropped from 2.4% before treatment began to 0.2% 12 months later, which was statistically significant. (umn.edu)
The prevalence of high-titer latent yaws among children declined from 18.3% to 6.5%, "with a near-absence of high-titer seroreactivity in children 1 to 5 years of age. (umn.edu)

Progression to secondary syphilis manifests as a generalized maculopapular rash, which includes the palms and soles. (lecturio.com)

Overall, the incidence of yaws was reduced to isolated foci of endemicity. (medscape.com)

In children, treponemal infection as indicated by positive screening and confirmatory tests might be caused by 1) nonsexual exposure to a person infected with non-venereal T. pallidum subspecies, 2) congenital transmission from an infected mother (occurs only with syphilis), or 3) consensual or nonconsensual sexual exposure (occurs only with syphilis). (cdc.gov)
Yaws (frambesia) is the most prevalent of the endemic treponematoses and occurs in humid equatorial countries. (msdmanuals.com)
Yaws is the most common of all and occurs primarily in the warm, humid and tropical areas of Africa, Central and South America, the Caribbean, Indian peninsula and the equatorial islands of South-East Asia. (ncdc.gov.in)

Because information on JYNNEOS vaccine effectiveness (VE) is limited, a matched case-control study was conducted in 12 U.S. jurisdictions,() including nine Emerging Infections Program sites and three Epidemiology and Laboratory Capacity sites,() to evaluate VE against mpox among MSM and transgender adults aged 18-49 years. (cdc.gov)

In the late 1980s in Gombe National Park in Tanzania, olive baboons ( Papio anubis ) with genital ulcerations were found to have yaws-like infections of the skin ( 5 ). (cdc.gov)
Later genetic and serologic studies confirmed infections with T. pallidum in olive baboons at many sites in Tanzania ( 6 , 7 ). (cdc.gov)
Suspected cases of yaws or other non-venereal treponemal infections can be reported to CDC at telephone 404-639-8368. (cdc.gov)
Tetracyclines are highly effective in the treatment of most chlamydial infections, including urogenital infections caused by Chlamydia trachomatis, respiratory tract infections caused by C. pneumoniae, respiratory tract infections caused by C. psittaci (psittacosis), and lymphogranuloma venereum caused by invasive serovars of C. trachomatis. (antiinfectivemeds.com)

citation needed] Secondary yaws affects the skin and bones. (wikipedia.org)

Whole-genome sequencing of the isolate collected from these baboons later revealed similarities with TPE causing yaws in humans ( 3 , 4 ). (cdc.gov)

After primary and secondary yaws (and possibly, in some cases, without these phases), a latent infection develops. (wikipedia.org)

Anthrax due to Bacillus anthracis, including inhalational anthrax (post-exposure): to reduce the incidence or progression of disease following exposure to aerosolized Bacillus anthracis. (mlivehosted.com)

By its late stage, yaws may have already caused damage to the skin and bones. (medlineplus.gov)
Yaws may damage the skin and bones. (medlineplus.gov)

Contributing factors include pregnancy, chronic constipation, diarrhoea or prolonged straining, weight lifting, and weakening of supporting tissue as a result of aging or genetics. (passmed.uk)
Hypertensive disorders of pregnancy include chronic hypertension, gestational hypertension, preeclampsia/eclampsia, and hemolysis, elevated liver enzymes, and low platelet count (HELLP) syndrome. (lecturio.com)

You have stayed in tropical areas where yaws is known to occur. (medlineplus.gov)

Yaws is transmitted by direct contact with the skin sores of infected people. (medlineplus.gov)

It has many symptoms, including a distinctive rash. (ada.com)
[1] Other symptoms may include bad breath , large lymph nodes , and fatigue. (mdwiki.org)

Fifty years ago, the WHO recognized that endemic treponematoses-yaws in particular-were a major cause of disfigurement and disability and a significant economic burden in poor countries. (medscape.com)

Organisms7

Diseases8

Chemicals and Drugs3

Analytical, Diagnostic and Therapeutic Techniques and Equipment4

Pertenue12

Pinta9

Bejel2

Carateum1

Bacteria8

Bacterium1

Syphilis and yaws1

Subsp4

Spirochete4

Particle agglutination4

Antibodies7

Species4

Penicillin4

Mother yaw4

Diseases5

Lesion3

Causative1

Pathogenic treponemes1

World Health Organization's2

Eradication4

Lesions13

Ulcer2

Spirochetes include1

Treponemal subspecies1

Tertiary1

Enlarges1

Nontreponemal tests1

Bacterial2

Sexually transmi1

Trunk and extremities1

Complications3

Prevalence4

Palms and soles1

Endemicity1

Occurs3

Epidemiology1

Infections4

Affects the skin1

Humans1

Secondary1

Bacillus1

Bones2

Chronic2

Occur1

Skin1

Symptoms2

Endemic treponematoses1