Treatments placebo. Medical search. Frequent questions

We conducted double-blind, placebo-controlled trials assessing the efficacy and tolerability of favipiravir in acute influenza. (nih.gov)
Here, we report the results of a double-blind, placebo-controlled study of olanzapine as a treatment for BPD. (psychiatrist.com)
In a randomized, double-blind, sham-controlled clinical trial, patients with either chronic generalized pain from fibromyalgia (FM) or chronic localized musculoskeletal or inflammatory pain were exposed to a PEMF (400 μT) through a portable device fitted to their head during twice-daily 40 min treatments over seven days. (hindawi.com)
Prospective, randomized, double-blind, placebo- (vehicle) controlled, multicenter, escalating dose study of a single administration of drug (48 or 150 mg) or vehicle (1 or 3 mL). (erowid.org)
Mirogabalin for the Treatment of Diabetic Peripheral Neuropathic Pain: A Randomized, Double-Blind, Placebo-Controlled Phase 3 Study in Asian Patients. (iasp-pain.org)
The present study (RAPIDS-2, for 'RAndomized, double-blind, Placebo-controlled study with bosentan on healing and prevention of Ischemic Digital ulcers in patients with systemic Sclerosis') was conducted to more fully evaluate the effects of bosentan treatment on DUs associated with SSc. (bmj.com)
This 6-week, randomized, double-blind, placebo-controlled trial used simultaneous depression and mania criteria to compare a single mood stabilizer, divalproex, with and without adjunctive olanzapine in patients with bipolar I disorder experiencing acute mixed episodes. (psychiatrist.com)
Methods Randomised double-blind, placebo-controlled clinical trial comparing a 12-week programme of using a GTN or placebo patch in combination with eccentric squats on a decline board. (bmj.com)
METHODS: In this randomised, double-blind, placebo-controlled, investigator-initiated phase 4 trial of the sequestrant colesevelam in bile acid diarrhoea (SINBAD), we enrolled consecutive patients aged 18-79 years without inflammatory bowel disease attending SeHCAT testing for suspected bile acid diarrhoea at four Danish secondary care centres. (aau.dk)
Here we further evaluate NSAID treatment with piroxicam in a double blind RCT and investigate the role of cytokines and heat shock proteins (Hsp) with respect to muscle performance. (biomedcentral.com)
Both trials were identical in their design: a 4-week run-in phase before a randomized, double-blind treatment phase that tested two dosing regimens of secukinumab (300 mg administered subcutaneously) every 2 or 4 weeks vs placebo for 16 weeks. (medscape.com)
Q-CABG is a phase II, prospectively registered, randomized, double-blind and placebo-controlled clinical trial. (frontiersin.org)
Objectives This phase II randomized double-blind placebo-controlled clinical trial aimed at testing the efficacy and safety of a three-week squalamine ointment regimen for the treatment of tinea capitis. (hal.science)
Methods: Thirty patients with CFS were enrolled in a 2-month, double-blind, placebo- controlled trial of terfenadine. (umn.edu)
Data from 58 double-blind placebo-controlled trials were retrieved from the FDA for the second-generation antidepressants for the treatment of anxiety disorders. (rug.nl)
Nitroglycerin for treatment of retained placenta: A randomised, placebo-controlled, multicentre, double-blind trial in the UK. (bvsalud.org)
We did a randomised, placebo-controlled, double-blind, crossover trial of a quadpill-a single capsule containing four blood pressure-lowering drugs each at quarter-dose (irbesartan 37·5 mg, amlodipine 1·25 mg, hydrochlorothiazide 6·25 mg, and atenolol 12·5 mg). (edu.au)

A randomised placebo controlled superiority trial was performed. (bmj.com)

Mean ' ‰ ± ' ‰ SE score changes from baseline to last observation carried forward for CGI-BP measures were −1.34 ' ‰ ± 0 .11 for adjunctive olanzapine versus −1.06 ' ‰ ± 0 .11 for adjunctive placebo, P ' ‰ = ' ‰ .056. (psychiatrist.com)
Statistically, usually the NI margin is set to preserve 50% of the lower bound of the CI of the magnitude of the effect of the active control versus placebo as determined in systematic review meta-analysis of historic trials. (bmj.com)
Effects on muscle performance of NSAID treatment with Piroxicam versus placebo in geriatric patients with acute infection-induced inflammation. (biomedcentral.com)
0.05) improved versus placebo at various time points within the first 8 h in cats receiving robenacoxib. (biomedcentral.com)
Indirect treatment comparison of nivolumab versus placebo for the adjuvant treatment of melanoma. (ox.ac.uk)
The phase III randomised controlled trial (RCT) CheckMate 238 (238) demonstrated the safety and efficacy of nivolumab as an adjuvant treatment for melanoma in patients with stage IIIB/C or IV disease (American Joint Committee on Cancer [AJCC], 7th edition) versus ipilimumab. (ox.ac.uk)
METHODS: Indirect treatment comparisons (ITCs) of nivolumab versus placebo were constructed using data from 238 and EORTC 18071. (ox.ac.uk)
CONCLUSION: Nivolumab was associated with significantly improved efficacy outcomes versus placebo, whereas maintaining patient's overall HRQoL. (ox.ac.uk)
p=0.048) for (223)Ra versus placebo, respectively. (researchgate.net)
Treatment decisions should balance the anticipated reduction in transmission versus the likelihood of reinfection in patients whose risk of HCV transmission is high and in whom HCV treatment may result in a reduction in transmission (eg, men who have high-risk sex with men, active injection drug users, incarcerated persons, and those on hemodialysis). (medscape.com)
Cochrane Abstracts , Evidence Central , evidence.unboundmedicine.com/evidence/view/Cochrane/434600/all/Anticoagulants_versus_non‐steroidal_anti‐inflammatories_or_placebo_for_treatment_of_venous_thromboembolism. (unboundmedicine.com)

Prof Abbott says this highlights the power of the placebo effect. (menopause.org.au)
This show demonstrated the power of the placebo effect through a fake clinical trial. (scienceblog.com)

Methods The STEM-AMI Trial was a prospective, placebo-controlled, multicentre study. (bmj.com)
METHODS Histologically determined NASH patients with elevated alanine aminotransferase (ALT) and decreased 25-OH vitamin D level at baseline received vitamin D3 or placebo orally over a 48-week period. (uzh.ch)
Patients and methods Patients were divided into a 3L group (126 and 64 in FTD/TPI and placebo arms, respectively) and 4L+ group (211 and 106 in FTD/TPI and placebo arms, respectively). (gencat.cat)
Methods: We performed a placebo-controlled pilot trial to evaluate the efficacy and safety of rifaximin in patients with active pouchitis. (elsevierpure.com)
A multitude of randomized clinical trials and other treatment studies have demonstrated that currently available therapeutic methods are 22%-94% effective in clearing external exophytic genital warts, and that recurrence rates are high (usually at least 25% within 3 months) with all modalities. (cdc.gov)

Based on our study, we hope that women don't go for commercial laser treatment for postmenopausal symptoms. (menopause.org.au)
This study evaluated the efficacy and safety of mirogabalin, a novel, potent, selective ligand of the α δ subunit of voltage-dependent Ca channels, for the treatment of diabetic peripheral neuropathic pain (DPNP). (iasp-pain.org)
112/146 patients (76.7%) taking ropinirole and 109/138 (79.0%) taking placebo completed the study. (bmj.com)
The primary endpoint of this study was the change in ALT from baseline to the end-of-treatment. (uzh.ch)
In a previous single blind study we have demonstrated improved recovery of muscle endurance following celecoxib treatment in hospitalized geriatric patients with acute infection. (biomedcentral.com)
Superior efficacy of oral robenacoxib in reducing post-operative pain compared to placebo was reported in a previous US field study [ 9 ]. (biomedcentral.com)
The study was a multi-center, randomized, masked, placebo-controlled, parallel-group clinical trial at 13 companion animal veterinary clinics located at various geographic locations within the US. (biomedcentral.com)
The purpose of this study is to assess the efficacy and safety of pembrolizumab (MK-3475) plus one of four platinum-based chemotherapy regimens compared to the efficacy and safety of placebo plus one of four platinum-based chemotherapy regimens in the treatment of adult women with persistent, recurrent, or metastatic cervical cancer. (clinicaltrials.gov)
The primary study hypotheses are that the combination of pembrolizumab plus chemotherapy is superior to placebo plus chemotherapy with respect to: 1) Progression-free Survival (PFS) per Response Evaluation Criteria in Solid Tumors (RECIST 1.1) as assessed by the Investigator, or, 2) Overall Survival (OS). (clinicaltrials.gov)
But the study showed that suggestion, or a placebo, works in a similar way. (health-alphabet.com)
A new study published in the Journal of Developmental and Behavioral Pediatrics reports that using half a dose of prescription medication, supplemented with a placebo, to treat patients with attention deficit hyperactivity disorder (ADD/ADHD) produced the same results as the full dosage. (additudemag.com)
It is unclear what effect the study will have on treatment, but it does suggest the incorporation of placebos in medicating ADD/ADHD patients could be an effective use of "mind-body medicine," according to the study's author, Dr. Adrian Sandler. (additudemag.com)
Objective: Because of anecdotal reports and uncontrolled trials showing antihistamine efficacy in CFS, we evaluated the clinical efficacy of the antihistamine terfenadine (60 mg twice daily) in a placebo-controlled study. (umn.edu)
In the TAGS study, trifluridine/tipiracil (FTD/TPI) improved overall survival (OS) compared with placebo in heavily pre-treated patients. (gencat.cat)
This unplanned, exploratory subgroup analysis of the TAGS study aimed to clarify outcomes when FTD/TPI was used as third-line (3L) treatment and fourth- or later-line (4L+) treatment. (gencat.cat)
One study claimed that of 22 patients with diagnosed terminal cancer, 14 remained alive after treatment. (scienceblog.com)
A recent study in the US has suggested that genes may also play an important role in deciding whether or not an individual responds to a placebo. (scienceblog.com)
A study from 1985 hypothesised that the placebo effect relies heavily upon a belief that the medicine will make you feel better. (scienceblog.com)
[ 1 ] Treatment for chronic HCV is based on guidelines from the Infectious Diseases Society of America (IDSA) and the American Associations for the Study of Liver Diseases (AASLD), in collaboration with the International Antiviral Society-USA (IAS-USA). (medscape.com)
After completion of study treatment, patients are followed up at 30 days, then every 6 months for 10 years. (orlandohealth.com)
As researchers continue to study the placebo effect, count on UCLA practitioners to take the time to provide the compassionate care necessary to healing. (uclahealth.org)
An influential 1955 study entitled The Powerful Placebo firmly established the idea that placebo effects were clinically important, and were a result of the brain's role in physical health. (wikipedia.org)
A 1997 reassessment found no evidence of any placebo effect in the source data, as the study had not accounted for regression to the mean. (wikipedia.org)
In this study, we found that nitroglycerin is neither clinically effective nor cost -effective as a medical treatment for retained placenta , and has increased side effects, suggesting it should not be used. (bvsalud.org)
this treatment was followed by a 2-week washout, then the other study treatment was administered for 4 weeks. (edu.au)
Study staff and participants were unaware of treatment allocations, and masking was achieved by use of identical opaque capsules. (edu.au)
If we want to study this psychosocial context, we need to eliminate the specific action of a therapy and to simulate a context that is similar in all respects to that of a real treatment. (jneurosci.org)
Therefore, it is important to emphasize that the study of the placebo effect is the study of the psychosocial context around the patient. (jneurosci.org)
The study of the placebo effect, at its core, is the study of how the context of beliefs and values shape brain processes related to perception and emotion and, ultimately, mental and physical health. (jneurosci.org)
The study of the placebo effect reflects a current neuroscientific thought that has as its central tenet the idea that "subjective" constructs such as expectation and value have identifiable physiological bases, and that these bases are powerful modulators of basic perceptual, motor, and internal homeostatic processes. (jneurosci.org)
The study of the placebo effect also has immediate clinical and ethical implications, because the use of inactive (placebo) conditions in clinical trials when effective treatments are available has created an ethical controversy. (jneurosci.org)
In the same study, if the placebo response was obtained after exposure to opioid drugs, it was naloxone reversible, whereas if it was obtained after exposure to non-opioid drugs, it was naloxone insensitive. (jneurosci.org)
Did you participate in a research study or clinical trial as a part of your cancer treatment? (cdc.gov)

The trial continued after this time, with patients in the placebo arm re-randomly assigned to treatment with one of the two secukinumab regimens out to a year. (medscape.com)
Two of 9 patients in the placebo group withdrew prior to week 4 due to lack of efficacy and were categorized as treatment failures. (elsevierpure.com)

In US317 (526 favipiravir, 169 placebo), favipiravir did not significantly reduce time to alleviation (median, 77.8 vs 83.9 hours). (nih.gov)
RESULTS Serum 25-OH vitamin D levels significantly increased only in the vitamin D3 group over the 48-week treatment phase indicating compliance. (uzh.ch)
EMS scores, FR and grip work (GW), a measure taking into account GS and FR, significantly improved with piroxicam, but not with placebo. (biomedcentral.com)
Basal expression of Hsp27 in monocytes without heat challenge (WHC) was positively correlated with FR at baseline and significantly increased by treatment with piroxicam compared to placebo. (biomedcentral.com)
only the dyspnoea domain significantly favoured placebo. (ox.ac.uk)
The 15-year survival rate was statistically significantly better for those who experienced SVR (93%) compared to those whose treatment had failed (82%) or for those who remained untreated (88%) ( P =.003). (medscape.com)

Knoller N, Levi L, Shoshan I, Reichenthal E, Razon N, Rappaport ZH, Biegon A. "Dexanabinol (HU-211) in the treatment of severe closed head injury: a randomized, placebo-controlled, phase II clinical trial" Crit Care Med . (erowid.org)
In contrast to placebo, patients in the vitamin D group had markedly decreased ALT levels after the end-of-treatment phase. (uzh.ch)
This will make most providers very comfortable offering it as a potential treatment option sooner rather than later given that its efficacy has now been demonstrated in phase 3 trials," added Sayed, associate professor of dermatology at the University of North Carolina, Chapel Hill. (medscape.com)
EORTC 18071 is a phase III RCT comparing ipilimumab with placebo in patients with resected stage IIIA-IIIC melanoma (AJCC, 6th edition). (ox.ac.uk)

We investigated the efficacy and safety of a 48-week treatment with vitamin D3 in NASH patients. (uzh.ch)
Conclusions This analysis confirms the efficacy and safety of FTD/TPI in patients with GC/EGJ in third and later lines with a survival benefit that seems slightly superior in 3L treatment. (gencat.cat)
We also did a systematic review of trials evaluating the efficacy and safety of quarter-standard-dose blood pressure-lowering therapy against placebo. (edu.au)

To evaluate whether treatment with tucatinib plus T-DM1 compared to treatment with T-DM1 alone (T-DM1 plus placebo) reduces the incidence of brain metastases. (orlandohealth.com)

The primary endpoint was the percentage of patients achieving a Hidradenitis Suppurativa Clinical Response (HiSCR) after 16 weeks of treatment, with key secondary endpoints, which were abscess and inflammatory nodule (AN) count, occurrence of flares, and at least a 30% reduction in Patient's Global Assessment of Skin Pain assessed using a numeric rating scale (NPRS30). (medscape.com)
Most often they are caused by the patient's bad attitude to the therapy, e.g. the appearance of the drug that is not accepted by him, the negative attitude of the doctor, suggesting that the treatment is harmful. (health-alphabet.com)
Recent studies have shown that COMT levels can affect the strength of a patient's response to placebo. (uclahealth.org)
That's because placebos do not appear to affect the actual diseases, or outcomes that are not dependent on a patient's perception. (wikipedia.org)

Objectives To assess if continuous topical glyceryl trinitrate (GTN) treatment improves outcome in patients with chronic patellar tendinopathy when compared with eccentric training alone. (bmj.com)
Conclusion It seems that continuous topical GTN treatment in addition to an eccentric exercise programme does not improve clinical outcome compared to placebo patches and an eccentric exercise programme in patients with chronic patellar tendinopathy. (bmj.com)
The idea of a placebo effect-a therapeutic outcome derived from an inert treatment-was discussed in 18th century psychology, but became more prominent in the 20th century. (wikipedia.org)
The primary outcome was placebo-corrected 24-h systolic ambulatory blood pressure reduction after 4 weeks and analysis was by intention to treat. (edu.au)
Any medical treatment is surrounded by a psychosocial context that affects the therapeutic outcome. (jneurosci.org)
The placebo effect, or response, is the outcome after the sham treatment. (jneurosci.org)

Thus, placebo effects may represent points of either strength or vulnerability for the expression and maintenance of various pathological states and their inherent therapeutic interventions. (jneurosci.org)

The four-armed trial (no pill, placebo, Echinacea blinded and Echinacea unblinded), which included 719 randomized participants aged 12 to 80 years, revealed that patients randomized to the no-pill group had longer and more severe illnesses than those who received pills, regardless of the pills content. (infectioncontroltoday.com)
Placebo Effects and the Common Cold: A Randomized Controlled Trial. (infectioncontroltoday.com)
But a new UNSW Sydney-led trial, the results of which are published today in The Journal of the American Medical Association (JAMA) , compared the results of the laser to results from a placebo treatment - and surprisingly, it found there was no difference between the two. (menopause.org.au)
In the present placebo-controlled randomized controlled trial (RCT) we investigated the effect of piroxicam on the evolution of muscle performance and mobility in hospitalized geriatric patients with acute infection. (biomedcentral.com)
Subjects on this trial were given a placebo drug (Rumyodin) and were told that it could inhibit feelings of fear. (scienceblog.com)
In a placebo-controlled clinical trial any change in the control group is known as the placebo response, and the difference between this and the result of no treatment is the placebo effect. (wikipedia.org)
The placebo response may include improvements due to natural healing, declines due to natural disease progression, the tendency for people who were temporarily feeling either better or worse than usual to return to their average situations (regression toward the mean), and errors in the clinical trial records, which can make it appear that a change has happened when nothing has changed. (wikipedia.org)
The objective of the trial was to determine whether sublingual nitroglycerin spray was clinically effective and cost -effective for medical treatment of retained placenta following vaginal delivery. (bvsalud.org)
A larger trial would be required to determine if rifaximin is effective for the treatment of active pouchitis. (elsevierpure.com)
Randomized controlled trial of oral vancomycin treatment in Clostridioides difficile-colonized patients. (cdc.gov)

Scientists are using imaging techniques to probe brains on placebos and watch the placebo effect in real time. (bmj.com)
Statistical analysis of these differences by a logistic model using dose, entry Glasgow coma scale score, and computed tomograph as covariates yielded p values for the effect of treatment of .03 and .14 at 3 and 6 months, respectively. (erowid.org)
The placebo effect can have a very profound arrangement on the way that someone perceives their symptoms," he says. (menopause.org.au)
We're very keen to try and better understand how that happens and how the placebo effect works. (menopause.org.au)
Conclusions Bosentan treatment reduced the occurrence of new DUs in patients with SSc but had no effect on DU healing. (bmj.com)
Generalised estimated equation was used to analyse the treatment, time and treatment×time effect. (bmj.com)
0.01) but no effect for treatment×time (p=0.80). (bmj.com)
It was apparent that the effect determined after GH therapy in part was due to a placebo effect. (lu.se)
Participants were randomly allocated 1:1 to receive 12 days of treatment with colesevelam (overencapsulated tablets of 625 mg) or placebo, with the starting dose of two capsules twice daily and titrated to effect during the first 5 days of treatment. (aau.dk)
The placebo effect has been used in medicine for centuries. (health-alphabet.com)
Until the nineteenth century, the placebo effect was quite often used unconsciously in medicine. (health-alphabet.com)
The experiment by Thomas Luparello of the University of New York confirmed the effect of a placebo in the treatment of asthma. (health-alphabet.com)
The placebo effect in neoplastic diseases cannot be overestimated. (health-alphabet.com)
The Placebo Effect: A treatment of the mind? (scienceblog.com)
The so-called 'placebo effect' appears, at first glance, to make no sense whatsoever. (scienceblog.com)
However, these results do offer an explanation as to why some people are more susceptible to the placebo effect than others. (scienceblog.com)
Placebo effect: sugar pills as medicine? (uclahealth.org)
The placebo effect occurs when people respond to treatments that have no medical reason to be effective. (uclahealth.org)
Although the placebo effect is generally accepted as being real, exactly why these treatments work remains a mystery. (uclahealth.org)
Improvements that patients experience after being treated with a placebo can also be due to unrelated factors, such as regression to the mean (a statistical effect where an unusually high or low measurement is likely to be followed by a less extreme one). (wikipedia.org)
While it was once assumed that this deception was necessary for placebos to have any effect, there is some evidence that placebos may have subjective effects even when the patient is aware that the treatment is a placebo (known as "open-label" placebo). (wikipedia.org)
the placebo effect is the difference between that response and no treatment. (wikipedia.org)
A 2001 Cochrane Collaboration meta-analysis of the placebo effect looked at trials in 40 different medical conditions, and concluded the only one where it had been shown to have a significant effect was for pain. (wikipedia.org)
Measuring the extent of the placebo effect is difficult due to confounding factors. (wikipedia.org)
The primary patient -sided outcomes were satisfaction with treatment and side-effect profile, assessed by questionnaires pre-discharge and 6 weeks post-delivery. (bvsalud.org)
The placebo effect is a psychobiological phenomenon that can be attributable to different mechanisms, including expectation of clinical improvement and pavlovian conditioning. (jneurosci.org)
Thus, we have to look for different mechanisms in different conditions, because there is not a single placebo effect but many. (jneurosci.org)
The effect of treatment on the natural history of HPV is unknown. (cdc.gov)

P = .004) in time to illness alleviation vs placebo. (nih.gov)
The ability of a placebo to alleviate symptoms is variable both in how often they succeed and the strength of the resulting symptom alleviation. (scienceblog.com)

C4 and SeHCAT diagnostic results were blinded during treatment. (aau.dk)
And they should not, because one of these people took the so-called Placebo, which is something that is not a medicinal substance but still gives good results. (health-alphabet.com)
Only the results of patients treated (also regularly and irregularly) with placebo were astonishing. (health-alphabet.com)
In 1984, the Hungarian psychiatrist Mihly Arato assessed the results of research into the treatment of depression. (health-alphabet.com)
The results are so encouraging that it is tempting to start deliberately treating a placebo in the onset of depression. (health-alphabet.com)
Results Baseline characteristics were generally well balanced between FTD/TPI and placebo for 3L and 4L+ treatment. (gencat.cat)
So if placebos can offer such amazing results without the need for any active ingredient and all the side effects these may bring, why are they not used more regularly? (scienceblog.com)
Preliminary results indicate that if a particular gene is present, individuals with irritable bowel syndrome are more likely to respond to placebo acupuncture. (scienceblog.com)
Placebos in clinical trials should ideally be indistinguishable from so-called verum treatments under investigation, except for the latter's particular hypothesized remedial factor(s). [1] This is to prevent the recipient or others from knowing (with their consent) whether a treatment is active or inactive, as expectations about efficacy can influence results. (wikipedia.org)
Results: Eight patients were randomized to rifaximin and 10 patients were randomized to placebo. (elsevierpure.com)
Both the recurrence of il ness and positive test results improved or resolved (median of 3 days) without additional anti-COVID-19 treatment. (cdc.gov)
PCR test results after testing negative, or an increase in the amount of SARS-CoV-2 detected by PCR, after completing their treatment course (5). (cdc.gov)
the low positive predictive value of these assays results in patients colonized with C. difficile unnecessarily receiving CDI treatment antibiotics. (cdc.gov)

Safety ITCs indicated that patients receiving nivolumab had a greater hazard of experiencing an adverse event (AE) and AEs leading to treatment discontinuation, whereas there was a non-significant increased hazard of experiencing a serious AE. (ox.ac.uk)

Chloramphenicol ointment is an antibiotic indicated for the treatment of bacterial conjunctivitis, but it is often used as prophylaxis for, or treatment of, wound infection, although little evidence exists for its effectiveness. (bmj.com)
The control treatment was placebo ointment, which consisted of a mixture of soft white and liquid paraffin with no known anti-infective properties. (bmj.com)
In total, 972 patients were recruited and randomised to topical chloramphenicol ointment (n=488) or placebo (n=484). (bmj.com)
Patients Males aged 6-15 years presenting with tinea capitis were treated with either topical squal-amine ointment or placebo for 3 weeks. (hal.science)

Clinicians are familiar with randomised controlled trials (RCTs), which compare a new and a standard treatment (or placebo) to determine whether the new treatment is superior. (bmj.com)

During quadpill treatment, 18 (100%) of 18 participants achieved office blood pressure less than 140/90 mm Hg, compared with six (33%) of 18 during placebo treatment ( p = 0·0013). (edu.au)
Our systematic review identified 36 trials ( n = 4721 participants) of one drug at quarter-dose and six trials ( n = 312) of two drugs at quarter-dose, against placebo. (edu.au)

Other research shows that placebos can reduce anxiety. (bmj.com)
The efficacy of FDA-approved antidepressants for the treatment of anxiety disorders was re-evaluated in a Bayesian framework that quantifies the strength of the evidence. (rug.nl)

ARM I: Patients receive T-DM1 intravenously (IV) over 30-90 minutes on day 1 and placebo orally (PO) twice daily (BID) on days 1-21. (orlandohealth.com)

Besides treatment of the underlying acute disease, interventions able to reduce inflammation-related adverse outcomes may be warranted. (biomedcentral.com)
However, exceptions do exist: one example is Parkinson's disease, where recent research has linked placebo interventions to improved motor functions. (wikipedia.org)

Placebos can improve patient-reported outcomes such as pain and nausea but also objective outcomes such as motor functions and immune/endocrine parameters. (wikipedia.org)

The effectiveness of placebo treatment seems to be closely related to the relationship between the patient and caregiver. (uclahealth.org)
Further examination of the quadpill concept is needed to investigate effectiveness against usual treatment options and longer term tolerability. (edu.au)
Effectiveness of antiviral treatment in human influenza A(H5N1) infections: analysis of a Global Patient Registry. (cdc.gov)

Cats were randomized to receive daily subcutaneous (s.c.) injection of robenacoxib, at a target dosage of 2.0 mg/kg ( n = 174), or placebo ( n = 175) once prior to surgery and for an additional two days post-operatively. (biomedcentral.com)

In treatment-resistant depression, repetitive transcranial magnetic stimulation had higher. (psychiatrist.com)
People with Parkinson's disease, depression and schizophrenia have shown a strong response to placebos in clinical trials. (uclahealth.org)

Common placebos include inert tablets (like sugar pills), inert injections (like saline), sham surgery, and other procedures. (wikipedia.org)

Ropinirole improves restless legs syndrome compared with placebo, with benefits apparent by week 1. (bmj.com)

Forty BPD patients (25 female, 15 male) were randomly assigned in equal numbers to olanzapine and placebo. (psychiatrist.com)

CONCLUSIONS Treatment with 2100 IE vitamin D q.d. over 48 weeks was well tolerated and led to a significant improvement of serum ALT levels in patients with hypovitaminosis D and histology-proven NASH as the primary endpoint together with a trend toward reduction of hepatic steatosis, which was not significant due to a small number of available biopsy specimens. (uzh.ch)
The placebo-corrected reduction in systolic 24-h blood pressure with the quadpill was 19 mm Hg (95% CI 14-23), and office blood pressure was reduced by 22/13 mm Hg ( p (edu.au)

41 patients had C4 concentration greater than 46 ng/mL (22 assigned to the colesevelam group and 19 to the placebo group). (aau.dk)
For example, a patient may feel better after taking a placebo due to regression to the mean (i.e. a natural recovery or change in symptoms), but this can be ruled out by comparing the placebo group with a no treatment group (as all the placebo research does). (wikipedia.org)
One patient in the placebo group did not have a post-baseline efficacy evaluation and was excluded from the efficacy analysis. (elsevierpure.com)
To help learn more subjects will either be assigned to a group that is taking the supplement (5HTP) or a group that is taking a placebo. (centerwatch.com)

Remission was defined as the absence of both these criteria during treatment days 6-12. (aau.dk)
INTERPRETATION: Colesevelam was superior to placebo at inducing remission of bile acid diarrhoea diagnosed with C4 concentration greater than 46 ng/mL. (aau.dk)
Two of 8 patients (25%) treated with rifaximin were in clinical remission at week 4 compared to 0 of 9 patients (0%) treated with placebo (P = 0.2059). (elsevierpure.com)

Of note, fewer patients treated with secukinumab (about 15%-20% among those treated every 2 weeks and about 15% to 23% among those treated every 4 weeks) than those on placebo (27%-29%) experienced flares, defined as at least a 25% increase in AN count and at least a two-point increase relative to baseline values. (medscape.com)

05) superior to placebo on the CGI-BPD at endpoint, with separation occurring as early as 4 weeks. (psychiatrist.com)
I. To determine if the invasive disease-free survival (iDFS) with T-DM1 and tucatinib is superior to the iDFS in the control arm (T-DM1 + placebo) when administered to high risk patients with HER2-positive breast cancer and residual disease after neoadjuvant HER2-directed therapy. (orlandohealth.com)

Median overall survival was 65.3 weeks (48.7-infinity) for (223)Ra and 46.4 weeks (32.1-77.4) for placebo (p=0.066, log rank). (researchgate.net)

The treatment of laser for postmenopausal vaginal symptoms just wasn't effective," says gynaecologist Jason Abbott , a professor at UNSW Sydney. (menopause.org.au)
Patel, who was not involved in either of the studies, added: "There is definitely a huge need for alternative medication for this condition, which still has a lack of effective treatment options. (medscape.com)
Placebos appear to be more effective when symptoms are subjective such as pain or nausea and less effective for non-subjective symptoms such as abnormal blood pressure or heart rate. (scienceblog.com)
Currently, the only effective treatments for a retained placenta are the surgical procedures of manual removal of placenta (MROP) and uterine curettage , which are not universally available, particularly in low- and middle- income countries. (bvsalud.org)
Further research is required to identify an effective medical treatment for retained placenta to reduce the morbidity caused by this condition, particularly in low- and middle- income countries where surgical management is not available. (bvsalud.org)
However, it has been well documented that placebo effects can obscure those of active conditions, even for treatments that were eventually demonstrated to be effective. (jneurosci.org)
These therapies and more cost-effective treatments do not eliminate HPV infection. (cdc.gov)
Two randomized trials established systemic interferon alpha to be no more effective than placebo. (cdc.gov)

Sixty consecutive patients with a first anterior STEMI, who underwent primary percutaneous coronary intervention 2-12 h after symptom onset, with LV ejection fraction (LVEF) ≤45% measured by echocardiography within 12 h after successful revascularisation (TIMI flow score ≥2), were randomised 1:1 to G-CSF (5 µg/Kg body weight b.i.d . ) or placebo. (bmj.com)

Background: There is no established treatment for chronic fatigue syndrome (CFS), an illness characterized by disabling fatigue exacerbated by physical activity. (umn.edu)
1. The progressive globalization of biomedical and behavioural research holds much promise for developing treatments that would prevent illness, cure disease and improve health. (who.int)

Scientists are interested in placebo responses because the effects of belief on human experience and behavior provide an entry point for studying internal control of affective, sensory, and peripheral processes. (jneurosci.org)

Patients don't always know that these treatments don't need to have a strong evidence backing before they're rolled out and recommended from clinicians. (menopause.org.au)

Now placebo phenomena are demonstrated in the multicelled organism's genes and genomes, in our primal first stratum and 2nd stratum base organisms. (bmj.com)
Now an interesting chain is exposed to our view, the GGRPVR Chain, the Genes-God-Religion-Placebo-Virtual Reality chain, a most intriguing cultural evolution chain, extending from the genes genesis to nowadays. (bmj.com)

intervention, N = 543) or placebo spray (control, N = 564). (bvsalud.org)

Sixteen patients with pruritus of chronic cholestasis were randomized to receive naltrexone (4-week course of 50 mg naltrexone daily) or placebo. (nih.gov)
Additional hidradenitis suppurativa (HS) treatments could be on the horizon with the news that both secukinumab and the investigational drug brepocitinib reduced the effects of the chronic and painful skin condition in separate trials. (medscape.com)
However, IFN-sparing regimens are safer and are currently recommended for the treatment of acute HCV infection as with chronic HCV infection. (medscape.com)
More recently, the AASLD/ISDA guidelines have removed their prioritization tables but continue to strongly recommend treatment for all patients with chronic HCV infection, barring those with shortened life expectancies that cannot be resolved by HCV treatment, liver transplantation, or another directed therapy. (medscape.com)
Treatment of chronic HCV infection has two goals. (medscape.com)
People with chronic and stress-related conditions have the strongest response to placebos. (uclahealth.org)

To assess the efficacy, safety, and tolerability of ropinirole in the treatment of patients with restless legs syndrome. (bmj.com)
During the late-breaking sessions at the annual EADV Congress, Kimball presented data from two trials - SUNSHINE and SUNRISE - that investigated the efficacy, safety and tolerability of the interleukin (IL) 17A inhibitor secukinumab ( Cosentyx ) vs placebo in the treatment of moderate to severe HS. (medscape.com)

Objective To assess whether granulocyte colony-stimulating factor (G-CSF) treatment induces a sustained benefit on adverse remodelling in patients with large anterior ST-elevation myocardial infarction (STEMI) and left ventricular (LV) dysfunction after successful reperfusion. (bmj.com)

Placebo (pronounced /plaˈkebo/ or /plaˈt͡ʃebo) is Latin for [I] shall be pleasing. (wikipedia.org)

Patients were randomised (1:1) to receive either ropinirole 0.25-4.0 mg once daily or placebo. (bmj.com)
10 mg/L were included and randomized to active treatment with 10 mg piroxicam daily or placebo. (biomedcentral.com)
Recruited patients awaiting CABG surgery at the Montreal Heart Institute (n = 100) will be randomly assigned in a 1:1 ratio to receive either quercetin supplementation (500 mg twice daily) or placebo, starting 2 days before surgery and until the seventh postoperative day. (frontiersin.org)
Eighteen patients with active pouchitis were randomized to receive oral rifaximin 400 mg or placebo 3 times daily for 4 weeks. (elsevierpure.com)

A patient on disulfiram treatment developed erythematous plaques and papules after consump. (psychiatrist.com)
Patient satisfaction showed no difference between GTN and placebo groups (p=0.25) after 24 weeks, but did show a significant difference over time (p=0.01). (bmj.com)
However, it must be clearly stated: in some cases the mere fact of undergoing treatment (visiting a doctor and taking pills) helps the patient to recover. (health-alphabet.com)
No patient discontinued (223)Ra because of treatment toxicity. (researchgate.net)
The key to the placebo's success is ensuring the patient believes the treatment will improve their condition. (scienceblog.com)
The use of placebos in clinical medicine raises ethical concerns, especially if they are disguised as an active treatment, as this introduces dishonesty into the doctor-patient relationship and bypasses informed consent. (wikipedia.org)
Regimens - Treatment of genital warts should be guided by the preference of the patient. (cdc.gov)

We hypothesized that NSAID treatment would preserve muscle performance better than antibiotic treatment alone, by reducing infection-associated inflammation and by increasing expression of cytoprotective Hsp. (biomedcentral.com)
The risks and benefits of antibiotic treatment in individuals with such cases are unknown. (cdc.gov)

Investigating placebo effects in treatment of the common cold, Bruce Barrett, MD, PhD, of the University of Wisconsin, Madison, and colleagues, report finding modest and nuanced effects related to receiving pills regardless of their content, especially among those who believe in a particular therapy. (infectioncontroltoday.com)

Vaginal laser therapy treatments claim to reduce negative vaginal symptoms of menopause - experienced by about half of all women - by up to 100 per cent. (menopause.org.au)
Before treatment, the patients had lowered quality of life as determined by the HSCL and NHP inventories, and a correlation between the duration of GHD and the reported symptoms was observed. (lu.se)
Treatment The goal of treatment is removal of exophytic warts and the amelioration of signs and symptoms -- not the eradication of HPV. (cdc.gov)

People with COVID-19 rebound should fol ow CDC recommendations regarding isolation of infected patients regardless of treatment with an antiviral agent and/or previous isolation after the initial infection. (cdc.gov)
What [HA561 trade name] is and what it is used for [HA561 trade name] is a treatment for human immunodeficiency virus (HIV) infection in adults and adolescents over 10 years of age weighing more than 30 kg. (who.int)
Both of these are antiretroviral medicines for the treatment of HIV infection. (who.int)

Your tax-deductible donation funds lung disease and lung cancer research, new treatments, lung health education, and more. (lung.org)
New research suggests that there may be a biochemical reason for why placebos help people feel better. (uclahealth.org)
Placebos are used in randomized clinical trials to test the efficacy of medical treatments, so they serve as epistemological tools to screen out the 'noise' of clinical research. (wikipedia.org)

It turned out that in nearly half of the sick patientsless than three months, and those treated with placebo showed a marked improvement. (health-alphabet.com)
Belief in the treatment can lead to a perceived or actual improvement of the condition. (scienceblog.com)

Anatomy1

Diseases29

Chemicals and Drugs142

Analytical, Diagnostic and Therapeutic Techniques and Equipment57

Psychiatry and Psychology12

Phenomena and Processes17

Disciplines and Occupations1

Anthropology, Education, Sociology and Social Phenomena2

Technology, Industry, Agriculture4

Humanities1

Named Groups1

Health Care24

Double-blind17

Randomised placebo controlled1

Versus11

Power of the placebo effect2

Methods5

Study33

Patients in the placebo2

Significantly6

Phase4

Efficacy and safety3

Plus Placebo1

Patient's4

Outcome6

Therapeutic1

Trial10

Effect28

Alleviation2

Results13

Nivolumab1

Ointment4

Controlled trials1

Participants2

Anxiety2

Orally1

Interventions2

Outcomes1

Effectiveness3

Dosage1

Depression2

Tablets1

Improves1

Olanzapine1

Reduction2

Group4

Remission3

Baseline1

Superior2

Survival1

Effective8

Symptom1

Illness2

Scientists1

Clinicians1

Genes2

Intervention1

Chronic6

Tolerability2

Adverse1

Latin1

Daily4

Patient7

Antibiotic2

Pills1

Symptoms3

Infection3

Research3

Improvement2