Treatments metastasis. Medical search. Frequent questions

In the clinical trial, patients were treated with high-dose arginine or placebo oral suspensions an hour before radiotherapy for their brain metastases-;tumors in the brain that represent the spread from primary tumors elsewhere, such as the lungs. (news-medical.net)
In principle any tumor that overexpresses NO-producing enzymes would be vulnerable to arginine treatment-;and such tumors are very common,' said Dr. Cerchietti, who is also a member of the Sandra and Edward Meyer Cancer Center at Weill Cornell Medicine. (news-medical.net)
The automated planning and delivery streamlines the entire process while the proprietary treatment algorithm allows us to treat simultaneously a number of metastases with optimal dose to the tumors and extremely limited dose spill to surrounding healthy tissue. (brainlab.com)
In a preoperative window study, a sacituzumab in patients with breast cancer brain metastases, or glioblastoma multiforme, patients who received at least 1 dose of sacituzumab and then went to brain resection had therapeutic levels of SG in their resected brain tumors, showing that ADCs can in fact penetrate the blood-brain barrier. (reachmd.com)
Background/Aim: Intradural cauda equina metastases (ICEM) are rare tumors that reduce functional status. (iiarjournals.org)
Neoplastic CES may arise from cauda equina primary tumors or secondary metastases, which may involve the vertebral bones, resulting in fracture and external nerve compression ( 5 ). (iiarjournals.org)
Lung metastases are cancerous tumors that start somewhere else in the body and spread to the lungs. (medlineplus.gov)
Once these cancerous cells find a new "home" in other organs/body parts, they start to form new tumors, these are called metastasis. (oncology-clinics.com)
This runs counter to the prevailing assumption that metastasis occurs late in advanced primary tumors. (genomeweb.com)
There was substantial agreement regarding the expression of HER2 in primary tumors and metastases, and ER at metastases, between local and central laboratories. (springer.com)
Recently, the 12th St Gallen International Breast Cancer Conference Expert Panel recommends that the subtype classification of breast cancer, namely 'HR positive' (including 'luminal A' and 'luminal B' tumors), 'HER2 amplified' and 'triple negative,' should guide the treatment plan for breast cancer patients. (springer.com)
The term "Krukenberg tumor" is used in practice to include all metastatic ovarian tumors although only 40% of ovarian metastases are due to Krukenberg tumor which is a signet cell gastrointestinal malignancy [1]. (symptoma.com)
Krukenberg tumors are associated with bilateral, asymmetrical enlargement of the ovaries without peritoneal adhesions and deposits while metastases from other tumors are embedded within the ovarian capsule or in the peritoneum [1]. (symptoma.com)
Treatment strategies for liver metastatic lesions vary significantly between different tumors, because of their unique biological characteristics. (cancertreatmentjournal.com)
In this review, we have summarized the therapeutic options for non-colorectal cancer liver metastases in neuroendocrine tumors, gastrointestinal stromal tumors, pancreatic cancer, kidney cancer, and breast cancer. (cancertreatmentjournal.com)
Criteria for patients to receive surgery include: well-differentiated G1/G2 tumors, absence of distant lymph node metastasis, absence of extrahepatic metastasis, absence of diffuse peritoneal metastasis, and absence of right cardiac dysfunction. (cancertreatmentjournal.com)
Compared to the non-surgical group, palliative resection of the primary tumor significantly improved the 5-year survival rate (35.7%-83% versus 5.4%-50%), even in patients with primary tumors and unresectable metastases sites 4 . (cancertreatmentjournal.com)
The term "liver metastases" refers to cancerous tumors that have spread to the liver from somewhere else in the body. (liversurgeryny.com)
Liver metastases refer to tumors that could be in just one lobe of the liver or in many liver segments . (liversurgeryny.com)
Although brain metastases are thought to be at least 5 times as common as primary brain tumors-affecting about 200,000 people each year in the United States-suboptimal treatment impairs quality of life and survival. (medlink.com)
How to spot the symptoms of pancreatic neuroendocrine tumors so your patients can receive the right treatment. (mayoclinic.org)
However, several key problems have not been solved, including the sequence of local intervention and systemic treatment, the selection of surgical resection or RFA for local treatment, and the evaluation of tumors' sensitivity to chemotherapy or RT. (biomedcentral.com)
Metastasis is a process of migration of tumour cells from the primary cancer site to a distant location where the cancer cells form secondary tumors. (wikipedia.org)
These PDXs display invasive growth, spontaneous metastasis, and recapitulate the histology, protein marker expression, and clinically important gene copy number changes of the original tumors. (lu.se)
We combine next generation sequencing, in vitro drug testing , cell- and molecular biology techniques, in vivo drug testing and advanced in vivo imaging to understand and target metastatic and treatment resistant tumors. (lu.se)

Ovarian cancer comes back, or recurs, after treatment in more than 80% of cases. (webmd.com)
At 18 Spanish hospitals, when a patient with brain metastasis undergoes surgery, they can donate a tiny part of their brain to the first repository of brain metastasis living samples in the world, based at CNIO (Spanish National Cancer Research Centre). (news-medical.net)
It is a pioneering collection in the world, created to accelerate the search for therapies against brain metastasis, a disease that affects up to 30% of patients with systemic cancer. (news-medical.net)
The creators of this repository are two researchers from CNIO, Manuel Valiente, head of the Brain Metastasis Group, and Eva Ortega-Paíno, director of the Biobank, who set out in the journal Trends in Cancer the advantages of the collection, called RENACER -Spanish acronym for the National Brain Metastasis Network-, which in just three years has compiled samples from more than 150 patients. (news-medical.net)
Treatment with arginine, one of the amino-acid building blocks of proteins, enhanced the effectiveness of radiation therapy in cancer patients with brain metastases, in a proof-of-concept, randomized clinical trial from investigators at Weill Cornell Medicine and Angel H. Roffo Cancer Institute. (news-medical.net)
Cancer in this location has different names, including leptomeningeal metastases (LM), carcinomatous meningitis, and neoplastic meningitis. (newhopemedicalcenter.com)
Leptomeningeal metastases are uncommon, but they are serious complications of cancer, including melanoma , breast cancer , and lung cancer . (newhopemedicalcenter.com)
Signs of leptomeningeal metastases result from cancer cells blocking the normal exits for CSF, which causes fluid buildup and increased pressure in the brain. (newhopemedicalcenter.com)
Our LM treatments here at New Hope Unlimited are strategically designed by a team of experts in cancer, medicine, and holistic healing methods. (newhopemedicalcenter.com)
At New Hope Unlimited, we pride ourselves in providing superior comfort, cleanliness, and cancer care at our 8,000 square foot medical treatment center in San Luis Rio Colorado, Mexico. (newhopemedicalcenter.com)
Breast cancer is responsible for more than 50% of cutaneous metastases. (karger.com)
Method s: Between February 2015 and October 2016, in 3 centers in Poland, 47 ECT procedures were performed in 38 patients with metastasis of breast cancer to the skin. (karger.com)
The results of our study demonstrate a high effectiveness of ECT in the treatment of cutaneous metastasis from breast cancer. (karger.com)
Munich, Germany, August 27, 2014 -New Automatic Brain Metastases Planning¹ software by Brainlab has been clinically used to successfully deliver fast, efficient radiosurgery treatment to a patient with metastatic brain cancer. (brainlab.com)
Assuta Hospital used the Brainlab software to plan and deliver treatment to a 62-year-old female patient with breast cancer. (brainlab.com)
The breast cancer had metastasized to the patient's brain and she previously responded to treatment with whole brain radiotherapy (WBRT). (brainlab.com)
Over the past several years, multiple treatment advancements have given oncologists the ability to better target brain metastases in patients with HER2-positive metastatic breast cancer. (curetoday.com)
Substantial advancements over the past several years have given rise to a more tailored approach in the treatment of active central nervous system disease - particularly brain metastases - in patients with HER2-postive metastatic breast cancer, according to an expert. (curetoday.com)
Tukysa)-based therapy improves overall survival for patients with HER2-positive breast cancer with brain metastases, while maintaining overall health-related quality of life, with some potential benefit also seen in leptomeningeal metastasis. (curetoday.com)
Certain risk factors that are associated with brain metastases in this patient population, according to Pegram, include a triple-negative histology, presence of cancer cells in the lymph nodes, a short time to distant disease relapse and young age. (curetoday.com)
Within the HER2 subtype, the SystHERs study of 977 patients further identified an age of less than 50 years, recurrent metastatic breast cancer and hormone-receptor negative status as additional risk factors for central nervous system metastases. (curetoday.com)
Brain metastases often occur quickly during the course of HER2-positive metastatic breast cancer, and (that) negatively impacts quality of life and overall survival," Pegram said. (curetoday.com)
In these studies, a high-dose version of Herceptin (trastuzumab) was tested in combination with Perjeta (pertuzumab) for patients with HER2-positive metastatic breast cancer with progressive brain metastases, with promising results demonstrated in the phase 2 PATRICIA study (NCT02536339). (curetoday.com)
Recently, Peritoneal Surface Oncology Group International (PSOGI) developed a novel comprehensive treatment consisting of cytoreductive surgery (CRS) and perioperative chemotherapy (POC) for the treatment of peritoneal metastases (PM) from gastric cancer with curative intent. (lu.se)
And today we're going to learn a little bit about antibody drug conjugates in HER2-expressing breast cancer to brain metastases. (reachmd.com)
Breast cancer to brain metastases are a very common complication of metastatic breast cancer. (reachmd.com)
Their prevalence is about 30 to 50% in HER2-positive and triple-negative breast cancer, and about 14% of patients that have hormone receptor-positive HER2-negative breast cancer will ultimately develop brain metastases. (reachmd.com)
While chemotherapy has very limited activity in breast cancer brain metastases, antibody drug conjugates such as trastuzumab deruxtecan, are showing very promising and somewhat surprising results in this critical unmet need trastuzumab deruxtecan has shown impressive activity in both stable and active HER2-positive brain metastases. (reachmd.com)
The first antibody drug conjugate to show intracranial activity in breast cancer brain metastases was trastuzumab emtansine, or T-DM1. (reachmd.com)
The spread of cancer from its site of origin to another location in the body is called metastasis. (yourcancercare.com)
Consequently, they are commonly attributed to either the cancer treatment or the malignancy itself. (yourcancercare.com)
Experts are working hard to test out new cancer treatments every day. (healthline.com)
While recognizing cancer warning signs may help people with cancer seek diagnosis and treatment, some cancers may be harder to detect early and may not show symptoms until the later stages. (healthline.com)
The new location must allow the cancer to thrive, if it's not adequate for cancer growth, metastasis may not form. (oncology-clinics.com)
By identifying the primary location doctors can target cancer with specific treatment. (oncology-clinics.com)
When a cancer then metastases, doctors may mistake the metastasis as the primary location, in some cases, administering a treatment that doesn't fit with a specific cancer. (oncology-clinics.com)
Metastasis are almost always found in the last-and most severe-stage of cancer. (oncology-clinics.com)
Their presence signifies a strong cancer that may be resistant to many treatments. (oncology-clinics.com)
Also, when a cancer metastasizes, it usually changes and evolves somewhat, meaning treatment options which may have worked in the primary location will no longer be as effective, or may now be completely useless. (oncology-clinics.com)
The key to cancer treatment is speed. (oncology-clinics.com)
The sooner you identify a cancer, the better chance you have of beating the condition before it metastases. (oncology-clinics.com)
Lung cancer metastasis is a serious health concern, with cancer cells spreading from the lungs to other parts of the body. (cancercenterforhealing.com)
The Cancer Center for Healing in Irvine, CA, under the expert guidance of Dr. Leigh Erin Connealy, offers comprehensive and holistic treatment modalities for individuals with lung cancer metastasis. (cancercenterforhealing.com)
This article will provide an overview of lung cancer metastasis, including its causes, symptoms, diagnosis, and treatment options, with a focus on the integrative therapies offered at the Cancer Center for Healing. (cancercenterforhealing.com)
What is Lung Cancer Metastasis? (cancercenterforhealing.com)
Metastasis is a significant factor in determining the prognosis and treatment options for lung cancer. (cancercenterforhealing.com)
The presence of metastasis indicates that cancer has progressed to an advanced stage, making it more challenging to manage and treat. (cancercenterforhealing.com)
By focusing on personalized treatment plans, the Cancer Center for Healing helps individuals with lung cancer metastasis achieve optimal health and well-being. (cancercenterforhealing.com)
Environmental factors, such as smoking, exposure to air pollution, and a weakened immune system, can also increase the risk of lung cancer metastasis. (cancercenterforhealing.com)
Their team of cancer specialists works together to develop personalized treatment plans that address the root causes of cancer and promote holistic healing. (cancercenterforhealing.com)
By targeting the underlying factors that contribute to metastasis, they can help improve the overall health and well-being of cancer patients. (cancercenterforhealing.com)
For more information on the holistic treatment modalities available for lung cancer metastasis at the Cancer Center for Healing, schedule a consultation by calling (949) 680-1880. (cancercenterforhealing.com)
NEW YORK (GenomeWeb) - Many colorectal cancer metastases may have arisen and spread even before the primary tumor was large enough to be detected, according to a new study. (genomeweb.com)
Generally, metastases have been thought to arise as a subset of cancer cells accumulates additional genomic alterations that enable them to spread. (genomeweb.com)
She and her colleagues analyzed exome sequencing data from 23 patients with colorectal cancer who had distant metastases to the liver, a common metastatic site, or the brain, a less common, but often fatal metastatic site. (genomeweb.com)
At the same time, the researchers found in a separate cohort of 2,751 patients with colorectal cancer, including 938 patients with metastatic cancer, that most metastases harbored a set of core colorectal cancer driver genes, but also an additional candidate metastasis driver gene. (genomeweb.com)
Topic: How Does the Prostate Cancer Microenvironment Affect the Metastatic Process and/or Treatment Outcome? (oaepublish.com)
These results reinforce the recommendation for performing confirmatory biopsies of metastases, not only to avoid misdiagnosis of breast cancer relapse, but also to optimize treatment (clinicaltrials.gov identifier: NCT01377363). (springer.com)
Breast cancer metastases are most commonly found in bone, an indication of poor prognosis. (degruyter.com)
Pathway-based biomarkers identification may help elucidate the cellular signature of breast cancer metastasis in bone, further characterizing the etiology and promoting new therapeutic approaches. (degruyter.com)
A total of 61 DEGs, included 27 down-regulated and 34 up-regulated, were found to be significant in breast cancer bone metastasis. (degruyter.com)
DEGs Bcl3, ADGRG7, FABP4, IRF4, their regulating miRNAs and TFs have strong impact on proliferation and metastasis of breast cancer in bone tissues. (degruyter.com)
Bone cancer metastases usually occur in the axial skeleton, in areas with active hematopoiesis and high red marrow content. (degruyter.com)
In this study, we explore different signaling pathways and associated molecular mechanisms of underlying primary breast cancer development, along with the formation of metastases in the bone. (degruyter.com)
Why does cancer therapy lack effective anti-metastasis drugs? (nih.gov)
The suppression of cancer metastasis is an urgent therapeutic need. (nih.gov)
There are two complementary anti-metastasis strategies, the prevention of cancer cell dissemination and the suppression of already existing metastases. (nih.gov)
Because cancer metastasis is often fatal, improved and innovative approaches to anti-metastasis drugs are eminently suited to play a lead role in changing the standards of drug development. (nih.gov)
Activated NF-kB then translocates into the nucleus, and drive transactivation of anti-apoptotic genes, inflammatory cytokines, and oncogenic miRNAs, resulting in therapeutic resistance and aggressive metastasis in cancer cells. (oaepublish.com)
J Cancer Metastasis Treat 2017;3:217. (oaepublish.com)
J Cancer Metastasis Treat 2017;3:45-59. (oaepublish.com)
J Cancer Metastasis Treat 2017;3:190-205. (oaepublish.com)
J Cancer Metastasis Treat 2017;3:231-43. (oaepublish.com)
J Cancer Metastasis Treat 2017;3:278-87. (oaepublish.com)
J Cancer Metastasis Treat 2017;3:288-301. (oaepublish.com)
Similar to colorectal cancer, liver metastases of neuroendocrine cancer, gastrointestinal stromal tumor, and pancreatic cancer also determine patient prognosis to some extent. (cancertreatmentjournal.com)
With the development of surgical techniques, pharmaceutical research, and perioperative treatment, therapeutic strategies for non-colorectal cancer liver metastases have improved greatly during the last two decades, inevitably leading to some controversies. (cancertreatmentjournal.com)
Here, we have reviewed the current treatment options for non-colorectal cancer with the aim of enhancing our understanding of the latest developments in this field. (cancertreatmentjournal.com)
A systematic review of the therapeutic approaches for various cancer-related liver metastases would provide a better understanding of the latest progression and controversies regarding the surgical options, systematic chemotherapy, and palliative treatment. (cancertreatmentjournal.com)
6. What is the systematic therapy scheme for different cancer liver metastases? (cancertreatmentjournal.com)
Purpose The aim of this study was to evaluate the outcomes of(68)Ga prostate-specific membrane antigen (Ga-68-PSMA) positron-emission tomography (PET)/CT-based metastasis-directed treatment (MDT) for oligometastatic prostate cancer (PC). (uludag.edu.tr)
In their new editorial, researchers Marta Vaz Batista, José Perez-Gracia, Inês Eiriz, Maria Gion, Antonio Llombart, Sofia Braga, and Javier Cortés from Medica Scientia Innovation Research (MEDSIR) and Hospital Professor Doutor Fernando Fonseca discuss new drugs available for breast cancer (BC) patients with brain metastasis (BM). (oncotarget.net)
Breast cancer deaths are most commonly caused by the metastasis of tumor cells to distant organ sites that favor their growth. (grantome.com)
Bone is a frequent site of metastasis of some of the most common human malignancies including breast, prostate and lung cancer. (grantome.com)
Despite decades of research on these later stages, the early stages of cancer metastasis are not well-understood. (grantome.com)
Furthermore we have obtained a TGF-beta inhibitory antibody for testing in pre-clinical models of breast cancer metastasis to bone. (grantome.com)
Importantly, Veterans have a higher incidence of breast cancer than civilians3, and have poorer survival 4, 5, likely due to an increase of metastases. (grantome.com)
Some liver cancer researchers say that because liver metastases have spread from the original cancer site, the disease is so advanced that liver resection is pointless. (liversurgeryny.com)
Based on these results, the best in class liver cancer surgeon believes from experience and from performing more than 650 liver resections since 2003, the NYC liver surgeon favors surgical removal of liver metastases whenever possible. (liversurgeryny.com)
Every patient is unique and the liver surgeon's world-class team develops a personalized cancer treatment strategy for each patient based on the patient's current and original liver scans, current liver function, overall health condition, and many other factors. (liversurgeryny.com)
The colon cancer surgery treatment ( Liver Metastases Surgery ) is always coordinated with all the doctors involved in the patient's care. (liversurgeryny.com)
Patients and medical professionals from America and around the world seek out Dr. Alden's specialized best in class individualized cancer treatments and services including his expert surgical management of the patient's unique condition. (liversurgeryny.com)
For more information regarding Colon Cancer Surgery / Liver Metastases Surgery or to schedule a consultation, please feel free to contact the NYC Liver, Pancreatic & Bile Duct Oncological Surgeon, Dmitri Alden, MD, FACS, today by phoning his NYC office (212) 434-6216 or contacting us online . (liversurgeryny.com)
Our scientists pursue every aspect of cancer research-from exploring the biology of genes and cells, to developing immune-based treatments, uncovering the causes of metastasis, and more. (mskcc.org)
One-third of patients with colon cancer will develop metastases to the liver. (mayoclinic.org)
Sean P. Cleary, M.D., surgical oncologist for Mayo Clinic in Rochester, Minnesota, explains the safe and aggressive treatment options used by Mayo Clinic physicians when colorectal cancer has metastasized to the liver. (mayoclinic.org)
Mayo Clinic head and neck cancer specialists discuss de-escalation and transoral surgery treatment advances and the benefits to patients. (mayoclinic.org)
Mayo Clinic specialists share their approach to head and neck cancer treatment and reconstruction using 3D printing. (mayoclinic.org)
Learn about the latest strategies for effective breast cancer treatment. (mayoclinic.org)
The technique holds tremendous potential in improving the diagnosis and treatment of pancreatic cancer. (frontiersin.org)
Moreover, single-cell sequencing provides unique insights into the mechanisms of pancreatic cancer metastasis and cachexia, paving the way for developing novel preventive strategies. (frontiersin.org)
Overall, single-cell sequencing has immense potential in promoting early diagnosis, guiding personalized treatment, and preventing complications of pancreatic cancer. (frontiersin.org)
Emerging single-cell sequencing technologies will undoubtedly enhance our understanding of the complex biology of pancreatic cancer and pave the way for new directions in its clinical diagnosis and treatment. (frontiersin.org)
Surgical resection is currently the sole curative treatment for pancreatic cancer. (frontiersin.org)
Presently, the standard first-line treatment for advanced pancreatic cancer is gemcitabine-based chemotherapy. (frontiersin.org)
Applications of single-cell sequencing technology in the diagnosis and treatment of pancreatic cancer. (frontiersin.org)
Resection for colorectal cancer liver metastases is indicated when an R0 resection with preservation of a sufficient future liver remnant (FLR) is achievable. (nih.gov)
However, the advent of PSMA PET is opening up this stage of prostate cancer to earlier treatment and hopefully better outcomes. (kakbik.info)
The Prostate Cancer Research Institute (PCRI) is a 501(c)(3) not-for-profit organization that is dedicated to helping you research your treatment options. (kakbik.info)
For over 150 years, scientists have used changes in nuclear size prognostically, because such changes strongly correlate with increased metastasis for many cancer types. (uef.fi)
Mechanisms underlying this are still not well understood, especially as the nuclear size changes can be in both directions: for instance, size increases in prostate and breast cancer, and decreases in lung cancer both correlate with increased metastasis. (uef.fi)
As these drugs acted cancer cell-type specifically in the study and they are already known to be non-toxic to people, they could potentially be helpful in reducing metastasis without increasing the already high toxicity of chemotherapy regimens. (uef.fi)
Engaging similar screens for other cancer types using nuclear size as a simple, easy-to-access readout will likely identify many more cancer-type specific drugs with potential to reduce metastasis with limited systemic toxicity", says Senior Researcher Sylvain Tollis , leader of the Quantitative Cell Biology group at the Institute of Biomedicine, University of Eastern Finland. (uef.fi)
To study the pattern and treatment outcome of rectal cancer (RC) with concurrent locoregional recurrence (LR) and distant metastasis (DM) after total mesorectal excision (TME) and to identify patient-, disease-, and treatment-related factors associated with differences in prognosis after concurrent LR and DM. (biomedcentral.com)
All patients received single or multiple treatment modalities under the guidance of multidisciplinary team (MDT) of colorectal cancer in Fudan University Shanghai Cancer Center. (biomedcentral.com)
Breast cancer metastatic mouse models are experimental approaches in which mice are genetically manipulated to develop a mammary tumor leading to distant focal lesions of mammary epithelium created by metastasis. (wikipedia.org)
It also confirms the genetic heterogeneity between the primary neoplasm of breast cancer patients and their respective metastases. (wikipedia.org)
Breast cancer phenotypes periodically express genes in metastasis that are indispensable for the metastatic process. (wikipedia.org)
Primary Treatment for Clinically Early Cervical Cancer with Lymph Node Metastasis: Radical Surgery or Radiation? (bvsalud.org)
In early cervical cancer stage T1a, T1b1, and T2a1, primary surgery may result in longer OS than primary radiation for patients with and without lymph node metastasis . (bvsalud.org)
Spread of the cancer to other organs ( metastasis ). (medlineplus.gov)
Salivary gland cancer treatment (adult) (PDQ) - health professional version. (medlineplus.gov)
Treatment protocols for cancer of unknown primary (CUP) are provided below, including treatment for metastasis to cervical lymph nodes, in women with isolated axillary adenopathy, for metastatic melanoma to a single nodal site, and for cancer of unknown primary in unselected patients, as well as common chemotherapeutic agents in clinical practice. (medscape.com)
Patients with cancer of unknown primary should always be offered clinical trial enrollment as an option for treatment. (medscape.com)
If a guy learns that he has prostate cancer, he should work with his doctor to tailor the treatment that works for him. (cdc.gov)
CDC's prostate cancer expert, Dr. Ingrid Hall, explained, "George's experience highlights the importance of social support in the decision-making, treatment, and follow-up period following a cancer diagnosis. (cdc.gov)
Hi everyone, my name is Marco and I have stage 4 prostate cancer with metastasis. (cdc.gov)
Troeschel AN, Leach CR, Shuval K, Stein KD, Patel AV. Physical Activity in Cancer Survivors During "Re-Entry" Following Cancer Treatment. (cdc.gov)
The transition from active cancer treatment into survivorship, known as re-entry , remains understudied. (cdc.gov)
When breast cancer metastasizes to bone, treatment options are limited. (cdc.gov)
Crizotinib Versus Conventional Chemotherapy in First-Line Treatment for ALK-Positive Non-Small Cell Lung Cancer: A Systematic Review and Meta-Analysis. (cdc.gov)

Therapies are very limited for patients that experience brain metastases, and newer therapies are always needed. (reachmd.com)
The treatment options for NET liver metastases include surgical resection, liver transplantation, loco-regional therapies, and medical treatment. (cancertreatmentjournal.com)
2) Evaluate the effectiveness of early bone-specific TGF-beta inhibition on bone metastases, 3) Test the effectiveness of combination therapies that inhibit both TGF-beta with Gli2 on bone metastases. (grantome.com)
Since bone metastases occur in 70% of women with metastatic disease causing severe morbidity and increased mortality, it is critical that more effective therapies for the treatment of bone metastases are developed6. (grantome.com)
Understanding and targeting earlier stages of tumor metastasis to bone will be more effective for treating bone metastases than current therapies that focus on late stages of disease. (grantome.com)
Mayo Clinic myeloma specialists discuss the latest in treatment and risk adaptive therapies. (mayoclinic.org)
It unlocks novel dimensions by uncovering elusive cell populations and tumor heterogeneities for early detection, unraveling mechanisms of treatment resistance, tailoring therapies to individuals, and illuminating metastasis and cachexia pathways, thereby opening fresh avenues for preventive strategies. (frontiersin.org)

Recent developments in surgical treatment, radiotherapy, and chemotherapy have improved patient outcomes. (iiarjournals.org)
Surgery is the primary treatment of skeletal metastases from renal cell carcinoma, because radiation and chemotherapy frequently are not effecting the survival. (biomedcentral.com)
Gender, location of metastases, time between diagnosis of renal cell carcinoma and treatment of metastatic disease, incidence of local recurrence, radiation and chemotherapy did not influence survival. (biomedcentral.com)
In the liver surgeon's opinion, a combination of liver resection and chemotherapy, possibly along with other oncological treatments, offers the best chance of a successful outcome. (liversurgeryny.com)
Hence, continued advancements in diagnostic techniques, chemotherapy and radiation therapy regimens, targeted therapy strategies, and cachexia treatments will be critical for improving patient outcomes ( Figure 1 ). (frontiersin.org)
Treatments that include platinum-based chemotherapy are used in patients with squamous cell carcinoma. (medscape.com)
The chemotherapy, radiation, hormone treatment and the medication are helping. (cdc.gov)
Combination chemotherapy versus temozolomide for patients with methylated MGMT (m-MGMT) glioblastoma: results of computational biological modeling to predict the magnitude of treatment benefit. (cdc.gov)

The procedure was performed at Assuta Hospital in Tel Aviv, where clinicians treated a patient with multiple metastases during a single fraction, 20-minute radiosurgery session with only six minutes of 'beam-on' time, establishing a new benchmark in treatment consistency, conformity and efficiency. (brainlab.com)
This multiple metastases software will impact the way brain metastases are treated with radiosurgery from now on. (brainlab.com)
The Brainlab Automatic Brain Metastases Planning provides a very fast planning and delivery solution resulting in a very conformal and 'monitor-unit-efficient' treatment of multiple metastases. (brainlab.com)
0.001) compared to patients with multiple metastases. (biomedcentral.com)
Patients with oligometastatic disease (OMD) achieved no evidence of disease (NED) status more frequently than those with multiple metastases ( P = 0.003). (biomedcentral.com)

In this clinical talk, Christopher P. Cifarelli, MD and Henning Kahl, MD share their experiences with intraoperative radiotherapy (IORT) during brain metastases treatments and illustrate how the treatment workflow looks like when conventional radiotherapy is complemented by IORT. (zeiss.com)
In the first part, Christopher P. Cifarelli, MD introduces the intraoperative radiotherapy treatment approach and explains in detail the pre- and intraoperative workflow factors for a brain metastases treatment using IORT - from patient selection over resection techniques to IORT specific procedure steps, like applicator sizing, draping, applicator placement and treatment. (zeiss.com)
Nine months later, her metastases recurred and her radiotherapy team at Assuta was able to use Brainlab Automatic Brain Metastases Planning software to treat all four of her metastases in a single twenty-minute session. (brainlab.com)
This new software is opportune and comes at a time when the paradigm of treatment of multiple brain metastases is shifting from whole brain radiotherapy to stereotactic treatment of the metastases whilst reducing toxicity to normal brain. (brainlab.com)

We've learned that following surgical removal of a brain metastases that localized radiation can help 'sterilize' the borders to decrease local recurrence," Schiff explained. (curetoday.com)
Perioperative variables collected were age and gender of the patient, type of surgery, complications, time period after first diagnosis of RCC and after onset of symptoms, metastatic pattern, location of metastases, incidence of pathologic fracture and local recurrence and time of survival. (biomedcentral.com)
Although 80% of the patients experienced recurrence within 5 years after resection, the outcome of liver resection was still better when compared to other treatments 3 . (cancertreatmentjournal.com)

The ALSYMPCA trial was a phase III, randomized, double-blind, placebo-controlled international study of radium-223 chloride (Xofigo®) plus best standard of care vs. placebo plus best standard of care in patients with CRPC, symptomatic bone metastases, and no known visceral metastatic disease. (urotoday.com)
Bone metastases usually occur by way of the bloodstream. (yourcancercare.com)
Bone metastases may cause pain, may make the bones more susceptible to fractures, and may cause increased levels of calcium in the blood. (yourcancercare.com)
Bone metastases result in lesions or injury to the bone tissue. (yourcancercare.com)
Bone metastases generally occur in the central parts of the skeleton, although they may be found anywhere in the skeletal system. (yourcancercare.com)
Complications that are associated with bone metastases include pain, bone loss, hypercalcemia, and decreased blood cell production. (yourcancercare.com)
A common complication, and often the initial symptom of bone metastases, is bone pain. (yourcancercare.com)
Damage or pressure to this tissue caused by bone metastases may result in a great deal of pain. (yourcancercare.com)
Bone pain due to metastases may be hard to differentiate from ordinary low back pain or arthritis. (yourcancercare.com)
The most notable difference is that pain due to bone metastasis is typically more constant, even at night. (yourcancercare.com)
This disorder results from the destruction of bone associated with metastases. (yourcancercare.com)
Bone metastases can also cause a decrease in blood cell production. (yourcancercare.com)
27 patients had a solitary bone metastasis, 20 patients multiple bone metastases and 54 patients had concomitant visceral metastases. (biomedcentral.com)
Patients with solitary bone metastasis from RCC reportedly have the best prognosis, with a 5 year-survival rate between 35% and 60% [ 8 ]. (biomedcentral.com)
Owing to the longer survival of patients with solitary bone metastasis, a number of authors recommend a surgical approach with curative intent and implant stabilization to prevent local disease progression [ 7 - 11 ]. (biomedcentral.com)
The surgical treatment for bone metastases varied in each patient. (biomedcentral.com)
Factors influencing the choice of surgery included age, disease status, symptoms, morbidity of the patient, the location and extend of bone disease, existence of extraosseous metastases and the patient's wishes. (biomedcentral.com)
In conclusion, present study revealed that DEGs are directly involved in of breast tumor metastasis in bone tissues. (degruyter.com)
Metastasis to bone typically results in a poor prognosis, reducing life expectancy to 2-3 years post-diagnosis. (degruyter.com)
Bone metastases are devastating to the patient as they are associated with intractable pain, hypercalcemia (abnormally high concentration of calcium in the blood), disabling pathologic fractures, and nerve compression syndromes. (grantome.com)
This strongly suggests that better therapeutic approaches are required to more effectively treat patients with bone metastases. (grantome.com)
However, it is clear that multiple factors and cell types within the tumor-microenvironment are important in these early stages of bone metastases. (grantome.com)
is a major contributor to bone metastases and is likely important to these early stages. (grantome.com)
This will allow us to investigate the importance of TGF-beta signaling in specific cell populations during the development of bone metastases. (grantome.com)
This proposal seeks to better understand the role of TGF-beta signaling in the tumor micro-environment and to develop strategies for treating bone metastases early. (grantome.com)
A bone scan showed widespread skeletal metastasis. (urotoday.com)
However, when bone metastasis occurs, it is the second most common site after the lung [1]. (urotoday.com)
There are few case reports describing clear RCC and bone metastasis in the literature. (urotoday.com)
Failure to treat bone metastases is thought to be due to therapy-resistant features of the bone marrow microenvironment. (cdc.gov)
Using a murine model of bone metastatic mammary carcinoma, we demonstrate that systemic delivery of polymer nanoparticle s loaded with cyclic dinucleotide (CDN) agonists of stimulator of interferon genes (STING) inhibited tumor growth and bone destruction after 7 days of treatment. (cdc.gov)
While acquired resistance mechanisms, including increased levels of immunosuppressive cytokines and the infiltration of regulatory T cells, ultimately limited antitumor efficacy after 2 weeks of treatment, bone protective effects remained. (cdc.gov)
Significance: Bone metastases are difficult to treat due to the inaccessibility of the bone marrow compartment and the immunosuppressive microenvironment that protects resident stem cells. (cdc.gov)
Rarely, lymph node, lung, or bone metastases cause the presenting symptoms of small thyroid cancers. (msdmanuals.com)

While various risk factors have been reported for distant metastases, risk factors for distant metastases early after treatment of primary tumor have not been investigated. (iiarjournals.org)
This study aimed to evaluate the factors of early distant metastasis after primary tumor resection in patients with STS. (iiarjournals.org)
Additionally, we evaluated risk factors for metastases in patients with distant metastases as early as 6 months after the initial resection of the primary tumor. (iiarjournals.org)
Multivariate analysis revealed that the size of the primary tumor (p=0.0011 and p=0.0167), consultation in a short period after onset (p=0.0325 and p=0.0402), histological high grade (p=0.0006 and p=0.0002), and inadequate surgical margin (p=0.0151 and p=0.0055) were significant predictors for poor prognosis for all distant and lung metastases, respectively. (iiarjournals.org)
Conclusion: The only risk factor for early distant metastasis after primary tumor resection in patients with STS was young age, even though large tumor diameter and histological high grade were risk factors for distant metastasis. (iiarjournals.org)
However, distant metastases still appear frequently after excision of the primary tumor. (iiarjournals.org)
While various risk factors have been reported for distant metastases that significantly affect the prognosis of soft tissue sarcoma ( 12 - 17 ), risk factors for the appearance of distant metastases early after treatment of the primary tumor have not been investigated. (iiarjournals.org)
Further, they noted most of these metastases actually diverged early in the emergence of the primary tumor. (genomeweb.com)
The cells that formed the metastasis were more closely related to the ancestors of the primary tumor than its present-day relatives," Curtis said. (genomeweb.com)
In spite of the relevance of receptor status, the choice of systemic treatment for advanced disease is more often based on the biological characteristics of the primary tumor at the time of initial diagnosis than of the recurrent lesion at the time of relapse. (springer.com)
This may be because for many years, it has been assumed that the biomarker status of the primary tumor and its corresponding metastasis was not different. (springer.com)
Clinical manifestations are due to the primary tumor as well as due to the metastases. (symptoma.com)
Synchronous resection of the primary tumor and liver metastases showed acceptable complication rates (18%-25%) and favorable 5-year survival rates (70%-71%) 6-10 . (cancertreatmentjournal.com)

Solitary bony metastasis from renal cell carcinoma: significance of surgical treatment. (orthobullets.com)
To define the importance of the type of surgical treatment, we retrospectively analyzed the survival rate of 60 patients with solitary bony metastasis from renal cell carcinoma. (orthobullets.com)
Our results indicate that wide surgical excision of a solitary bony metastasis from renal cell carcinoma is not mandatory to improve survival. (orthobullets.com)
We retrospectively reviewed 101 patients operatively treated for skeletal metastases of renal cell carcinoma between 1980 and 2005. (biomedcentral.com)
Adding surgery and/or radiation to systemic therapy (multimodal therapy) improved clinical outcomes in patients with renal cell carcinoma (RCC) with brain metastases, reports a university-based research team. (medpagetoday.com)

We found that the surgical approach to treatment of uveal melanoma with liver metastases improves prognosis. (wjgnet.com)
Background/Aim: Distant metastasis has a strong influence on prognosis in patients with soft tissue sarcoma (STS). (iiarjournals.org)
Particularly, distant metastasis, primarily involving the lungs, has a strong effect on the prognosis of patients with STS. (iiarjournals.org)
In such cases, it is predicted that the prognosis will be worse if distant metastasis appears earlier. (iiarjournals.org)
The main reason for the poor prognosis is the poor response of RCC metastases to radiation and chemotherapeutic regimens [ 7 ]. (biomedcentral.com)
Treatment of liver metastases, to some extent, determines the prognosis of patients. (cancertreatmentjournal.com)
1. What are the incidence, prevalence, and prognosis characteristics of different tumor liver metastases? (cancertreatmentjournal.com)
Although the prognosis remains poor, pursuing NED status through comprehensive treatments may improve the survival of RC patients with concurrent LR and DM after TME. (biomedcentral.com)
Here, our study was designed to study the pattern and treatment outcome of RC with concurrent LR and DM after TME and to identify patient-, disease-, and treatment-related factors associated with differences in prognosis after concurrent LR and DM. (biomedcentral.com)

Rory L. Smoot, M.D., Mayo Clinic surgical oncologist, discusses the discoveries made in the treatment of cholangiocarcinoma and other biliary tract cancers. (mayoclinic.org)

Most of the liver and all of the brain metastases harbored many private clonal somatic SNVs, but no subclonal ones. (genomeweb.com)
Liver metastases occur during the progression of various malignancies. (cancertreatmentjournal.com)
The liver is one of the most common sites of metastases in various malignancies. (cancertreatmentjournal.com)
In addition, we attempt to answer the following questions for different pathological liver metastases. (cancertreatmentjournal.com)
Curative surgical resection is possible in only 10%-25% of NET patients with liver metastases. (cancertreatmentjournal.com)
summarized 29 studies on NET liver metastases, and reported that 63% of the patients achieved R0 resection, with the 5- and 10-year overall survival rates of 70.5% and 42%, respectively 1,2 . (cancertreatmentjournal.com)
Except for CRLM, neuroendocrine tumor (NET) liver metastases are brought into indications of liver transplantation. (cancertreatmentjournal.com)
Modern technology, proper training, and advanced techniques and tools make it possible to remove liver metastases safely, with very little blood loss. (liversurgeryny.com)
Learn more about how Mayo Clinic physicians offer surgery to more patients and improve patient outcomes in treatment of liver metastases. (mayoclinic.org)

The risk of lymph node metastases is influenced by the primary site of the lesion, the degree of histologic differentiation, the degree of the lesion's depth of invasion, and the density of capillary lymphatics. (medscape.com)
When contralateral lymph node metastases occur, the level II lymph nodes are involved most frequently, followed by the level III and level IV nodes. (medscape.com)

Finally, the latest clinical data about IORT in brain metastases is discussed and the main advantages of this treatment approach are summarized. (zeiss.com)
These guidelines, prepared by an expert panel from the American Society of Clinical Oncology (ASCO), implement many of the advances in brain metastases care that have been made over the last few decades. (curetoday.com)
Clinical use of this technology represents a significant paradigm shift for patients with brain metastases," said Stefan Vilsmeier, CEO and Founder, Brainlab. (brainlab.com)
In the KAMILLA clinical trial, where 2,000 patients were enrolled, approximately 400 of them had stable brain metastases at baseline, 126 of those patients had measurable brain metastases, evaluable for intracranial overall response. (reachmd.com)
Clinical characteristics, management strategies, and treatment outcomes were analyzed. (iiarjournals.org)
We evaluated clinical information as a risk factor for distant or lung metastases. (iiarjournals.org)
The aim of this study was to identify clinical, pathological and surgical factors that are associated with better survival of patients after surgical treatment of skeletal metastases from RCC. (biomedcentral.com)
For agents that treat existing metastases, the clinical trial system needs to be modernized. (nih.gov)
In 1990, the value of surgical excision of a single brain metastasis was demonstrated in a landmark prospective, randomized controlled clinical trial. (medlink.com)
Paromomycine, an aminoglycoside, has been tested as a topical ointment for the possible treatment of CL but more clinical trials are needed against the main parasite causing CL [4]. (who.int)
Treatment of children with high-risk neuroblastoma remains largely unsuccessful, because of metastasis and treatment resistance, and is a serious clinical problem. (lu.se)

Patients, '[because they act] as donors during a difficult brain metastasis neurosurgery, play a crucial role and we strongly believe that it is pivotal to empower them,' the researchers explain. (news-medical.net)
The III General Assembly of RENACER took place on 30 October at the Fundación Ramón Areces, in Madrid, an institution that is also funding the project entitled 'National Brain Metastasis Network: Implementation, Development and Coordination. (news-medical.net)
The performance of a brain metastases treatment with IORT from a surgical and radiation oncology point of view. (zeiss.com)
Following, Henning Kahl, MD shares his experiences with IORT in brain metastases from a radiation oncology point of view. (zeiss.com)
He presents the Augsburg IORT concept for patients with brain metastases fostered by illustrative examples. (zeiss.com)
The study, published Nov. 5 in Science Advances, reported the results of administering arginine, which can be delivered in oral form, prior to standard radiation therapy in 31 patients who had brain metastases. (news-medical.net)
Dissecting the treatment-naive ecosystem of human melanoma brain metastasis. (stembook.org)
Guidelines for the treatment of patients with brain metastases is moving from whole brain radiation therapy to less toxic treatment options to potentially improve care and increase survival. (curetoday.com)
Recently released guidelines for the treatment of brain metastases may improve care and survival in these patients by providing evidence-based information on best treatments and outcomes. (curetoday.com)
Schiff, who was co-chair of the ASCO panel that prepared the guidelines, believes that this guidance may improve and even extend the lives of patients with brain metastases , although it may somewhat complicate the decision-making process. (curetoday.com)
When I started in the field, development of brain metastases typically resulted in immediate referral to a radiation oncologist," he said. (curetoday.com)
Twenty years ago, the majority of patients with brain metastases were treated with whole brain radiation, during which radiation is applied to the entire brain (versus a targeted approach) to kill tumor cells. (curetoday.com)
Now, we've learned that patients with only a few brain metastases can be treated with high-dose local therapy (called radiosurgery), which is better at providing long-term control of metastases and doesn't carry the risk of cognitive toxicity. (curetoday.com)
When patients have too many metastases for radiosurgery to be feasible, whole brain radiation's side effects can be reduced by blocking out brain structures crucial for memory (so-called hippocampal-avoidant whole brain radiation) and administering the brain-protective medicine memantine. (curetoday.com)
Lately the brain metastases space has been opening up to the potential of tactics to avoid radiation and surgery altogether. (curetoday.com)
We are starting to see strong evidence that in some cases, new medicines and immunotherapies can control brain metastases , sparing patients (from) radiation, radiosurgery and surgery," Schiff said. (curetoday.com)
The medicines that are starting to show promise in treating patients with brain metastases may provide a glimpse into what this space may be headed in the next two decades, if not sooner. (curetoday.com)
The new software improves the planning of radiosurgery for multiple brain metastases such that each treatment arc covers many metastases, thereby also helping to improve patient comfort by shortening the treatment delivery time. (brainlab.com)
This week we are already treating our third patient with multiple brain metastases with the new software. (brainlab.com)
The Automatic Brain Metastases Planning software effectively articulates the Brainlab vision of indication-specific and highly automated software applications aimed at transforming practice patterns in radiosurgery. (brainlab.com)
There is an approximate four-time greater risk of central nervous system disease in a HER2-positive population, Pegram explained, with brain metastasis appearing in approximately half of those who present with HER2-positive metastatic disease. (curetoday.com)
Although local therapy (defined as treatment - such surgery, radiation, cryotherapy and laser therapy -directed toward a specific organ or area of the body) is commonly used to treat brain metastases in this population, this method is often associated with side effects, according to Pegram. (curetoday.com)
CME: How Do Brain Metastases Affect Your Choice of Systemic Treatment in a Patient with HR+/HER2-low MBC? (reachmd.com)
In the DESTINY-Breast01 subgroup analysis of stable - of patients that had previous stable brain metastases, the median progression-free survival was the same, regardless of whether or not patients had brain metastases, showing that the drug had efficacy in those that had prior CNS disease. (reachmd.com)
We also have several small studies including DEBBRAH, a real-life cohort of patients with active brain metastases treated with T-DXd, and TUXEDO, showing excellent activity of trastuzumab deruxtecan in patients that have active brain metastases. (reachmd.com)
Many brain metastases can be cured or controlled with a combination of surgical resection, stereotactic radiosurgery, and/or whole brain radiation therapy. (medlink.com)
The optimum management of a patient with brain metastasis or metastases benefits from a multidisciplinary team consisting of neurosurgery, radiation oncology, medical oncology, neuroradiology, neuropathology, and the patient's primary physician. (medlink.com)
Surgical resection of brain metastases in modern neurosurgery typically utilizes state-of-the-art techniques including image-guidance or neuronavigation, intraoperative CT, MRI, or ultrasound imaging, electrophysiologic monitoring or mapping, operating microscope, and ultrasonic aspiration. (medlink.com)
Background and Purpose: The addition of systemic drugs to whole-brain irradiation has not improved the survival of patients with multiple brain metastases, most likely because the agents did not readily cross the blood-brain barrier (BBB). (uni-luebeck.de)
Conclusion: This is the first demonstration of cetuximab crossing the BBB and accumulating in brain metastasis. (uni-luebeck.de)

For all but one of the cases analyzed, they found the distant metastases corresponded to a monophyletic clade. (genomeweb.com)
Primary and secondary endpoints were the potential association between the post-CCRT NLR measures and distant metastasis-free survival (DMFS) and overall survival (OS) outcomes. (hindawi.com)
Despite rigorous therapy, the estimated median survival time of such patients is only around 12 months [ 7 ], and 70% of all cases die as a result of extensive distant metastases (DM) [ 8 ]. (hindawi.com)

The site of metastasis shouldn't be immune system adjacent. (oncology-clinics.com)

The major drawback associated with the treatment is that it is painful and costly, relapses occur and above all, resistance develops. (who.int)

ABSTRACT A placebo-controlled trial compared 6% hexadecyl-phosphorylcholine (HePC) and 12% benzethonium chloride ointment with placebo ointment for treatment of cutaneous leishmaniasis. (who.int)

It's a strategy that helps to improve knowledge as well as diagnosis and treatment options, but also brings all the people involved closer together: patients, core researchers, chemical researchers, healthcare professionals, and the biobank. (news-medical.net)
A licensed physician should be consulted for diagnosis and treatment of any and all medical conditions. (medlineplus.gov)
An experienced team involved in the diagnosis and treatment (surgical and/or radiosurgical where indicated) will enhance functional survival. (medlink.com)

Surgery and radiation are feasible and effective treatments but may have debilitating complications. (iiarjournals.org)

Levels of metastasis to cervical lymph nodes. (medscape.com)

Ovarian metastasis is not a rare condition and occurs secondary to malignancies originating from the stomach, colon , breast, endometrium, fallopian tubes , or cervix. (symptoma.com)
Ovarian metastasis accounts for up to 30% of all ovarian malignancies. (symptoma.com)

Treatment outcomes of metastasis-directe. (uludag.edu.tr)
Proper patient selection might improve treatment outcomes. (uludag.edu.tr)

Several chemotherapeutic molecules have proven their potential in treatment of breast tumour. (degruyter.com)
There are various patterns of prevalence of genetic mutations in the genomes of primary breast tumour and its metastases. (wikipedia.org)

A majority of patients with ovarian metastases may be asymptomatic . (symptoma.com)

This article addresses the role of radiation therapy in the management of patients with squamous cell carcinoma metastases of the head and neck . (medscape.com)

We therefore explored factors potentially affecting the survival of patients after surgical treatment. (biomedcentral.com)
A recent study showed that the median tumor progression time of TACE treatment was 14 ± 16 months and median overall survival was 22 ±18 months 12 . (cancertreatmentjournal.com)
However, several research articles have reported 5-year survival rates of more than 50% for the same type of patients who are treated with surgical removal of the metastases. (liversurgeryny.com)
Learn about the latest treatment innovations for pancreatic adenocarcinoma and how these innovations have extended survival. (mayoclinic.org)
The MWA group showed a 4-year overall survival of 41%, compared to 70% for a historic cohort of primarily resected patients and 4% for patients with palliative treatment. (nih.gov)

Advances in neuroimaging have facilitated earlier detection of smaller metastatic lesions, thereby allowing for earlier treatment than had previously been possible. (medlink.com)
Historically, the treatment of oligometastatic disease was complicated by the limitations of imaging-that is, it was usually impossible to detect these lesions before they grew and multiplied. (kakbik.info)
After treatment, all lesions were significantly reduced in size in the treatment group compared with the placebo ointment. (who.int)

Lastly, the impact of receptor discordance on the choice of subsequent systemic treatment was assessed. (springer.com)
Over the last years, new therapeutic strategies targeting the HER2 protein have been introduced for systemic treatment of HER2+ BC - either tyrosine kinase inhibitors, monoclonal antibodies, or antibody-drug conjugates. (oncotarget.net)

Treatment is surgical removal, usually followed by ablation of residual tissue with radioactive iodine. (msdmanuals.com)
Treatment may be repeated after 6 to 12 months to ablate any remaining thyroid tissue. (msdmanuals.com)

Symptoms improve in 70-80% of patients within 48 hours of the start of treatment. (medscape.com)
In a Novartis-sponsored study in the New England Journal of Medicine, researchers found that a CRISPR-Cas9-based treatment targeting promoters of genes encoding fetal hemoglobin could reduce disease symptoms. (genomeweb.com)

Targeting nuclear size: a new approach to reduce metastasis? (uef.fi)
Combination treatment provides better response and control of the disease and is often used in patients with advanced or metastatic disease who clinically are able to tolerate this approach. (medscape.com)

yet, there are currently no effective treatments for metastatic uveal melanoma. (wjgnet.com)

Although it often results in lung metastasis, bony metastases are uncommon. (urotoday.com)

A subset of neoplastic CES, intradural cauda equina metastases (ICEM), represent a rare but challenging entity ( 6 , 7 ). (iiarjournals.org)

Anatomy11

Organisms7

Diseases95

Chemicals and Drugs56

Analytical, Diagnostic and Therapeutic Techniques and Equipment68

Phenomena and Processes24

Disciplines and Occupations1

Information Science2

Health Care16

Tumors25

Cancer131

Therapies7

Chemotherapy8

Multiple metastases5

Radiotherapy4

Recurrence3

Bone33

Primary tumor13

Renal cell carc5

Prognosis9

Cancers1

Liver9

Lymph Node Metastases2

Clinical11

Brain30

Distant3

Site of metastasis1

Occur1

Abstract1

Diagnosis and treatment3

Complications1

Cervical lymph1

Malignancies2

Outcomes2

Breast2

Asymptomatic1

Radiation therapy1

Survival5

Lesions3

Systemic Treatment2

Tissue2

Symptoms2

Approach2

Melanoma1

Bony1

Neoplastic1