Myeloproliferative DisordersMyelodysplastic-Myeloproliferative DiseasesMyelodysplastic SyndromesAnemia, RefractoryLeukemia, Myelomonocytic, ChronicThrombocytosisAnemia, SideroblasticPolycythemia VeraJanus Kinase 2Primary MyelofibrosisThrombocythemia, EssentialLeukemia, Myelogenous, Chronic, BCR-ABL PositiveLeukemia, Myelomonocytic, JuvenileSplenomegalyHematopoiesis, ExtramedullaryFusion Proteins, bcr-ablBone MarrowReceptors, ThrombopoietinLeukemia, Myeloid, AcuteAnemia, Refractory, with Excess of BlastsOncogene Proteins, FusionLeukocytosisGenes, ablHematopoietic Stem CellsSTAT5 Transcription Factorfms-Like Tyrosine Kinase 3Bone Marrow TransplantationBone Marrow CellsMutationLeukemiaGene Expression Regulation, LeukemicCell Transformation, NeoplasticLeukemia, MyeloidHematopoiesisBenzamidesMyeloid CellsChromosomes, Human, Pair 5Translocation, GeneticLeukemia, Myeloid, Chronic, Atypical, BCR-ABL NegativePyrimidinesRetroviridaeMutation, MissensePiperazinesReceptors, ErythropoietinBone Marrow NeoplasmsMice, Inbred C57BLDisease Models, AnimalSignal TransductionProtein-Tyrosine KinasesKaryotypingTransduction, GeneticPreleukemiaProto-Oncogene ProteinsChromosome AberrationsCell ProliferationMonosomyAzacitidineMice, KnockoutFlow CytometryPhenotypeBlast CrisisMegakaryocytesLeukemia, Neutrophilic, ChronicTreatment OutcomePrognosisBone Marrow DiseasesChromosomes, Human, Pair 7Mice, Inbred BALB C