Treatment philadelphia chromosome. Medical search. Frequent questions

To determine whether dasatinib given at a daily dosage of 80 mg/m2 is more effective than imatinib mesylate at a daily dosage of 300 mg/m2 to improve event-free survival of children with Philadelphia chromosome-positive ALL in the context of intensive chemotherapy without prophylactic cranial irradiation. (nih.gov)
A standard bone marrow transplant, aggressive chemotherapy and radiation therapy were revoked, with treatment being deemed a failure after 34 months. (karger.com)
This phase II clinical trial tests a chemotherapy regimen (dose-adjusted etoposide, prednisone, vincristine, cyclophosphamide and doxorubicin with or without rituximab [DA-EPOCH+/-R]) with the addition of targeted therapy (tafasitamab) for the treatment of patients with newly diagnosed Philadelphia chromosome negative (Ph-) B acute lymphoblastic leukemia (B-ALL). (fredhutch.org)
Patients with Philadelphia chromosome-positive (Ph+) ALL receive a tyrosine kinase inhibitor (TKI) in combination with chemotherapy. (medscape.com)
After chemotherapy treatment and disease remission, patients traditionally undergo a stem cell transplant to reduce the chance of disease recurrence. (mdanderson.org)
Hydroxyurea (Droxia, Hydrea), an older chemotherapy, is often given early in the treatment process when there is an urgent need to lower the number of white blood cells. (cancercare.org)
Options may include chemotherapy, targeted therapies that are designed to silence specific proteins, radiation, certain procedures, or no treatment at all. (everydayhealth.com)
Infants may enter remission, but cancer treatments, such as chemotherapy, may lead to adverse long-term effects . (healthline.com)
Since then, chemotherapy has been one of the main therapeutic strategies in cancer treatment, but, to paraphrase Paul Ehrlich, resistance has followed as a faithful shadow. (nature.com)
She says cancer patients may need blood products during chemotherapy, surgery or treatment for complications. (wfyi.org)
The incorporation of blinatumomab into conventional chemotherapy backbones, potentially including other monoclonal antibodies, should produce opportunities to assess the feasibility of such combinations and to increase treatment efficacy," he writes. (medscape.com)
For example, can it improve long-term outcomes compared with standard chemotherapy, and can it be used earlier in the course of the disease and in combination with other treatment approaches? (medscape.com)
A scalp-cooling device was found safe and effective in preventing chemotherapy-induced hair loss in women undergoing adjuvant treatment for breast cancer in an interim analysis of the first prospective, randomized trial of a modern scalp-cooling system. (ascopost.com)
1- Previous treatment of CML with any other anticancer agents including chemotherapy and/or biologic agents or prior stem cell transplant, with the exception of hydroxyurea and/or anagrelide. (who.int)

A combination of ponatinib and blinatumomab was found to be safe and highly effective in patients with newly diagnosed or relapsed/refractory Philadelphia chromosome-positive acute lymphoblastic leukemia (ALL), according to researchers at The University of Texas MD Anderson Cancer Center . (mdanderson.org)
adults with Philadelphia chromosome-negative CD19 positive relapsed or refractory B-precursor acute lymphoblastic leukemia (ALL). (gurufocus.com)
pediatric patients aged 1 year or older with Philadelphia chromosome negative CD19 positive B-precursor ALL which is refractory or in relapse after receiving at least two prior therapies or in relapse after receiving prior allogeneic hematopoietic stem cell transplantation. (gurufocus.com)
Lisaftoclax is a novel, oral, small-molecule, BCL-2 selective inhibitor being evaluated for treatment of relapsed/refractory chronic lymphocytic leukemia or small lymphocytic lymphoma. (pharmacytimes.com)
Ruxolitinib in Pediatric Patients with Treatment-Naive or Steroid Refractory Chronic Graft-Versus-Host Disease: Primary Findings from the Phase 2 REACH 5 Study (Abstract #S245. (businesswire.com)
The drug was recently approved by the US Food and Drug Administration for patients with Philadelphia chromosome-negative precursor B-cell ALL who have relapsed or who were refractory to previous treatment. (medscape.com)
The study reported by Dr Topp and colleagues enrolled 189 patients with Philadelphia chromosome-negative, primary refractory or relapsed disease (first relapse within 12 months of first remission, relapse within 12 months after allogeneic hemopoietic stem cell transplantation, or no response to or relapse after first salvage therapy or beyond). (medscape.com)
Amgen, Inc.) for treatment of Philadelphia chromosome-negative relapsed or refractory precursor B-cell acute lymphoblastic leukemia (R/R ALL). (aacrjournals.org)

The result is that a fusion gene is created by juxtaposing the ABL1 gene on chromosome 9 (region q34) to a part of the BCR (breakpoint cluster region) gene on chromosome 22 (region q11). (wikipedia.org)
It attaches (fuses) to part of the BCR gene on chromosome 22. (medlineplus.gov)

It is a treatment for a type of acute lymphoblastic leukaemia (ALL) called precursor B cell ALL. (cancerresearchuk.org)
The spectrum of acute central nervous system symptoms during the treatment of childhood acute lymphoblastic leukaemia. (cancercentrum.se)

The Philadelphia chromosome or Philadelphia translocation (Ph) is a specific genetic abnormality in chromosome 22 of leukemia cancer cells (particularly chronic myeloid leukemia (CML) cells). (wikipedia.org)
This chromosome is defective and unusually short because of reciprocal translocation, t(9;22)(q34;q11), of genetic material between chromosome 9 and chromosome 22, and contains a fusion gene called BCR-ABL1. (wikipedia.org)
Some cases are confounded by either a cryptic translocation that is invisible on G-banded chromosome preparations, or a variant translocation involving another chromosome or chromosomes as well as the long arm of chromosomes 9 and 22. (wikipedia.org)
The chromosomal defect in the Philadelphia chromosome is a reciprocal translocation, in which parts of two chromosomes, 9 and 22, swap places. (wikipedia.org)
The symbol BCR is derived from breakpoint cluster region, a gene which encodes a protein that acts as a guanine nucleotide exchange factor for Rho GTPase proteins Translocation results in an oncogenic BCR-ABL1 gene fusion that can be found on the shorter derivative chromosome 22. (wikipedia.org)
As technology advanced over subsequent decades, the translocation resulting in the Philadelphia chromosome has been identified, its role in the development of CML has been confirmed, and a therapy directed against the abnormal protein it produces has shown promising results in the treatment of patients with CML. (jci.org)
Chronic Myeloid Leukemia (CML) is associated with translocation between chromosome 9 & chromosome 22, t(9;22)(q34;q11.2) and with the formation of BCR-ABL fusion gene. (who.int)
Here in, we describe a 45 yrs old male, diagnosed as CML in Chronic phase with a complex translocation involving chromosomes 7, 9 & 22. (who.int)

It arises when a piece of chromosome 9 fuses with a chromosome 22. (news-medical.net)
The broken piece of chromosome 9 includes part of the ABL1 gene. (medlineplus.gov)

A new international study of children with a severe form of acute lymphoblastic leukemia (ALL) shows that certain chromosome losses can signal an especially poor response to therapy, but that other chromosome abnormalities have no effect on treatment survival. (news-medical.net)
We expected that additional chromosome abnormalities would mean a worse outcome. (news-medical.net)
that is, abnormalities present in addition to the Philadelphia chromosome. (news-medical.net)
Heerema and her colleagues wanted to learn if secondary chromosome abnormalities contributed to a poor prognosis in children with ALL. (news-medical.net)
They found that having most secondary chromosome abnormalities had little affect on a child's prognosis. (news-medical.net)
That rate held true even when other chromosome abnormalities were present.Surprisingly, cases of this kind of leukemia that showed a second Philadelphia chromosome also did better than all cases combined. (news-medical.net)
This arrest is caused by an abnormal expression of genes, often as a result of chromosomal translocations or abnormalities of chromosome number. (medscape.com)

A complete molecular remission is associated with superior outcomes in patients with Philadelphia chromosome-positive ALL," said Short. (mdanderson.org)
Ponatinib can also benefit people whose CML has not gone into remission after several TKI treatments and those with more advanced CML. (cancercare.org)
But newer treatments that target bcr-abl can also help many people get into remission. (webmd.com)
Patients remain on study treatment until they complete study, relapse from complete remission (CR), have progressive disease, have unacceptable toxicity, withdraw consent, proceed to hematopoietic stem cell transplant (HSCT), or sponsor terminates study. (confex.com)
Alexander Kiani Introduction: Treatment-free remission (TFR) is increasingly considered as treatment goal for patients with chronic myeloid leukemia (CML), but information. (karger.com)
There was no significant difference in rates of complete remission or allogeneic stem-cell transplantation between the two treatments," said Shahin. (medpagetoday.com)

BCR-ABL is the genetic abnormality that drives Philadelphia chromosome-positive ALL. (mdanderson.org)
This chromosomal abnormality is called the Philadelphia (Ph) chromosome. (cancercare.org)
95 % of patients have a characteristic abnormality of the 22nd chromosome-the Philadelphia chromosome. (rxmed.com)

A randomized clinical trial is needed to determine whether the second-generation Abl-tyrosine kinase inhibitor dasatinib is more effective than the first-generation inhibitor imatinib mesylate for childhood Philadelphia chromosome-positive acute lymphoblastic leukemia (ALL). (nih.gov)
Tyrosine kinase inhibitors (TKIs) have improved the outcomes of patients with Philadelphia chromosome positive (Ph+) acute lymphoblastic leukemia (ALL). (clevelandclinic.org)
The treatment regimen for patients with ALL is determined primarily by the Philadelphia chromosome status of the leukemia and the age of the patient. (medscape.com)
However, the presence of the Philadelphia (Ph) chromosome is not sufficiently specific to diagnose CML, since it is also found in acute lymphoblastic leukemia (aka ALL, 25-30% of adult cases and 2-10% of pediatric cases) and occasionally in acute myelogenous leukemia (AML) as well as mixed-phenotype acute leukemia (MPAL). (wikipedia.org)
The leukemia is slow-growing and generally responds well to treatment. (cancercare.org)
Chronic myelogenous leukemia (CML) that is Philadelphia chromosome positive. (cancer.gov)
When choosing a treatment center for acute lymphoblastic leukemia (ALL), you want a team of experienced and compassionate experts. (dana-farber.org)
The Adult Leukemia Program team at Dana-Farber Brigham Cancer Center has extensive experience caring for patients with ALL and are world leaders in advancing the treatment of leukemia. (dana-farber.org)
Specialized program with expertise in cutting-edge leukemia diagnostics, treatment planning, management of therapy and complications. (dana-farber.org)
Role of signal transduction inhibition in treatment of acute myelogenous leukemia/myelodysplasia. (rochester.edu)
Methods: We evaluated the IRF4 expression kinetics during tyrosine kinase inhibitor (TKI) treatment in a cohort of 116 chronic myeloid leukemia (CML) patients to elucidate its role in the disease course. (karger.com)
It's approved by the Food and Drug Administration (FDA) to treat Philadelphia chromosome-positive (Ph+) chronic myeloid leukemia (CML) . (medicalnewstoday.com)
We describe a case of B. breve sepsis in a child with Philadelphia chromosome-positive acute B-cell lymphoblastic leukemia. (cdc.gov)
Philadelphia-positive acute lymphoblastic leukemia (Ph+ ALL). (medlineplus.gov)
This is a type of acute lymphoblastic leukemia that has the Philadelphia chromosome. (medlineplus.gov)
As with any cancer, an early diagnosis and prompt treatment for childhood leukemia is crucial to preventing its spread. (healthline.com)
While leukemia remains the second leading cause of cancer-related death in children, treatment advances have increased the overall survival rates. (healthline.com)
However, despite its rarity, infant leukemia tends to be more aggressive, and requires intense treatment. (healthline.com)
and Sprycel for the treatment of Philadelphia chromosome-positive chronic myeloid leukemia. (seekingalpha.com)
The last decade has witnessed great advances in our understanding of the genetic and biological basis of childhood acute lymphoblastic leukemia (ALL), the development of experimental models to probe mechanisms and evaluate new therapies, and the development of more efficacious treatment stratification. (haematologica.org)
Almost 50 years ago, David Hungerford and I noticed an abnormally small chromosome in cells from patients with chronic myelogenous leukemia (CML). (jci.org)
The Pharmacy Times ® Chronic Lymphocytic Leukemia Resource Center is a comprehensive resource for clinical news and expert insights on treatments for chronic lymphocytic leukemia. (pharmacytimes.com)
Ponatinib could be the first targeted treatment approved in the United States for Philadelphia chromosome-positive acute lymphoblastic leukemia. (pharmacytimes.com)
Philadelphia chromosome-positive chronic myeloid leukemia (Ph+ CML) in chronic phase (CP), previously treated with two or more tyrosine kinase inhibitors (TKIs). (nih.gov)
HOUSTON -- Pediatric treatment protocols outperformed standard therapy for adolescents and young adults (AYAs) with Philadelphia chromosome-negative acute lymphocytic leukemia (ALL), a retrospective cohort study showed. (medpagetoday.com)
Shahin O, et al "A comparison of treatment outcomes in adolescents and young adults (AYA) with Philadelphia-negative acute lymphoblastic leukemia (ALL) treated with hyperCVAD and pediatric-inspired protocols" SOHO 2023: Abstract ALL-363. (medpagetoday.com)
Cooper is a student at Greenwood High School and was diagnosed at age 11 with Philadelphia chromosome positive B-cell acute lymphoblastic leukemia (ALL). (wfyi.org)
Vincristine liposome injection is used to treat Philadelphia chromosome-negative acute lymphoblastic leukemia (Ph- ALL) that has worsen or come back or in patients who have received at least 2 previous cancer treatments that did not work well. (mayoclinic.org)
ÓG, Vaitkeviciene G, Lepik K, Forslund A, Heyman M, Harila-Saari A. Impact of body mass index on relapse in children with acute lymphoblastic leukemia treated according to Nordic treatment protocols. (cancercentrum.se)

You have blinatumomab as cycles of treatment. (cancerresearchuk.org)

Dasatinib is also being studied in the treatment of other types of cancer. (cancer.gov)

By October 2008, ten treatments of radiation therapy had been administered to the brain. (karger.com)
there is no role for radiation or surgical treatment in the induction phase. (medscape.com)
As breast cancer treatment is multimodality approach Radiation therapy has significant impact on prevention of local recurrence. (who.int)

Ponatinib is often used to treat CML that has a specific additional alteration in the BCR-ABL gene known as T315I, which makes CML cells resistant to treatment with other TKIs. (cancercare.org)

All the children had cancers showing the Philadelphia chromosome , an alteration in the genes that indicates a poorer response to treatment. (news-medical.net)
Our scientists pursue every aspect of cancer research-from exploring the biology of genes and cells, to developing immune-based treatments, uncovering the causes of metastasis, and more. (mskcc.org)
See how well your treatment is working (if treatment is helping, the number of cells with BCR-ABL1 genes will decrease. (medlineplus.gov)

Of the 225 patients with the diagnosis, 35 declined participation and 1 died before treatment, leaving 189 patients available for analysis. (nih.gov)
A CML diagnosis is confirmed by looking for the presence of the Ph chromosome through specialized tests or bone marrow samples. (cancercare.org)
From diagnosis to treatment, our experts provide the care and support you need, when you need it. (mskcc.org)
This information aim is educational only and is not devoted for medical recommendations, diagnosis or treatment. (rxmed.com)
Non-epithelial ovarian cancer: ESMO clinical recommendations for diagnosis, treatment and follow-up. (cancercentrum.se)

Some cancer treatments can cause severe side effects. (macmillan.org.uk)

This gene is the ABL1 gene of chromosome 9 juxtaposed onto the breakpoint cluster region BCR gene of chromosome 22, coding for a hybrid protein: a tyrosine kinase signaling protein that is "always on", causing the cell to divide uncontrollably by interrupting the stability of the genome and impairing various signaling pathways governing the cell cycle. (wikipedia.org)
The abnormal BCR-ABL1 gene is formed when pieces of chromosomes 9 and 22 break off and trade places. (medlineplus.gov)
Certain types of BCR-ABL1 testing may also be used to help plan treatment for these blood cancers. (medlineplus.gov)
During treatment, BCR-ABL1 tests may be used to see if cancer treatment working. (medlineplus.gov)
In most forms of CML, a deviant chromosome is present - the Philadelphia chromosome - which gives rise to BCR-ABL1 fusion kinase. (eurekalert.org)

Tyrosine kinase inhibitors (TKIs), a type of targeted therapy, are used in the treatment of CML. (cancercare.org)
Together, these findings suggest that autophagy inhibitors may enhance the therapeutic effects of TKIs in the treatment of CML. (lu.se)
When TKIs can't control the disease, there are other treatment options. (webmd.com)

As part of our mission to eliminate cancer, MD Anderson researchers conduct hundreds of clinical trials to test new treatments for both common and rare cancers. (mdanderson.org)
Active clinical research program with clinical trials available for newly diagnosed and relapsed ALL patients based on age, disease sub-type, and treatment phase. (dana-farber.org)
Some people may be given this treatment as part of a clinical trial . (macmillan.org.uk)
He or she can tell you whether these advances in cancer treatment affect your treatment plan and whether a clinical trial is right for you. (cancercare.org)
Some of the treatments discussed in this booklet are still in the very early stages of research and may not be available to the general public outside of a clinical trial. (cancercare.org)
If current drugs or other types of cancer treatment no longer benefit you, you may wish to explore joining a clinical trial. (cancercare.org)
In this study, we performed IgH HTS on the diagnostic bone marrow of 105 children treated between 2004 and 2008 in Belgium for BCP-ALL in the European Organization for Research and Treatment of Cancer (EORTC)-58951 clinical trial. (frontiersin.org)

When standard treatment options were unsuccessful, a bone marrow transplant was pursued. (karger.com)
Except for cases in which bone marrow transplantation can be used successfully, treatment is not curative. (rxmed.com)

Although mutation- or pathway-directed targeted therapy (e.g., using tyrosine kinase inhibitors to treat Philadelphia chromosome [Ph]-positive and Phlike B-cell-ALL) is currently available for only a minority of children with ALL, many of the newly identified molecular alterations have led to the exploration of approaches targeting deregulated cell pathways. (haematologica.org)

During treatment you will see a haematologist (doctor who treats blood cancers) or a cancer doctor, a specialist nurse and a specialist pharmacist. (macmillan.org.uk)
At the ASH meeting, one expert commented that she believes that new therapies such as this one will revolutionize treatment of hematologic cancers. (medscape.com)

The Philadelphia chromosome, which occurs in 2 to 5 percent of children with ALL, is an abnormal chromosome that sometimes occurs in several types of childhood and adult leukemias. (news-medical.net)

In a recent review, 5 cases of probiotic treatment-related bacteremia were identified in oncology patients, although no cases of invasive Bifidobacterium spp. (cdc.gov)
Our data at ASCO and EHA highlight our unique approach to harnessing the power of multiple treatment platforms to deliver transformative medicines to people living with cancer and blood disorders," said Susanne Schaffert, PhD, President, Novartis Oncology. (novartis.com)

To establish how aggressive the disease is, further chromosome testing is required to determine whether the cancer is myeloblastic and involves neutrophils, eosinophils or basophils, or lymphoblastic involving B or T lymphocytes. (karger.com)

This case study is on a 14-year-old patient diagnosed with a very aggressive form of ALL (positive for the Philadelphia chromosome mutation). (karger.com)
Cannabinoid resin extract is used as an effective treatment for ALL with a positive Philadelphia chromosome mutation and indications of dose-dependent disease control. (karger.com)
Upon further analysis, she was found to be positive for the Philadelphia chromosome mutation. (karger.com)
10 Germline variants of IKZF1 are observed in familial B-ALL and immunodeficiency, 16 , 17 and somatic IKZF1 alterations are enriched in Philadelphia chromosome (Ph)-positive, Phlike, and DUX4 -rearranged B-ALL. (haematologica.org)

Patients aged 15-39 years are referred to as "AYA" (adolescent and young adult) and are eligible for more intensive pediatric-style treatment regimens. (medscape.com)
Treatment of adult patients with chronic hepatitis B associated with evidence of hepatitis-B viral replication (presence of DNA of hepatitis-B virus (HBV-DNA) and hepatitis-B antigen (HBeAg), elevated alanine aminotransferase (ALT) and histologically proven active liver inflammation and / or fibrosis. (europa.eu)
4 Bosutinib was first approved as BOSULIF ® in the United States (U.S.) in September 2012 for the treatment of adult patients with chronic, accelerated, or blast phase Ph+ CML with resistance, or intolerance to prior therapy. (aol.com)

In few newly diagnosed CML cases, complex cytogenetics variants of the Philadelphia (Ph) chromosome can be observed with the involvement of a third chromosome other than chromosome 9 & chromosome 22. (who.int)

Monitor patients for signs and symptoms and initiate appropriate treatment as clinically indicated. (nih.gov)

Liver enzyme elevation usually occurs early in treatment. (aol.com)

She was observed posttransplant by following the presence of blast cells, noted 6 months after treatment. (karger.com)
This is to check that your blood cells are at a safe level for you to have your treatment. (macmillan.org.uk)
This treatment can reduce the number of white blood cells in your blood. (macmillan.org.uk)
DNA is packaged into structures in your cells called chromosomes. (medlineplus.gov)
Normally, most of your cells have the same set of 23 pairs of chromosomes. (medlineplus.gov)

Classical Hodgkin lymphoma is one of the malignancies most susceptible to treatment with monoclonal antibodies targeting the programmed cell death protein (PD-1). (ascopost.com)

This treatment combination is very attractive since it minimizes the risk of treatment-related complications for the patient, especially for older patients who have existing medical comorbidities and typically have a poor prognosis. (mdanderson.org)

Philadelphia Chromosome Negative Myeloproliferative Neoplasms only. (lls.org)
Philadelphia-negative myeloproliferative neoplasms (MPNs) include polycythemia vera (PV), essential thrombocythemia (ET), and primary myelofibrosis (PMF). (researchgate.net)

A mutation in the Philadelphia chromosome is a much more aggressive form of ALL. (karger.com)
Choosing high-risk screening vs. surgery and the effect of treatment modality on anxiety and breast-specific sensuality in BRCA mutation carriers. (cdc.gov)

A low dose of the combination treatment inhibited AML cell cycle and increased apoptosis. (pharmacytimes.com)
Monitor complete blood counts regularly during therapy and manage by treatment interruption or dose reduction. (nih.gov)
After an initial regression of the disease, a second course of therapy was given at a reduced dose due to the toxicity of the treatment, with an associated lesser therapeutic effect. (nature.com)
Radiotherapy treatment dose was - 45Gy/20#, 2.25Gy/#, 5 days/week, total 4 weeks of treatment. (who.int)

Session: Immune Therapeutic Treatment in ALL. (businesswire.com)

Available treatments are limited by severe side-effects and reduced efficacy in the chronic phase of the disease. (researchgate.net)

The changed chromosome 22 is called a "Philadelphia chromosome" after the city where researchers discovered it. (medlineplus.gov)

As CML is a chronic disease, continual monitoring is essential no matter what treatment option is chosen. (cancercare.org)
On the other hand, 31 to 43 percent of children with intact chromosomes 7 and 9 remained disease-free at five years. (news-medical.net)
About 80 percent of children with ALL have a curable form of the disease, while the others respond less well to therapy, sometimes depending on which chromosome changes are present. (news-medical.net)
The Blum Resource Center provides patients and family members with a comfortable environment to learn more about disease treatment and management. (dana-farber.org)
Your treatment will depend on how advanced your disease is, the type of CLL you have, and whether your cancer has come back. (everydayhealth.com)
Resistance to cancer chemotherapeutic treatment is a common phenomenon, especially in progressive disease. (nature.com)
Sometimes the disease is already too advanced at the start of treatment, or there is resistance. (eurekalert.org)
During the course of initial treatment some patients may never respond, may develop drug-resistant disease or may not be able to tolerate their therapy. (aol.com)

Conclusion: Local recurrence after treatment of breast cancer with mastectomy+radiotherapy+/-systemic therapy is associated with a significantly higher risk of distant metastasis and death. (who.int)

Initiate appropriate treatment as clinically indicated. (nih.gov)

Anatomy59

Organisms1

Diseases29

Chemicals and Drugs21

Analytical, Diagnostic and Therapeutic Techniques and Equipment26

Psychiatry and Psychology1

Phenomena and Processes98

Disciplines and Occupations1

Anthropology, Education, Sociology and Social Phenomena1

Humanities1

Information Science4

Health Care6

Geographicals2

Chemotherapy14

Refractory8

Gene on chromosome 222

Acute lymphobla2

Translocation8

Piece of chromosome2

Abnormalities7

Remission6

Abnormality3

Leukemia29

Blinatumomab1

Dasatinib1

Radiation3

Ponatinib1

Genes3

Diagnosis5

Cancer treatments1

ABL15

TKIs3

Clinical7

Bone2

Targeted Therapy1

Cancers2

Childhood1

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Positive4

Adult3

Variants1

Symptoms1

Occurs1

Cells5

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Complications1

Myeloproliferative2

Mutation2

Dose4

Therapeutic1

Severe side effects1

Researchers1

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Clinically1