Treatment outcomes and toxicity of radiotherapy. Medical search. Frequent questions

To assess the effects of conventional radiotherapy (with or without chemotherapy) versus other therapies (including different radiotherapy techniques) for newly diagnosed diffuse brainstem gliomas in children and young adults aged 0 to 21 years. (cochrane.org)
All randomised controlled trials (RCTs), quasi-randomised trials (QRCTs), or controlled clinical trials (CCTs) that compared conventional fractionated radiotherapy (with or without chemotherapy) versus other therapies (including different radiotherapy techniques) for newly diagnosed diffuse brainstem glioma in children and young adults aged 0 to 21 years. (cochrane.org)
Advanced head and neck squamous cell carcinoma (HNSCC) is treated with radiotherapy, chemotherapy, targeted therapy or a combination of these treatments. (researchsquare.com)
Findings were categorized by type of treatment (radiotherapy, chemotherapy, targeted therapy, or combination therapy). (researchsquare.com)
Treatment of HNSCCs includes one of the surgery, radiotherapy or chemotherapy treatments or a combination of these treatments. (researchsquare.com)
Some cases have been associated with resistance to radiotherapy or chemotherapy and local recurrence. (researchsquare.com)
Chemotherapy and radiotherapy are associated with side effects which reduce tolerance to treatment and likelihood of tumour response. (cambridge.org)
Clinical use of a combination of radiotherapy and chemotherapy continues to increase, while the development of immunotherapy, such as checkpoint inhibitors, offers hope in improving treatment outcome. (hkmj.org)
Our results indicate that the GSTP1 polymorphism may be associated with increased toxicity, especially in patients treated with chemotherapy ± surgery. (oncotarget.com)
Chemotherapy and/or radiotherapy are frequently given before or after surgery. (stanford.edu)
NEW YORK, November 13, 2023 - Pfizer Inc. (NYSE: PFE) announced today that the Committee for Medicinal Products for Human Use (CHMP) of the European Medicines Agency (EMA) issued a positive opinion for TALZENNA® (talazoparib), an oral poly ADP-ribose polymerase (PARP) inhibitor, in combination with XTANDI® (enzalutamide), for the treatment of adult patients with metastatic castration-resistant prostate cancer (mCRPC) in whom chemotherapy is not clinically indicated. (pfizer.com)
Although the commonest cause of pain in children with cancer is chemotherapy treatment, these children report that medical procedures or surgery cause the worst pain during their treatment. (aneskey.com)
Direct effects of the tumor give way to systemic effects of treatment-particularly hematopoietic effects of chemotherapy that can result in potentially life-threatening complications. (aneskey.com)
Chemotherapy has significant side effects, and multiple agents are usually used to improve outcome and reduce toxicity. (aneskey.com)
The treatment of AML requires more aggressive chemotherapy with an increased risk of complications, but treatment is shorter and without a maintenance phase. (aneskey.com)
Patients with non-Hodgkin's lymphoma may be treated with radiotherapy, chemotherapy, or a combination of the two, depending on the specific type and stage of the disease. (northshore.org)
CHICAGO - Many patients with locally advanced rectal cancer who do not have high-risk disease can skip radiotherapy to the pelvic area, and instead be treated with chemotherapy alone and then surgery, say researchers reporting results from the PROSPECT trial. (medscape.com)
An all-chemotherapy approach may make curative intent treatment accessible for patients in these resource-constrained settings. (medscape.com)
Whereas there were worse neuropathy outcomes at 12 months with mFOLFOX6, the toxicities with chemoradiotherapy "tip the scale" in favor of chemotherapy. (medscape.com)
According to treatment guidelines in the regional care pro- recur in spite of chemotherapy. (lu.se)
In order to achieve a more effec- were recommended postoperative radiation and adjuvant tive and individualised chemotherapeutic treatment of breast chemotherapy. (lu.se)
However, even those who have poor prognostic factors (eg, poor PS, medically significant concomitant conditions) may still be considered for chemotherapy if appropriate precautions are taken to avoid excessive toxicity and further decline in PS. (medscape.com)
Several platinum-based and non-platinum-based chemotherapy regimens have been used in the treatment of small cell lung cancer (SCLC) with varying results. (medscape.com)
In this study, we observed and followed up our chemotherapy and radiotherapy ( 1 ). (who.int)
as monotherapy for the treatment of those patients who have received at least two chemotherapy regimens for their metastatic disease. (who.int)
Prior chemotherapy must have included at least an anthracycline and a taxane unless patients are unsuitable for these treatments. (who.int)
Biocon Biologics Ltd), BT-ON014 - in combination with docetaxel for the treatment of those patients who have not received chemotherapy for their metastatic disease - in combination with an aromatase inhibitor for the treatment of postmenopausal patients with hormone-receptor positive MBC, not previously treated with trastuzumab. (who.int)
following surgery, chemotherapy (neoadjuvant or adjuvant) and radiotherapy (if applicable) (see section 5.1) - following adjuvant chemotherapy with doxorubicin and cyclophosphamide, in combination with paclitaxel or docetaxel - in combination with adjuvant chemotherapy consisting of docetaxel and carboplatin. (who.int)
BT-ON014 trade name] treatment should only be initiated by a health care provider experienced in the administration of cytotoxic chemotherapy (see section 4.4), and should be administered by a health care provider only. (who.int)

Background: Treatment of childhood glioma has evolved to reduce radiotherapy exposure with the goal of limiting late toxicity. (lu.se)
Neoadjuvant treatment results in less late toxicity paralleled by improved functional outcome but comes along with increased wound complications compared to postoperative radiation. (springermedizin.at)
secondary endpoints included acute and late toxicity, the proportion of adaptive fractions used, patient-reported outcomes, disease control, disease progression, and overall survival. (medpagetoday.com)
Daily image guidance with online correction is associated with a decreased incidence of late toxicity. (ima.org.il)
According to Sandeep Samant, MD , Chief of Head and Neck Surgery at Northwestern Medicine and symposium Chair, "The goal of deintensification is to reduce late toxicity, while maintaining high survival and normal functioning related to swallowing, saliva, and taste. (ascopost.com)
The goal of deintensification is to reduce late toxicity, while maintaining high survival and normal functioning related to swallowing, saliva, and taste. (ascopost.com)
Optimizing the therapeutic ratio for radiation therapy (RT) in head and neck squamous cell carcinoma (HNSCC) is uniquely challenging owing to high rates of early and late toxicity involving nearby organs at risk. (biomedcentral.com)
Early and late toxicity data were collected and reported based on Common Terminology Criteria for Adverse Events version 5.0. (biomedcentral.com)
Dose limitations are uniquely challenging in HNSCC due to the proximity of critical OARs with early and late toxicity resulting in mucositis, dysphagia, xerostomia, tooth decay, vocal dysfunction and loss of taste [ 11 ]. (biomedcentral.com)
CTCAE v4.0 was used for acute and RTOG/EORTC Late Radiation Morbidity Scoring Schema was used for late toxicity evaluation. (uludag.edu.tr)
Radiation-induced acute and late toxicity depends on several parameters. (bvsalud.org)

Day-of-treatment modifications, called adaptive radiotherapy, are critical for responding to changes in patient anatomy that occur as a result of cancer treatment, and to lowering toxicity to improve outcomes," said Thorsten Melcher, Ph.D., chief business officer at RefleXion. (biospace.com)
1 In this study, a multicentre randomised phase II study of hypofractionated bladder radiotherapy with or without image guided adaptive radiotherapy (the HYBRID trial), is a noncomparative, multicenter, randomized, phase 2 trial investigating the treatment of muscle-invasive bladder cancer with ultrahypofractionated bladder radiation therapy, with or without image-guided adaptive planning. (medpagetoday.com)
Purpose: To present pilot toxicity and survival outcomes for a prospective trial investigating adaptive radiotherapy (ART) for oropharyngeal squamous cell carcinoma. (elsevierpure.com)

Currently, the RefleXion X1 machine is cleared for the delivery of stereotactic body radiotherapy (SBRT), stereotactic radiosurgery (SRS) and intensity modulated radiotherapy (IMRT). (biospace.com)
Should patients with recurrent or residual nonfunctioning pituitary adenomas (NFPAs) undergo stereotactic radiosurgery (SRS), fractionated radiation therapy (eg, XRT, fractionated stereotactic radiotherapy [SRT], or intensity modulated radiotherapy[IMRT]), or repeat resection? (cns.org)
External radiotherapy (RT) techniques include 'conventional' or 2-dimensional (2D) RT, 3-dimensional (3D) conformal RT, and intensity-modulated radiation therapy (IMRT). (bcbsnd.com)
Treatment planning and delivery are more complex, time-consuming, and labor-intensive for IMRT than for 3D-CRT. (bcbsnd.com)
IMRT has been compared with 3-dimensional conformal radiotherapy (3D-CRT) for the treatment of stomach, hepatobiliary, and pancreatic cancers. (bcbsnd.com)
Evidence has been inconsistent with the outcome of survival, with some studies reporting increased survival among individuals receiving IMRT compared with individuals receiving 3D-CRT, and other studies reporting no difference between groups. (bcbsnd.com)
However, most studies found that individuals receiving IMRT experienced significantly less GI toxicity compared with individuals receiving 3D-CRT. (bcbsnd.com)
The available comparative evidence, together with dosimetry studies of organs at risk, would suggest that IMRT decreases toxicity compared with 3D-CRT in individuals who had GI cancers. (bcbsnd.com)
There is limited comparative evidence on survival outcomes following IMRT or 3D-CRT. (bcbsnd.com)
However, results are generally consistent that IMRT reduces GI and genitourinary toxicity. (bcbsnd.com)
Based on evidence with other cancers of the pelvis and abdomen that are proximate to organs at risk, it is expected that OS with IMRT would be at least as good as 3D-CRT, with a decrease in toxicity. (bcbsnd.com)
Acute toxicity was comparable to that observed with conventional intensity-modulated radiotherapy (IMRT). (elsevierpure.com)
The PET-linac may be used to deliver intensity-modulated radiotherapy (IMRT), stereotactic surgery (SRS), and stereotactic ablative radiation therapy (SABR). (frontiersin.org)

Mirada Medical specializes in simplifying technically complex image processing tasks, allowing clinicians to diagnose disease, assess response to treatment, and plan radiation therapy or surgical intervention more confidently. (biospace.com)
In modern radiation therapy, 3D dose distributions are typically created in a computerized treatment planning system (TPS) based on a 3D reconstruction of a CT scan. (wikipedia.org)
We conclude that CR and KDs may act synergistically with radiation therapy for the treatment of cancer patients and provide some guidelines for implementing these dietary interventions into clinical practice. (springer.com)
Despite these advancements, several cancer types continue to elude modern treatment techniques with radiation therapy (RT). (springer.com)
Outcomes after radiation therapy for T2N0/stage II glottic squamous cell carcinoma. (mdanderson.org)
Radiation therapy (RT) is an integral part of the treatment of adult soft tissue sarcomas (STS). (springermedizin.at)
Randomized prospective study of the benefit of adjuvat radiation therapy in the treatment of soft tissue sarcomas of the extremity. (springermedizin.at)
A study of treatment of muscle-invasive bladder cancer with ultrahypofractionated radiation therapy found that plan-of-the-day (image-guided) therapy was less toxic than a standard plan but still had effective local disease control. (medpagetoday.com)
1 The patients in the standard planning cohort were administered the same radiation therapy plan during their entire treatment. (medpagetoday.com)
To determine outcomes and toxicity of contemporary salvage radiation therapy (SRT) to the prostate bed. (ima.org.il)
In this review, the authors critically evaluated the evidence to support the options of repeat microsurgical resection, stereotactic radiosurgery (SRS), stereotactic radiotherapy (SRT), and fractionated radiation therapy (XRT). (cns.org)
Radiosurgery and radiation therapy are recommended for treatment of residual or recurrent NFPAs to lower the risk of subsequent tumor progression. (cns.org)
Radiosurgery using single-session doses of 12 or more Gy or radiation therapy with fractionated doses of 45 to 54 Gy is recommended for greater local tumor control rate of 90% or higher at 5 years after treatment. (cns.org)
Biology-guided radiotherapy (BgRT) uses real-time functional imaging to guide radiation therapy treatment. (frontiersin.org)
Biology-guided radiotherapy (BgRT) is a novel therapeutic modality that intends to guide radiation therapy using functional imaging such as positron emission tomography (PET) ( 1 - 3 ). (frontiersin.org)
However, unlike many specialties, morbidity and mortality reviews procedures are not developed as part of quality governance programs in radiation therapy departments for the monitoring of toxicity which sometimes hinder the patients' quality of life. (bvsalud.org)
Radiation Therapy Oncology Group (RTOG) grade 2 or worst (G2+) genitourinary toxicity at five years occurred in 3.2 percent of control patients and 5.5 percent of patients in the SBRT group. (msdmanuals.com)
As breast cancer treatment is multimodality approach Radiation therapy has significant impact on prevention of local recurrence. (who.int)

Permanent seed brachytherapy is as good at treating localised prostate cancer that has a low risk of spreading as surgery (radical prostatectomy) or external beam radiotherapy . (prostatecanceruk.org)
You may be able to have brachytherapy together with external beam radiotherapy if you have localised or locally advanced prostate cancer . (prostatecanceruk.org)
You may also have hormone therapy alongside your external beam radiotherapy and brachytherapy boost. (prostatecanceruk.org)
But, if you have locally advanced prostate cancer , you may be offered brachytherapy together with external beam radiotherapy (see above). (prostatecanceruk.org)

In challenging patients, such as those with metastatic disease where more than one tumor may be treated, adaptation requires robust tools such as Mirada's sophisticated RegEngine software, so that clinicians can quickly assess patient anatomy and, in the future their biology, to implement changes to the treatment plan. (biospace.com)
RefleXion is a privately-held company developing the first biology-guided radiotherapy system, a significant change in strategy from single tumor therapy to the ability to one day treat multiple tumors in cancers that have metastasized. (biospace.com)
We review the possible roles for calorie restriction (CR) and very low carbohydrate ketogenic diets (KDs) in modulating the five R's of radiotherapy to improve the therapeutic window between tumor control and normal tissue complication probability. (springer.com)
Correction to: Radiotherapy for Atypical Teratoid/Rhabdoid Tumor (ATRT) on the Pediatric Proton/Photon Consortium Registry (PPCR). (mayo.edu)
Radiotherapy for Atypical Teratoid/Rhabdoid Tumor (ATRT) on the Pediatric Proton/Photon Consortium Registry (PPCR). (mayo.edu)
2004 ). One problem with cancers, especially HNSCCs, is the unpredictability of treatment outcomes, both in terms of tumor response and host toxicity. (researchsquare.com)
However, the resected margins showed no tumor-free tissue, and therefore a subsequent postoperative radiotherapy was performed. (hindawi.com)
Given the vast differences in metabolism between healthy and tumor cells, there is hope that selective targeting of tumor metabolism may be achieved while limiting toxicity to healthy tissue. (spandidos-publications.com)
The toxicity profile of each intervention, along with the patient and tumor characteristics, should be considered in decision-making on management [6,7]. (researchsquare.com)
Treatment of rectal cancer often consists of surgical resection of the tumor. (stanford.edu)
Medical information on your tumor, treatment received, and side effects will be compiled and maintained in a database to learn more about outcomes of treatment for rectal cancer. (stanford.edu)
Is maximum primary tumor diameter still a prognostic factor in patients with nasopharyngeal carcinoma treated using intensity-modulated radiotherapy? (biomedcentral.com)
Radiation treatment planning has evolved to use 3D images, usually from computed tomography (CT) scans, to more precisely delineate the boundaries of the tumor and to discriminate tumor tissue from adjacent normal tissue and nearby organs at risk for radiation damage. (bcbsnd.com)
Baseline tumor size correlated with absolute volumetric treatment response (p = 0.018). (elsevierpure.com)
In addition, an exciting avenue in cancer prognostication is the use of machine-learning approaches to MRI image features to predict brain tumor outcomes. (ualberta.ca)
The three-year local control rate ranges from 70 to 95% depending on the tumor and the patients' baseline characteristics, and the risk of toxicity is quite low. (biomedcentral.com)
Anesthetists may also provide IV access, anesthesia for imaging procedures, surgical tumor resection, radiotherapy and pain management. (aneskey.com)

For treatment recommendations for patients with a life expectancy ≥20 y, see initial therapy for Low Risk of Recurrence, below. (medscape.com)
Subsequent radiotherapy in case of incompletely resected tumors can be an important option to avoid recurrence or metastasis even though this occurs rarely. (hindawi.com)
Although valuable progress has been made in the treatment of NSCLC in previous years, the high metastasis rate, post-operative recurrence rate and resistance to chemotherapeutic drugs in lung cancer have led to unsatisfactory outcomes ( 4 , 5 ). (spandidos-publications.com)
Specifically, missing two or more treatments has been associated with increased recurrence risk and inferior overall survival, with decrement to overall survival estimated at 1% per one missed day [ 9 ]. (biomedcentral.com)
The indication for salvage radiotherapy (RT) (SRT) in patients with biochemically-recurrent prostate cancer after surgery is based on prostate-specific antigen (PSA) levels at the time of biochemical recurrence. (wjgnet.com)
After a first resection, local recurrence required a new excision and external radiotherapy. (bvsalud.org)
Highly specific monoclonal antibodies (such as Rituximab, Rituxan) directed at lymphoma cells are used for initial treatment, and recurrence of some types of non-Hodgkin's lymphoma. (northshore.org)
Adjuvant polychemotherapy (e.g. with 58% to 68%) for patients under the age of 50.1 Besides an cyclophosphamide, methotrexate and 5-fluorouracil (CMF)) or improvement in clinical outcome, these figures indicate that anthracycline-containing regimes, produce substantial reduc- a large proportion of the patients will never recur after the tion in recurrence and mortality. (lu.se)
Possible mechanisms for gram for breast cancer in southern Sweden issued 1991, pre- recurrence after treatment are low initial drug sensitivity or menopausal lymph node positive (N+) breast cancer patients an acquired drug resistance. (lu.se)
So, purpose of the study is to assess 5 year rates of local recurrence following post-operative 2D Radiotherapy treatment planning. (who.int)
Conclusion: Local recurrence after treatment of breast cancer with mastectomy+radiotherapy+/-systemic therapy is associated with a significantly higher risk of distant metastasis and death. (who.int)

HAYWARD, Calif.--( BUSINESS WIRE )-- RefleXion Medical a therapeutic oncology company pioneering the use of biology-guided radiotherapy ( BgRT )* for all stages of cancer, today announced a non-exclusive, worldwide licensing agreement with Mirada Medical . (biospace.com)
Radiotherapy and Oncology. (wikipedia.org)
Results from the first randomised phase III clinical trial to directly compare MRI-guided stereotactic body radiotherapy (SBRT) with the same therapy guided by CT are published in JAMA Oncology . (ecancer.org)
Dave Fredrickson, executive vice president, oncology business unit, AstraZeneca, said, 'There is a critical unmet need for new first-line treatment options for patients with BRCA m mCRPC, and this approval underscores the importance of BRCA testing at metastatic diagnosis. (yahoo.com)
The issues arising in the oncology patient vary over the course of their treatment. (aneskey.com)
Many children participate in oncology trials that follow set treatment protocols. (aneskey.com)
The efficacy results were published simultaneously in the New England Journal of Medicine , while the patient reported outcomes were published in the Journal of Clinical Oncology . (medscape.com)
MONDAY, Oct. 16, 2023 (HealthDay News) -- At five years, five-fraction stereotactic body radiotherapy (SBRT) is noninferior to control radiotherapy for biochemical/clinical failure (BCF) in men with localized prostate cancer (LPCa), according to a study presented at the annual meeting of the American Society for Radiation Oncology (ASTRO), held from Oct. 1 to 4 in San Diego. (msdmanuals.com)

Our patients are asking us to do better and reduce toxicity. (ascopost.com)

The second study, with 71 participants included, compared hypofractionated radiotherapy (three-week course with treatment once a day ) with conventional radiotherapy. (cochrane.org)
For the hyperfractionated radiotherapy, when compared with conventional therapy, the quality of evidence was low for OS and EFS, and very low for radiological response and toxicities. (cochrane.org)
For the hypofractionated radiotherapy, when compared with conventional therapy, the quality of evidence was moderate for OS, and low for PFS and toxicities. (cochrane.org)
The most commonly used radiological treatment is conventional fractionated radiation. (cochrane.org)
Conventional 2D treatment planning utilizes X-ray films to guide and position radiation beams. (bcbsnd.com)
MDT was delivered with conventional fractionation or stereotactic body radiotherapy (SBRT) techniques. (uludag.edu.tr)
Compared to conventional photon radiotherapy techniques, proton radiotherapy offers dosimetric advantages because of its superior physical properties. (biomedcentral.com)
Our data have provided evidence for a comparable prediction of clinical outcome in CMF-treated breast cancer patients using conventional clinical variables and gene expression based markers. (lu.se)
All patients had been treated with 2D conventional Radiotherapy treatment plan with tangential fields and supraclavicular and axillary fields according to histopathology report. (who.int)
In this One-on-One, Eric Topol talks with UCSF breast cancer specialist Laura Esserman about her approach to individualizing patient care at every stage of cancer screening and treatment, which has both made her an iconoclast and occasionally put her at odds with conventional wisdom in the field. (medscape.com)
We documented the demographics of each patient, the method of administering the urine, reasons for refusing conventional treatment, period of follow-up, and the outcome and side effects. (who.int)
We estimated that a sample size of 66 patients would who are still in active conventional treatment, but many be needed, based on the local prevalence of camel milk/ of our patients still insist on trying it. (who.int)

RefleXion's biology-guided radiotherapy has the potential to offer a new treatment option for patients with all stages of cancer, and we are excited and proud to have RegEngine selected as a key component of the treatment planning process in this exciting novel technology. (biospace.com)

Much research has been published on post-treatment morbidity related to radiotherapy [8-10]. (researchsquare.com)
Conclusion: This is the first prospective evaluation of morbidity and survival outcomes in patients with locally advanced head-and-neck cancer treated with automated adaptive replanning. (elsevierpure.com)

Although surgical resection remains the cornerstone of treatment, local and distant failure rates are high after complete resection, and debate continues as to the appropriate adjuvant therapy. (cancernetwork.com)
Further therapeutic advances and prospective trials are needed to better define the optimal role of adjuvant and neoadjuvant treatment in patients with resectable pancreatic cancer. (cancernetwork.com)
4,5] Despite the use of neoadjuvant and adjuvant therapies, little progress has been made in the last three decades, and the search for more efficacious treatment continues. (cancernetwork.com)
7] Additionally, the inclusion of both CRT and adjuvant CT after surgery evaluated two treatment variables, making it difficult to discern the true effect of either treatment alone. (cancernetwork.com)
The present article reviewed the therapeutic effects of metformin against NSCLC, both as a single agent and combined with other anticancer treatments, in order to provide a theoretical basis for its clinical use in adjuvant therapy for NSCLC. (spandidos-publications.com)
Although there are clear criteria (pT3-pT4 disease and/or positive margins) for the use of adjuvant radiotherapy, no specific clinical or tumour-related criteria have yet been defined for SRT. (wjgnet.com)
Breast cancer is a heterogeneous disease with a large variabil- survival after adjuvant polychemotherapy was 10% (from ity in clinical outcome. (lu.se)
Patients and methods proportion of the patients will recur despite treatment with adjuvant polychemotherapy. (lu.se)

The team is developing techniques and trials aimed at improving outcomes for cancer patients and reducing treatment-related toxicities, in both radical and palliative radiotherapy. (icr.ac.uk)

Concurrent chemoradiotherapy is still the mainstay of HNSCCs treatment, especially in unresectable ones, which has been associated with variable individual clinical outcomes despite similar clinical-pathological features (Nogueira et al. (researchsquare.com)
Our preliminary clinical outcomes document functional recovery and preservation of disease control at 1-year follow-up and beyond. (elsevierpure.com)
We therefore compared the clinical outcomes of the two modalities using medical research databases from our medical foundation. (biomedcentral.com)
Therefore, in this study, we investigated and compared the clinical outcomes of the two modalities using medical research databases from our multi-institution medical foundation with propensity score matching (PSM). (biomedcentral.com)

Permanent seed brachytherapy, also known as low dose-rate (LDR) brachytherapy, is a type of radiotherapy where tiny radioactive seeds are put into your prostate. (prostatecanceruk.org)
Proton beam therapy (PBT) is a type of radiotherapy which results in less radiation to healthy tissues surrounding the cancer compared to photon radiotherapy. (hra.nhs.uk)

Odds ratios (ORs) and 95% confidence intervals (95% CIs) were calculated for the association of GSTP1 polymorphism with tumour response and toxicities, and the hazard ratios (HRs) and 95% CIs were calculated for the association between GSTP1 polymorphism and overall survival (OS). (oncotarget.com)

time from cancer diagnosis, or treatment, to death from any cause) ranges from 8 to 11 months. (cochrane.org)
Soon after the discovery of X-rays by Wilhelm Conrad Röntgen in 1895, ionizing radiation was utilized for cancer treatment. (springer.com)
As part of our mission to eliminate cancer, MD Anderson researchers conduct hundreds of clinical trials to test new treatments for both common and rare cancers. (mdanderson.org)
This PDQ cancer information summary for health professionals provides comprehensive, peer-reviewed, evidence-based information about the treatment of bile duct cancers. (tri-kobe.org)
This summary is reviewed regularly and updated as necessary by the PDQ Adult Treatment Editorial Board, which is editorially independent of the National Cancer Institute (NCI). (tri-kobe.org)
Less certainty exists on the role of nutrition therapy in improving cancer patients' body composition and clinical outcome. (cambridge.org)
It is undeniable that medical anti-cancer options significantly improved over the past 10-15 years, yet it is also self-evident that they did not translate into improved outcome for advanced cancer patients in the real world, at least as far as survival rate is considered. (cambridge.org)
Many reasons could explain the challenges still posed by advanced cancer in achieving clinically meaningful outcomes, among which patient-reported outcomes are gaining more relevance. (cambridge.org)
U.K.-based investigators compared a standard planning approach for the treatment of bladder cancer to a "plan-of-the-day" (adaptive) approach, which includes a collection of plans. (medpagetoday.com)
The plan-of-the-day approach can be used successfully to treat bladder cancer, with less toxicity and adequate disease control. (medpagetoday.com)
2 Other reports have stated that between 23% and 50% of patients 65 years of age and older who have muscle-invasive bladder cancer do not receive treatment, or only receive non-aggressive treatments. (medpagetoday.com)
3 In the absence of treatment, patients can experience local or distant progression of their disease as well as significant symptoms related to their cancer, including hematuria, increased urinary frequency, dysuria, pelvic pain, incontinence, and obstruction. (medpagetoday.com)
One challenge with treating bladder cancer with radiotherapy is that the bladder is mobile and changes volume and shape. (medpagetoday.com)
For men who undergo radiotherapy for localised prostate cancer, the precise targeting capabilities of MRI guidance resulted in fewer toxicities and better quality of life, as judged by patients and the doctors treating them, according to new research from UCLA Jonsson Comprehensive Cancer Center. (ecancer.org)
MRI guidance offers several advantages over standard CT guidance, most notably the ability to dramatically reduce planning margins, providing more focused treatment with less injury to nearby normal tissues and organs," said Amar Kishan, M.D., a radiation oncologist at the David Geffen School of Medicine at UCLA and the UCLA Jonsson Comprehensive Cancer Center and the study's lead author. (ecancer.org)
Stereotactic body radiotherapy for prostate cancer usually delivers radiation in five or fewer precisely targeted doses. (ecancer.org)
This clinical trial, Magnetic Resonance Imaging-Guided Stereotactic Body Radiotherapy for Prostate Cancer (MIRAGE), was led at UCLA and included 154 analyzable patients with prostate cancer who were randomised to either a CT-guidance arm (76 patients) or an MRI-guidance arm (78 patients). (ecancer.org)
Although additional studies will need to confirm these benefits over time, we're hopeful that these results will lead to better outcomes for men with prostate cancer. (ecancer.org)
Radiotherapy to the prostate bed is used to eradicate residual microscopic disease following radical prostatectomy for prostate cancer. (ima.org.il)
0.2 ng/ml, metastases on follow-up imaging, commencement of anti-androgen treatment for any reason, or death from prostate cancer. (ima.org.il)
Andrew Armstrong, MD, ScM, Duke Cancer Institute, Durham, N.C. and an investigator in the trial, said, 'Preventing or delaying radiographic progression is an important clinical endpoint in assessing cancer treatment and is very important to patients, their caregivers and their families. (yahoo.com)
Results: The patient developed vulvar cancer and multiple clinical complications that prevented the application of full treatment leading to a fatal outcome. (alliedacademies.org)
Read more about other treatment options for localised prostate cancer . (prostatecanceruk.org)
If you have localised or locally advanced prostate cancer , your Cambridge Prognostic Group (CPG) will help your doctor decide what treatment options are suitable for you. (prostatecanceruk.org)
To assist with the prognosis and guide treatment decisions, NPC can be further stratified into five different stages (stages I, II, III, IVA, and IVB), as suggested by the latest American Joint Committee on Cancer (8th edition) cancer staging manual. (hkmj.org)
This study aimed to investigate the association of the GSTP1 gene polymorphism with the outcomes and toxicities of treatments in breast cancer. (oncotarget.com)
Technology in Cancer Research & Treatment. (eur.nl)
The long life expectancy and the possibility of quality of life being compromised by chronic adverse events of current head and neck cancer treatments are reasons for considering deintensification. (ascopost.com)
A reduction in GI toxicity is likely to improve the quality of life in individuals with gynecologic cancer. (bcbsnd.com)
Purpose The aim of this study was to evaluate the outcomes of(68)Ga prostate-specific membrane antigen (Ga-68-PSMA) positron-emission tomography (PET)/CT-based metastasis-directed treatment (MDT) for oligometastatic prostate cancer (PC). (uludag.edu.tr)
Are all prostate cancer patients 'fit' for salvage radiotherapy? (wjgnet.com)
González-San Segundo C, Gómez-Iturriaga A, Couñago F. Are all prostate cancer patients "fit" for salvage radiotherapy? (wjgnet.com)
When price is no barrier, we will likely see a surge in BRCA testing (possibly in all breast cancer patients), and the downstream effects of this will be more imaging, more prophylactic surgery, and a modest reduction in systemic treatment because of interventions that occur before the medical oncologist is needed," he noted. (ascopost.com)
The majority of PSMA PET/CT-defined radiotherapy targets would be suitable for BgRT by using a 10-mm tracking zone in prostate cancer. (frontiersin.org)
BACKGROUND: Acute radiation dermatitis (ARD) is a frequent complication after breast cancer radiotherapy and is usually assessed by semi-quantitative clinical scores, which may be subject to inter-observer variability. (bvsalud.org)
We aimed to compare the relative increase in dermal thickness of the irradiated zone in breast-cancer patients undergoing radiotherapy, with clinical severity. (bvsalud.org)
METHODS: A consecutive series of patients undergoing treatment for breast cancer by lumpectomy and radiotherapy in a 6-month period also underwent clinical and ultrasound evaluation of ARD. (bvsalud.org)
Our facility is the only comprehensive cancer treatment and research facility in Alberta north of Calgary. (ualberta.ca)
However cancer care was fragmentary and limited until the passage in 1940 of the first Cancer Treatment and Prevention Act. (ualberta.ca)
The Edmonton Cancer Clinic, Radiotherapy, was staffed by two British Radiation Oncologists treating patients with a Eldorado Cobalt 60 unit, a Cesium teletherapy unit, a Picker 270 KV, Picker 120 KV units plus radium applicators for brachytherapy. (ualberta.ca)
Children with cancer have multiple anesthetics during their treatment. (aneskey.com)
General anesthesia during medical procedures such as lumbar punctures and bone marrow biopsies avoids this pain-anesthetists can make a huge contribution to the care of these children by reducing the most severe pain during cancer treatment. (aneskey.com)
One of the most promising developments in cancer treatments in recent years, this approach spurs the body's own immune function to attack cancer cells. (northshore.org)
Kellogg Cancer Center's unique services and resources assist patients and family members with a variety of challenges they may face from diagnosis, treatment and beyond. (northshore.org)
11. Any previous treatment for rectal cancer. (who.int)
Radiotherapy was delivered to ipsilateral axil- cancer patients in the future, it is essential to increase our lary and supraclavicular lymph nodes and the remaining knowledge in mechanisms responsible for drug resistance, breast parenchyma after breast conservation surgery or tho- and to define reliable indicators for response to therapy. (lu.se)
See Small Cell Lung Cancer Treatment Protocols for summarized information. (medscape.com)
To be able to sit with a patient and say, 'We can treat you with a low-toxicity treatment in five days, and your chance of keeping the cancer at bay for five years is 96 percent' -- it's a positive conversation to have. (msdmanuals.com)
It is indicated for the reduction of cytotoxicity when used in combination with 5-fluorouracil in the treatment of colorectal cancer and for the treatment of megaloblastic anemia due to folic acid deficiency when folic acid cannot be replaced orally. (janusinfo.se)
The following regimens have been used in adults and elderly in the treatment of advanced or metastatic colorectal cancer and are given as examples. (janusinfo.se)
This report examines pricing approaches adopted by the pharmaceutical industry and authorities responsible for the pricing of medicines, with a specific focus on medicines for the prevention and treatment of cancer. (who.int)
Cancer has broad societal impacts beyond the negative effects it has on individual health outcomes, including productivity losses for cancer patients and their family caregivers. (who.int)
Over the past decades, governments have worked with stakeholders to implement a spectrum of preventative and therapeutic interventions, from vaccination and screening programmes to surgical, pharmacological, radiological and social interventions for the treatment, rehabilitation and palliation of people with cancer. (who.int)
These collective efforts in diagnosis and treatment have resulted in great improvements in survival rates, which nonetheless continue to vary considerably by type of cancer and geographical region. (who.int)
Existing approaches to managing the prices of cancer medicines have not resulted in outcomes that meet policy and economic objectives. (who.int)
One of the common practices is the use of camel urine alone or mixed with camel milk for the treatment of cancer, which is often supported by religious beliefs. (who.int)
We observed 20 cancer patients (15 male, 5 female) from September 2020 to January 2022 who insisted on using camel urine for treatment. (who.int)

Professor Nicholas van As is clinical lead for stereotactic body radiotherapy (SBRT) at The Royal Marsden, Co-Chair of the UK SBRT consortium and the national clinical lead for NHS England's Commissioning Through Evaluation programme for SBRT. (icr.ac.uk)
3 acute toxicity, but one patient had a late grade 3 toxicity of compression fracture after spinal SBRT. (uludag.edu.tr)
The researchers found that at a median follow-up of 73.1 months, the five-year BCF event-free rate was 94.6 percent for control radiotherapy and 95.7 percent for the SBRT groups. (msdmanuals.com)

The investigators looked at toxicity, patient-reported outcomes, and disease control. (medpagetoday.com)

Dermal thickness is a quantitative variable that could help quantify the efficacy of drugs and improve the treatment of this disease in patients undergoing radiotherapy. (bvsalud.org)
8. Patients with a prior or concurrent malignancy whose natural history or treatment has the potential to interfere with the safety or efficacy assessment. (who.int)

Proton radiotherapy has a dosimetric advantage over photon radiotherapy. (biomedcentral.com)
Proton radiotherapy could deliver a higher radiation dose than photon radiotherapy without increasing the risk of RILD and result in a better overall survival rate for those diagnosed with HCC and treated with radiotherapy with curative intent. (biomedcentral.com)
Among them, two medical centers and two regional hospitals provide photon radiotherapy services. (biomedcentral.com)

On the other hands, researches have been conducted to find molecular markers for predicting the development of treatment-induced acute or chronic toxicity before initiation of treatment (Venkatesh et al. (researchsquare.com)
However, the associations between treatment changes and neurocognition, and the contribution of neurocognition and chronic health conditions to attainment of adult independence, remain unknown. (lu.se)
Path analysis tested associations among treatment exposures, neurocognitive impairment, chronic health conditions, and functional independence. (lu.se)
However, functional nonindependence is associated with treatment-related neurocognitive impairment and chronic health conditions. (lu.se)
Chronic toxicity and functional outcomes beyond 1 year were tabulated. (elsevierpure.com)
Evaluation of machine learning algorithms for predicting direct-acting antiviral treatment failure among patients with chronic hepatitis C infection. (cdc.gov)

Using PBT to limit these side effects would provide an invaluable way to improve outcomes and life expectancy for these patients whilst maintaining their quality of life. (hra.nhs.uk)

Integrating RegEngine into BgRT will allow clinicians to rapidly adapt the daily treatment plan by precisely registering images and image components crucial for treatment planning and dose calculation. (biospace.com)
Split-course radiotherapy (RT) was administered to a total dose of 40 Gy, with a 2-week treatment break. (cancernetwork.com)
The RT approach in this trial was considered low-dose and antiquated by contemporary standards due to the use of a split-course technique and the use of large treatment fields, which encompassed the entire pancreas/pancreatic bed and the celiac, pancreaticosplenic, peripancreatic, and retroperitoneal regional lymph nodes. (cancernetwork.com)
Follow-up included assessments for adverse events and laboratory studies during treatment (weekly) and then at 4 weeks and at 3, 6, 12, and 24 months after the final dose of radiation. (medpagetoday.com)
Among patients who received LYNPARZA in combination with abi/pred, 16% permanently discontinued treatment with LYNPARZA due to an AR, 48% had a dosage interruption of LYNPARZA and 21% had their dose of LYNPARZA reduced. (yahoo.com)
No dose constraints were given to the vestibule during optimization in treatment planning. (researchsquare.com)
Further investigations are needed to determine dose-volume parameters and their effects on vestibular toxicity. (researchsquare.com)
To assess dose-limiting toxicities (DLTs) of capecitabine +/- oxaliplatin in a combination regimen with capecitabine and radiotherapy (Phase 1) 2. (stanford.edu)
To determine the maximum-tolerated dose (MTD) when capecitabine - oxaliplatin in a combination regimen with capecitabine and radiotherapy (Phase 1) 3. (stanford.edu)
There is pulsed dose rate and high dose rate brachytherapy, permanent interstitial implantation, and stereotactic body radiation treatment. (ualberta.ca)
Radiotherapy treatment dose was - 45Gy/20#, 2.25Gy/#, 5 days/week, total 4 weeks of treatment. (who.int)
Prevention: Calcium folinate should be administered every day during treatment with trimetrexate and for 72 hours after the last dose of trimetrexate. (janusinfo.se)
In case of high dose pyrimethamine or prolonged treatment with low doses, calcium folinate 5 to 50 mg/day should be simultaneously administered, based on the results of the peripheral blood counts. (janusinfo.se)

BgRT is designed to one day overcome the technical limitations of existing radiotherapy approaches by using a PET radiotracer to create a unified motion management solution for one or multiple tumors. (biospace.com)
The BgRT technology will synchronize these data with the linear accelerator to direct radiotherapy to tumors with subsecond latency. (biospace.com)
As treatment progresses and time elapses, if there are changes (i.e. if patients lose weight, if tumors shrink, if organs change shape, etc.), the original DVH loses its accuracy. (wikipedia.org)
For tumors that cannot be located, medical treatment with phosphate supplements and active vitamin D (calcitriol or alpha calcitriol) is a therapeutic option [ 9 ]. (hindawi.com)

Conclusion Ga-68-PSMA-PET/CT-based MDT is an efficient and safe treatment for oligometastatic PC patients. (uludag.edu.tr)

Preoperative versus postoperative radiotherapy in soft-tissue sarcoma of the limbs: a randomized trial. (springermedizin.at)

Repeat resection is recommended for the treatment of symptomatic recurrent or residual NFPAs. (cns.org)

Identifying molecular markers that are effective in responding to treatment is important in order to optimize therapies (Ansell et al. (researchsquare.com)
Currently, there are many approved Pharmacotherapy and Psychotherapy treatment options for PTSD, but unfortunately, half of the patients do not respond to traditional therapies. (preprints.org)
These targeted therapies have been shown to significantly improve response rates without increasing toxicity. (northshore.org)

197 Survival outcomes and toxicity among patients treated with concomitant radiotherapy and immunotherapy for advanced melanoma: two faces of the abscopal effect? (bmj.com)
The combination of cyclophosphamide, doxorubicin (Adriamycin), and vincristine (CAV) has been compared with PE in at least 2 randomized trials of previously untreated extensive-stage SCLC and showed similar survival outcomes. (medscape.com)

Acute toxicity is significant with our current treatments," Dr. Agrawal said. (ascopost.com)
Patients were assessed for acute toxicity every week. (who.int)

Two phase 3 trials have compared SRT with and without androgen deprivation therapy (ADT), finding that combined treatment (SRT+ADT) improves both PFS and overall survival. (wjgnet.com)
to determine how PBT impacts progression free and overall survival, safety and toxicity, quality of life and health economics. (hra.nhs.uk)

A systematic review of the treatment options for residual or recurrent NFPAs was performed. (cns.org)

Chemotherapeutic agents cause myelotoxicity with anemia, neutropenia and thrombocytopenia, as well as gastrointestinal toxicity with nausea, vomiting and mucositis. (aneskey.com)

For RTOG G2+ gastrointestinal toxicity, there was no significant difference observed between the groups. (msdmanuals.com)

Methods and Materials: We have selected 198 patients treated for post-operative 2D Radiotherapy treatment planning from September 2009-September 2010. (who.int)

Genetic alterations in BRCA2, ERBB3, NOTCH1 and CCND1 were all associated with higher mean grade of toxicity with BRCA2 alteration implicated in all toxicity parameters evaluated including mucositis, early dysphagia, xerostomia and to a lesser extent, late dysphagia. (biomedcentral.com)

time from diagnosis, study entry, or treatment to disease progression, disease relapse, a second tumour, or death), radiological response (a reduction in tumour size of more than 50%), and toxicities (damage to the body due to radiotherapy). (cochrane.org)
Recently, treatment outcomes have been improved in conjunction with a reduction in toxicity through technological innovations such as intensity modulated radiotherapy or stereotactic body radiotherapy. (springer.com)
In this trial, we demonstrated that the reduction in treatment volumes facilitated by MRI guidance leads to a significant reduction in moderate physician-scored toxicity and to a reduction in the proportion of patients noting significant decrements in patient-reported outcome metrics in the near term," said Dr. Kishan. (ecancer.org)
She said that the reduction in long-term radiotherapy-related toxicities make the novel regimen a good choice, although the decision should be made with the patient. (medscape.com)

The department currently utilizes Varian's ARIA RO operating system, and most treatment planning is performed using Varian's Eclipse TPS including adaptive image-guided intensity-modulated radiotherapy. (ualberta.ca)

It may depend on whether the long-term neuropathy associated with chemoradiotherapy may be more relevant for some, such as musicians, while the early toxicities with mFOLFOX6 may be unsupportable for people looking after young families. (medscape.com)

Many retrospective studies have shown promising results with proton radiotherapy in treating hepatocellular carcinoma (HCC). (biomedcentral.com)

Influence of systemic rituximab treatment on the incidence of CNS relapse in DLBCL and risk factors for CNS disease. (haematologica.org)
The data regarding the incidence and outcome of pancreatic injuries are scarce. (ima.org.il)

proton: 64) who were diagnosed with HCC and primarily treated with radiotherapy with curative intent were enrolled. (biomedcentral.com)
Patients in the proton radiotherapy group tended to have lower median Child-Pugh scores and better median albumin-bilirubin (ALBI) scores, which may raise concern regarding selection bias. (biomedcentral.com)
Cyclotron-based proton radiotherapy was available at one of the medical centers during the study period. (biomedcentral.com)

Methods: We present the case of a 20-year-old female patient with Fanconi Anemia who developed gynecological and hematological neoplasms that were treated with surgery, radiotherapy and chemoterapy treatment in a limited manner due to the toxicity presented. (alliedacademies.org)

Clinical studies have shown that DVH metrics correlate with patient toxicity outcomes. (wikipedia.org)

Our team also provides treatment through the use of immunotherapy. (northshore.org)
An early adopter of immunotherapy, NorthShore offers progressive treatment options to our patients and supports ongoing clinical trials and research to further advance this revolutionary field. (northshore.org)

Daily doses of calcium folinate should be adjusted depending on the hematological toxicity of trimetrexate. (janusinfo.se)

A web-based search of all original articles about the impact of gene polymorphisms on toxicity and response to therapy in HNSCCs was done until September 2021 using international English language databases including Google Scholar, Scopus, PubMed and Web of science. (researchsquare.com)

Diagnosis of the specific lymphoma subtype enables our clinical team to personally tailor a treatment plan to each individual to optimize outcomes. (northshore.org)

Radiotherapy to improve local control regardless of surgical margin and malignancy grade in extremity and trunk wall soft tissue sarcoma: a Scandinavian sarcoma group study. (springermedizin.at)
The rates of acute ≥ grade 3 nongenitourinary toxicity were 6% (95% confidence interval [CI] 0.7% to 20.2%) in the adaptive planning group, compared to 13% (95% CI 3.8% to 30.7%) in the standard planning cohort. (medpagetoday.com)
An estimated 80% of patients will have grade 3 toxicity with current treatments, and up to 25% to 60% will "continue to suffer from grade 3 toxicity. (ascopost.com)
3. Presence of grade =1 peripheral neuropathy according to the Common Toxicity Criteria for Adverse Events (CTCAE) v.5.0. (who.int)

Having these other treatments at the same time as permanent seed brachytherapy can help make the treatment more effective. (prostatecanceruk.org)
Brachytherapy won't be suitable if you've had surgery to remove your rectum (back passage), because the treatment involves using an ultrasound probe in the back passage to make sure the seeds are put in the correct place. (prostatecanceruk.org)
Some hospitals don't offer brachytherapy to men who've had a TURP because it can make the treatment more difficult to perform. (prostatecanceruk.org)

Three-dimensional conformal RT (3D-CRT) involves initially scanning the individual in the position that will be used for the radiation treatment. (bcbsnd.com)

The algorithms align patient anatomy between different imaging modalities or between radiotherapy treatments. (biospace.com)
Radiotherapy is one of the crucial local treatment modalities for hepatocellular carcinoma (HCC). (biomedcentral.com)

PTSD symptoms often compound with pre-existing issues further deteriorating health outcomes for these patients. (preprints.org)

Treatment includes intrathecal methotrexate or cytarabine, which has decreased the need for central nervous system radiotherapy and its longer-term effects on neurodevelopment and body growth. (aneskey.com)

Anatomy3

Diseases63

Chemicals and Drugs48

Analytical, Diagnostic and Therapeutic Techniques and Equipment102

Psychiatry and Psychology14

Phenomena and Processes16

Disciplines and Occupations6

Anthropology, Education, Sociology and Social Phenomena1

Humanities2

Information Science8

Named Groups2

Health Care58

Geographicals4

Chemotherapy29

Late toxicity11

Adaptive radiotherapy3

IMRT13

Radiation therapy18

External beam radioth4

Tumor17

Recurrence11

Oncology8

Reduce toxicity1

Conventional12

Biology-guided radiotherapy1

Morbidity2

Adjuvant8

Palliative radiotherapy1

Clinical outcomes4

Type of radiotherapy2

Response and toxicities1

Cancer57

SBRT3

Patient-reported outcomes1

Efficacy2

Photon radiotherapy3

Chronic6

Improve outcomes1

Dose13

Tumors4

PSMA PET1

Postoperative1

Resection1

Therapies3

Survival outcomes2

Acute toxicity2

Overall survival2

Systematic review1

Chemotherapeutic1

Gastrointestinal1

Patients treated1

Mucositis1

Reduction4

Image-guided1

Chemoradiotherapy1

Retrospective1

Incidence2

Proton3

Methods1

Metrics1

Immunotherapy2

Hematological1

Scopus1

Optimize1

Grade4

Brachytherapy3

Conformal1

Modalities2

Health outcomes1

Body1