ChemotherapyGimeracil and oteracilRecurrenceTreated patientsUracilChemoradiotherapyPathologicalCapecitabineComplicationsMetastaticTumorsPerioperativeChemotherapeuticLobectomyPredictorTherapeuticAdjuvant treatmentLung cancer patientsCurativeResectionPrognosticUsefulnessPrognosisProtocolsTrialsCancersGastrointestinalRegimensResectablePatientCommonOralEvaluationStudyCancerMedianStatusDisease
Chemotherapy12
- Introduction In patients with non-small cell lung cancer, surgical treatment with postoperative adjuvant chemotherapy is performed. (bmj.com)
- However, the improvement of overall survival achieved by postoperative adjuvant chemotherapy may be insufficient in consideration of the deterioration of quality of life (QOL). (bmj.com)
- 3 Although there have been no randomised controlled trials to compare surgery with radiation therapy or chemotherapy, observational studies have suggested that surgery is the most curative treatment for lung cancer. (bmj.com)
- This international, multicenter, randomized, double-blind phase III study intends to recruit 680 patients who have received radical gastrectomy (R0 resection, D2 or more extended lymphadenectomy) with postoperative pathological stage II or III (AJCC Cancer Staging Manual, 8th Edition) gastric or EGJ adenocarcinoma to evaluate the efficacy and safety of JS001 combined with postoperative adjuvant chemotherapy versus placebo combined with postoperative adjuvant chemotherapy. (centerwatch.com)
- During the past decade perioperative chemotherapy, pre- or postoperative radio-chemotherapy, and, in Asian populations, adjuvant chemotherapy have been shown to improve the outcome of patients with advanced GC and GEJ cancers suited for surgery. (docksci.com)
- Therefore, the identification of reliable criteria and/or novel biomarkers for predicting a risk of recurrence is needed to identify the patients who should receive postoperative adjuvant chemotherapy. (spandidos-publications.com)
- Overall, 44.1% of patients treated with lenvatinib plus pembrolizumab received subsequent systemic anti-cancer treatment (34.9% tyrosine kinase inhibitor, 14.4% immunotherapy, 3.5% chemotherapy). (medicom-publishers.com)
- For patients with unresectable tumors, treatment with fluoropyrimidine- or taxane-based chemoradiotherapy (category 1 recommendation) or chemotherapy is acceptable. (medscape.com)
- For description of chemotherapy and chemoradiotherapy regimens, see Gastric Cancer Treatment Protocols . (medscape.com)
- Ramosetron HCL Injection is a serotonin 5-HT3 receptor antagonist, and its Injection is used for the treatment of nausea and vomiting associated with cancer chemotherapy. (advacarepharma.com)
- Therefore, chemotherapy followed by surgical resection, with or without radiotherapy, is the treatment of choice for patients with locally advanced maxillary sinus squamous cell carcinoma (MSSCC) ( 7 - 10 ). (brieflands.com)
- Due to the unobvious early symptoms and the influence of some adverse factors such as tumor heterogeneity and low immunogenicity, patients with advanced gastric cancer (AGC) cannot benefit significantly from treatments such as radical surgical resection, radiotherapy, chemotherapy, and targeted therapy. (frontiersin.org)
Gimeracil and oteracil1
- As a prodrug to 5-FU it is used in the treatment of the following cancers: Stomach (when combined with gimeracil and oteracil) Breast (with uracil) Gallbladder Lung (specifically adenocarcinoma, typically with uracil) Colorectal (usually when combined with gimeracil and oteracil) Head and neck Liver (with uracil) Pancreatic It is often given in combination with drugs that alter its bioavailability and toxicity such as gimeracil, oteracil or uracil. (wikipedia.org)
Recurrence18
- Considering the relationships among surgical treatments, inflammation and carcinogenesis, non-steroidal anti-inflammatory drugs (NSAIDs) are a candidate postoperative treatment for preventing recurrence and maintaining QOL. (bmj.com)
- In this study, we investigate the effects of the perioperative administration of flurbiprofen axetil on postoperative recurrence in patients with non-small cell lung cancer. (bmj.com)
- The primary analysis will evaluate the treatment effect of flurbiprofen axetil on postoperative recurrence. (bmj.com)
- This is the first study to evaluate the effect of the perioperative administration of non-steroidal anti-inflammatory drugs (NSAIDs) on postoperative recurrence in non-small cell lung cancer. (bmj.com)
- JS001/placebo will be given for up to 17 cycles after surgery, until intolerable toxicity, disease recurrence, patient's withdrawal of consent, investigator's judgment that the patient needs to be withdrawn from the study treatment, or death, whichever comes first. (centerwatch.com)
- Although surgical resection is the most powerful treatment for the complete cure of CRC, a local or distant tumor recurrence sometimes develops even after a curative resection of the primary tumor is achieved. (spandidos-publications.com)
- The primary evaluation item was postoperative clustered CTC detection, and the secondary outcome measures were the 2-year overall survival and recurrence-free survival rates according to the status of VFL and postoperative clustered CTC. (cancerdiagnosisprognosis.org)
- Conclusion: The status of postoperative clustered CTC was similar regardless of VFL or not, although the detection of clustered CTC was a predictor of recurrence. (cancerdiagnosisprognosis.org)
- In practice, the presence of clustered CTCs is a significantly reliable predictor of lung cancer existence ( Lung Cancer 134 (2019)">15 ) and postoperative recurrence ( Surg Today 46(12) (2016)">16 ). (cancerdiagnosisprognosis.org)
- The risk of postoperative recurrence is higher in lung cancer patients who smoke than non-smokers. (biomedcentral.com)
- However, objective evaluation of the postoperative recurrence risk is difficult using conventional pathological prognostic factors because of their lack of reproducibility. (biomedcentral.com)
- Because cigarette smoking and oncogenesis alter lipid metabolism in lung tissue, we hypothesized that the lipid profiles in lung cancer tissues are influenced by cigarette smoking and can reflect the postoperative recurrence risk in smoking lung cancer patients. (biomedcentral.com)
- This study aimed to identify lipid biomarkers that reflect the smoking status and the postoperative recurrence risk. (biomedcentral.com)
- Lipids that were influenced by smoking status and reflected postoperative recurrence and pathological prognostic factors were screened. (biomedcentral.com)
- From our data, we propose three PC isomers, PC (14:0_18:2), PC (16:1_16:1), and PC (16:0_16:2), and a lipid peak of m/z 736.5276 as novel candidate biomarkers for postoperative recurrence risk in lung ADC and SQCC patients who are smokers. (biomedcentral.com)
- Hence, predicting the postoperative recurrence risk in individual NSCLC patients who are smokers will contribute to developing a qualified postoperative therapeutic strategy. (biomedcentral.com)
- Therefore, identifying novel and objective biomarkers that reflect postoperative recurrence risk in smokers NSCLC patients is needed. (biomedcentral.com)
- Specific lipids in cancer tissues have been reported as potential biomarkers reflecting patient prognosis and the risk of postoperative recurrence. (biomedcentral.com)
Treated patients1
- 4 5 However, surgery alone may not be a sufficient treatment because an observational study of 11 663 surgically treated patients with NSCLC showed that the 5-year overall survival (OS) rate in all patients was 69.6%, while the rates in patients with clinical stage IA, IB, IIA and IIB were 82.0%, 66.1%, 54.5% and 46.1%, respectively. (bmj.com)
Uracil5
- It is a component of the combination drug tegafur/uracil. (wikipedia.org)
- Tegafur/uracil Tegafur/gimeracil/oteracil El Sayed YM, Sadée W (September 1983). (wikipedia.org)
- This study aimed to assess the postoperative esophageal displacement after lobectomy and to clarify its impact on the continuity of tegafur-uracil treatment. (nii.ac.jp)
- Methods: Patients who received adjuvant tegafur-uracil therapy after lobectomy between April 2009 and March 2019 were retrospectively analyzed. (nii.ac.jp)
- Phase II trials of the oral regimen, UFT (tegafur and uracil) plus leucovorin, have demonstrated that this combination has antitumor activity similar to intravenous regimens of fluorouracil (5-FU) plus leucovorin. (cancernetwork.com)
Chemoradiotherapy1
- This study aimed to identify the optimal treatment regimen for patients with MSSCC by retrospectively reviewing the outcomes of MSSCC patients, who were treated with neoadjuvant intra-arterial chemoradiotherapy (NACR) followed by surgery, as well as patients who received definitive intra-arterial chemoradiotherapy alone. (brieflands.com)
Pathological1
- The postoperative pathological examination confirmed the consistent diagnosis of gastric adenocarcinoma between the nodule and the stomach lesion, which was found by preoperative random biopsy of the mucosa. (springeropen.com)
Capecitabine2
- The dihydropyrimidine dehydrogenase (DPD) enzyme is responsible for the detoxifying metabolism of fluoropyrimidines, a class of drugs that includes 5-fluorouracil, capecitabine, and tegafur. (wikipedia.org)
- Adjuvant treatments include: 5-fluorouracil administered together with folinic acid, or more recently, oral fluoropyrimidines such as capecitabine, in combination with oxaliplatin or irinotecan. (biomedcentral.com)
Complications4
- Postoperative complications were compared via propensity score matching based on inverse probability of treatment weighting (IPTW). (bvsalud.org)
- After adjusting for the IPTW method, although AL rates did not differ significantly between groups, postoperative complications of both grade ≥ II (odds ratio [OR] 0.66, 95% confidence interval [CI] 0.50-0.87, p (bvsalud.org)
- The main outcome measures were postoperative complications and facial nerve recovery: Yanagihara score and House-Brackmann grading system. (nagoya-u.ac.jp)
- 1. Kato H, Seishima R, Nakamura K, Matsui S, Shigeta K, Okabayashi K, Kitagawa Y. The Prognostic Nutritional Index is a Predictive Marker for Postoperative Complications in Patients with Late-Onset Ulcerative Colitis. (keio-colorectalsurgery.com)
Metastatic2
- Less progress has been made in the treatment of metastatic disease. (docksci.com)
- Metastatic colorectal cancer patients can benefit from other additional treatments such as cetuximab or bevacizumab. (biomedcentral.com)
Tumors1
- AL after anterior or low anterior resection in rectal tumors is a fatal postoperative complication. (bvsalud.org)
Perioperative1
- Patient background, perioperative characteristics, treatment findings, and the degree of esophageal displacement measured by computed tomography were compared between the treatment completion group and the discontinuation group. (nii.ac.jp)
Chemotherapeutic1
- Tegafur is a chemotherapeutic prodrug of 5-fluorouracil (5-FU) used in the treatment of cancers. (wikipedia.org)
Lobectomy2
- Some patients experience treatment discontinuation due to gastrointestinal disorders such as anorexia, and the associated factors and the impact of lobectomy remain unclear. (nii.ac.jp)
- A recent prospective randomised study ( JAMA Surg 154(7) (2019)">6 ) has revealed that among lung cancer patients undergoing lobectomy, the postoperative increase in CTC count was more limited in the VFL group than in the no-VFL group. (cancerdiagnosisprognosis.org)
Predictor1
- The degree of esophageal displacement at the Th7 level was a significant predictor of treatment discontinuation (p = 0.046, odds ratio [OR]: 1.138, 95% confidence interval [CI]: 1.002-1.291). (nii.ac.jp)
Therapeutic1
- It is hoped that, with rapid development of nanomedicine in cancer immunotherapy, TAMs-focused therapeutic strategies may be anticipated to become an emerging immunotherapeutic modality for future clinical cancer treatment. (thno.org)
Adjuvant treatment3
- Neratinib: A tyrosine kinase inhibitor approved for the extended adjuvant treatment of patients with early-stage Her2Neu-positive breast cancer, following adjuvant trastuzumab-based therapy. (medscape.com)
- Adjuvant treatment of breast cancer is designed to treat potential micrometastatic disease, or breast cancer cells that have escaped the breast and regional lymph nodes but have not yet established an identifiable metastasis. (medscape.com)
- A total of 41 patients completed the 2-year adjuvant treatment and 27 patients discontinued it. (nii.ac.jp)
Lung cancer patients1
- Consequently, novel objective biomarkers that reflect postoperative risk in lung cancer patients who smoke must be identified. (biomedcentral.com)
Curative1
- To promote cure, it is mandatory to determine which treatment is more curative in terms of having a higher cure rate. (scirp.org)
Resection1
- Results: Eighty-six patients with similar backgrounds, except for lobe resection and pulmonary vein dissection time, showed postoperative clustered CTC identification rates of 43.8% and 37.9% in the VFL group (n=57) and no-VFL group (n=29), respectively. (cancerdiagnosisprognosis.org)
Prognostic1
- The treatment method was the only significant prognostic factor for OS. (brieflands.com)
Usefulness1
- However, the study supports the potential usefulness of lenvatinib as a standard first-line treatment for advanced HCC. (medicom-publishers.com)
Prognosis1
- Although the prognosis of gastric cancer has significantly improved because of improvements in disease diagnosis and treatment, the prognosis of recurrent gastric cancer remains poor [ 2 ]. (biomedcentral.com)
Protocols1
- For more information, see Breast Cancer , HER2 Breast Cancer , and Breast Cancer Treatment Protocols . (medscape.com)
Trials3
- Sign up as volunteer to help accelerate the development of new treatments and to get notified about similar trials. (centerwatch.com)
- In the largest of these trials, postoperative morbidity (43% versus 25%) and mortality (10% versus 4%) were higher in the D2 group. (medscape.com)
- This review integrates most experimental studies and clinical trials of various oncolytic viruses (OVs) in the diagnosis and treatment of GC. (frontiersin.org)
Cancers1
- For early and some locoregional cancers, surgery is the primary treatment. (medscape.com)
Gastrointestinal2
- The major side effects of tegafur are similar to fluorouracil and include myelosuppression, central neurotoxicity and gastrointestinal toxicity (especially diarrhoea). (wikipedia.org)
- Gastrointestinal toxicity is the dose-limiting side effect of tegafur. (wikipedia.org)
Regimens2
- Efficacy, safety, and quality of life assessments of the two treatment regimens also were compared. (cancernetwork.com)
- Finally, the pharmacoeconomic data of the two treatment regimens were compared by calculating their incremental cost- effectiveness ratios. (cancernetwork.com)
Resectable1
- Our experience suggests that HAIC should be considered as a treatment option in patients with resectable liver metastasis from gastric cancer. (biomedcentral.com)
Patient2
- His postoperative course was uneventful, and the patient was discharged on the 20th postoperative day. (biomedcentral.com)
- The results not only help the practitioner and patient choose an effective combination of therapies, but also helps them understand which cancer genes (oncogenes) are blocked by which treatments. (dunphynunley.com)
Common2
- Central neurotoxicity is more common with tegafur than with fluorouracil. (wikipedia.org)
- BACKGROUND: The most common postoperative complication in malignant rectal surgery is anastomotic leakage (AL). (bvsalud.org)
Oral1
- Background: We aimed to define the indications for sentinel lymph node biopsy (SLNB), the third option for cervical treatment in oral cancer with negative cervical lymph nodes. (nagoya-u.ac.jp)
Evaluation1
- Safety evaluation, including vital signs, ECOG score, physical examination and laboratory examinations, will be performed on a regular basis during the treatment. (centerwatch.com)
Study1
- Safety follow-up: adverse events will be closely followed up and recorded, until 60 days after the last dose of treatment or the end of study follow-up (death, loss to follow-up, withdrawal of consent form and the end of study), whichever comes first. (centerwatch.com)
Cancer7
- however, the treatment strategy for liver metastasis of gastric cancer has not yet been established. (biomedcentral.com)
- thus, we need to increase and to control the accuracy of lung cancer treatment. (cancerdiagnosisprognosis.org)
- Our findings thus show that the in vitro activation of lymphocytes by PSK can help identify the candidates with either gastric or colorectal cancer who are the best suited to undergo immunochemotherapy including treatment with PSK. (unboundmedicine.com)
- Yes to Life was set up specifically to address these shortcomings, and for over a decade it has provided direct support to people with cancer in building and pursuing their own integrative treatment plans. (thecancerrevolution.co.uk)
- His interests currently include nutrition and dietary therapy, herbal treatments, bio-identical HRT and intravenous nutritional therapy for chronic diseases such as CFS, adrenal fatigue, thyroid disorders, male and female menopause and cancer. (thecancerrevolution.co.uk)
- It is the same for the treatment and regulation of cancer. (dunphynunley.com)
- Radiochemotherapy and brachytherapy could be the standard treatment for anal canal cancer in elderly patients? (insa-lyon.fr)
Median1
- Nonetheless, median OS in the lenvatinib monotherapy arm was longer than what was observed in REFLECT (14.5 months), which supports its role as a standard first-line treatment for advanced HCC. (medicom-publishers.com)
Status1
- The association of OS with age, performance status, T factor (mean tumor size according to the tumor-node-metastasis [TNM] grading system), N factor (mean lymph node involvement according to the TNM grading system), and treatment method was assessed. (brieflands.com)
Disease1
- By utilising EHRs, researchers can measure treatment effects, demonstrate trends in disease incidence and prevalence, and further explore possible disease aetiologies. (e-epih.org)