Treatment of solid tumors certain anticancer drugs or radiation. Medical search. Frequent questions

Main reasons for the varying efficacy of anti-cancer medications include the individual variability of cancer, the heterogeneity of solid tumors, and the high complexity of the tumor microenvironment and pharmacological processes. (bosch.com)
The microenvironment surrounding tumor tissues provides a favorable niche for bacteria to inhabit. (nature.com)
Although FAP has limited expression in normal adult tissues, it is highly expressed in the tumor microenvironment of many solid cancers - a characteristic that makes it an ideal target for anticancer therapy. (doaj.org)
The ImPRESS project main objective is to develop a novel imaging paradigm coined Restricted Perfusion Imaging (RPI) to reveal - for the first time in humans - vascular restrictions in solid cancers caused by mechanical solid stress, and use RPI to demonstrate that alleviating this force will repair the cancerous microenvironment and improve therapeutic response. (europa.eu)
Herein, we report near-infrared light and tumor microenvironment (TME), dual responsive as well as size-switchable nanocapsules. (nature.com)
Within the microenvironment of a tumor, TAMs can play a "pro-cancer" role that suppresses the host immune system, enables tumor tissue repair, and promotes tumor growth, or they can play an "anti-cancer" role by triggering strong and focused immune system attacks on tumor tissue. (holisticprimarycare.net)
Some of the new approaches depend on tumor biology and aim specifically to inhibit tumor growth and metastasis by targeting the tumor microenvironment or vasculature (leaving normal cells unaffected) or focusing on specific protein or signal transduction pathways. (medscape.com)

2600 BC - Egyptian physician Imhotep diagnosed several types of tumour and therapies for them. (wikipedia.org)
Other drug-based treatment approaches are targeted therapies, immunotherapies, and hormonal therapies. (bosch.com)
Q3) Can RPI show that matrix-depleting drugs improve patient response to conventional chemo- and radiation therapy as well as new targeted therapies? (europa.eu)
With successful delivery, ImPRESS will have a direct impact on patient treatment and establish an imaging paradigm that will pave the way for new scientific knowledge on how to revitalize cancer therapies. (europa.eu)
This will be applied to deliver many anticancer drugs, such as doxorubicin, and we hope that it could increase the efficacy of cancer therapies compared to other delivery systems," said Zhenjia Wang, an assistant professor of pharmaceutical sciences who led the study. (belmarrahealth.com)
Despite recent advances in imaging, surgery, radiation, and systemic therapies, overall survival (OS) has improved only 5% in the last decade. (afcr.org)
Our focus is translational research that advances the understanding of cancer treatment resistance mechanisms through the development of novel targeted therapies in order to improve patient survival. (massgeneral.org)
Findings from the Cusack Laboratory have shown that conventional anti-cancer therapies, such as radiation and chemotherapy, induce resistance mechanisms under the control of the gene transcription factor NF-kappaB. (massgeneral.org)
This would increase CSC sensitivity to conventional cancer therapies, circumventing treatment resistance and enhancing treatment efficacy. (weeksmd.com)
Further, Winters and Kelley explain how to harness the anticancer potential of phytonutrients abundant in low-glycemic plant and animal foods to address the 10 hallmarks of cancer―an approach Western medicine does with drug based therapies. (oneradionetwork.com)
Other components of their approach include harm-reductive herbal therapies like mistletoe (considered the original immunotherapy and common in European cancer care centers) and cannabinoids (which shrink tumors and increase quality of life, yet are illegal in more than half of the United States). (oneradionetwork.com)
Controlled administration of radionuclides falls in the field of loco-regional therapies for the treatment of tumors. (betaglue.com)

Dose expansion (Phase 2) will be to further explore the safety and tolerability of the MTD and/or RP2D, PK, PD, anti-tumor activity, and efficacy of TT-10. (survivornet.com)
The post will also give you some insights into the background and targeted novel approach to improving the efficacy of anti-cancer drug treatment. (bosch.com)
The emerging technology known as targeted therapy facilitates selective delivery of chemotherapeutic agents involving therapeutic genes and drugs to tumor sites, which enhances the therapeutic efficacy and reduces side effects 2 . (nature.com)
It enables in situ delivery of the produced bioactive molecules to tumor site, which improves the therapeutic efficacy. (nature.com)
However, the efficacy of traditional treatments is hindered by systemic toxicity, limited therapeutic effects, and drug resistance. (doaj.org)
Most cytotoxic drugs have a steep dose-response curve, and small increments in dose can significantly influence a drug's therapeutic efficacy. (mhmedical.com)
The TAPUR Study aims to describe the safety and efficacy of Food and Drug Administration (FDA)-approved, targeted anticancer drugs prescribed for treatment of patients with advanced cancer that has a potentially actionable genomic alteration. (facingourrisk.org)
In Privo's Phase I / II safety and efficacy study in patients with squamous cell carcinoma of the oral cavity and lips, PRV111 demonstrated compelling results meeting all primary and secondary endpoints, including the ability to reduce tumor size by over 70% in a single week. (afcr.org)
Furthermore, we demonstrated that viable tumor tissue from ovarian cancer patients can be used to screen tumor radiosensitivity ex-vivo, enabling the direct assessment of therapeutic efficacy. (osti.gov)
This is an open-label, two-part, phase 1-2 dose-finding study designed to determine the safety, tolerability, PK, PD, and proof-of-concept efficacy of ST101 administered IV in patients with advanced solid tumors. (ucbraid.org)
Administration of β-emitting radionuclides vs external radiotherapy presents several advantages: high radiation dose delivery (improved efficacy), low surrounding tissue penetration, low impact on blood vessels, high control of administered energy (limited side effects). (betaglue.com)
Thus, asymptomatic subjects did not benefit from early treatment, and delayed treatment did not affect treatment efficacy (ie, survival). (medscape.com)
More commonly, multidrug regimens incorporating drugs with different mechanisms of action and different toxicities are used to increase efficacy, reduce dose-related toxicity, and decrease the probability of drug resistance. (msdmanuals.com)

and (III) there are no available imaging technologies for medical diagnostics of solid stress in human cancers. (europa.eu)
Using RPI, ImPRESS will conduct a comprehensive series of innovative studies in brain cancer patients to answer three key questions: (Q1) Can we image vascular restrictions in human cancers and map how the vasculature changes with tumor growth or treatment? (europa.eu)
Certain factors related to treatment increase the risk of second cancers. (angelsofcourage.com)
Risk of second cancers after radiation therapy is increased if alkylating agents were also used and if the patient is female, was younger at the time of diagnosis, or had Hodgkin lymphoma or soft tissue cancer. (angelsofcourage.com)
Our Featured Research Page lists cancer prevention, treatment and quality of life studies enrolling people with or at high risk for hereditary cancers. (facingourrisk.org)
This study is looking at how well the drug elimusertib (a type of targeted therapy known as an ATR inhibitor) works when combined with chemotherapy for treating people with advanced cancers, including urothelial, ovarian, gastric, endometrial, triple-negative breast cancer and others. (facingourrisk.org)
Patients with HPV positive tumors possess a far better prognosis than those with HPV negative cancers. (oncotarget.com)
Solid Tumors, Mucosal Cancers. (afcr.org)
PRV111 is a nanoengineered treatment for invasive locoregionally accessible mucosal cancers/high grade dysplasias and PRV211 is an intraoperative treatment for all solid tumors. (afcr.org)
Cancers such as mucosal and cutaneous tumors can be treated topically with PRV111 topical PRV111 topical system can be used in neoadjuvant settings to reduce the chance of recurrence and disfiguring surgeries. (afcr.org)
Radiation treatments as a young child or adult to treat other cancers of the chest can increase the risk of developing breast cancer. (tourmyindia.com)
This information supports past studies that have suggested ivermectin has anticancer activity against cancers of the digestive system, reproductive system, brain, respiratory system, hematological and breast. (freelysocial.com)
ivermectin may regulate the expression of crucial molecules … Therefore, current results indicate that Ivermectin might be a new potential anticancer drug for treating human colorectal cancer and other cancers. (freelysocial.com)
Single drugs may cure selected cancers (eg, choriocarcinoma, hairy cell leukemia). (msdmanuals.com)

The purpose of this study is to assess the anti-tumor activity and safety of amivantamab which will be administered as a co-formulation with recombinant human hyaluronidase PH20 (rHuPH20) (subcutaneous co-formulation [SC-CF]) in combination treatment (all cohorts except Cohort 4) and to characterize the safety of amivantamab SC-CF (Cohort 4). (stanford.edu)

In recent decades, the treatment of cancer has evolved and improved significantly, so that cancer patients and medical professionals have a selection of powerful therapeutic approaches to choose from. (bosch.com)
Basilea's Chief Executive Officer Ronald Scott said: 'We are very pleased with the strong sales performance of Cresemba in Europe and the U.S., which reflects its increasing recognition as a valuable treatment option for patients suffering from potentially life-threatening invasive fungal infections. (basilea.com)
Basilea continued to explore the safety and tolerability of BAL101553 in two phase 1/2a clinical studies in patients with solid tumors. (basilea.com)
In addition to its standalone treatments, Privo is planning to combine its products with immunotherapy to improve immunotherapy's outcome as 70% to 85% of patients taking immunotherapy drugs fail to respond to the treatment. (afcr.org)
It is thought that CBD may help cancer patients manage some of the symptoms of the disease, and side effects of treatment. (dsm.com)
Phesgo™ is indicated for use in combination with docetaxel for the treatment of adult patients with HER2-positive metastatic breast cancer (MBC) who have not received prior anti-HER2 therapy or chemotherapy for metastatic disease. (accc-cancer.org)
ENHERTU is a HER2-directed antibody and topoisomerase inhibitor conjugate indicated for the treatment of adult patients with unresectable or metastatic HER2-positive breast cancer who have received two or more prior anti-HER2-based regimens in the metastatic setting. (accc-cancer.org)
On June 29, 2020, the U.S. Food and Drug Administration approved pembrolizumab (Keytruda, Merck & Co.) for the first-line treatment of patients with unresectable or metastatic microsatellite instability-high (MSI-H) or mismatch repair deficient (dMMR) colorectal cancer. (accc-cancer.org)
On June 24, 2020, the U.S. Food and Drug Administration (FDA) approved pembrolizumab (Keytruda, Merck & Co., Inc.) for patients with recurrent or metastatic cutaneous squamous cell carcinoma (cSCC) that is not curable by surgery or radiation. (accc-cancer.org)
To determine the event-free survival (EFS) in patients with HB whose tumor is completely resected at diagnosis and either receive no adjuvant chemotherapy (completely resected well differentiated fetal [WDF] histology HB) or 2 cycles of standard dose cisplatin monotherapy (completely resected non-well differentiated fetal histology HB - 100 mg/m 2 /cycle given 3 weeks apart). (ucsf.edu)
In patients whose tumors are deemed unresectable after 2 cycles of cisplatin monotherapy, to determine the proportion of tumors rendered completely resectable by an additional 2 or 4 cycles of chemotherapy. (ucsf.edu)
Group C) V. To determine the EFS in patients with HCC whose tumor is completely resected at diagnosis who receive no adjuvant chemotherapy (completely resected HCC arising in the context of underlying liver disease) or 4 cycles of cisplatin/doxorubicin (PLADO) (completely resected de novo HCC). (ucsf.edu)
In patients whose metastatic disease does not resolve with the administration of SIOPEL 4 Induction therapy, to determine in a randomized comparison which post induction treatment (irinotecan and vincristine sulfate [vincristine] alternating with carboplatin and doxorubicin or carboplatin and etoposide alternating with carboplatin and doxorubicin) results in superior outcomes. (ucsf.edu)
To determine if the Childhood Hepatic tumor International Consortium (CHIC) hepatoblastoma risk stratification analysis of very low risk (Group A), low risk (Group B), intermediate risk (Group C) and high risk (Group D) groups stratifies patients allowing appropriate utilization of varying intensity chemotherapy regimens and surgical resection strategies. (ucsf.edu)
But these treatments, to some extent, easily produce side effects on normal cells, organs, and other tissues of the human body, thus accelerating the death process of cancer patients. (hindawi.com)
Phase 1/2a study of BAL101553, a novel tumor checkpoint controller (TCC), administered as 48-hour infusion in adult patients with advanced solid tumors. (basilea.com)
Although the incidence of acute nonlymphocytic leukemia is increased in PV, the incidence of acute leukemia in patients not exposed to chemotherapy or radiation therapy is low. (basicmedicalkey.com)
The combination of selinexor and radiation therapy may be effective in treating patients with newly-diagnosed DIPG and H3 K27M-Mutant HGG. (ucbraid.org)
Introduction In patients with non-small cell lung cancer, surgical treatment with postoperative adjuvant chemotherapy is performed. (bmj.com)
4 5 However, surgery alone may not be a sufficient treatment because an observational study of 11 663 surgically treated patients with NSCLC showed that the 5-year overall survival (OS) rate in all patients was 69.6%, while the rates in patients with clinical stage IA, IB, IIA and IIB were 82.0%, 66.1%, 54.5% and 46.1%, respectively. (bmj.com)
In February 2020, the United States Food and Drug Administration granted regulatory Fast Track designation for the investigation of NBTXR3 activated by radiation therapy, with or without cetuximab, for the treatment of patients with locally advanced HNSCC who are not eligible for platinum-based chemotherapy. (fintechnews.org)
In an era of personalized medicine, there is an urgent need for better knowledge of the biology leading to the disease, which can lead to the design of increasingly accurate drugs against patients' specific molecular aberrations. (123dok.org)
This study will initially treat up to approximately 300 patients with advanced solid tumors at approximately 30 sites, worldwide. (astrazenecaclinicaltrials.com)
A systematic review by He et al demonstrated a reduction in vertebral compressions and time to progression with early systemic treatment for asymptomatic patients, but this study also revealed an increase in acute leukemia in the early treatment group. (medscape.com)
Overall, the care of patients with MM is complex and should focus on treatment of the disease process and any associated complications. (medscape.com)
Several studies are evaluating the role of treatment in patients with high-risk smoldering multiple myeloma (SMM). (medscape.com)
In a phase III trial that was restricted to patients with high-risk SMM, the PETHEMA group found evidence of benefit from treatment with lenalidomide versus observation. (medscape.com)
Dose modification or exclusion of certain drugs may be necessary in patients with lung disease (eg, bleomycin), kidney failure (eg, methotrexate), liver dysfunction (eg, taxanes) or heart disease (daunorubicin, cyclophosphamide). (msdmanuals.com)
Postchemotherapy excision of the tumor is indicated in patients with bilateral tumors, tumors that extended beyond the midline and have shrunk, and tumors with vascular extension. (medscape.com)
Large tumors that extend beyond the midline, have vascular extension, or both are relative contraindications, since some surgeons elect to obtain tissue via surgical excision, but this may expose patients to increased surgical risks. (medscape.com)
In patients with bilateral Wilms tumors, solitary kidney, or kidney insufficiency, partial nephrectomy is a reasonable consideration. (medscape.com)
Although end-stage kidney disease after unilateral radical nephrectomy is uncommon (0.25% in the NWTSG trial), preserving healthy kidney tissue may prevent this complication, especially in patients with an underlying intrinsic kidney disease (eg, WAGR [Wilms tumor, aniridia, genitourinary anomalies, and mental retardation] syndrome, Denys-Drash syndrome). (medscape.com)
The results from this prevali- the field of cancer biomarkers (11-13), and that approach was dation study showed that patients could be classified into high- adopted here to define predictive serum biomarkers associated versus low-risk groups for developing metastatic breast cancer with tumor relapse in breast cancer patients. (lu.se)
Patients whose thyroid cancer has developed following radiation to the head and neck area may present with more extensive disease. (medscape.com)
Gastrointestinal toxicities were the most frequent (97.1%) and all patients received antineoplastic/chemotherapeutic and antiemetic treatment. (bvsalud.org)
Moreover, oral mucositis induces pediatric patients to reduce food intake, which affects their nutritional status and makes them less responsive to treatment 4-5 . (bvsalud.org)
5 reported that 78% of chemotherapy patients presented with mucositis at some point during treatment. (bvsalud.org)

Aktuell werden noch zwei weitere Studien mit einmal täglicher oraler Gabe von BAL101553 durchgeführt: die Dosiseskalation in einem separaten Arm für Patienten mit rezidivierendem Glioblastom in der Phase-1/2a-Studie, und eine Phase-1-Studie, bei der in Zusammenarbeit mit dem Adult Brain Tumor Consortium (ABTC) in den USA die Kombination mit einer Standard-Strahlentherapie bei neu diagnostiziertem Glioblastom untersucht wird. (basilea.com)

CSCs have been described in several solid tumors, including prostate cancer, and contribute to therapeutic resistance and tumor recurrence. (weeksmd.com)
Targeted molecular therapy against EGFR has shown promise as an adjuvant therapy in preliminary studies in several solid tumors, including head and neck cancer. (medscape.com)

Once injected, the spores begin to destroy the tumor cells that traditional cancer treatments can not reach. (voanews.com)
This task can be accomplished by replacing tumor suppressor genes that have been lost or mutated, selectively inserting genes that produce cytotoxic substances, or modifying the immune system to destroy the tumor cells. (medscape.com)

It is well known that the rapid growth of tumor cells and distortion of tumor blood vessels often results in insufficient oxygen supply and acidification in solid tumors. (nature.com)
Drugs used in chemotherapy, such as temozolomide, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. (ucbraid.org)

Researchers are developing a promising therapy to treat cancerous tumors - by injecting them with a bacterium found in soil. (voanews.com)
So far, the experimental treatment has mostly been tested in pet dogs, but investigators hope they have found an effective anti-cancer therapy for people. (voanews.com)
But despite promising results, the microbial therapy fell out of favor with the advent of powerful chemotherapy drugs and radiation. (voanews.com)
Rats with brain tumors that had the microbial therapy survived 33 days after treatment compared to 18 days for rats that did not receive C. novyi spores. (voanews.com)
It's possible,he says, that the bacterial therapy can be combined with chemotherapy and radiation for a more powerful anti-cancer effect. (voanews.com)
1900 - Swedish Dr. Stenbeck cures a skin cancer with small doses of radiation 1920s - Dr. William B. Coley's immunotherapy treatment, regressed tumors in hundreds of cases, the success of Coley's Toxins attracted heavy resistance from his rival and supervisor, Dr. James Ewing, who was an ardent supporter of radiation therapy for cancer. (wikipedia.org)
Is it possible to improve the treatment of a cancer patient by selecting an appropriate individualized drug therapy? (bosch.com)
A commonly used form of drug therapy is chemotherapy, which uses agents that inhibit the rapid growth of cancer cells or destroy them. (bosch.com)
Despite great efforts in the development and clinical application of anti-cancer drugs, the individual response of a patient to a specific pharmacological cancer therapy can unfortunately vary strongly. (bosch.com)
Apparently, there is a pressing need to rationally design delivery systems for tumor therapy. (nature.com)
In this study, we constructed a nano-drug delivery system (NPF@DOX) targeting FAP to increase the therapeutic efficiency of synergistic chemo-photothermal therapy against OSCC.Methods: We utilized PEGylated nano-graphene oxide (NGO) to link doxorubicin (DOX) and fluorescently-labeled, FAP-targeted peptide chains via hydrogen bonding and π-π bonding to enhance the targeting capability of NPF@DOX. (doaj.org)
Importantly, FAP-targeted NPF@DOX in combination with PTT showed better tumor suppression performance in vivo and in vitro than did either therapy individually.Conclusion: NPF@DOX can precisely target OSCC, and combined treatment with chemical and photothermal therapy can improve the therapeutic outcomes of OSCC. (doaj.org)
Developing biomarkers that can measure how mechanical forces in a solid tumor impair perfusion and promotes therapy resistance is essential for treatment of disease. (europa.eu)
Radiation therapy may cause solid tumors and leukemia. (angelsofcourage.com)
Inclusion Criteria: - Histologically, or cytologically documented, advanced stage, malignant adult solid tumors (except prostate cancer ) that are refractory to, or recurrent from, standard therapy or for which no curative standard therapy exists. (mycancergenome.org)
Subjects must have recovered from the acute toxicities of any prior therapy , and not received chemotherapy , radiation therapy or other investigational anticancer therapeutic drug for at least 4 weeks prior to J591 administration in this trial - All subjects must have archived or current tissue (from a primary or metastatic focus) available for PSMA determination. (mycancergenome.org)
The fundamental principle of curative therapy for children and adolescents with cancer is eradication of malignant cells and their precursors by tailoring treatment plans to incorporate surgery, radiation, and systemic chemotherapy, as required for specific cancer types and subtypes. (mhmedical.com)
For many children and adolescents with solid tumors, complete surgical resection is a critical component of therapy. (mhmedical.com)
The established cornerstones of successful treatment with chemotherapy and radiation are (1) combination therapy, (2) dose intensity, and (3) adjuvant and neoadjuvant therapy. (mhmedical.com)
Systemic chemotherapy can be administered prior to or following local control of solid tumors and may be administered concurrently or sequentially with radiation therapy in children or adolescents with leukemia or solid tumors. (mhmedical.com)
The non-myelosuppressive effect also makes it useful for treating solid tumors, especially when paired with a radiation therapy. (eaavmadrid2011.es)
Smartly engineered nanocapsules can not only shrink and decompose into small-sized nanodrugs upon drug release but also can regulate the TME to overproduce reactive oxygen species for enhanced synergistic therapy in tumors. (nature.com)
This study is comparing safety and effectiveness of a new drug called giredestrant compared to standard hormone therapy in people with early-stage, ER-positive breast cancer. (facingourrisk.org)
This often means the use of chemo or radiation therapy, which possess a bevy of different side effects that may introduce alternative complications in addition to cancerous cell development. (belmarrahealth.com)
Lab principal investigator James C. Cusack, MD , is co-inventor of the patent "Use of NF-kappaB inhibition in combination therapy for cancer," (United States patent 6,831,057), which describes the therapeutic strategy noted above and is now licensed to two pharmaceutical companies for novel drug development. (massgeneral.org)
We reported the development of an effective cancer treatment using a multidisciplinary treatment, including photodynamic therapy (PDT) with indocyanine green (ICG) liposomes and a combination of Lentinula edodes mycelia (LEM) and hydrogen gas inhalation therapy. (mdpi.com)
This World Cancer Day (4 th February) we're highlighting what we know about CBD and cancer, including the potential benefits of the molecule in anti-cancer therapy and management for the side effects of cancer or its treatment. (dsm.com)
While there are no studies to date that have confirmed CBD eases the side effects of cancer or cancer therapy, the molecule is understood to have some potential in modulating the most common and debilitating symptoms 15 Although largely based on THC, there are also already some cannabinoid-based drugs on the market prescribed to help relieve symptoms caused by chemotherapy. (dsm.com)
Localized disease can be effectively treated with radiation therapy or radical prostatectomy. (weeksmd.com)
Hormone replacement therapy (HRT) can give you a higher risk of breast cancer if you have received such treatments with estrogen for several years or more at a time. (tourmyindia.com)
Here we will review the research progress of active components of Polygonum cuspidatum in tumor diseases therapy, mainly including resveratrol, polydatin, emodin, and chrysophanic acid (Figure 1 ). (hindawi.com)
Endothelial cell proliferation as a novel approach to targeting tumour therapy. (sagepub.com)
Radiation therapy uses high-energy x-rays to kill tumor cells. (ucbraid.org)
This phase I/II trial tests the safety, side effects, and best dose of selinexor given in combination with standard radiation therapy in treating children and young adults with newly diagnosed diffuse intrinsic pontine glioma (DIPG) or high-grade glioma (HGG) with a genetic change called H3 K27M mutation. (ucbraid.org)
It also tests whether combination of selinexor and standard radiation therapy works to shrink tumors in this patient population. (ucbraid.org)
Has received prior systemic anticancer therapy for metastatic NSCLC. (who.int)
Has received radiation therapy to the lung (>30 Gray) within 6 months of start of study intervention. (who.int)
3 Although there have been no randomised controlled trials to compare surgery with radiation therapy or chemotherapy, observational studies have suggested that surgery is the most curative treatment for lung cancer. (bmj.com)
[ 1 ] Early stage head and neck squamous cell carcinoma (HNSCC) is treated relatively well with single-modality therapy (either surgery or radiation alone). (medscape.com)
The management of advanced HNSCC consists of multiple-modality therapy with surgery, radiation, and chemotherapy. (medscape.com)
Various techniques have been developed for targeting cancer cells: gene therapy, monoclonal antibodies (MAbs), antibody toxin conjugates, small-molecule inhibitors, antisense molecules, and tumor vaccines. (medscape.com)
Radionuclides are administered through a proprietary device engineered to guarantee a precise delivery of the required dose of energy where it is needed, thus overcoming some disadvantages of external beam radiation therapy (EBRT). (betaglue.com)
Radiation therapy may also be used. (medlineplus.gov)
Physicians must understand both the natural history of multiple myeloma (MM) and the limitations of current therapy in the treatment of the disease. (medscape.com)
The major modalities of therapy are Surgery (for local and local-regional disease) Radiation. (msdmanuals.com)
From the abstract: 'The greatest change in the treatment of people living with type 1 diabetes in the last decade has been the explosion of technology assisting in all aspects of diabetes therapy, from glucose monitoring to insulin delivery and decision making. (cdc.gov)
Although the NWTSG/COG and SIOP guidelines concur that combined surgery, chemotherapy and radiotherapy is the initial treatment for Wilms tumor in children, they differ on the preferred strategy for delivery of therapy. (medscape.com)
The treatment protocol included the use of 10ml of a mucositis mouthwash and low-level laser therapy. (bvsalud.org)
The use of a treatment protocol consisting of a mucositis solution associated with low-level laser therapy effectively resolved a case of severe chemotherapy-induced oral mucositis. (bvsalud.org)

Currently adjuvant treatment is used after recovery from surgery such as radiation and chemotherapy. (afcr.org)
It is not yet known whether giving radiation with concomitant and adjuvant temozolomide versus radiation with adjuvant PCV is more effective in treating anaplastic glioma or low grade glioma. (ucbraid.org)
the investigators suggested that adjuvant treatment or completion inguinofemoral lymph node dissection be performed for such sentinel lymph nodes. (medscape.com)

Meanwhile, in one human patient with an advanced soft tissue tumor that had spread to her abdomen, the spore treatment significantly reduced the tumor in and around the bone in the woman's arm where the cancer originated. (voanews.com)
Cohort E Only: Fresh tissue sample obtained prior to treatment initiation and agree to on-treatment biopsy from same lesion. (survivornet.com)
EGFR mutation must have been identified as determined by Food and Drug Administration (FDA) approved or other validated test of either circulating tumor deoxyribonucleic acid (ctDNA) or tumor tissue in a clinical laboratory improvement amendments (CLIA) certified laboratory (sites in the United states [US]) or an accredited local laboratory (sites outside of the US). (stanford.edu)
Recently, adipose tissue-derived stem cells (ADSCs) have been shown to have anti-inflammatory, immunosuppressive, and tissue-repair characteristics and are considered a useful treatment for inflammatory disease. (bvsalud.org)
However, for the first time, a new type of tumor treatment method was utilized that could let doctors target the tumor with anticancer drugs that might otherwise damage healthy tissue. (belmarrahealth.com)
Breast cancer is a cancerous tumor that is found in the tissue surrounding the breast area. (tourmyindia.com)
Dr. Gunn, a co-founder of InspireHealth , Canada's leading integrative cancer center, will highlight the role of tumor associated macrophages (TAMs) in determining the growth potential (or lack thereof) of tumor tissue. (holisticprimarycare.net)
Must provide archival tumor tissue sample or newly obtained core, incisional, or excisional biopsy of a tumor lesion not previously irradiated. (who.int)
Has a history of allogenic tissue/solid organ transplant. (who.int)
The current conventional modalities (surgery, radiation, chemotherapy) are nonselective and can cause damage to normal tissue. (medscape.com)
Neuroblastoma is a very rare type of cancerous tumor that develops from nerve tissue. (medlineplus.gov)
Wilms tumor arises from the primitive embryonal renal tissue. (medscape.com)

There was at least a 30 percent reduction in the size of the cancerous tumors in three other dogs in the group. (voanews.com)
The treatment of cancerous tumors can be tricky and dangerous. (belmarrahealth.com)

This in turn renders the supply of oxygen in tumor vasculature insufficient, consequently leading to formation of hypoxia or anoxia regions in malignant tumors. (nature.com)
In recent years, the utilization of Chinese native medicine and other plant extracts in the treatment of diseases has attracted extensive attention, especially in the area of malignant tumors. (hindawi.com)
With the changes of the diet types and the bad living habits, malignant tumors have gradually developed into a serious threat to human health and life. (hindawi.com)

Uses high doses of radiation to kill cancer cells and shrink tumors, with two types currently available-external beam and internal beam. (belmarrahealth.com)

The occurrence of angiogenesis in tumors develops irregular and poorly-organized blood vessels. (nature.com)
Zirconium-89 (89Zr) is a radioactive tracer that allows special scans to be performed prior to administration of the study drug to determine where the antibody goes in the body and to screen the tumor's blood vessels to see if they attract J591. (mycancergenome.org)
What they did was attach these tiny particles to infection-fighting white blood cells, essentially piggybacking antitumor drugs so they could get past the protection of blood vessels that typically shield a tumor with great success. (belmarrahealth.com)

2 AD - Ancient Greeks describe surgical treatment of cancer. (wikipedia.org)
Standard of care surgical/radiation treatments for OC can severely damage a patient's ability to speak, chew, and swallow. (afcr.org)
Considering the relationships among surgical treatments, inflammation and carcinogenesis, non-steroidal anti-inflammatory drugs (NSAIDs) are a candidate postoperative treatment for preventing recurrence and maintaining QOL. (bmj.com)
Applications of this β-emitting radiotherapy platform vary from the intra-tumoral treatment of unresectable or metastatic tumors, to the treatment of surgical margins after tumor excision to avoid local recurrences. (betaglue.com)
Indications for primary surgical excision of a Wilms tumor include tumors confined to the kidney, extending beyond the kidney but not crossing the midline, and with or without vascular extension. (medscape.com)
According to the NWTSG protocol, the first step in the treatment of Wilms tumor is surgical staging followed by radical nephrectomy, if possible. (medscape.com)

We have developed a new approach to delivering therapeutics into tumors using the white blood cells of our body. (belmarrahealth.com)
Letter: On drugs and therapeutics 44(1121):1-4. (cdc.gov)

Anticancer drugs that inhibit the molecular signaling pathways in malignant cells and drugs that overcome cancer's ability to evade immune response may provide a new foundation to improve outcome for children and adolescents with cancer. (mhmedical.com)
Downregulation of NF-kB and STAT3 can inhibit solid tumor proliferation and invasion. (holisticprimarycare.net)

This study is looking at the effectiveness of combining a PARP inhibitor called niraparib and an immunotherapy called dostarlimab for treating people with an inherited BRCA mutation (found with genetic testing) or a tumor mutation (found through tumor testing) who have breast, pancreatic, ovarian, fallopian tube or primary peritoneal cancer that is metastatic or advanced and cannot be removed by surgery (unresectable). (facingourrisk.org)

1. Equipped with HlyE, EcNe significantly caused tumor regression in mice xenografted with human colorectal cancer cells. (nature.com)
S. Choofong, P. Cloutier, L. Sanche, J. R. Wagner "Increased radio-sensitivity of colorectal tumor with intra-tumoral injection of low dose of gold nanoparticles. (usherbrooke.ca)
New evidence published in Frontiers in Pharmacology show the antiparasitic medication ivermectin may have a new application in the treatment of colorectal cancer (CRC). (freelysocial.com)

Wilms tumor is bilateral in 6% of cases. (medscape.com)
Contraindications to primary surgery for Wilms tumor include bilateral tumors and documented metastatic disease. (medscape.com)
New protocols in the management of bilateral Wilms tumor are being explored. (medscape.com)

Pharmacological research has proved that fatty acids, such as unsaturated linoleic, α-linolenic, eicosapentaenoic and docosahexaenoic acids, retard tumor growth, inducing apoptotic processes in tumor cells, inhibiting angiogenesis, as well as improving efficiency of chemical drugs and alleviating their side effects 12, 15-19) . (prolekare.cz)

Following bloodstream clearance mediated by inflammation, bacteria are generally entrapped in the tumor vasculature. (nature.com)

These PRV-based products are capable of treating a broad spectrum of oncologic malignancies through either topical application to the tumor or resected areas post-surgery to reduce the chance of micrometastasis and cancer recurrence. (afcr.org)
Dr. Cusack wrote the first clinical trial of combination chemotherapy with the drug bortezomib for solid organ malignancies, reported in the journal Cancer . (massgeneral.org)
The Hematopoietic stem cell transplantation (HSCT) is used in children as a definitive treatment for various oncological, immune deficiencies, hemoglobinopathy, and malignancies diseases that involve the hematological system, congenital metabolism disorders, among others. (bvsalud.org)

One hurdle specific to treating solid tumors is a protective layer called an extracellular matrix that can prevent chemotherapeutic agents from penetrating the tumor's core. (nanowerk.com)
Their current application in oncology has revolutionized cancer treatment by improving the antitumor activity of several chemotherapeutic agents. (mdpi.com)
Unfortunately, so do many chemotherapeutic drugs and radiotherapy. (holisticprimarycare.net)
Although older chemotherapeutic drugs are often toxic to normal cells, advances in genetics and cellular and molecular biology have led to development of more selective drugs. (msdmanuals.com)

From the abstract: 'This international consensus report on precision diabetes medicine summarizes the findings from a systematic evidence review across the key pillars of precision medicine (prevention, diagnosis, treatment, prognosis) in four recognized forms of diabetes (monogenic, gestational, type 1, type 2). (cdc.gov)

This is a historical timeline of the development and progress of cancer treatments, which includes time of discovery, progress, and approval of the treatments. (wikipedia.org)
Anti-Cancer Drugs. (wikipedia.org)
Hyperthermia In Cancer Treatment: A Primer. (wikipedia.org)
In the photiomics research project, we are working with industrial, academic, and clinical partners to improve cancer treatment. (bosch.com)
We are investigating and developing innovative technological solutions for the personalization of cancer treatment by using a patient tumor sample to perform drug screening and determine the appropriate medication for the cancer patient. (bosch.com)
A cancer diagnosis changes a person's life and those of their family and friends in a drastic way, as cancer requires complex treatment and is unfortunately still one of the most common causes of death. (bosch.com)
In Germany alone, about 500,000 people are newly diagnosed with cancer every year and appropriate treatment options must be selected for every cancer patient. (bosch.com)
There are currently several different options for cancer treatment, depending primarily on the type and stage of the cancer. (bosch.com)
Currently, the accurate prediction of an individual patient's response to established or novel anti-cancer drugs is an unsolved challenge in cancer treatment. (bosch.com)
There is a high need for personalization of the drug-based cancer treatment of tumors in order to administer the adequate and successful individual medication for each cancer patient. (bosch.com)
Even the perfect cancer drug must reach its target to have an effect. (europa.eu)
Delivery of anti-cancer drugs to the tumor is critically dependent on a functional vascular bed. (europa.eu)
Improvements in cancer treatment have decreased the number of deaths from primary cancer. (angelsofcourage.com)
Smart drug delivery systems (SDDSs) for cancer treatment are of considerable interest in the field of theranostics. (nature.com)
A team of scientists from the Institute of Molecular Genetics of the Czech Academy of Sciences has discovered which places in the DNA molecule inside cancer cells are the basis of the effect of anticancer drugs. (cas.cz)
These cancer cells divide and grow excessively in those affected, with treatment type being dictated by various factors such as the type of tumor, its location, and if the patient can tolerate the procedure. (belmarrahealth.com)
Currently, when it comes to anti-cancer or tumor treatment, there exist a number of different methods that can be used. (belmarrahealth.com)
External beam involves the use of a radiation producing machine that aims radiation at the particular part of the body where the cancer is located. (belmarrahealth.com)
Uses drugs to kill cancer cells or slow down their growth. (belmarrahealth.com)
This is a very common type of cancer treatment and often the only type received. (belmarrahealth.com)
There are several types of anti-cancer drugs, and what you receive will depend on the type of cancer being treated. (belmarrahealth.com)
Involves a surgeon removing cancer directly from the body and works best with solid tumors that are contained in one area. (belmarrahealth.com)
This form of treatment may need to be combined with other methods of cancer treatment. (belmarrahealth.com)
Scientists now report results in ACS' Chemistry of Materials ( 'Multifunctional Protocells for Enhanced Penetration in 3D Extracellular Tumoral Matrices' ) showing that, by cloaking anti-cancer drugs in a specially designed particle, they could target and destroy tumor cells deep inside a malignant mass in vitro . (nanowerk.com)
Researchers have long known that, thanks to the unique blood vessel architecture surrounding tumors, nanoparticles can easily pass into the cancer zone, offering a potential route for the specific delivery of chemotherapies to cancer cells. (nanowerk.com)
The company's pivotal-ready assets, PRV111 and PRV211 are potent locoregional anti-cancer treatments. (afcr.org)
However, advances in cancer care are continuously made, with new treatment approaches being explored all the time. (dsm.com)
The use of cannabinoids, including CBD, for the treatment of cancer has been of interest to the scientific community for some time. (dsm.com)
As well as acting on cancer cells directly, it has been suggested that CBD affects the tumor environment too by stopping the development of blood cells that feed the cancer, preventing its ability to spread and reducing inflammation. (dsm.com)
Cancer and cancer treatments, such as chemotherapy and radiation, can produce a number of side effects, including nausea and vomiting, loss of appetite and pain. (dsm.com)
Metformin, the first-line drug for treating diabetes, inhibits cellular transformation and selectively kills cancer stem cells in breast cancer cell lines. (weeksmd.com)
Conventional treatment continues to rely on chemotherapy, surgery, and radiation to attack cancer cells. (oneradionetwork.com)
As poly adenosine diphosphate (ADP)-ribose polymerase 1 (PARP-1) is overexpressed in various cancer types, and is localized to the nucleus, PARP-1 can be safely targeted with Auger emitters to induce DNA damage in tumors. (osti.gov)
Here, we investigated a radioiodinated PARP inhibitor, [ 125 I]KX1, and show drug target specific DNA damage and subsequent killing of BRCA1 and non-BRCA mutant ovarian cancer cells at sub-pharmacological concentrations several orders of magnitude lower than traditional PARP inhibitors. (osti.gov)
Finally, we showed tumors can be imaged by single-photon computed tomography (SPECT) with PARP theranostic, [ 123 I]KX1, in a human ovarian cancer xenograft mouse model. (osti.gov)
Women with HER-2 positive breast cancer refers to women with a gene in their cancerous tumor that helps cells grow, divide, and repair themselves. (tourmyindia.com)
The younger you started with such radiations and the higher dosage of radiation received, the more likely you are to get breast cancer in the future. (tourmyindia.com)
Therefore, the full utilization of some natural products and their active components will provide unique ideas and methods for cancer prevention and treatment. (hindawi.com)
A growing number of researches have shown that the effect of Polygonum cuspidatum and its active ingredients in cancer treatment is remarkable. (hindawi.com)
Efforts are needed to refine strategies for risk management, avoiding unintended consequences that negatively affect patient access and clinical development of promising new cancer treatments. (sagepub.com)
Well-recognized common cancer risk factors including exposure to radiation, environmental pollutants, high calorie intake, use of tobacco, and many others share a common link in that they induce inflammation, particularly through activation of transcription factors STAT3 and NF-kB. (holisticprimarycare.net)
Dr. Aggarwal has shown that constitutively active NF-kB and STAT3 is found in most types of cancer, and that the hypoxic and acidic conditions seen in most solid tumors further activate inflammatory transcription factors. (holisticprimarycare.net)
The term, risk, refers to the chance of the cancer coming back after treatment. (ucbraid.org)
Has a diagnosis of small cell lung cancer or, for mixed tumors, presence of small cell elements. (who.int)
This is the first study to evaluate the effect of the perioperative administration of non-steroidal anti-inflammatory drugs (NSAIDs) on postoperative recurrence in non-small cell lung cancer. (bmj.com)
In the presence of a combination of systemic chemotherapy, radiotherapy and loco-regional is the standard approach, whereby radiotherapy can trigger an anti-cancer immune response that can be further exploited by the new immune-stimulator drugs. (betaglue.com)
The product candidate's physics-based mechanism of action (MoA) is designed to induce significant tumor cell death in the injected tumor when activated by radiotherapy, subsequently triggering adaptive immune response and long-term anti-cancer memory. (fintechnews.org)
Pursuant to this strategy, in 2019 Nanobiotix entered into a broad, comprehensive clinical research collaboration with The University of Texas MD Anderson Cancer Center to sponsor several phase I and phase II studies to evaluate NBTXR3 across tumor types and therapeutic combinations. (fintechnews.org)
[ 2 ] The treatment of vulvar cancer in this article focuses on squamous cell histology and does not include the treatment of preinvasive disease. (medscape.com)
Treatment is often successful if the cancer has not spread. (medlineplus.gov)
The National Cancer Institute maintains an up-to-date list of drugs used to treat cancer. (msdmanuals.com)
The ideal drug would target only cancer cells and have no adverse effects on normal cells. (msdmanuals.com)
Most cancer drugs are given systemically, usually intravenously or subcutaneously, but some are given by mouth. (msdmanuals.com)
Resistance to cancer drugs is common. (msdmanuals.com)
Cytotoxic drugs damage DNA and kill many normal cells as well as cancer cells. (msdmanuals.com)
In contrast, other drugs (eg, DNA cross-linkers, also known as alkylating agents) have a linear dose-response relationship, killing more cancer cells at higher doses. (msdmanuals.com)
The most common thyroid tumor to develop after exposure to radiation is papillary thyroid cancer. (medscape.com)
A male 13-year-old patient with chondroblastic osteosarcoma in the left distal thigh and acute lymphoblastic leukemia undergoing cancer treatment with methotrexate presented with severe oral mucositis. (bvsalud.org)
Chemotherapy-induced mucositis is one of the most important undesirable side effects of cancer treatment, promoting the worst cases of morbidity, increasing length of hospital stay, and frequently reducing the odds of controlling the tumor and the patient's life expectancy 1 . (bvsalud.org)
According to the medical record, the patient had been undergoing cancer treatment for one year and eight months. (bvsalud.org)
Inflammatory Drugs and Risk of Breast Cancer: Evidence from a General Female Population and a Mammographic Screening Cohort in Sweden. (cancercentrum.se)
Associations of a Breast Cancer Polygenic Risk Score With Tumor Characteristics and Survival. (cancercentrum.se)

Osimertinib must have been administered as either the first-line treatment for locally advanced or metastatic disease or in the second-line setting after prior treatment with first- or second-generation EGFR tyrosine kinase inhibitor (TKI) as a monotherapy. (stanford.edu)
The combination of amivantamab and lazertinib must have been administered as the first-line treatment for locally advanced or metastatic disease. (stanford.edu)

In addition, the presence of available nutrients in necrotic tumor tissues attracts facultative anaerobes like Salmonella and Escherichia to the cancerous site via chemotaxis. (nature.com)
On the contrary, small size NPs with a diameter of 4-20 nm easily penetrate into deep tumor tissues, but they are more prone to rapid clearance and insufficient drug retention. (nature.com)
Relapse of neuroblastoma commonly occurs in hypoxic tissues, and is associated with an acquired and sustained high-level drug resistance, often due to p53 loss of function. (aacrjournals.org)
Or, the tissues of the tumor may mature and develop into a non-cancerous (benign) tumor called a ganglioneuroma , which can be surgically removed. (medlineplus.gov)
Tumour the fetus via the maternal circulation utero, but when the reactive metab multiplicity rises to a maximum in must have crossed the placenta, and olites formed in maternal tissues are offspring exposed at approximate consequently are generally referred too unstable to circulate in the mater ly 21 days of gestation, a few days to as transplacental carcinogens. (who.int)

The ability of metformin to block tumor growth and prolong remission in xenografts in combination with doxorubicin is associated with decreased function of the inflammatory feedback loop. (weeksmd.com)

X-ray or other imaging tests are done to locate the main (primary) tumor and to see where it has spread. (medlineplus.gov)
before resection of the primary tumor and then postoperatively every 6-12 mo, resulting in three to five samples per patient. (lu.se)

Systemic chemotherapy generally combines several cytotoxic drugs that have synergistic mechanisms of action and nonoverlapping toxicity. (mhmedical.com)
Bioreductive agents, such as Tirapazamine (TPZ), are preferentially cytotoxic in hypoxia and show activity against a variety of tumor cell lines ( 1 - 4 ). (aacrjournals.org)

All cohorts except Cohort 4: Participants must have at least 1 measurable lesion, according to Response Evaluation Criteria in Solid Tumors (RECIST) version 1.1. (stanford.edu)

Cohort A dose escalation: RCC, CRPC and NSCLC who have failed or are not eligible for standard of care treatment. (survivornet.com)
Cohort E: Exploratory Biopsy - Inclusive of participants with RCC, CRPC and/or NSCLC who have failed or are not eligible for standard of care treatment and have an accessible tumor for pre- and post dose biopsies. (survivornet.com)
A participant must agree not to donate eggs (ova, oocytes) or freeze for future use for the purposes of assisted reproduction during the study and for a period of 6 months after receiving the last dose of study treatment. (stanford.edu)
The only difference in treatment between the two parts is that some subjects treated in Part 1 may receive a different dose of selinexor than the subjects treated in Part 2. (ucbraid.org)
Studies in experimental incidence and multiplicity of tumours to Wilms tumour in humans - in the animals increase and the latency period de adult rat after perinatal exposure to a creases with increasing dose. (who.int)

Research from all over the globe shows that the best outcomes come from comprehensive interdisciplinary approaches that focus not only on eradicating tumors, but also on optimizing health, minimizing side effects and helping people restore strength and vitality. (holisticprimarycare.net)
For a summary of treatment approaches to MM, see Multiple Myeloma Treatment Protocols . (medscape.com)

This article reports the resolution of a case of severe oral mucositis and the treatment protocol that promoted complete remission of the lesions. (bvsalud.org)

Has received prior radiotherapy within 2 weeks of start of study intervention or has radiation-related toxicity requiring corticosteroids. (who.int)
Given the MoA, Nanobiotix believes that NBTXR3 could be scalable across any solid tumor that can be treated with radiotherapy and across any therapeutic combination, particularly, with immune checkpoint inhibitors. (fintechnews.org)

The primary analysis will evaluate the treatment effect of flurbiprofen axetil on postoperative recurrence. (bmj.com)

Wilms tumor, treatment for which includes surgery (radical or partial nephrectomy), is the fifth most common pediatric malignancy and the most common type of renal tumor in children. (medscape.com)
Wilms tumor is rare in adults, accounting for only 0.5% of renal lesions. (medscape.com)
The outcome of current treatment for Wilms tumor is an example of success achieved through a multidisciplinary collaboration of the National Wilms' Tumor Study Group (NWTSG), which merged with other pediatric groups to form the Children's Oncology Group (COG), and the Societe Internationale d'Oncologie Pediatrique (SIOP). (medscape.com)
Gross nephrectomy specimen shows a Wilms tumor pushing the normal renal parenchyma to the side. (medscape.com)
For unilateral Wilms tumor, the NWTSG/COG guidelines, primarily followed in North America, recommend surgery prior to chemotherapy, whereas the SIOP guidelines, followed in Europe, recommend both preoperative and postoperative chemotherapy. (medscape.com)
See Wilms Tumor: A Pediatric Oncology Success Story, a Critical Images slideshow, to help identify the clinical features, staging evaluation, prognostic factors, and therapeutic options for this disease. (medscape.com)
Grossly, Wilms tumor is typically an intrarenal solid or cystic mass, which may displace and, in rare cases, invade the renal collecting system. (medscape.com)
Surgery alone is not recommended for Wilms tumor, based on the results of the NWTSG-5 study. (medscape.com)

When the bacteria grow, they will deprive the tumor cells of their normal nutrients. (voanews.com)
And the immune response will attack not only the bacteria themselves, but also the tumor cells,' he said. (voanews.com)
Nevertheless, they have intrinsic limitations that most of the produced payloads are restricted to proliferating cells or/and afflicted with tumor penetration. (nature.com)
An international team of scientists led by Hana Hanzlíková from the Institute of Molecular Genetics of the Czech Academy of Sciences and Keith Caldecott from the University of Sussex in the United Kingdom discovered which sites in the DNA molecule inside tumour cells represent the basis of the effect of anticancer drugs (so-called PARP inhibitors). (cas.cz)
New findings from our Czech-British research team now show that PARP inhibitors prevent the joining of short stretches of DNA during DNA copying in the cell and that intermediates of unlinked Okazaki fragments are likely to be a major source of cytotoxicity in rapidly dividing tumour cells. (cas.cz)
The electron microscopy image shows a section of a dividing DNA molecule isolated from tumor cells. (cas.cz)
This was further complimented in tumor-implanted mice studies who were injected with gold nanoparticles treated with antibodies that, when exposed to infrared light, produced heat that killed the tumor cells. (belmarrahealth.com)
For tumors that can't be extracted with surgery, radiation and chemotherapy are the treatments of choice, but both can involve serious side effects due to a lack of specificity: They'll kill healthy cells along with malignant ones. (nanowerk.com)
The researchers tested the protocells in a 3-D cell culture model of a solid tumor, showing that the protocell penetrates and destroys malignant cells better than drug-loaded protocells without the enhanced toolkit. (nanowerk.com)
This forces tumor cells to compensate by increasing the rate of glycolysis. (weeksmd.com)
Giving combination chemotherapy may kill more tumor cells than one type of chemotherapy alone. (ucsf.edu)

Privo's treatments have been shown to be safe and effective locoregional chemo-immunotherapies based on results from its Phase I / II clinical trial investigating PRV111 in head and neck squamous cell carcinoma. (afcr.org)
The purpose of this review is to summarize the research progress of Chinese herb Polygonum cuspidatum and its active components in tumor diseases and provide theoretical basis for further scientific experiments and clinical applications. (hindawi.com)
Basilea Pharmaceutica AG (SIX: BSLN) berichtete heute über die Präsentation von Phase-1-Daten aus den Dosiseskalations-Teilen von zwei Phase-1/2a-Studien mit wöchentlicher 48-Stunden-Infusion sowie einmal täglicher oraler Gabe ihres neuartigen Tumor-Checkpoint-Controllers BAL101553 auf der Jahrestagung der American Society of Clinical Oncology (ASCO) am 4. (basilea.com)
clinical conditions of the patient, the existence of a tumors are considered rare (KLUSMANN et al. (bvsalud.org)

With our recent discovery of the molecule HB-EGF in resistance pathways, we worked with collaborators in Japan to bring a new drug to the clinic that targets this specific pathway. (massgeneral.org)
Abrogating p53 function with HPV 16 E6 transduction in drug-sensitive neuroblastoma cell lines caused high-level drug resistance. (aacrjournals.org)
For chemotherapy drugs, one of the best characterized resistance mechanisms is overexpression of MDR1 , a cell membrane transporter that causes efflux of certain drugs (eg, vinca alkaloids, taxanes, anthracyclines). (msdmanuals.com)
Attempts to alter MDR1 function and prevent drug resistance have been unsuccessful. (msdmanuals.com)

In der geplanten Studie soll deshalb der potenzielle klinische Nutzen, den unser neuartiger Tumor-Checkpoint-Controller in diesen Indikationen bieten könnte, untersucht werden. (basilea.com)

Metastatic or recurrent solid tumor malignancy defined by abnormal CT, MRI, PET scan, CXR and/or bone scan - Progressive disease manifest by: Development of new lesions or an increase in size of preexisting lesions on imaging study or by physical examination. (mycancergenome.org)
Has a known additional malignancy that is progressing or has required active treatment within the past 3 years. (who.int)

Surgery is the standard of care for resectable solid tumors. (betaglue.com)
In this respect, in contrast to predictors based for each serum protein was determined by comparing the samples upon tumor characteristics at the time of surgery, serum is a par- collected at the primary operation and then 3-6 mo later. (lu.se)

According to the Ebers medical papyrus, hard tumours were treated by placing a poultice near the tumour, followed by local incision. (wikipedia.org)
Therefore, the types of ious forms of radiation, carcinogen ifested as a higher incidence of the tumours that occur during childhood ic infectious agents, and chemicals same kinds of tumours that occur in in humans, including various embry and chemical mixtures. (who.int)
This chapter exposed adults, with a shorter laten onal solid tumours, are observed as summarizes the literature that docu cy period from the time of exposure tumours of adult life in conventional ments this high susceptibility of the to the carcinogen until the appear rodents. (who.int)

However, efforts to exploit this phenomenon have fallen short, with experimental drug-loaded particles failing because they can't get through the dense extracellular matrix or they lose the therapeutic payload en route to the tumor's interior. (nanowerk.com)
The researchers created a "protocell," a nanoparticle that can carve through the extracellular matrix, delivering cell-killing doses of drug to the deepest tumor regions. (nanowerk.com)
They surrounded this skeleton with a lipid bilayer outfitted with an array of tools to help the protocell deliver its drug arsenal to the desired locale, including enzymes that cleave collagen, a major component of the tumor's extracellular matrix. (nanowerk.com)

Hingegen scheint gemäss nichtklinischen Modellen der Antitumor-Effekt des Medikamentenkandidaten von der insgesamt vom Tumor aufgenommenen Wirkstoffmenge (Area under the Curve, AUC) bestimmt zu werden. (basilea.com)

The monitoring and treatment of oral mucositis lesions in children and adolescents undergoing chemotherapy are necessary to prevent the patient from suffering from induced comorbidities. (bvsalud.org)

The HER (erbB) family of transmembrane receptor tyrosine kinases is one of the cytostatic targets in tumor cell growth and survival. (medscape.com)
Hematopoietic stem cell transplantation not responded to other therapeutic modalities, with (HSCT) is used in children as a definitive treatment an increase in survival after transplantation, for different oncological, immune deficiencies, contributing to its use (YEILIPEK, 2014). (bvsalud.org)

More important, Zhou says, is that the microbe can also prompt a strong immune response against the tumor. (voanews.com)
Consequently, they thrived in the hypoxic/necrotic regions of tumors to evade clearance by the immune system. (nature.com)

PAVO is an open-label Phase II study investigating if the study drug, a PARP inhibitor called niraparib (Zejula), is safe and effective for certain people who have been diagnosed with an advanced solid tumor with either an inherited or tumor PALB2 mutation. (facingourrisk.org)

Anatomy11

Organisms5

Diseases55

Chemicals and Drugs79

Analytical, Diagnostic and Therapeutic Techniques and Equipment62

Phenomena and Processes52

Disciplines and Occupations4

Technology, Industry, Agriculture5

Information Science4

Health Care19

Microenvironment7

Therapies12

Efficacy13

Cancers14

Anti-tumor activity1

Patients37

Adult Brain Tumor Cons1

Several solid tumors2

Destroy the tumor cells2

Growth of tumor cells2

Therapy49

Adjuvant3

Tissue12

Cancerous tumors2

Malignant tumors3

Shrink1

Blood vessels3

Surgical6

Therapeutics2

Inhibit2

Unresectable1

Colorectal3

Bilateral3

Angiogenesis1

Vasculature1

Malignancies3

Chemotherapeutic4

Prognosis1

Cancer62

Advanced or metastatic2

Tissues5

Block tumor1

Primary tumor2

Cytotoxic2

Lesion1

Dose5

Approaches2

Remission1

Radiotherapy2

Recurrence1

Wilms8

Cells11

Clinical4

Resistance4

Checkpoint controller1

Malignancy2

Surgery2

Tumours3

Extracellular matrix3

Area under1

Children and adolescents1

Survival2

Immune2

PARP Inhibitor1